APGE

SEC source: 0001104659-26-027802 · tm268769-1_4seq1.xml · nonDerivative · entry 2

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,156,405

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $74.525 to $75.400, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-027802 · tm268769-1_4seq1.xml · nonDerivative · entry 1

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,164,624

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $73.525 to $74.520, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-024831 · tm268128-1_4seq1.xml · derivative · entry 5

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 131,290

Underlying: Common Stock · 4,125 shares

Expires 2033-12-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: This option represents the right to purchase 175,345 shares of the Issuer's common stock, which will vest in forty-eight equal monthly installments through December 18, 2027, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001104659-26-024831 · tm268128-1_4seq1.xml · nonDerivative · entry 4

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 209,773

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

F4 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $73.20 to $73.31, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-024831 · tm268128-1_4seq1.xml · nonDerivative · entry 3

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 209,973

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $71.51 to $72.45, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-024831 · tm268128-1_4seq1.xml · nonDerivative · entry 2

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 212,048

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $70.30 to $70.82, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission ("SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-024831 · tm268128-1_4seq1.xml · nonDerivative · entry 1

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 215,273

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-26-023651 · tm267888-1_4seq1.xml · nonDerivative · entry 4

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 181,371

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 2, 2025.

F5 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $71.04 to $71.98, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-023651 · tm267888-1_4seq1.xml · nonDerivative · entry 3

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 181,777

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 2, 2025.

F4 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $70.03 to $70.91, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-023651 · tm267888-1_4seq1.xml · nonDerivative · entry 2

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 182,771

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 2, 2025.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $68.91 to $69.78, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-023651 · tm267888-1_4seq1.xml · nonDerivative · entry 1

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 183,071

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 2, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $67.77 to $68.55, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-015453 · tm266326-1_4seq1.xml · nonDerivative · entry 3

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,172,987

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F4 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $64.95 to $65.50, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-015453 · tm266326-1_4seq1.xml · nonDerivative · entry 2

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,173,942

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $63.33 to $64.32, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-015453 · tm266326-1_4seq1.xml · nonDerivative · entry 1

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,181,493

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $62.33 to $63.32, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-010454 · tm265045-2_4seq1.xml · derivative · entry 7

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 135,415

Underlying: Common Stock · 4,125 shares

Expires 2033-12-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · derivative.exercise_date: This option represents the right to purchase 175,345 shares of the Issuer's common stock, which will vest in forty-eight equal monthly installments through December 18, 2027, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001104659-26-010454 · tm265045-2_4seq1.xml · nonDerivative · entry 6

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 211,148

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

F6 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $68.90 to $68.98, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-010454 · tm265045-2_4seq1.xml · nonDerivative · entry 5

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 211,348

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

F5 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $67.80 to $67.95, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-010454 · tm265045-2_4seq1.xml · nonDerivative · entry 4

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 211,448

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

F4 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $66.37 to $67.24, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-010454 · tm265045-2_4seq1.xml · nonDerivative · entry 3

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 212,747

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $65.27 to $66.25, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-010454 · tm265045-2_4seq1.xml · nonDerivative · entry 2

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 214,167

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $64.24 to $65.22, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission ("SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-010454 · tm265045-2_4seq1.xml · nonDerivative · entry 1

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 216,648

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-26-010453 · tm265045-1_4seq1.xml · nonDerivative · entry 3

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 183,371

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 2, 2025.

SEC source: 0001104659-26-010453 · tm265045-1_4seq1.xml · nonDerivative · entry 2

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 183,471

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 2, 2025.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $65.84 to $66.75, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-010453 · tm265045-1_4seq1.xml · nonDerivative · entry 1

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 184,579

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 2, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $64.80 to $65.61, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-005921 · tm263873-1_4seq1.xml · nonDerivative · entry 1

Fairmount Funds Management LLC · CIK 0001802528 · Director

Fairmount Healthcare Fund II L.P. · CIK 0001769651 · Director

Kiselak Tomas · CIK 0001830177 · Director

Harwin Peter Evan · CIK 0001663607 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By Fairmount Healthcare Fund II LP

Disclosed balance after: 298,647

F1 · ownership.nature: Fairmount Funds Management LLC ("Fairmount") is the investment manager for Fairmount Healthcare Fund II L.P. The managers of Fairmount are Peter Harwin and Tomas Kiselak. Fairmount, Mr. Harwin, and Mr. Kiselak disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

SEC source: 0001104659-26-004659 · tm263357-1_4seq1.xml · nonDerivative · entry 6

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,192,987

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F7 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $83.73 to $83.84, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-004659 · tm263357-1_4seq1.xml · nonDerivative · entry 5

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,193,457

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F6 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $82.71 to $83.68, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-004659 · tm263357-1_4seq1.xml · nonDerivative · entry 4

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,198,843

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F5 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $81.70 to $82.69, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-004659 · tm263357-1_4seq1.xml · nonDerivative · entry 3

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,200,697

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F4 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $80.69 to $81.55, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-004659 · tm263357-1_4seq1.xml · nonDerivative · entry 2

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,203,071

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $79.28 to $80.02, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-004659 · tm263357-1_4seq1.xml · nonDerivative · entry 1

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,211,547

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $78.16 to $79.10, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-002574 · tm262641-1_4seq1.xml · derivative · entry 6

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 139,540

Underlying: Common Stock · 14,025 shares

Expires 2033-12-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: This option represents the right to purchase 175,345 shares of the Issuer's common stock, which will vest in forty-eight equal monthly installments through December 18, 2027, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001104659-26-002574 · tm262641-1_4seq1.xml · nonDerivative · entry 5

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 212,523

F2 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

SEC source: 0001104659-26-002574 · tm262641-1_4seq1.xml · nonDerivative · entry 4

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 212,623

F2 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

F5 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $78.70 to $79.24, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-002574 · tm262641-1_4seq1.xml · nonDerivative · entry 3

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 213,449

F2 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

F4 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $77.45 to $78.44, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-002574 · tm262641-1_4seq1.xml · nonDerivative · entry 2

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 228,269

F2 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $76.44 to $77.43, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission ("SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-002574 · tm262641-1_4seq1.xml · nonDerivative · entry 1

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 231,223

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Due to an administrative error, the amount reported in Column 5 on the reporting person's Form 4 filed on October 3, 2025 was overstated by 53,910 shares. As a result, the beneficial ownership totals reported in the reporting person's Forms 4 filed after October 3, 2025 were each overstated by 53,910 shares. This Form 4 reflects the correct amount of common stock beneficially owned by the reporting person.

SEC source: 0001104659-26-001483 · tm261906-1_4seq1.xml · nonDerivative · entry 3

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 185,371

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 27, 2024.

SEC source: 0001104659-26-001483 · tm261906-1_4seq1.xml · derivative · entry 4

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 83,690

Underlying: Common Stock · 83,690 shares

Expires 2036-01-02

F4 · derivative.exercise_date: This option represents the right to purchase 83,690 shares of the Issuer's common stock, which will vest in forty-eight equal monthly installments over a four-year period from the date of grant, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001104659-26-001483 · tm261906-1_4seq1.xml · nonDerivative · entry 2

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 187,371

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 27, 2024.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $74.73 to $75.67, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-001483 · tm261906-1_4seq1.xml · nonDerivative · entry 1

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 191,451

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 27, 2024.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $73.67 to $74.65, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-001484 · tm261906-3_4seq1.xml · derivative · entry 1

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 253,016

Underlying: Common Stock · 253,016 shares

Expires 2036-01-02

F1 · derivative.exercise_date: This option represents the right to purchase 253,016 shares of the Issuer's common stock, which will vest in forty-eight equal monthly installments over a four-year period from the date of grant, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001104659-26-001485 · tm261906-2_4seq1.xml · derivative · entry 1

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 83,690

Underlying: Common Stock · 83,690 shares

Expires 2036-01-02

F1 · derivative.exercise_date: This option represents the right to purchase 83,690 shares of the Issuer's common stock, which will vest in forty-eight equal monthly installments over a four-year period from the date of grant, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001104659-25-124354 · tm2534063-1_4seq1.xml · nonDerivative · entry 1

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 193,371

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 27, 2024.

SEC source: 0001104659-25-120758 · tm2533301-1_4seq1.xml · nonDerivative · entry 3

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,212,987

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

SEC source: 0001104659-25-120758 · tm2533301-1_4seq1.xml · nonDerivative · entry 2

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,213,547

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $75.30 to $76.28, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-25-120758 · tm2533301-1_4seq1.xml · nonDerivative · entry 1

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,223,552

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $74.30 to $75.29, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-25-118985 · tm2532835-2_4seq1.xml · nonDerivative · entry 1

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 194,871

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 27, 2024.

SEC source: 0001104659-25-118983 · tm2532835-1_4seq1.xml · nonDerivative · entry 1

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,232,987

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $75.00 to $75.24, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-25-118986 · tm2532835-3_4seq1.xml · nonDerivative · entry 1

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 271,108

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 21, 2024.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $75.00 to $75.01, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.