APGE

SEC source: 0001104659-26-092838 · tm2622546-1_4seq1.xml · nonDerivative · entry 2

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 168,498

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

SEC source: 0001104659-26-092838 · tm2622546-1_4seq1.xml · nonDerivative · entry 1

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 173,998

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-26-086729 · tm2621304-1_4seq1.xml · nonDerivative · entry 1

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 158,371

F1 · kind: This transaction involves a bona fide gift of securities from the reporting person to a donor advised fund.

SEC source: 0001104659-26-084344 · tm2620587-1_4seq1.xml · nonDerivative · entry 1

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 169,873

F1 · kind: This transaction involves a bona fide gift of securities from the reporting person to a donor advised fund.

SEC source: 0001104659-26-082758 · tm2620107-1_4seq1.xml · nonDerivative · entry 2

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 920,941

F3 · kind: This transaction involves a bona fide gift of securities from the reporting person to a donor advised fund.

SEC source: 0001104659-26-082758 · tm2620107-1_4seq1.xml · nonDerivative · entry 1

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 995,987

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $133.52 to $133.70, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-080477 · tm2619720-1_4seq1.xml · derivative · entry 3

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 114,790

Underlying: Common Stock · 4,125 shares

Expires 2033-12-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: This option represents the right to purchase 175,345 shares of the Issuer's common stock, which will vest in forty-eight equal monthly installments through December 18, 2027, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001104659-26-080477 · tm2619720-1_4seq1.xml · nonDerivative · entry 2

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 177,873

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

SEC source: 0001104659-26-080477 · tm2619720-1_4seq1.xml · nonDerivative · entry 1

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 183,373

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-26-077426 · tm2618514-2_4seq1.xml · nonDerivative · entry 1

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,015,987

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $132.50 to $132.68, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-077427 · tm2618514-1_4seq1.xml · nonDerivative · entry 1

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 179,248

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $132.550 to $132.645, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-073567 · tm2617750-1_4seq1.xml · nonDerivative · entry 6

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,095,987

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F7 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $86.835 to $87.165, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-073567 · tm2617750-1_4seq1.xml · nonDerivative · entry 5

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,096,601

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F6 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $85.74 to $86.70, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-073567 · tm2617750-1_4seq1.xml · nonDerivative · entry 4

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,098,906

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F5 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $84.71 to $85.665, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-073567 · tm2617750-1_4seq1.xml · nonDerivative · entry 3

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,100,483

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F4 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $83.595 to $84.50, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-073567 · tm2617750-1_4seq1.xml · nonDerivative · entry 2

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,101,563

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $82.57 to $83.33, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-073567 · tm2617750-1_4seq1.xml · nonDerivative · entry 1

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,109,217

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $81.57 to $82.56, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-073061 · tm2617578-6_4seq1.xml · derivative · entry 1

Shah Nimish P · CIK 0001698082 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,657

Underlying: Common Stock · 7,657 shares

Expires 2036-06-09

F1 · derivative.exercise_date: This option represents the right to purchase 7,657 shares of the Issuer's common stock and will vest on the one-year anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer on such vesting date.

F2 · ownership.direct: Under an agreement between the Reporting Person and Venrock Management, LLC (the "Management Company"), the Reporting Person is deemed to hold the reported option and the shares underlying the option for the sole benefit of the Management Company and must exercise the reported option solely upon the direction of the Management Company, which is entitled to the shares underlying the option. The Management Company may be deemed the indirect beneficial owner of the shares underlying the option, and the Reporting Person may be deemed the indirect beneficial owner of the reported shares underlying the option through his interest in the Management Company. The Reporting Person disclaims beneficial ownership of the reported shares except to the extent of his pecuniary interest therein.

SEC source: 0001104659-26-073059 · tm2617578-1_4seq1.xml · derivative · entry 1

JONES WILLIAM A JR · CIK 0001373097 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,657

Underlying: Common Stock · 7,657 shares

Expires 2036-06-09

F1 · derivative.exercise_date: This option represents the right to purchase 7,657 shares of the Issuer's common stock and will vest on the one-year anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer on such vesting date.

SEC source: 0001104659-26-073060 · tm2617578-5_4seq1.xml · derivative · entry 1

McKenna Mark C. · CIK 0001749623 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,657

Underlying: Common Stock · 7,657 shares

Expires 2036-06-09

F1 · derivative.exercise_date: This option represents the right to purchase 7,657 shares of the Issuer's common stock and will vest on the one-year anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer on such vesting date.

SEC source: 0001104659-26-073062 · tm2617578-2_4seq1.xml · derivative · entry 1

Fairmount Funds Management LLC · CIK 0001802528 · Director

Kiselak Tomas · CIK 0001830177 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By: Tomas Kiselak

Disclosed balance after: 7,657

Underlying: Common Stock · 7,657 shares

Expires 2036-06-09

F1 · derivative.exercise_date: This option represents the right to purchase 7,657 shares of the Issuer's common stock and will vest on the one-year anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer on such vesting date.

F2 · ownership.direct: Under Mr. Kiselak's arrangement with Fairmount Funds Management LLC ('Fairmount'), Mr. Kiselak holds the option for one or more investment vehicles managed by Fairmount (each, a "Fairmount Fund"). Mr. Kiselak is obligated to turn over to Fairmount any net cash or stock received from the option for the benefit of such Fairmount Fund. Mr. Kiselak therefore disclaims beneficial ownership of the option and underlying common stock. Fairmount disclaims beneficial ownership of any of the reported securities, except to the extent of its pecuniary interest therein.

SEC source: 0001104659-26-073058 · tm2617578-3_4seq1.xml · derivative · entry 1

Fox Jennifer A. · CIK 0001841557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,657

Underlying: Common Stock · 7,657 shares

Expires 2036-06-09

F1 · derivative.exercise_date: This option represents the right to purchase 7,657 shares of the Issuer's common stock and will vest on the one-year anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer on such vesting date.

SEC source: 0001104659-26-073056 · tm2617578-4_4seq1.xml · derivative · entry 1

Bollinger Lisa · CIK 0002024557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,657

Underlying: Common Stock · 7,657 shares

Expires 2036-06-09

F1 · derivative.exercise_date: This option represents the right to purchase 7,657 shares of the Issuer's common stock and will vest on the one-year anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer on such vesting date.

SEC source: 0001104659-26-071076 · tm2616980-1_4seq1.xml · derivative · entry 3

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 118,915

Underlying: Common Stock · 4,125 shares

Expires 2033-12-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: This option represents the right to purchase 175,345 shares of the Issuer's common stock, which will vest in forty-eight equal monthly installments through December 18, 2027, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001104659-26-071076 · tm2616980-1_4seq1.xml · nonDerivative · entry 2

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 205,648

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

SEC source: 0001104659-26-071076 · tm2616980-1_4seq1.xml · nonDerivative · entry 1

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 211,148

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-26-062867 · tm2614621-1_4seq1.xml · nonDerivative · entry 2

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,115,987

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $82.470 to $83.265, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-062867 · tm2614621-1_4seq1.xml · nonDerivative · entry 1

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,117,328

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $81.455 to $82.440, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-058129 · tm2613976-1_4seq1.xml · derivative · entry 4

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 123,040

Underlying: Common Stock · 4,125 shares

Expires 2033-12-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: This option represents the right to purchase 175,345 shares of the Issuer's common stock, which will vest in forty-eight equal monthly installments through December 18, 2027, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001104659-26-058129 · tm2613976-1_4seq1.xml · nonDerivative · entry 3

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 207,023

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $84.44 to $84.69, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-058129 · tm2613976-1_4seq1.xml · nonDerivative · entry 2

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 208,823

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $83.35 to $84.28, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission ("SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-058129 · tm2613976-1_4seq1.xml · nonDerivative · entry 1

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 212,523

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-26-055091 · tm2613425-1_4seq1.xml · nonDerivative · entry 3

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 173,371

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 2, 2025.

F4 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $83.090 to $83.190, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-055091 · tm2613425-1_4seq1.xml · nonDerivative · entry 2

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 173,660

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 2, 2025.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $82.040 to $82.995, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-055091 · tm2613425-1_4seq1.xml · nonDerivative · entry 1

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 174,560

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 2, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $80.640 to $81.260, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-045062 · tm2612090-1_4seq1.xml · nonDerivative · entry 1

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 175,371

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 2, 2025.

SEC source: 0001104659-26-045482 · tm2612090-2_4seq1.xml · derivative · entry 2

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 387,012

Underlying: Common Stock · 3,000 shares

Expires 2033-12-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: This option represents the right to purchase 398,512 shares of the Issuer's common stock, which will vest in forty-eight equal monthly installments over a four-year period from the date of grant, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001104659-26-045482 · tm2612090-2_4seq1.xml · nonDerivative · entry 1

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,135,987

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-26-042155 · tm2611503-1_4seq1.xml · nonDerivative · entry 3

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,132,987

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

SEC source: 0001104659-26-042155 · tm2611503-1_4seq1.xml · nonDerivative · entry 2

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,133,187

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $83.00 to $83.50, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-042155 · tm2611503-1_4seq1.xml · nonDerivative · entry 1

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,135,187

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $82.00 to $82.97, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-039708 · tm2611042-2_4seq1.xml · nonDerivative · entry 2

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 177,371

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 2, 2025.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $85.17 to $85.79, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-039708 · tm2611042-2_4seq1.xml · nonDerivative · entry 1

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 178,471

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 2, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $84.15 to $85.05, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission ("SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-039709 · tm2611042-1_4seq1.xml · derivative · entry 5

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 127,165

Underlying: Common Stock · 4,125 shares

Expires 2033-12-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: This option represents the right to purchase 175,345 shares of the Issuer's common stock, which will vest in forty-eight equal monthly installments through December 18, 2027, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001104659-26-039709 · tm2611042-1_4seq1.xml · nonDerivative · entry 4

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 208,398

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

SEC source: 0001104659-26-039709 · tm2611042-1_4seq1.xml · nonDerivative · entry 3

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 208,498

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $84.87 to $85.80, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-039709 · tm2611042-1_4seq1.xml · nonDerivative · entry 2

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 211,200

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 22, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $83.87 to $84.84, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission ("SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-26-039709 · tm2611042-1_4seq1.xml · nonDerivative · entry 1

Dambkowski Carl · CIK 0001983476 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 213,898

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-26-036332 · tm269945-1_4seq1.xml · nonDerivative · entry 1

Henderson Jane · CIK 0001422304 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 179,371

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 2, 2025.

SEC source: 0001104659-26-027802 · tm268769-1_4seq1.xml · nonDerivative · entry 3

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,152,987

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025.

F4 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $75.585 to $76.480, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.