AORT

SEC source: 0000784199-24-000061 · wk-form4_1709157861.xml · nonDerivative · entry 4

GREEN ANDREW M · CIK 0001191000 · VP Regulatory

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 44,544

F2 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-24-000061 · wk-form4_1709157861.xml · nonDerivative · entry 2

GREEN ANDREW M · CIK 0001191000 · VP Regulatory

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,848

F2 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-24-000059 · wk-form4_1709157669.xml · nonDerivative · entry 4

Stanton Marshall S. · CIK 0001849615 · SVP, Clinical & MD Affair

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 81,685

F2 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-24-000059 · wk-form4_1709157669.xml · nonDerivative · entry 2

Stanton Marshall S. · CIK 0001849615 · SVP, Clinical & MD Affair

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 72,489

F2 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-24-000057 · wk-form4_1709157504.xml · nonDerivative · entry 1

Tyrs Florian · CIK 0001983377 · VP, Global Operations

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,897

F1 · shares: These shares were sold upon the vesting of restricted stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-24-000156 · wk-form4a_1710463100.xml · nonDerivative · entry 4

Horton Amy · CIK 0001371523 · VP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 137,888

F5 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction. This amendment is being filed to address an administrative error in reporting the number of shares sold in the sell to cover transaction on February 26, 2024. The original Form 4 reported that 980 shares were sold, when in fact, 966 shares were sold.

F3 · balance_after: As a result of the administrative error in reporting the number of shares sold in the sell to cover transactions on February 26, 2024, the number of shares reported as beneficially owned in this amendment reflects an increase in the number of shares reported as beneficially owned in the original Form 4.

SEC source: 0000784199-24-000156 · wk-form4a_1710463100.xml · nonDerivative · entry 2

Horton Amy · CIK 0001371523 · VP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 132,436

F2 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction. This amendment is being filed to address an administrative error in reporting the number of shares sold in the sell to cover transaction on February 26, 2024. The original Form 4 reported that 1,186 shares were sold, when in fact, 1,168 shares were sold.

F3 · balance_after: As a result of the administrative error in reporting the number of shares sold in the sell to cover transactions on February 26, 2024, the number of shares reported as beneficially owned in this amendment reflects an increase in the number of shares reported as beneficially owned in the original Form 4.

SEC source: 0000784199-24-000154 · wk-form4a_1710462983.xml · nonDerivative · entry 4

Stanton Marshall S. · CIK 0001849615 · SVP, Clinical & MD Affair

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 81,726

F5 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction. This amendment is being filed to address an administrative error in reporting the number of shares sold in the sell to cover transaction on February 26, 2024. The original Form 4 reported that 1,448 shares were sold, when in fact, 1,431 shares were sold.

F3 · balance_after: As a result of the administrative error in reporting the number of shares sold in the sell to cover transactions on February 26, 2024, the number of shares reported as beneficially owned in this amendment reflects an increase in the number of shares reported as beneficially owned in the original Form 4.

SEC source: 0000784199-24-000154 · wk-form4a_1710462983.xml · nonDerivative · entry 2

Stanton Marshall S. · CIK 0001849615 · SVP, Clinical & MD Affair

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 72,513

F2 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction. This amendment is being filed to address an administrative error in reporting the number of shares sold in the sell to cover transaction on February 26, 2024. The original Form 4 reported that 1,600 shares were sold, when in fact, 1,576 shares were sold.

F3 · balance_after: As a result of the administrative error in reporting the number of shares sold in the sell to cover transactions on February 26, 2024, the number of shares reported as beneficially owned in this amendment reflects an increase in the number of shares reported as beneficially owned in the original Form 4.

SEC source: 0000784199-24-000152 · wk-form4a_1710462815.xml · nonDerivative · entry 4

Maney Rochelle L. · CIK 0001850597 · VP, Quality

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 44,518

F5 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction. This amendment is being filed to address an administrative error in reporting the number of shares sold in the sell to cover transaction on February 26, 2024. The original Form 4 reported that 1,130 shares were sold, when in fact, 1,114 shares were sold.

F3 · balance_after: As a result of the administrative error in reporting the number of shares sold in the sell to cover transactions on February 26, 2024, the number of shares reported as beneficially owned in this amendment reflects an increase in the number of shares reported as beneficially owned in the original Form 4.

SEC source: 0000784199-24-000152 · wk-form4a_1710462815.xml · nonDerivative · entry 2

Maney Rochelle L. · CIK 0001850597 · VP, Quality

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,214

F2 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction. This amendment is being filed to address an administrative error in reporting the number of shares sold in the sell to cover transaction on February 26, 2024. The original Form 4 reported that 1,185 shares were sold, when in fact, 1,168 shares were sold.

F3 · balance_after: As a result of the administrative error in reporting the number of shares sold in the sell to cover transactions on February 26, 2024, the number of shares reported as beneficially owned in this amendment reflects an increase in the number of shares reported as beneficially owned in the original Form 4.

SEC source: 0000784199-24-000150 · wk-form4a_1710462676.xml · nonDerivative · entry 4

Holloway Jean F · CIK 0001540065 · SVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 166,852

F5 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction. This amendment is being filed to address an administrative error in reporting the number of shares sold in the sell to cover transaction on February 26, 2024. The original Form 4 reported that 1,566 shares were sold, when in fact, 1,543 shares were sold.

F3 · balance_after: As a result of the administrative error in reporting the number of shares sold in the sell to cover transactions on February 26, 2024, the number of shares reported as beneficially owned in this amendment reflects an increase in the number of shares reported as beneficially owned in the original Form 4.

SEC source: 0000784199-24-000150 · wk-form4a_1710462676.xml · nonDerivative · entry 2

Holloway Jean F · CIK 0001540065 · SVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 155,559

F2 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction. This amendment is being filed to address an administrative error in reporting the number of shares sold in the sell to cover transaction on February 26, 2024. The original Form 4 reported that 1,314 shares were sold, when in fact, 1,295 shares were sold.

F3 · balance_after: As a result of the administrative error in reporting the number of shares sold in the sell to cover transactions on February 26, 2024, the number of shares reported as beneficially owned in this amendment reflects an increase in the number of shares reported as beneficially owned in the original Form 4.

SEC source: 0000784199-24-000148 · wk-form4a_1710462542.xml · nonDerivative · entry 4

GREEN ANDREW M · CIK 0001191000 · VP Regulatory

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 44,580

F5 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction. This amendment is being filed to address an administrative error in reporting the number of shares sold in the sell to cover transaction on February 26, 2024. The original Form 4 reported that 1,218 shares were sold, when in fact, 1,199 shares were sold.

F3 · balance_after: As a result of the administrative error in reporting the number of shares sold in the sell to cover transactions on February 26, 2024, the number of shares reported as beneficially owned in this amendment reflects an increase in the number of shares reported as beneficially owned in the original Form 4.

SEC source: 0000784199-24-000148 · wk-form4a_1710462542.xml · nonDerivative · entry 2

GREEN ANDREW M · CIK 0001191000 · VP Regulatory

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,865

F2 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction. This amendment is being filed to address an administrative error in reporting the number of shares sold in the sell to cover transaction on February 26, 2024. The original Form 4 reported that 1,185 shares were sold, when in fact, 1,168 shares were sold.

F3 · balance_after: As a result of the administrative error in reporting the number of shares sold in the sell to cover transactions on February 26, 2024, the number of shares reported as beneficially owned in this amendment reflects an increase in the number of shares reported as beneficially owned in the original Form 4.

SEC source: 0000784199-24-000146 · wk-form4a_1710462424.xml · nonDerivative · entry 4

Davis John E · CIK 0001653206 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 162,572

F5 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction. This amendment is being filed to address an administrative error in reporting the number of shares sold in the sell to cover transaction on February 26, 2024. The original Form 4 reported that 1,904 shares were sold, when in fact, 1,875 shares were sold.

F3 · balance_after: As a result of the administrative error in reporting the number of shares sold in the sell to cover transactions on February 26, 2024, the number of shares reported as beneficially owned in this amendment reflects an increase in the number of shares reported as beneficially owned in the original Form 4.

SEC source: 0000784199-24-000146 · wk-form4a_1710462424.xml · nonDerivative · entry 2

Davis John E · CIK 0001653206 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 151,711

F2 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction. This amendment is being filed to address an administrative error in reporting the number of shares sold in the sell to cover transaction on February 26, 2024. The original Form 4 reported that 1,610 shares were sold, when in fact, 1,586 shares were sold.

F3 · balance_after: As a result of the administrative error in reporting the number of shares sold in the sell to cover transactions on February 26, 2024, the number of shares reported as beneficially owned in this amendment reflects an increase in the number of shares reported as beneficially owned in the original Form 4.

SEC source: 0000784199-24-000134 · wk-form4a_1710461680.xml · nonDerivative · entry 4

Mackin James P · CIK 0001408470 · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 696,253

F5 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction. This amendment is being filed to address an administrative error in reporting the number of shares sold in the sell to cover transaction on February 26, 2024. The original Form 4 reported that 13,168 shares were sold, when in fact, 12,968 shares were sold.

F3 · balance_after: As a result of the administrative error in reporting the number of shares sold in the sell to cover transactions on February 26, 2024, the number of shares reported as beneficially owned in this amendment reflects an increase in the number of shares reported as beneficially owned in the original Form 4.

SEC source: 0000784199-24-000134 · wk-form4a_1710461680.xml · nonDerivative · entry 2

Mackin James P · CIK 0001408470 · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 650,573

F2 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction. This amendment is being filed to address an administrative error in reporting the number of shares sold in the sell to cover transaction on February 26, 2024. The original Form 4 reported that 18,144 shares were sold, when in fact, 17,868 shares were sold.

F3 · balance_after: As a result of the administrative error in reporting the number of shares sold in the sell to cover transactions on February 26, 2024, the number of shares reported as beneficially owned in this amendment reflects an increase in the number of shares reported as beneficially owned in the original Form 4.

SEC source: 0000784199-24-000126 · wk-form4a_1710461069.xml · nonDerivative · entry 4

Getz Matthew A · CIK 0001784253 · VP, Human Resources

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,440

F5 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction. This amendment is being filed to address an administrative error in reporting the number of shares sold in the sell to cover transaction on February 26, 2024. The original Form 4 reported that 1,128 shares were sold, when in fact, 1,112 shares were sold.

F3 · balance_after: As a result of the administrative error in reporting the number of shares sold in the sell to cover transactions on February 26, 2024, the number of shares reported as beneficially owned in this amendment reflects an increase in the number of shares reported as beneficially owned in the original Form 4.

SEC source: 0000784199-24-000126 · wk-form4a_1710461069.xml · nonDerivative · entry 2

Getz Matthew A · CIK 0001784253 · VP, Human Resources

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,140

F2 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction. This amendment is being filed to address an administrative error in reporting the number of shares sold in the sell to cover transaction on February 26, 2024. The original Form 4 reported that 1,185 shares were sold, when in fact, 1,168 shares were sold.

F3 · balance_after: As a result of the administrative error in reporting the number of shares sold in the sell to cover transactions on February 26, 2024, the number of shares reported as beneficially owned in this amendment reflects an increase in the number of shares reported as beneficially owned in the original Form 4.

SEC source: 0000784199-24-000055 · wk-form4_1708989230.xml · nonDerivative · entry 1

Berry Lance A · CIK 0001478716 · Executive VP, CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 79,064

F1 · shares: Represents shares of restricted stock that vest 33 1/3% per year beginning on the first anniversary of the grant date, pursuant to the terms of the Equity and Cash Incentive Plan.

SEC source: 0000784199-24-000053 · wk-form4_1708989044.xml · nonDerivative · entry 1

Davis John E · CIK 0001653206 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 147,911

F1 · shares: Represents shares of restricted stock that vest 33 1/3% per year beginning on the first anniversary of the grant date, pursuant to the terms of the Equity and Cash Incentive Plan.

SEC source: 0000784199-24-000051 · wk-form4_1708988912.xml · nonDerivative · entry 1

Getz Matthew A · CIK 0001784253 · VP, Human Resources

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,942

F1 · shares: Represents shares of restricted stock that vest 33 1/3% per year beginning on the first anniversary of the grant date, pursuant to the terms of the Equity and Cash Incentive Plan.

SEC source: 0000784199-24-000049 · wk-form4_1708988699.xml · nonDerivative · entry 1

GREEN ANDREW M · CIK 0001191000 · VP Regulatory

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,667

F1 · shares: Represents shares of restricted stock that vest 33 1/3% per year beginning on the first anniversary of the grant date, pursuant to the terms of the Equity and Cash Incentive Plan.

SEC source: 0000784199-24-000047 · wk-form4_1708988421.xml · nonDerivative · entry 1

Holloway Jean F · CIK 0001540065 · SVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 151,468

F1 · shares: Represents shares of restricted stock that vest 33 1/3% per year beginning on the first anniversary of the grant date, pursuant to the terms of the Equity and Cash Incentive Plan.

SEC source: 0000784199-24-000045 · wk-form4_1708988273.xml · nonDerivative · entry 1

Horton Amy · CIK 0001371523 · VP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 130,238

F1 · shares: Represents shares of restricted stock that vest 33 1/3% per year beginning on the first anniversary of the grant date, pursuant to the terms of the Equity and Cash Incentive Plan.

SEC source: 0000784199-24-000043 · wk-form4_1708988118.xml · nonDerivative · entry 1

Mackin James P · CIK 0001408470 · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 628,037

F1 · shares: Represents shares of restricted stock that vest 33 1/3% per year beginning on the first anniversary of the grant date, pursuant to the terms of the Equity and Cash Incentive Plan.

SEC source: 0000784199-24-000041 · wk-form4_1708987968.xml · nonDerivative · entry 1

Maney Rochelle L. · CIK 0001850597 · VP, Quality

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,016

F1 · shares: Represents shares of restricted stock that vest 33 1/3% per year beginning on the first anniversary of the grant date, pursuant to the terms of the Equity and Cash Incentive Plan.

SEC source: 0000784199-24-000039 · wk-form4_1708987779.xml · nonDerivative · entry 1

Stanton Marshall S. · CIK 0001849615 · SVP, Clinical & MD Affair

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 68,703

F1 · shares: Represents shares of restricted stock that vest 33 1/3% per year beginning on the first anniversary of the grant date, pursuant to the terms of the Equity and Cash Incentive Plan.

SEC source: 0000784199-24-000037 · wk-form4_1708987643.xml · nonDerivative · entry 1

THOMSON ROBERT C · CIK 0001980521 · VP Research & Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,291

F1 · shares: Represents shares of restricted stock that vest 33 1/3% per year beginning on the first anniversary of the grant date, pursuant to the terms of the Equity and Cash Incentive Plan.

SEC source: 0000784199-24-000035 · wk-form4_1708987478.xml · nonDerivative · entry 1

Tyrs Florian · CIK 0001983377 · VP, Global Operations

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,790

F1 · shares: Represents shares of restricted stock that vest 33 1/3% per year beginning on the first anniversary of the grant date, pursuant to the terms of the Equity and Cash Incentive Plan.

SEC source: 0000784199-24-000074 · wk-form4_1709159070.xml · nonDerivative · entry 3

Horton Amy · CIK 0001371523 · VP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 138,836

F3 · shares: Represents performance stock units granted on Feb. 22, 2023. Fifty percent (50%) were issued on Feb. 23, 2024. The remaining shares earned in connection with the Feb. 2023 grant will be eligible to vest and be issued as follows: 25% on 02/22/2025; and 25% on 02/22/2026, assuming employment on the relevant vesting date.

SEC source: 0000784199-24-000074 · wk-form4_1709159070.xml · nonDerivative · entry 1

Horton Amy · CIK 0001371523 · VP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 133,604

F1 · shares: Represents performance stock units granted on Feb. 22, 2023. One hundred percent (100%) were issued on Feb. 23, 2024.

SEC source: 0000784199-24-000072 · wk-form4_1709158886.xml · nonDerivative · entry 3

Mackin James P · CIK 0001408470 · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 708,945

F3 · shares: Represents performance stock units granted on Feb. 22, 2023. Fifty percent (50%) were issued on Feb. 23, 2024. The remaining shares earned in connection with the Feb. 2023 grant will be eligible to vest and be issued as follows: 25% on 02/22/2025; and 25% on 02/22/2026, assuming employment on the relevant vesting date.

SEC source: 0000784199-24-000072 · wk-form4_1709158886.xml · nonDerivative · entry 1

Mackin James P · CIK 0001408470 · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 668,441

F1 · shares: Represents performance stock units granted on Feb. 22, 2023. One hundred percent (100%) were issued on Feb. 23, 2024.

SEC source: 0000784199-24-000070 · wk-form4_1709158686.xml · nonDerivative · entry 3

Holloway Jean F · CIK 0001540065 · SVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 168,376

F3 · shares: Represents performance stock units granted on Feb. 22, 2023. Fifty percent (50%) were issued on Feb. 23, 2024. The remaining shares earned in connection with the Feb. 2023 grant will be eligible to vest and be issued as follows: 25% on 02/22/2025; and 25% on 02/22/2026, assuming employment on the relevant vesting date.

SEC source: 0000784199-24-000070 · wk-form4_1709158686.xml · nonDerivative · entry 1

Holloway Jean F · CIK 0001540065 · SVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 156,854

F1 · shares: Represents performance stock units granted on Feb. 22, 2023. One hundred percent (100%) were issued on Feb. 23, 2024.

SEC source: 0000784199-24-000068 · wk-form4_1709158544.xml · nonDerivative · entry 3

Maney Rochelle L. · CIK 0001850597 · VP, Quality

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,615

F3 · shares: Represents performance stock units granted on Feb. 22, 2023. Fifty percent (50%) were issued on Feb. 23, 2024. The remaining shares earned in connection with the Feb. 2023 grant will be eligible to vest and be issued as follows: 25% on 02/22/2025; and 25% on 02/22/2026, assuming employment on the relevant vesting date.

SEC source: 0000784199-24-000068 · wk-form4_1709158544.xml · nonDerivative · entry 1

Maney Rochelle L. · CIK 0001850597 · VP, Quality

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,382

F1 · shares: Represents performance stock units granted on Feb. 22, 2023. One hundred percent (100%) were issued on Feb. 23, 2024.

SEC source: 0000784199-24-000065 · wk-form4_1709158363.xml · nonDerivative · entry 3

Davis John E · CIK 0001653206 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 164,423

F3 · shares: Represents performance stock units granted on Feb. 22, 2023. Fifty percent (50%) were issued on Feb. 23, 2024. The remaining shares earned in connection with the Feb. 2023 grant will be eligible to vest and be issued as follows: 25% on 02/22/2025; and 25% on 02/22/2026, assuming employment on the relevant vesting date.

SEC source: 0000784199-24-000065 · wk-form4_1709158363.xml · nonDerivative · entry 1

Davis John E · CIK 0001653206 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 153,297

F1 · shares: Represents performance stock units granted on Feb. 22, 2023. One hundred percent (100%) were issued on Feb. 23, 2024.

SEC source: 0000784199-24-000063 · wk-form4_1709158049.xml · nonDerivative · entry 3

Getz Matthew A · CIK 0001784253 · VP, Human Resources

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,535

F3 · shares: Represents performance stock units granted on Feb. 22, 2023. Fifty percent (50%) were issued on Feb. 23, 2024. The remaining shares earned in connection with the Feb. 2023 grant will be eligible to vest and be issued as follows: 25% on 02/22/2025; and 25% on 02/22/2026, assuming employment on the relevant vesting date.

SEC source: 0000784199-24-000063 · wk-form4_1709158049.xml · nonDerivative · entry 1

Getz Matthew A · CIK 0001784253 · VP, Human Resources

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,308

F1 · shares: Represents performance stock units granted on Feb. 22, 2023. One hundred percent (100%) were issued on Feb. 23, 2024.

SEC source: 0000784199-24-000061 · wk-form4_1709157861.xml · nonDerivative · entry 3

GREEN ANDREW M · CIK 0001191000 · VP Regulatory

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,762

F3 · shares: Represents performance stock units granted on Feb. 22, 2023. Fifty percent (50%) were issued on Feb. 23, 2024. The remaining shares earned in connection with the Feb. 2023 grant will be eligible to vest and be issued as follows: 25% on 02/22/2025; and 25% on 02/22/2026, assuming employment on the relevant vesting date.

SEC source: 0000784199-24-000061 · wk-form4_1709157861.xml · nonDerivative · entry 1

GREEN ANDREW M · CIK 0001191000 · VP Regulatory

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,033

F1 · shares: Represents performance stock units granted on Feb. 22, 2023. One hundred percent (100%) were issued on Feb. 23, 2024.

SEC source: 0000784199-24-000059 · wk-form4_1709157669.xml · nonDerivative · entry 3

Stanton Marshall S. · CIK 0001849615 · SVP, Clinical & MD Affair

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 83,133

F3 · shares: Represents performance stock units granted on Feb. 22, 2023. Fifty percent (50%) were issued on Feb. 23, 2024. The remaining shares earned in connection with the Feb. 2023 grant will be eligible to vest and be issued as follows: 25% on 02/22/2025; and 25% on 02/22/2026, assuming employment on the relevant vesting date

SEC source: 0000784199-24-000059 · wk-form4_1709157669.xml · nonDerivative · entry 1

Stanton Marshall S. · CIK 0001849615 · SVP, Clinical & MD Affair

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 74,089

F1 · shares: Represents performance stock units granted on Feb. 22, 2023. One hundred percent (100%) were issued on Feb. 23, 2024.

SEC source: 0000784199-24-000156 · wk-form4a_1710463100.xml · nonDerivative · entry 3

Horton Amy · CIK 0001371523 · VP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 138,854

F4 · shares: Represents performance stock units granted on Feb. 22, 2023. Fifty percent (50%) were issued on Feb. 23, 2024. The remaining shares earned in connection with the Feb. 2023 grant will be eligible to vest and be issued as follows: 25% on 02/22/2025; and 25% on 02/22/2026, assuming employment on the relevant vesting date.

F3 · balance_after: As a result of the administrative error in reporting the number of shares sold in the sell to cover transactions on February 26, 2024, the number of shares reported as beneficially owned in this amendment reflects an increase in the number of shares reported as beneficially owned in the original Form 4.

SEC source: 0000784199-24-000156 · wk-form4a_1710463100.xml · nonDerivative · entry 1

Horton Amy · CIK 0001371523 · VP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 133,604

F1 · shares: Represents performance stock units granted on Feb. 22, 2023. One hundred percent (100%) were issued on Feb. 23, 2024.