AORT

SEC source: 0000784199-25-000105 · wk-form4_1748376652.xml · nonDerivative · entry 1

Burbank Jeffrey H · CIK 0001341411 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,796

F1 · shares: RSA Grant vests on May 22, 2026, pursuant to the terms of the Equity and Cash Incentive Plan.

SEC source: 0000784199-25-000103 · wk-form4_1748376476.xml · nonDerivative · entry 1

Bullock James · CIK 0001172340 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 68,647

F1 · shares: RSA Grant vests on May 22, 2026, pursuant to the terms of the Equity and Cash Incentive Plan.

SEC source: 0000784199-25-000087 · wk-form4_1747852974.xml · nonDerivative · entry 1

Holloway Jean F · CIK 0001540065 · SVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 187,258

F1 · price: Reflects the price the shares were sold.

SEC source: 0000784199-25-000076 · wk-form4_1747074683.xml · nonDerivative · entry 2

Stanton Marshall S. · CIK 0001849615 · SVP, Clinical & MD Affair

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,332

F2 · price: Reflects weighted average price for Performance Stock Units. Range of prices were between $28.97 to $29.25. The reporting person will provide upon request by the Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0000784199-25-000076 · wk-form4_1747074683.xml · nonDerivative · entry 1

Stanton Marshall S. · CIK 0001849615 · SVP, Clinical & MD Affair

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 110,143

F1 · price: Reflects weighted average price for Restricted Stock Units. Range of prices were between $28.97 to $29.25. The reporting person will provide upon request by the Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0000784199-25-000061 · wk-form4_1741808467.xml · derivative · entry 3

Holloway Jean F · CIK 0001540065 · SVP, General Counsel

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 19,092 shares

Expires 2025-03-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Stock option vests 33 1/3% per year beginning on the first anniversary of the grant date. The first exercisable date was March 12, 2019.

SEC source: 0000784199-25-000061 · wk-form4_1741808467.xml · nonDerivative · entry 2

Holloway Jean F · CIK 0001540065 · SVP, General Counsel

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 197,184

F1 · shares: The sale reported on this form was effected pursuant to a 10b5-1 trading plan adopted by the reporting person on August 30, 2024.

F2 · price: Reflects weighted average price. Range of prices were between $23.220 to $23.895. The reporting person will provide upon request by the Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0000784199-25-000061 · wk-form4_1741808467.xml · nonDerivative · entry 1

Holloway Jean F · CIK 0001540065 · SVP, General Counsel

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 215,204

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: The sale reported on this form was effected pursuant to a 10b5-1 trading plan adopted by the reporting person on August 30, 2024.

SEC source: 0000784199-25-000059 · wk-form4_1741807937.xml · derivative · entry 3

Davis John E · CIK 0001653206 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 15,910 shares

Expires 2025-03-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Stock option vests 33 1/3% per year beginning on the first anniversary of the grant date. The first exercisable date was March 12, 2019.

SEC source: 0000784199-25-000059 · wk-form4_1741807937.xml · nonDerivative · entry 2

Davis John E · CIK 0001653206 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 208,778

F1 · shares: The sale reported on this form was effected pursuant to a 10b5-1 trading plan adopted by the reporting person on August 30, 2024.

F2 · price: Reflects weighted average price. Range of prices were between $23.14 to $23.89. The reporting person will provide upon request by the Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0000784199-25-000059 · wk-form4_1741807937.xml · nonDerivative · entry 1

Davis John E · CIK 0001653206 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 223,878

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: The sale reported on this form was effected pursuant to a 10b5-1 trading plan adopted by the reporting person on August 30, 2024.

SEC source: 0000784199-25-000057 · wk-form4_1741641526.xml · derivative · entry 5

Mackin James P · CIK 0001408470 · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 75,615 shares

Expires 2025-03-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: Stock option vests 33 1/3% per year beginning on the first anniversary of the grant date. The first exercisable date was March 12, 2019.

SEC source: 0000784199-25-000057 · wk-form4_1741641526.xml · nonDerivative · entry 4

Mackin James P · CIK 0001408470 · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 865,283

F3 · shares: The sale reported on this form was effected pursuant to a 10b5-1 trading plan adopted by the reporting person on August 30, 2024.

F4 · price: Reflects weighted average price. Range of prices were between $24.40 to $25.10. The reporting person will provide upon request by the Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0000784199-25-000057 · wk-form4_1741641526.xml · nonDerivative · entry 3

Mackin James P · CIK 0001408470 · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 935,983

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · shares: The sale reported on this form was effected pursuant to a 10b5-1 trading plan adopted by the reporting person on August 30, 2024.

SEC source: 0000784199-25-000057 · wk-form4_1741641526.xml · nonDerivative · entry 2

Mackin James P · CIK 0001408470 · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 860,368

F2 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-25-000057 · wk-form4_1741641526.xml · nonDerivative · entry 1

Mackin James P · CIK 0001408470 · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 878,107

F1 · shares: Represents performance stock units granted on February 23, 2024. One third (1/3) were issued on March 6, 2025. The remaining shares earned in connection with the February 2024 grant will be eligible to vest and be issued as follows: one third (1/3) on February 23, 2026; and one third (1/3) on February 23, 2027, assuming employment on the relevant vesting date.

SEC source: 0000784199-25-000055 · wk-form4_1741641055.xml · nonDerivative · entry 2

Horton Amy · CIK 0001371523 · VP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 146,651

F2 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-25-000055 · wk-form4_1741641055.xml · nonDerivative · entry 1

Horton Amy · CIK 0001371523 · VP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 147,699

F1 · shares: Represents performance stock units granted on February 23, 2024. One third (1/3) were issued on March 6, 2025. The remaining shares earned in connection with the February 2024 grant will be eligible to vest and be issued as follows: one third (1/3) on February 23, 2026; and one third (1/3) on February 23, 2027, assuming employment on the relevant vesting date.

SEC source: 0000784199-25-000053 · wk-form4_1741640907.xml · nonDerivative · entry 2

Berry Lance A · CIK 0001478716 · Executive VP, CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 153,431

F2 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-25-000053 · wk-form4_1741640907.xml · nonDerivative · entry 1

Berry Lance A · CIK 0001478716 · Executive VP, CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 158,340

F1 · shares: Represents performance stock units granted on February 23, 2024. One third (1/3) were issued on March 6, 2025. The remaining shares earned in connection with the February 2024 grant will be eligible to vest and be issued as follows: one third (1/3) on February 23, 2026; and one third (1/3) on February 23, 2027, assuming employment on the relevant vesting date.

SEC source: 0000784199-25-000051 · wk-form4_1741640754.xml · nonDerivative · entry 2

Davis John E · CIK 0001653206 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 207,968

F2 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-25-000051 · wk-form4_1741640754.xml · nonDerivative · entry 1

Davis John E · CIK 0001653206 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 210,586

F1 · shares: Represents performance stock units granted on February 23, 2024. One third (1/3) were issued on March 6, 2025. The remaining shares earned in connection with the February 2024 grant will be eligible to vest and be issued as follows: one third (1/3) on February 23, 2026; and one third (1/3) on February 23, 2027, assuming employment on the relevant vesting date.

SEC source: 0000784199-25-000049 · wk-form4_1741640586.xml · nonDerivative · entry 2

Stanton Marshall S. · CIK 0001849615 · SVP, Clinical & MD Affair

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 115,880

F2 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-25-000049 · wk-form4_1741640586.xml · nonDerivative · entry 1

Stanton Marshall S. · CIK 0001849615 · SVP, Clinical & MD Affair

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 117,483

F1 · shares: Represents performance stock units granted on February 23, 2024. One third (1/3) were issued on March 6, 2025. The remaining shares earned in connection with the February 2024 grant will be eligible to vest and be issued as follows: one third (1/3) on February 23, 2026; and one third (1/3) on February 23, 2027, assuming employment on the relevant vesting date.

SEC source: 0000784199-25-000047 · wk-form4_1741640437.xml · nonDerivative · entry 2

Holloway Jean F · CIK 0001540065 · SVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 196,112

F2 · shares: These shares were sold upon the vesting of performance stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-25-000047 · wk-form4_1741640437.xml · nonDerivative · entry 1

Holloway Jean F · CIK 0001540065 · SVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 198,236

F1 · shares: Represents performance stock units granted on February 23, 2024. One third (1/3) were issued on March 6, 2025. The remaining shares earned in connection with the February 2024 grant will be eligible to vest and be issued as follows: one third (1/3) on February 23, 2026; and one third (1/3) on February 23, 2027, assuming employment on the relevant vesting date.

SEC source: 0000784199-25-000043 · wk-form4_1741208453.xml · nonDerivative · entry 2

SEMEDO ANTHONY B. · CIK 0001886324 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 600

F2 · shares: Reflects open market purchase of shares to be held in Mr. Semedo's spouse's IRA.

SEC source: 0000784199-25-000043 · wk-form4_1741208453.xml · nonDerivative · entry 1

SEMEDO ANTHONY B. · CIK 0001886324 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,659

F1 · shares: Reflects open market purchase of shares to be held in Mr. Semedo's IRA.

SEC source: 0000784199-25-000045 · wk-form4_1741269183.xml · nonDerivative · entry 1

Holloway Jean F · CIK 0001540065 · SVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 172,743

F1 · price: Reflects the price the shares were sold.

SEC source: 0000784199-25-000039 · wk-form4_1741118781.xml · nonDerivative · entry 1

Mackin James P · CIK 0001408470 · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 762,406

F1 · shares: Represents shares of restricted stock that vest 33 1/3% per year beginning on the first anniversary of the grant date, pursuant to the terms of the Equity and Cash Incentive Plan.

SEC source: 0000784199-25-000041 · wk-form4_1741118887.xml · nonDerivative · entry 1

Stanton Marshall S. · CIK 0001849615 · SVP, Clinical & MD Affair

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 98,243

F1 · shares: Represents shares of restricted stock that vest 33 1/3% per year beginning on the first anniversary of the grant date, pursuant to the terms of the Equity and Cash Incentive Plan.

SEC source: 0000784199-25-000035 · wk-form4_1741118540.xml · nonDerivative · entry 1

Holloway Jean F · CIK 0001540065 · SVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 173,215

F1 · shares: Represents shares of restricted stock that vest 33 1/3% per year beginning on the first anniversary of the grant date, pursuant to the terms of the Equity and Cash Incentive Plan.

SEC source: 0000784199-25-000037 · wk-form4_1741118677.xml · nonDerivative · entry 1

Horton Amy · CIK 0001371523 · VP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 137,438

F1 · shares: Represents shares of restricted stock that vest 33 1/3% per year beginning on the first anniversary of the grant date, pursuant to the terms of the Equity and Cash Incentive Plan.

SEC source: 0000784199-25-000033 · wk-form4_1741118390.xml · nonDerivative · entry 1

Davis John E · CIK 0001653206 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 184,932

F1 · shares: Represents shares of restricted stock that vest 33 1/3% per year beginning on the first anniversary of the grant date, pursuant to the terms of the Equity and Cash Incentive Plan.

SEC source: 0000784199-25-000031 · wk-form4_1741118173.xml · nonDerivative · entry 1

Berry Lance A · CIK 0001478716 · Executive VP, CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 110,240

F1 · shares: Represents shares of restricted stock that vest 33 1/3% per year beginning on the first anniversary of the grant date, pursuant to the terms of the Equity and Cash Incentive Plan.

SEC source: 0000784199-25-000024 · wk-form4_1740601989.xml · nonDerivative · entry 4

Horton Amy · CIK 0001371523 · VP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 131,141

F1 · shares: These shares were sold upon the vesting of restricted stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-25-000024 · wk-form4_1740601989.xml · nonDerivative · entry 3

Horton Amy · CIK 0001371523 · VP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 131,626

F1 · shares: These shares were sold upon the vesting of restricted stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-25-000024 · wk-form4_1740601989.xml · nonDerivative · entry 2

Horton Amy · CIK 0001371523 · VP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 131,944

F1 · shares: These shares were sold upon the vesting of restricted stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-25-000024 · wk-form4_1740601989.xml · nonDerivative · entry 1

Horton Amy · CIK 0001371523 · VP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 132,758

F1 · shares: These shares were sold upon the vesting of restricted stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-25-000022 · wk-form4_1740596426.xml · nonDerivative · entry 4

Mackin James P · CIK 0001408470 · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 663,882

F1 · shares: These shares were sold upon the vesting of restricted stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-25-000022 · wk-form4_1740596426.xml · nonDerivative · entry 3

Mackin James P · CIK 0001408470 · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 668,778

F1 · shares: These shares were sold upon the vesting of restricted stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-25-000022 · wk-form4_1740596426.xml · nonDerivative · entry 2

Mackin James P · CIK 0001408470 · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 675,590

F1 · shares: These shares were sold upon the vesting of restricted stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-25-000022 · wk-form4_1740596426.xml · nonDerivative · entry 1

Mackin James P · CIK 0001408470 · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 689,374

F1 · shares: These shares were sold upon the vesting of restricted stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-25-000020 · wk-form4_1740596244.xml · nonDerivative · entry 4

Holloway Jean F · CIK 0001540065 · SVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 149,799

F1 · shares: These shares were sold upon the vesting of restricted stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-25-000020 · wk-form4_1740596244.xml · nonDerivative · entry 3

Holloway Jean F · CIK 0001540065 · SVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 151,449

F1 · shares: These shares were sold upon the vesting of restricted stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-25-000020 · wk-form4_1740596244.xml · nonDerivative · entry 2

Holloway Jean F · CIK 0001540065 · SVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 152,259

F1 · shares: These shares were sold upon the vesting of restricted stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-25-000020 · wk-form4_1740596244.xml · nonDerivative · entry 1

Holloway Jean F · CIK 0001540065 · SVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 152,749

F1 · shares: These shares were sold upon the vesting of restricted stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-25-000018 · wk-form4_1740596042.xml · nonDerivative · entry 4

Davis John E · CIK 0001653206 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 160,631

F1 · shares: These shares were sold upon the vesting of restricted stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-25-000018 · wk-form4_1740596042.xml · nonDerivative · entry 3

Davis John E · CIK 0001653206 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 162,666

F1 · shares: These shares were sold upon the vesting of restricted stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.

SEC source: 0000784199-25-000018 · wk-form4_1740596042.xml · nonDerivative · entry 2

Davis John E · CIK 0001653206 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 163,651

F1 · shares: These shares were sold upon the vesting of restricted stock units to pay tax withholding obligations. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction.