AMRN

SEC source: 0001562180-21-001705 · primarydocument.xml · nonDerivative · entry 6

THERO JOHN F · CIK 0001199637 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,135,046

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F4 · kind: Represents withholding by the Issuer of shares in respect of tax liability incident to the vesting of a security issued in accordance with Rule 16b-3, and not a market sale of securities.

SEC source: 0001562180-21-001705 · primarydocument.xml · nonDerivative · entry 5

THERO JOHN F · CIK 0001199637 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,145,650

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F5 · kind: As previously reported on February 27, 2020 and herewith in Footnote 2, on May 15, 2017, the Reporting Person was granted 970,000 RSUs under the Plan, of which the performance criteria related to two tranches representing 25% of the total award each was deemed achieved on February 25, 2020 pursuant to reporting of audited net product revenues for 2019 exceeding $400 million and of which the performance criteria related to one tranche representing 50% of the total award was deemed achieved on February 25, 2021 pursuant to reporting of audited net product revenues for 2020 exceeding $500 million. The tranches vest ratably over 36 months beginning September 30, 2018 subject to achievement of the performance criteria and continued service of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. The thirtieth vesting event occurred on February 26, 2021.

F3 · price: Not applicable.

SEC source: 0001562180-21-001705 · primarydocument.xml · nonDerivative · entry 4

THERO JOHN F · CIK 0001199637 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,132,178

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F5 · kind: As previously reported on February 27, 2020 and herewith in Footnote 2, on May 15, 2017, the Reporting Person was granted 970,000 RSUs under the Plan, of which the performance criteria related to two tranches representing 25% of the total award each was deemed achieved on February 25, 2020 pursuant to reporting of audited net product revenues for 2019 exceeding $400 million and of which the performance criteria related to one tranche representing 50% of the total award was deemed achieved on February 25, 2021 pursuant to reporting of audited net product revenues for 2020 exceeding $500 million. The tranches vest ratably over 36 months beginning September 30, 2018 subject to achievement of the performance criteria and continued service of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. The thirtieth vesting event occurred on February 26, 2021.

F3 · price: Not applicable.

SEC source: 0001562180-21-001705 · primarydocument.xml · nonDerivative · entry 3

THERO JOHN F · CIK 0001199637 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,125,442

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F5 · kind: As previously reported on February 27, 2020 and herewith in Footnote 2, on May 15, 2017, the Reporting Person was granted 970,000 RSUs under the Plan, of which the performance criteria related to two tranches representing 25% of the total award each was deemed achieved on February 25, 2020 pursuant to reporting of audited net product revenues for 2019 exceeding $400 million and of which the performance criteria related to one tranche representing 50% of the total award was deemed achieved on February 25, 2021 pursuant to reporting of audited net product revenues for 2020 exceeding $500 million. The tranches vest ratably over 36 months beginning September 30, 2018 subject to achievement of the performance criteria and continued service of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. The thirtieth vesting event occurred on February 26, 2021.

F3 · price: Not applicable.

SEC source: 0001562180-21-001708 · primarydocument.xml · derivative · entry 9

Kalb Michael Wayne · CIK 0001678248 · SVP and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,386

Underlying: Ordinary Shares · 88,614 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · security: Each RSU represents a contingent right to receive one Ordinary Share or cash in lieu thereof at the Issuer's discretion.

F2 · derivative.exercise_date: As previously reported, on May 15 2017, the Reporting Person was granted 220,000 Restricted Stock Units ("RSUs") under the Amarin Corporation plc 2011 Stock Incentive Plan (the "Plan"). These RSUs consist of 3 tranches representing 25%, 25% and 50% of the total award. Each tranche vests ratably over 36 months beginning Sept. 30 2018 subject to achievement of certain prespecified performance criteria and continued service of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. On Feb. 25 2021, pursuant to reporting of audited net total revenue for 2020 exceeding $500 million, the performance criteria related to the 50% tranche was deemed achieved, resulting in the vesting of 88,614 RSUs (29 of 36 months' worth). The remaining RSUs in this tranche will continue to vest over 7 monthly installments, the first of which vested Feb. 26 2021. The performance criteria related to both 25% tranches were previously deemed achieved (see Footnote 5).

F3 · derivative.expiration_date: Not applicable.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001562180-21-001708 · primarydocument.xml · nonDerivative · entry 2

Kalb Michael Wayne · CIK 0001678248 · SVP and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 175,529

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F4 · kind: Represents withholding by the Issuer of shares in respect of tax liability incident to the vesting of a security issued in accordance with Rule 16b-3, and not a market sale of securities.

SEC source: 0001562180-21-001708 · primarydocument.xml · nonDerivative · entry 1

Kalb Michael Wayne · CIK 0001678248 · SVP and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 218,924

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · kind: As previously reported, on May 15 2017, the Reporting Person was granted 220,000 Restricted Stock Units ("RSUs") under the Amarin Corporation plc 2011 Stock Incentive Plan (the "Plan"). These RSUs consist of 3 tranches representing 25%, 25% and 50% of the total award. Each tranche vests ratably over 36 months beginning Sept. 30 2018 subject to achievement of certain prespecified performance criteria and continued service of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. On Feb. 25 2021, pursuant to reporting of audited net total revenue for 2020 exceeding $500 million, the performance criteria related to the 50% tranche was deemed achieved, resulting in the vesting of 88,614 RSUs (29 of 36 months' worth). The remaining RSUs in this tranche will continue to vest over 7 monthly installments, the first of which vested Feb. 26 2021. The performance criteria related to both 25% tranches were previously deemed achieved (see Footnote 5).

F3 · price: Not applicable.

SEC source: 0001562180-21-001709 · primarydocument.xml · derivative · entry 9

Berg Aaron · CIK 0001770259 · CHIEF COMMERCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,386

Underlying: Ordinary Shares · 88,614 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · security: Each RSU represents a contingent right to receive one Ordinary Share or cash in lieu thereof at the Issuer's discretion.

F2 · derivative.exercise_date: As previously reported, on May 15 2017, the Reporting Person was granted 220,000 Restricted Stock Units ("RSUs") under the Amarin Corporation plc 2011 Stock Incentive Plan (the "Plan"). These RSUs consist of 3 tranches representing 25%, 25% and 50% of the total award. Each tranche vests ratably over 36 months beginning Sept. 30 2018 subject to achievement of certain prespecified performance criteria and continued service of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. On Feb. 25 2021, pursuant to reporting of audited net total revenue for 2020 exceeding $500 million, the performance criteria related to the 50% tranche was deemed achieved, resulting in the vesting of 88,614 RSUs (29 of 36 months' worth). The remaining RSUs in this tranche will continue to vest over 7 monthly installments, the first of which vested Feb. 26 2021. The performance criteria related to both 25% tranches were previously deemed achieved (see Footnote 5).

F3 · derivative.expiration_date: Not applicable.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001562180-21-001709 · primarydocument.xml · nonDerivative · entry 2

Berg Aaron · CIK 0001770259 · CHIEF COMMERCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 272,076

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F4 · kind: Represents withholding by the Issuer of shares in respect of tax liability incident to the vesting of a security issued in accordance with Rule 16b-3, and not a market sale of securities.

SEC source: 0001562180-21-001709 · primarydocument.xml · nonDerivative · entry 1

Berg Aaron · CIK 0001770259 · CHIEF COMMERCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 315,714

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · kind: As previously reported, on May 15 2017, the Reporting Person was granted 220,000 Restricted Stock Units ("RSUs") under the Amarin Corporation plc 2011 Stock Incentive Plan (the "Plan"). These RSUs consist of 3 tranches representing 25%, 25% and 50% of the total award. Each tranche vests ratably over 36 months beginning Sept. 30 2018 subject to achievement of certain prespecified performance criteria and continued service of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. On Feb. 25 2021, pursuant to reporting of audited net total revenue for 2020 exceeding $500 million, the performance criteria related to the 50% tranche was deemed achieved, resulting in the vesting of 88,614 RSUs (29 of 36 months' worth). The remaining RSUs in this tranche will continue to vest over 7 monthly installments, the first of which vested Feb. 26 2021. The performance criteria related to both 25% tranches were previously deemed achieved (see Footnote 5).

F3 · price: Not applicable.

SEC source: 0001562180-21-001707 · primarydocument.xml · derivative · entry 9

Ketchum Steven B · CIK 0001289884 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,386

Underlying: Ordinary Shares · 88,614 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · security: Each RSU represents a contingent right to receive one Ordinary Share or cash in lieu thereof at the Issuer's discretion.

F2 · derivative.exercise_date: As previously reported, on May 15 2017, the Reporting Person was granted 220,000 Restricted Stock Units ("RSUs") under the Amarin Corporation plc 2011 Stock Incentive Plan (the "Plan"). These RSUs consist of 3 tranches representing 25%, 25% and 50% of the total award. Each tranche vests ratably over 36 months beginning Sept. 30 2018 subject to achievement of certain prespecified performance criteria and continued service of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. On Feb. 25 2021, pursuant to reporting of audited net total revenue for 2020 exceeding $500 million, the performance criteria related to the 50% tranche was deemed achieved, resulting in the vesting of 88,614 RSUs (29 of 36 months' worth). The remaining RSUs in this tranche will continue to vest over 7 monthly installments, the first of which vested Feb. 26 2021. The performance criteria related to both 25% tranches were previously deemed achieved (see Footnote 5).

F3 · derivative.expiration_date: Not applicable.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001562180-21-001707 · primarydocument.xml · nonDerivative · entry 2

Ketchum Steven B · CIK 0001289884 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 426,283

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F4 · kind: Represents withholding by the Issuer of shares in respect of tax liability incident to the vesting of a security issued in accordance with Rule 16b-3, and not a market sale of securities.

SEC source: 0001562180-21-001707 · primarydocument.xml · nonDerivative · entry 1

Ketchum Steven B · CIK 0001289884 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 471,610

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · kind: As previously reported, on May 15 2017, the Reporting Person was granted 220,000 Restricted Stock Units ("RSUs") under the Amarin Corporation plc 2011 Stock Incentive Plan (the "Plan"). These RSUs consist of 3 tranches representing 25%, 25% and 50% of the total award. Each tranche vests ratably over 36 months beginning Sept. 30 2018 subject to achievement of certain prespecified performance criteria and continued service of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. On Feb. 25 2021, pursuant to reporting of audited net total revenue for 2020 exceeding $500 million, the performance criteria related to the 50% tranche was deemed achieved, resulting in the vesting of 88,614 RSUs (29 of 36 months' worth). The remaining RSUs in this tranche will continue to vest over 7 monthly installments, the first of which vested Feb. 26 2021. The performance criteria related to both 25% tranches were previously deemed achieved (see Footnote 5).

F3 · price: Not applicable.

SEC source: 0001562180-21-001706 · primarydocument.xml · derivative · entry 9

Kennedy Joseph T · CIK 0001408920 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,272

Underlying: Ordinary Shares · 104,728 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · security: Each RSU represents a contingent right to receive one Ordinary Share or cash in lieu thereof at the Issuer's discretion.

F2 · derivative.exercise_date: As previously reported, on May 15 2017, the Reporting Person was granted 260,000 Restricted Stock Units ("RSUs") under the Amarin Corporation plc 2011 Stock Incentive Plan (the "Plan"). These RSUs consist of 3 tranches representing 25%, 25% and 50% of the total award. Each tranche vests ratably over 36 months beginning Sept. 30 2018 subject to achievement of certain prespecified performance criteria and continued service of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. On Feb. 25 2021, pursuant to reporting of audited net total revenue for 2020 exceeding $500 million, the performance criteria related to the 50% tranche was deemed achieved, resulting in the vesting of 104,728 RSUs (29 of 36 months' worth). The remaining RSUs in this tranche will continue to vest over 7 monthly installments, the first of which vested Feb. 26 2021. The performance criteria related to both 25% tranches were previously deemed achieved (see Footnote 5).

F3 · derivative.expiration_date: Not applicable.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001562180-21-001706 · primarydocument.xml · nonDerivative · entry 2

Kennedy Joseph T · CIK 0001408920 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 289,621

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F4 · kind: Represents withholding by the Issuer of shares in respect of tax liability incident to the vesting of a security issued in accordance with Rule 16b-3, and not a market sale of securities.

SEC source: 0001562180-21-001706 · primarydocument.xml · nonDerivative · entry 1

Kennedy Joseph T · CIK 0001408920 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 344,761

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · kind: As previously reported, on May 15 2017, the Reporting Person was granted 260,000 Restricted Stock Units ("RSUs") under the Amarin Corporation plc 2011 Stock Incentive Plan (the "Plan"). These RSUs consist of 3 tranches representing 25%, 25% and 50% of the total award. Each tranche vests ratably over 36 months beginning Sept. 30 2018 subject to achievement of certain prespecified performance criteria and continued service of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. On Feb. 25 2021, pursuant to reporting of audited net total revenue for 2020 exceeding $500 million, the performance criteria related to the 50% tranche was deemed achieved, resulting in the vesting of 104,728 RSUs (29 of 36 months' worth). The remaining RSUs in this tranche will continue to vest over 7 monthly installments, the first of which vested Feb. 26 2021. The performance criteria related to both 25% tranches were previously deemed achieved (see Footnote 5).

F3 · price: Not applicable.

SEC source: 0001562180-21-001705 · primarydocument.xml · derivative · entry 9

THERO JOHN F · CIK 0001199637 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,304

Underlying: Ordinary Shares · 390,696 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · security: Each RSU represents a contingent right to receive one Ordinary Share or cash in lieu thereof at the Issuer's discretion.

F2 · derivative.exercise_date: As previously reported, on May 15 2017, the Reporting Person was granted 970,000 Restricted Stock Units ("RSUs") under the Amarin Corporation plc 2011 Stock Incentive Plan (the "Plan"). These RSUs consist of 3 tranches representing 25%, 25% and 50% of the total award. Each tranche vests ratably over 36 months beginning Sept. 30 2018 subject to achievement of certain prespecified performance criteria and continued service of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. On Feb. 25 2021, pursuant to reporting of audited net total revenue for 2020 exceeding $500 million, the performance criteria related to the 50% tranche was deemed achieved, resulting in the vesting of 390,696 RSUs (29 of 36 months' worth). The remaining RSUs in this tranche will continue to vest over 7 monthly installments, the first of which vested Feb. 26 2021. The performance criteria related to both 25% tranches were previously deemed achieved (see Footnote 5).

F3 · derivative.expiration_date: Not applicable.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001562180-21-001705 · primarydocument.xml · nonDerivative · entry 2

THERO JOHN F · CIK 0001199637 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,118,706

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F4 · kind: Represents withholding by the Issuer of shares in respect of tax liability incident to the vesting of a security issued in accordance with Rule 16b-3, and not a market sale of securities.

SEC source: 0001562180-21-001705 · primarydocument.xml · nonDerivative · entry 1

THERO JOHN F · CIK 0001199637 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,272,445

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · kind: As previously reported, on May 15 2017, the Reporting Person was granted 970,000 Restricted Stock Units ("RSUs") under the Amarin Corporation plc 2011 Stock Incentive Plan (the "Plan"). These RSUs consist of 3 tranches representing 25%, 25% and 50% of the total award. Each tranche vests ratably over 36 months beginning Sept. 30 2018 subject to achievement of certain prespecified performance criteria and continued service of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. On Feb. 25 2021, pursuant to reporting of audited net total revenue for 2020 exceeding $500 million, the performance criteria related to the 50% tranche was deemed achieved, resulting in the vesting of 390,696 RSUs (29 of 36 months' worth). The remaining RSUs in this tranche will continue to vest over 7 monthly installments, the first of which vested Feb. 26 2021. The performance criteria related to both 25% tranches were previously deemed achieved (see Footnote 5).

F3 · price: Not applicable.

SEC source: 0001562180-21-000880 · primarydocument.xml · derivative · entry 8

Ketchum Steven B · CIK 0001289884 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 11,082 shares

Expires 2027-01-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: On February 1, 2017, the Reporting Person was granted an option to purchase 133,000 Ordinary Shares under the Plan. The shares subject to this option vested in 48 equal monthly installments on the last day of each month starting on February 28, 2017. This option was fully vested as of the date hereof.

F2 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001562180-21-000880 · primarydocument.xml · derivative · entry 7

Ketchum Steven B · CIK 0001289884 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 164,573 shares

Expires 2025-07-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: On July 6, 2015, the Reporting Person was granted an option to purchase 240,000 Ordinary Shares under the Plan. The vesting of the shares was subject to a certain performance milestone that was previously achieved. The shares subject to this option vested in 48 equal monthly installments on the last day of each month starting on July 31, 2015. This option was fully vested as of the date hereof.

F2 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001562180-21-000880 · primarydocument.xml · derivative · entry 6

Ketchum Steven B · CIK 0001289884 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 16,703 shares

Expires 2025-07-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: On July 6, 2015, the Reporting Person was granted an option to purchase 180,000 Ordinary Shares under the Plan. The vesting of the shares was subject to a certain performance milestone that was previously achieved. The shares subject to this option vested in 48 equal monthly installments on the last day of each month starting on July 31, 2015. This option was fully vested as of the date hereof.

F2 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001562180-21-000880 · primarydocument.xml · nonDerivative · entry 5

Ketchum Steven B · CIK 0001289884 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 382,996

F1 · security: Multiple reportable transactions are reported in the Form 4 including exercises of previously granted stock options and sale of certain shares. The market sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F2 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F7 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $8.00 to $8.20, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff at the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F8 · balance_after: Please see the section titled "Remarks" below for additional information.

SEC source: 0001562180-21-000880 · primarydocument.xml · nonDerivative · entry 4

Ketchum Steven B · CIK 0001289884 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 408,366

F1 · security: Multiple reportable transactions are reported in the Form 4 including exercises of previously granted stock options and sale of certain shares. The market sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F2 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $8.00 to $8.29, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff at the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001562180-21-000880 · primarydocument.xml · nonDerivative · entry 3

Ketchum Steven B · CIK 0001289884 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 600,724

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Multiple reportable transactions are reported in the Form 4 including exercises of previously granted stock options and sale of certain shares. The market sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F2 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F5 · kind: On February 1, 2017, the Reporting Person was granted an option to purchase 133,000 Ordinary Shares under the Plan. The shares subject to this option vested in 48 equal monthly installments on the last day of each month starting on February 28, 2017. This option was fully vested as of the date hereof.

SEC source: 0001562180-21-000880 · primarydocument.xml · nonDerivative · entry 2

Ketchum Steven B · CIK 0001289884 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 589,642

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Multiple reportable transactions are reported in the Form 4 including exercises of previously granted stock options and sale of certain shares. The market sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F2 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F4 · kind: On July 6, 2015, the Reporting Person was granted an option to purchase 240,000 Ordinary Shares under the Plan. The vesting of the shares was subject to a certain performance milestone that was previously achieved. The shares subject to this option vested in 48 equal monthly installments on the last day of each month starting on July 31, 2015. This option was fully vested as of the date hereof.

SEC source: 0001562180-21-000880 · primarydocument.xml · nonDerivative · entry 1

Ketchum Steven B · CIK 0001289884 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 425,069

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Multiple reportable transactions are reported in the Form 4 including exercises of previously granted stock options and sale of certain shares. The market sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F2 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F3 · kind: On July 6, 2015, the Reporting Person was granted an option to purchase 180,000 Ordinary Shares under the Plan. The vesting of the shares was subject to a certain performance milestone that was previously achieved. The shares subject to this option vested in 48 equal monthly installments on the last day of each month starting on July 31, 2015. This option was fully vested as of the date hereof.

SEC source: 0001562180-21-000649 · primarydocument.xml · derivative · entry 8

Berg Aaron · CIK 0001770259 · CHIEF COMMERCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,693

Underlying: Ordinary Shares · 1,528 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · security: Each RSU represents a contingent right to receive one Ordinary Share or cash in lieu thereof at the Issuer's discretion.

F5 · derivative.exercise_date: As previously reported on February 27, 2020, on May 15, 2017, the Reporting Person was granted 220,000 RSUs under the Plan, of which the performance criteria related to two tranches representing 50% of the total award was deemed achieved on February 25, 2020 pursuant to reporting of audited net product revenues for 2019 exceeding $400 million. The tranches vest ratably over 36 months beginning September 30, 2018 subject to achievement of the performance criteria and continued employment of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. The twenty-ninth vesting event occurred on January 29, 2021. The performance criteria related to the remaining 50% tranche has not yet been formally deemed achieved; such tranche has not lapsed as a result of achieving the other two tranches.

F3 · derivative.expiration_date: Not applicable.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001562180-21-000649 · primarydocument.xml · derivative · entry 7

Berg Aaron · CIK 0001770259 · CHIEF COMMERCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,693

Underlying: Ordinary Shares · 1,528 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · security: Each RSU represents a contingent right to receive one Ordinary Share or cash in lieu thereof at the Issuer's discretion.

F5 · derivative.exercise_date: As previously reported on February 27, 2020, on May 15, 2017, the Reporting Person was granted 220,000 RSUs under the Plan, of which the performance criteria related to two tranches representing 50% of the total award was deemed achieved on February 25, 2020 pursuant to reporting of audited net product revenues for 2019 exceeding $400 million. The tranches vest ratably over 36 months beginning September 30, 2018 subject to achievement of the performance criteria and continued employment of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. The twenty-ninth vesting event occurred on January 29, 2021. The performance criteria related to the remaining 50% tranche has not yet been formally deemed achieved; such tranche has not lapsed as a result of achieving the other two tranches.

F3 · derivative.expiration_date: Not applicable.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001562180-21-000649 · primarydocument.xml · derivative · entry 6

Berg Aaron · CIK 0001770259 · CHIEF COMMERCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,733

Underlying: Ordinary Shares · 12,733 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · security: Each RSU represents a contingent right to receive one Ordinary Share or cash in lieu thereof at the Issuer's discretion.

F2 · derivative.exercise_date: On February 1, 2019, the Reporting Person was granted 38,200 Restricted Stock Units ("RSUs") under the Amarin Corporation plc 2011 Stock Incentive Plan (the "Plan"). These RSUs vest in three equal installments on each of January 31, 2020, January 31, 2021, and January 31, 2022. The second vesting event occurred on January 29, 2021.

F3 · derivative.expiration_date: Not applicable.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001562180-21-000649 · primarydocument.xml · nonDerivative · entry 5

Berg Aaron · CIK 0001770259 · CHIEF COMMERCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 227,100

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F4 · kind: Represents withholding by the Issuer of shares in respect of tax liability incident to the vesting of a security issued in accordance with Rule 16b-3, and not a market sale of securities.

F6 · balance_after: Please see the section titled "Remarks" below for additional information.

SEC source: 0001562180-21-000649 · primarydocument.xml · nonDerivative · entry 4

Berg Aaron · CIK 0001770259 · CHIEF COMMERCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 228,195

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F5 · kind: As previously reported on February 27, 2020, on May 15, 2017, the Reporting Person was granted 220,000 RSUs under the Plan, of which the performance criteria related to two tranches representing 50% of the total award was deemed achieved on February 25, 2020 pursuant to reporting of audited net product revenues for 2019 exceeding $400 million. The tranches vest ratably over 36 months beginning September 30, 2018 subject to achievement of the performance criteria and continued employment of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. The twenty-ninth vesting event occurred on January 29, 2021. The performance criteria related to the remaining 50% tranche has not yet been formally deemed achieved; such tranche has not lapsed as a result of achieving the other two tranches.

F3 · price: Not applicable.

SEC source: 0001562180-21-000649 · primarydocument.xml · nonDerivative · entry 3

Berg Aaron · CIK 0001770259 · CHIEF COMMERCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 226,667

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F5 · kind: As previously reported on February 27, 2020, on May 15, 2017, the Reporting Person was granted 220,000 RSUs under the Plan, of which the performance criteria related to two tranches representing 50% of the total award was deemed achieved on February 25, 2020 pursuant to reporting of audited net product revenues for 2019 exceeding $400 million. The tranches vest ratably over 36 months beginning September 30, 2018 subject to achievement of the performance criteria and continued employment of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. The twenty-ninth vesting event occurred on January 29, 2021. The performance criteria related to the remaining 50% tranche has not yet been formally deemed achieved; such tranche has not lapsed as a result of achieving the other two tranches.

F3 · price: Not applicable.

SEC source: 0001562180-21-000649 · primarydocument.xml · nonDerivative · entry 2

Berg Aaron · CIK 0001770259 · CHIEF COMMERCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 225,139

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F4 · kind: Represents withholding by the Issuer of shares in respect of tax liability incident to the vesting of a security issued in accordance with Rule 16b-3, and not a market sale of securities.

SEC source: 0001562180-21-000649 · primarydocument.xml · nonDerivative · entry 1

Berg Aaron · CIK 0001770259 · CHIEF COMMERCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 230,325

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · kind: On February 1, 2019, the Reporting Person was granted 38,200 Restricted Stock Units ("RSUs") under the Amarin Corporation plc 2011 Stock Incentive Plan (the "Plan"). These RSUs vest in three equal installments on each of January 31, 2020, January 31, 2021, and January 31, 2022. The second vesting event occurred on January 29, 2021.

F3 · price: Not applicable.

SEC source: 0001562180-21-000648 · primarydocument.xml · derivative · entry 10

Kalb Michael Wayne · CIK 0001678248 · SVP and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,693

Underlying: Ordinary Shares · 1,528 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · security: Each RSU represents a contingent right to receive one Ordinary Share or cash in lieu thereof at the Issuer's discretion.

F6 · derivative.exercise_date: As previously reported on February 27, 2020, on May 15, 2017, the Reporting Person was granted 220,000 RSUs under the Plan, of which the performance criteria related to two tranches representing 50% of the total award was deemed achieved on February 25, 2020 pursuant to reporting of audited net product revenues for 2019 exceeding $400 million. The tranches vest ratably over 36 months beginning September 30, 2018 subject to achievement of the performance criteria and continued employment of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. The twenty-ninth vesting event occurred on January 29, 2021. The performance criteria related to the remaining 50% tranche has not yet been formally deemed achieved; such tranche has not lapsed as a result of achieving the other two tranches.

F3 · derivative.expiration_date: Not applicable.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001562180-21-000648 · primarydocument.xml · derivative · entry 9

Kalb Michael Wayne · CIK 0001678248 · SVP and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,693

Underlying: Ordinary Shares · 1,528 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · security: Each RSU represents a contingent right to receive one Ordinary Share or cash in lieu thereof at the Issuer's discretion.

F6 · derivative.exercise_date: As previously reported on February 27, 2020, on May 15, 2017, the Reporting Person was granted 220,000 RSUs under the Plan, of which the performance criteria related to two tranches representing 50% of the total award was deemed achieved on February 25, 2020 pursuant to reporting of audited net product revenues for 2019 exceeding $400 million. The tranches vest ratably over 36 months beginning September 30, 2018 subject to achievement of the performance criteria and continued employment of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. The twenty-ninth vesting event occurred on January 29, 2021. The performance criteria related to the remaining 50% tranche has not yet been formally deemed achieved; such tranche has not lapsed as a result of achieving the other two tranches.

F3 · derivative.expiration_date: Not applicable.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001562180-21-000648 · primarydocument.xml · derivative · entry 8

Kalb Michael Wayne · CIK 0001678248 · SVP and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,733

Underlying: Ordinary Shares · 12,733 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · security: Each RSU represents a contingent right to receive one Ordinary Share or cash in lieu thereof at the Issuer's discretion.

F4 · derivative.exercise_date: On February 1, 2019, the Reporting Person was granted 38,200 RSUs under the Plan. These RSUs vest in three equal installments on each of January 31, 2020, January 31, 2021, and January 31, 2022. The second vesting event occurred on January 29, 2021.

F3 · derivative.expiration_date: Not applicable.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001562180-21-000648 · primarydocument.xml · derivative · entry 7

Kalb Michael Wayne · CIK 0001678248 · SVP and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 26,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · security: Each RSU represents a contingent right to receive one Ordinary Share or cash in lieu thereof at the Issuer's discretion.

F2 · derivative.exercise_date: On February 1, 2018, the Reporting Person was granted 78,000 Restricted Stock Units ("RSUs") under the Amarin Corporation plc 2011 Stock Incentive Plan (the "Plan"). These RSUs vest in three equal installments on each of January 31, 2019, January 31, 2020, and January 31, 2021. The third and final vesting event occurred on January 29, 2021.

F3 · derivative.expiration_date: Not applicable.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001562180-21-000648 · primarydocument.xml · nonDerivative · entry 6

Kalb Michael Wayne · CIK 0001678248 · SVP and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130,310

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F5 · kind: Represents withholding by the Issuer of shares in respect of tax liability incident to the vesting of a security issued in accordance with Rule 16b-3, and not a market sale of securities.

F7 · balance_after: Please see the section titled "Remarks" below for additional information.

SEC source: 0001562180-21-000648 · primarydocument.xml · nonDerivative · entry 5

Kalb Michael Wayne · CIK 0001678248 · SVP and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 131,350

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F6 · kind: As previously reported on February 27, 2020, on May 15, 2017, the Reporting Person was granted 220,000 RSUs under the Plan, of which the performance criteria related to two tranches representing 50% of the total award was deemed achieved on February 25, 2020 pursuant to reporting of audited net product revenues for 2019 exceeding $400 million. The tranches vest ratably over 36 months beginning September 30, 2018 subject to achievement of the performance criteria and continued employment of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. The twenty-ninth vesting event occurred on January 29, 2021. The performance criteria related to the remaining 50% tranche has not yet been formally deemed achieved; such tranche has not lapsed as a result of achieving the other two tranches.

F3 · price: Not applicable.

SEC source: 0001562180-21-000648 · primarydocument.xml · nonDerivative · entry 4

Kalb Michael Wayne · CIK 0001678248 · SVP and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 129,822

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F6 · kind: As previously reported on February 27, 2020, on May 15, 2017, the Reporting Person was granted 220,000 RSUs under the Plan, of which the performance criteria related to two tranches representing 50% of the total award was deemed achieved on February 25, 2020 pursuant to reporting of audited net product revenues for 2019 exceeding $400 million. The tranches vest ratably over 36 months beginning September 30, 2018 subject to achievement of the performance criteria and continued employment of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. The twenty-ninth vesting event occurred on January 29, 2021. The performance criteria related to the remaining 50% tranche has not yet been formally deemed achieved; such tranche has not lapsed as a result of achieving the other two tranches.

F3 · price: Not applicable.

SEC source: 0001562180-21-000648 · primarydocument.xml · nonDerivative · entry 3

Kalb Michael Wayne · CIK 0001678248 · SVP and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 128,294

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F5 · kind: Represents withholding by the Issuer of shares in respect of tax liability incident to the vesting of a security issued in accordance with Rule 16b-3, and not a market sale of securities.

SEC source: 0001562180-21-000648 · primarydocument.xml · nonDerivative · entry 2

Kalb Michael Wayne · CIK 0001678248 · SVP and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 142,182

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F4 · kind: On February 1, 2019, the Reporting Person was granted 38,200 RSUs under the Plan. These RSUs vest in three equal installments on each of January 31, 2020, January 31, 2021, and January 31, 2022. The second vesting event occurred on January 29, 2021.

F3 · price: Not applicable.

SEC source: 0001562180-21-000648 · primarydocument.xml · nonDerivative · entry 1

Kalb Michael Wayne · CIK 0001678248 · SVP and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 129,449

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · kind: On February 1, 2018, the Reporting Person was granted 78,000 Restricted Stock Units ("RSUs") under the Amarin Corporation plc 2011 Stock Incentive Plan (the "Plan"). These RSUs vest in three equal installments on each of January 31, 2019, January 31, 2020, and January 31, 2021. The third and final vesting event occurred on January 29, 2021.

F3 · price: Not applicable.

SEC source: 0001562180-21-000647 · primarydocument.xml · derivative · entry 28

Ketchum Steven B · CIK 0001289884 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,693

Underlying: Ordinary Shares · 1,528 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F18 · security: Each RSU represents a contingent right to receive one Ordinary Share or cash in lieu thereof at the Issuer's discretion.

F16 · derivative.exercise_date: As previously reported on February 27, 2020, on May 15, 2017, the Reporting Person was granted 220,000 RSUs under the Plan, of which the performance criteria related to two tranches representing 50% of the total award was deemed achieved on February 25, 2020 pursuant to reporting of audited net product revenues for 2019 exceeding $400 million. The tranches vest ratably over 36 months beginning September 30, 2018 subject to achievement of the performance criteria and continued employment of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. The twenty-ninth vesting event occurred on January 29, 2021. The performance criteria related to the remaining 50% tranche has not yet been formally deemed achieved; such tranche has not lapsed as a result of achieving the other two tranches.

F13 · derivative.expiration_date: Not applicable.

F2 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001562180-21-000647 · primarydocument.xml · derivative · entry 27

Ketchum Steven B · CIK 0001289884 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,693

Underlying: Ordinary Shares · 1,528 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F18 · security: Each RSU represents a contingent right to receive one Ordinary Share or cash in lieu thereof at the Issuer's discretion.

F16 · derivative.exercise_date: As previously reported on February 27, 2020, on May 15, 2017, the Reporting Person was granted 220,000 RSUs under the Plan, of which the performance criteria related to two tranches representing 50% of the total award was deemed achieved on February 25, 2020 pursuant to reporting of audited net product revenues for 2019 exceeding $400 million. The tranches vest ratably over 36 months beginning September 30, 2018 subject to achievement of the performance criteria and continued employment of the Reporting Person as provided in the RSU Award Agreement between the Issuer and Reporting Person. The twenty-ninth vesting event occurred on January 29, 2021. The performance criteria related to the remaining 50% tranche has not yet been formally deemed achieved; such tranche has not lapsed as a result of achieving the other two tranches.

F13 · derivative.expiration_date: Not applicable.

F2 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001562180-21-000647 · primarydocument.xml · derivative · entry 26

Ketchum Steven B · CIK 0001289884 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,733

Underlying: Ordinary Shares · 12,733 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F18 · security: Each RSU represents a contingent right to receive one Ordinary Share or cash in lieu thereof at the Issuer's discretion.

F14 · derivative.exercise_date: On February 1, 2019, the Reporting Person was granted 38,200 RSUs under the Plan. These RSUs vest in three equal installments on each of January 31, 2020, January 31, 2021, and January 31, 2022. The second vesting event occurred on January 29, 2021.

F13 · derivative.expiration_date: Not applicable.

F2 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001562180-21-000647 · primarydocument.xml · derivative · entry 25

Ketchum Steven B · CIK 0001289884 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 26,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F18 · security: Each RSU represents a contingent right to receive one Ordinary Share or cash in lieu thereof at the Issuer's discretion.

F12 · derivative.exercise_date: On February 1, 2018, the Reporting Person was granted 78,000 Restricted Stock Units ("RSUs") under the Plan. These RSUs vest in three equal installments on each of January 31, 2019, January 31, 2020, and January 31, 2021. The third and final vesting event occurred on January 29, 2021.

F13 · derivative.expiration_date: Not applicable.

F2 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001562180-21-000647 · primarydocument.xml · nonDerivative · entry 16

Ketchum Steven B · CIK 0001289884 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 408,366

F1 · security: Multiple reportable transactions are reported in the Form 4 including exercises of previously granted stock options, vesting of previously granted restricted stock units, and sale of certain shares. The market sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F2 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F15 · kind: Represents withholding by the Issuer of shares in respect of tax liability incident to the vesting of a security issued in accordance with Rule 16b-3, and not a market sale of securities.

F17 · balance_after: Please see the section titled "Remarks" below for additional information.