ALNY

SEC source: 0001735276-26-000048 · edgardoc.xml · derivative · entry 14

Greenstreet Yvonne · CIK 0001446125 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 110,746

Underlying: Common Stock · 110,746 shares

Expires not disclosed

F15 · derivative.exercise_date: Stock price performance unit award (PSU) granted pursuant to the Second Amended and Restated 2018 Stock Incentive Plan. The amount reported is the maximum number of PSUs that may be earned upon achievement of pre-set stock price thresholds. Subject to the terms and conditions of the PSU award agreement, the PSU vests on December 31, 2029 (Vesting Date) and between 50% and 200% of the target number of 55,373 PSUs may be earned if the highest average closing price that is achieved over a 30 consecutive trading period (Future Average Stock Price) in the six months preceding the vesting date (Measurement Period) meets or exceeds certain thresholds. If the Future Average Stock Price does not meet or exceed the baseline threshold price during the Measurement Period, no portion of the PSU will be earned, and all PSUs will be forfeited on the Vesting Date.

F15 · derivative.expiration_date: Stock price performance unit award (PSU) granted pursuant to the Second Amended and Restated 2018 Stock Incentive Plan. The amount reported is the maximum number of PSUs that may be earned upon achievement of pre-set stock price thresholds. Subject to the terms and conditions of the PSU award agreement, the PSU vests on December 31, 2029 (Vesting Date) and between 50% and 200% of the target number of 55,373 PSUs may be earned if the highest average closing price that is achieved over a 30 consecutive trading period (Future Average Stock Price) in the six months preceding the vesting date (Measurement Period) meets or exceeds certain thresholds. If the Future Average Stock Price does not meet or exceed the baseline threshold price during the Measurement Period, no portion of the PSU will be earned, and all PSUs will be forfeited on the Vesting Date.

F15 · derivative.underlying_shares: Stock price performance unit award (PSU) granted pursuant to the Second Amended and Restated 2018 Stock Incentive Plan. The amount reported is the maximum number of PSUs that may be earned upon achievement of pre-set stock price thresholds. Subject to the terms and conditions of the PSU award agreement, the PSU vests on December 31, 2029 (Vesting Date) and between 50% and 200% of the target number of 55,373 PSUs may be earned if the highest average closing price that is achieved over a 30 consecutive trading period (Future Average Stock Price) in the six months preceding the vesting date (Measurement Period) meets or exceeds certain thresholds. If the Future Average Stock Price does not meet or exceed the baseline threshold price during the Measurement Period, no portion of the PSU will be earned, and all PSUs will be forfeited on the Vesting Date.

SEC source: 0001735276-26-000048 · edgardoc.xml · derivative · entry 13

Greenstreet Yvonne · CIK 0001446125 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,425

Underlying: Common Stock · 30,425 shares

Expires 2036-03-02

F14 · derivative.exercise_date: The stock option vests as to 25% of the shares on the first anniversary of the grant date and the remaining shares vest in equal installments at the end of each successive three-month period thereafter until the fourth anniversary of the grant date, subject to the Reporting Persons continuous service with the Issuer as of each such vesting date.

SEC source: 0001735276-26-000048 · edgardoc.xml · nonDerivative · entry 11

Greenstreet Yvonne · CIK 0001446125 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 98,628

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

F12 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $332.34 to $332.24. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000048 · edgardoc.xml · nonDerivative · entry 10

Greenstreet Yvonne · CIK 0001446125 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 98,788

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

F11 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $331.32 to $332.31. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000048 · edgardoc.xml · nonDerivative · entry 9

Greenstreet Yvonne · CIK 0001446125 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 99,187

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

F10 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $330.30 to $331.30. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000048 · edgardoc.xml · nonDerivative · entry 8

Greenstreet Yvonne · CIK 0001446125 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 99,533

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

F9 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $329.29 to $330.29. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000048 · edgardoc.xml · nonDerivative · entry 7

Greenstreet Yvonne · CIK 0001446125 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,255

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

F8 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $328.28 to $329.26. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000048 · edgardoc.xml · nonDerivative · entry 6

Greenstreet Yvonne · CIK 0001446125 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,679

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

F7 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $327.24 to $328.24. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000048 · edgardoc.xml · nonDerivative · entry 5

Greenstreet Yvonne · CIK 0001446125 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 102,078

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

F6 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $326.23 to $327.23. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000048 · edgardoc.xml · nonDerivative · entry 4

Greenstreet Yvonne · CIK 0001446125 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 103,747

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

F5 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $325.21 to $326.21. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000048 · edgardoc.xml · nonDerivative · entry 3

Greenstreet Yvonne · CIK 0001446125 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 104,845

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

F4 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $324.20 to $325.20. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000048 · edgardoc.xml · nonDerivative · entry 2

Greenstreet Yvonne · CIK 0001446125 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,227

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

F3 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $323.16 to $324.15. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000048 · edgardoc.xml · nonDerivative · entry 1

Greenstreet Yvonne · CIK 0001446125 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,427

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Second Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest over a three-year period, with one third vesting on each of the first, second and third anniversaries of the grant date, subject to the Reporting Persons continuous service with the Issuer as of each such vesting date.

SEC source: 0001735276-26-000041 · edgardoc.xml · derivative · entry 3

Greenstreet Yvonne · CIK 0001446125 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 5,921 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: These shares are represented by restricted stock units (RSUs) granted under the Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: On February 27, 2023, the reporting person was granted 17,763 restricted stock units that vest ratably on each of the first, second and third anniversaries of the Grant Date. On February 27, 2026, the third and final tranche of restricted stock units from the February 27, 2023 grant vested and was released, as reported on this Form 4.

F4 · derivative.expiration_date: The restricted stock units vest ratably in three installments, with one third vesting on each of the first, second and third anniversaries of the grant date.

SEC source: 0001735276-26-000041 · edgardoc.xml · nonDerivative · entry 1

Greenstreet Yvonne · CIK 0001446125 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 91,583

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001735276-26-000040 · edgardoc.xml · derivative · entry 3

Poulton Jeffrey V. · CIK 0001782962 · EVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,908 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: These shares are represented by restricted stock units (RSUs) granted under the Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: On February 27, 2023, the reporting person was granted 5,724 restricted stock units that vest ratably on each of the first, second and third anniversaries of the Grant Date. On February 27, 2026, the third and final tranche of restricted stock units from the February 27, 2023 grant vested and was released, as reported on this Form 4.

F4 · derivative.expiration_date: The restricted stock units vest ratably in three installments, with one third vesting on each of the first, second and third anniversaries of the grant date.

SEC source: 0001735276-26-000040 · edgardoc.xml · nonDerivative · entry 1

Poulton Jeffrey V. · CIK 0001782962 · EVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 61,710

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001735276-26-000039 · edgardoc.xml · derivative · entry 2

Tanguler Tolga · CIK 0001849458 · EVP, Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,666 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: These shares are represented by restricted stock units (RSUs) granted under the Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock.

F2 · derivative.exercise_date: On February 27, 2023, the reporting person was granted 5,000 restricted stock units that vest ratably on each of the first, second and third anniversaries of the Grant Date. On February 27, 2026, the third and final tranche of restricted stock units from the February 27, 2023 grant vested and was released, as reported on this Form 4.

F3 · derivative.expiration_date: The restricted stock units vest ratably in three installments, with one third vesting on each of the first, second and third anniversaries of the grant date.

SEC source: 0001735276-26-000039 · edgardoc.xml · nonDerivative · entry 1

Tanguler Tolga · CIK 0001849458 · EVP, Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,435

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001735276-26-000038 · edgardoc.xml · derivative · entry 9

Garg Pushkal · CIK 0001829252 · EVP Chief R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,908 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · derivative.exercise_price: These shares are represented by restricted stock units (RSUs) granted under the Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock.

F9 · derivative.exercise_date: On February 27, 2023, the reporting person was granted 5,724 restricted stock units that vest ratably on each of the first, second and third anniversaries of the Grant Date. On February 27, 2026, the third and final tranche of restricted stock units from the February 27, 2023 grant vested and was released, as reported on this Form 4.

F10 · derivative.expiration_date: The restricted stock units vest ratably in three installments, with one third vesting on each of the first, second and third anniversaries of the grant date.

SEC source: 0001735276-26-000038 · edgardoc.xml · nonDerivative · entry 6

Garg Pushkal · CIK 0001829252 · EVP Chief R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,129

F1 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on November 20, 2025.

SEC source: 0001735276-26-000038 · edgardoc.xml · nonDerivative · entry 5

Garg Pushkal · CIK 0001829252 · EVP Chief R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,269

F1 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on November 20, 2025.

F5 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $332.11 to $333.09. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000038 · edgardoc.xml · nonDerivative · entry 4

Garg Pushkal · CIK 0001829252 · EVP Chief R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,211

F1 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on November 20, 2025.

F4 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $331.09 to $332.02. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000038 · edgardoc.xml · nonDerivative · entry 3

Garg Pushkal · CIK 0001829252 · EVP Chief R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,370

F1 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on November 20, 2025.

F3 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $330.08 to $331.05. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000038 · edgardoc.xml · nonDerivative · entry 2

Garg Pushkal · CIK 0001829252 · EVP Chief R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,629

F1 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on November 20, 2025.

F2 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $328.90 to $329.24. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000038 · edgardoc.xml · nonDerivative · entry 1

Garg Pushkal · CIK 0001829252 · EVP Chief R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,756

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001735276-26-000032 · edgardoc.xml · nonDerivative · entry 1

Fitzgerald Kevin Joseph · CIK 0001886431 · CSO & EVP, Head of Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,422

F1 · kind: On February 23, 2026, the People, Culture, and Compensation Committee of the issuer approved the issuance of shares of Company common stock having an aggregate value of USD $100,000 to each employee who completes 20 consecutive years of employment. The shares issued and reported here on Form 4, net of the minimum statutory tax liability, were issued to the reporting person in recognition of 20 years of continuous employment on December 5, 2025.

SEC source: 0001735276-26-000026 · edgardoc.xml · nonDerivative · entry 3

Fitzgerald Kevin Joseph · CIK 0001886431 · CSO & EVP, Head of Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,264

F4 · kind: This transaction was made pursuant to a Rule 10b5-1 (c) trading plan adopted by the Reporting Person on August 14, 2025.

F5 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $329.10 to $334.51. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000029 · edgardoc.xml · nonDerivative · entry 2

Garg Pushkal · CIK 0001829252 · EVP Chief R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,848

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

F3 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $302.55 to $314.60. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000028 · edgardoc.xml · nonDerivative · entry 2

Greenstreet Yvonne · CIK 0001446125 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 85,662

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

F3 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $302.55 to $314.60. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000025 · edgardoc.xml · nonDerivative · entry 2

Poulton Jeffrey V. · CIK 0001782962 · EVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 59,802

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

F3 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $302.55 to $314.60. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000027 · edgardoc.xml · nonDerivative · entry 2

Tanguler Tolga · CIK 0001849458 · EVP, Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,769

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

F3 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $302.55 to $314.60. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000026 · edgardoc.xml · nonDerivative · entry 2

Fitzgerald Kevin Joseph · CIK 0001886431 · CSO & EVP, Head of Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,305

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

F3 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $302.55 to $314.60. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000029 · edgardoc.xml · nonDerivative · entry 1

Garg Pushkal · CIK 0001829252 · EVP Chief R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,090

F1 · kind: On February 27, 2023, the reporting person was granted a performance-based stock unit (PSU) under the 2018 Stock Incentive Plan. The shares subject to the PSU vest based on the achievement of three specified performance measures. The shares reported were issued to the reporting person upon vesting of forty (40) percent of the shares subject to the PSU based on the issuer publicly reporting the achievement of non-GAAP operating income for fiscal year 2025 on February 12, 2026, as determined by the People, Culture and Compensation Committee of the Issuer Board of Directors.

SEC source: 0001735276-26-000028 · edgardoc.xml · nonDerivative · entry 1

Greenstreet Yvonne · CIK 0001446125 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 92,620

F1 · kind: On February 27, 2023, the reporting person was granted a performance-based stock unit (PSU) under the 2018 Stock Incentive Plan. The shares subject to the PSU vest based on the achievement of three specified performance measures. The shares reported were issued to the reporting person upon vesting of forty (40) percent of the shares subject to the PSU based on the issuer publicly reporting the achievement of non-GAAP operating income for fiscal year 2025 on February 12, 2026, as determined by the People, Culture and Compensation Committee of the Issuer Board of Directors.

SEC source: 0001735276-26-000025 · edgardoc.xml · nonDerivative · entry 1

Poulton Jeffrey V. · CIK 0001782962 · EVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 62,044

F1 · kind: On February 27, 2023, the reporting person was granted a performance-based stock unit (PSU) under the 2018 Stock Incentive Plan. The shares subject to the PSU vest based on the achievement of three specified performance measures. The shares reported were issued to the reporting person upon vesting of forty (40) percent of the shares subject to the PSU based on the issuer publicly reporting the achievement of non-GAAP operating income for fiscal year 2025 on February 12, 2026, as determined by the People, Culture and Compensation Committee of the Issuer Board of Directors.

SEC source: 0001735276-26-000027 · edgardoc.xml · nonDerivative · entry 1

Tanguler Tolga · CIK 0001849458 · EVP, Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,728

F1 · kind: On February 27, 2023, the reporting person was granted a performance-based stock unit (PSU) under the 2018 Stock Incentive Plan. The shares subject to the PSU vest based on the achievement of three specified performance measures. The shares reported were issued to the reporting person upon vesting of forty (40) percent of the shares subject to the PSU based on the issuer publicly reporting the achievement of non-GAAP operating income for fiscal year 2025 on February 12, 2026, as determined by the People, Culture and Compensation Committee of the Issuer Board of Directors.

SEC source: 0001735276-26-000026 · edgardoc.xml · nonDerivative · entry 1

Fitzgerald Kevin Joseph · CIK 0001886431 · CSO & EVP, Head of Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,264

F1 · kind: On February 27, 2023, the reporting person was granted a performance-based stock unit (PSU) under the 2018 Stock Incentive Plan. The shares subject to the PSU vest based on the achievement of three specified performance measures. The shares reported were issued to the reporting person upon vesting of forty (40) percent of the shares subject to the PSU based on the issuer publicly reporting the achievement of non-GAAP operating income for fiscal year 2025 on February 12, 2026, as determined by the People, Culture and Compensation Committee of the Issuer Board of Directors.

SEC source: 0001735276-26-000011 · edgardoc.xml · nonDerivative · entry 28

Fitzgerald Kevin Joseph · CIK 0001886431 · CSO & EVP, Head of Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,264

F22 · kind: This transaction was made pursuant to a Rule 10b5-1 (c) trading plan adopted by the Reporting Person on August 14, 2025.

F28 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $374.28 to $374.66. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000011 · edgardoc.xml · nonDerivative · entry 27

Fitzgerald Kevin Joseph · CIK 0001886431 · CSO & EVP, Head of Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,386

F22 · kind: This transaction was made pursuant to a Rule 10b5-1 (c) trading plan adopted by the Reporting Person on August 14, 2025.

F27 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $372.70 to $373.11. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000011 · edgardoc.xml · nonDerivative · entry 26

Fitzgerald Kevin Joseph · CIK 0001886431 · CSO & EVP, Head of Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,666

F22 · kind: This transaction was made pursuant to a Rule 10b5-1 (c) trading plan adopted by the Reporting Person on August 14, 2025.

F26 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $370.52 to $371.47. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000011 · edgardoc.xml · nonDerivative · entry 25

Fitzgerald Kevin Joseph · CIK 0001886431 · CSO & EVP, Head of Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,151

F22 · kind: This transaction was made pursuant to a Rule 10b5-1 (c) trading plan adopted by the Reporting Person on August 14, 2025.

F25 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $369.36 to $370.35. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000011 · edgardoc.xml · nonDerivative · entry 24

Fitzgerald Kevin Joseph · CIK 0001886431 · CSO & EVP, Head of Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,795

F22 · kind: This transaction was made pursuant to a Rule 10b5-1 (c) trading plan adopted by the Reporting Person on August 14, 2025.

F24 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $368.25 to $369.23. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000011 · edgardoc.xml · nonDerivative · entry 23

Fitzgerald Kevin Joseph · CIK 0001886431 · CSO & EVP, Head of Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,357

F22 · kind: This transaction was made pursuant to a Rule 10b5-1 (c) trading plan adopted by the Reporting Person on August 14, 2025.

F23 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $367.18 to $367.96. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000015 · edgardoc.xml · nonDerivative · entry 22

Garg Pushkal · CIK 0001829252 · EVP Chief R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,511

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

SEC source: 0001735276-26-000015 · edgardoc.xml · nonDerivative · entry 21

Garg Pushkal · CIK 0001829252 · EVP Chief R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,526

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

SEC source: 0001735276-26-000015 · edgardoc.xml · nonDerivative · entry 20

Garg Pushkal · CIK 0001829252 · EVP Chief R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,545

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

F21 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $374.08 to $374.89. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000015 · edgardoc.xml · nonDerivative · entry 19

Garg Pushkal · CIK 0001829252 · EVP Chief R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,559

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

F20 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $372.35 to $372.50. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000015 · edgardoc.xml · nonDerivative · entry 18

Garg Pushkal · CIK 0001829252 · EVP Chief R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,562

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

F19 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $370.43 to $371.23. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000015 · edgardoc.xml · nonDerivative · entry 17

Garg Pushkal · CIK 0001829252 · EVP Chief R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,580

F2 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations.

F18 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $369.13 to $369.93. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.