ALEC

SEC source: 0001209191-21-039571 · doc4.xml · derivative · entry 6

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 115,083

Underlying: Common Stock · 7,292 shares

Expires 2028-07-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: One forty-eighth (1/48th) of the shares subject to the option vested on August 2, 2018, and one forty-eighth (1/48th) of the shares subject to the option vest monthly thereafter.

SEC source: 0001209191-21-039571 · doc4.xml · nonDerivative · entry 5

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 273,719

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on May 28, 2020.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $20.64 to $21.08, inclusive.

SEC source: 0001209191-21-039571 · doc4.xml · nonDerivative · entry 4

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 274,519

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on May 28, 2020.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.63 to $20.59, inclusive.

SEC source: 0001209191-21-039571 · doc4.xml · nonDerivative · entry 3

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 276,719

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on May 28, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $18.61 to $19.59, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3) and (4).

SEC source: 0001209191-21-039571 · doc4.xml · nonDerivative · entry 2

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 292,894

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-039571 · doc4.xml · nonDerivative · entry 1

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 281,011

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-037942 · doc4.xml · nonDerivative · entry 1

Yu Calvin · CIK 0001757799 · Vice President, Finance

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 126,686

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan.

F2 · shares: The shares were acquired pursuant to the Issuer's 2019 Employee Stock Purchase Plan on May 28, 2021.

SEC source: 0001209191-21-035791 · doc4.xml · derivative · entry 5

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 54,167

Underlying: Common Stock · 784 shares

Expires 2028-11-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: One-fourth (1/4th) of the shares subject to the option vested on November 1, 2019 and one forty-eighth (1/48th) of the shares vest monthly thereafter.

SEC source: 0001209191-21-035791 · doc4.xml · derivative · entry 4

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 122,375

Underlying: Common Stock · 14,191 shares

Expires 2028-07-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: One forty-eighth (1/48th) of the shares subject to the option vested on August 2, 2018, and one forty-eighth (1/48th) of the shares subject to the option vest monthly thereafter.

SEC source: 0001209191-21-035791 · doc4.xml · nonDerivative · entry 3

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 273,719

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on May 28, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $18.00 to $18.30, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-21-035791 · doc4.xml · nonDerivative · entry 2

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 288,694

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-035791 · doc4.xml · nonDerivative · entry 1

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 287,910

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-034508 · doc4.xml · derivative · entry 5

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 54,951

Underlying: Common Stock · 1,300 shares

Expires 2028-11-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: One-fourth (1/4th) of the shares subject to the option vested on November 1, 2019 and one forty-eighth (1/48th) of the shares vest monthly thereafter.

SEC source: 0001209191-21-034508 · doc4.xml · derivative · entry 4

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 136,566

Underlying: Common Stock · 2,900 shares

Expires 2028-07-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: One forty-eighth (1/48th) of the shares subject to the option vested on August 2, 2018, and one forty-eighth (1/48th) of the shares subject to the option vest monthly thereafter.

SEC source: 0001209191-21-034508 · doc4.xml · nonDerivative · entry 3

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 273,719

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on May 28, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $18.00 to $18.09, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-21-034508 · doc4.xml · nonDerivative · entry 2

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 277,919

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-034508 · doc4.xml · nonDerivative · entry 1

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 276,619

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-031831 · doc4.xml · nonDerivative · entry 1

Rosenthal Arnon · CIK 0001757770 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,455,226

F1 · shares: The reported shares are represented by performance share units, or PSUs. Fifty percent of the award will be earned if the Issuer's average closing stock price is $30 per share for 40 consecutive trading days and an additional fifty percent will be earned if the average closing stock price is $40 per share for 40 consecutive trading days. Upon attainment of the performance metrics, the shares vest in four equal quarterly installments beginning on the first vesting date as set forth in the PSU award agreement.

SEC source: 0001209191-21-031849 · doc4.xml · nonDerivative · entry 1

Yu Calvin · CIK 0001757799 · Vice President, Finance

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 126,686

F1 · shares: The reported shares are represented by performance share units, or PSUs. Fifty percent of the award will be earned if the Issuer's average closing stock price is $30 per share for 40 consecutive trading days and an additional fifty percent will be earned if the average closing stock price is $40 per share for 40 consecutive trading days. Upon attainment of the performance metrics, the shares vest in four equal quarterly installments beginning on the first vesting date as set forth in the PSU award agreement.

SEC source: 0001209191-21-031843 · doc4.xml · nonDerivative · entry 1

King Robert · CIK 0001635264 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 522,317

F1 · shares: The reported shares are represented by performance share units, or PSUs. Fifty percent of the award will be earned if the Issuer's average closing stock price is $30 per share for 40 consecutive trading days and an additional fifty percent will be earned if the average closing stock price is $40 per share for 40 consecutive trading days. Upon attainment of the performance metrics, the shares vest in four equal quarterly installments beginning on the first vesting date as set forth in the PSU award agreement.

SEC source: 0001209191-21-031846 · doc4.xml · nonDerivative · entry 1

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 273,719

F1 · shares: The reported shares are represented by performance share units, or PSUs. Fifty percent of the award will be earned if the Issuer's average closing stock price is $30 per share for 40 consecutive trading days and an additional fifty percent will be earned if the average closing stock price is $40 per share for 40 consecutive trading days. Upon attainment of the performance metrics, the shares vest in four equal quarterly installments beginning on the first vesting date as set forth in the PSU award agreement.

SEC source: 0001209191-21-031839 · doc4.xml · nonDerivative · entry 1

SULIMAN SHEHNAAZ · CIK 0001713070 · President and COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,000

F1 · shares: The reported shares are represented by performance share units, or PSUs. Fifty percent of the award will be earned if the Issuer's average closing stock price is $30 per share for 40 consecutive trading days and an additional fifty percent will be earned if the average closing stock price is $40 per share for 40 consecutive trading days. Upon attainment of the performance metrics, the shares vest in four equal quarterly installments beginning on the first vesting date as set forth in the PSU award agreement.

SEC source: 0001209191-21-026167 · doc4.xml · derivative · entry 8

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 146,875

Underlying: Common Stock · 3,125 shares

Expires 2029-11-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The shares subject to this option vest in 48 equal monthly installments beginning on December 6, 2019.

SEC source: 0001209191-21-026167 · doc4.xml · derivative · entry 7

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,251

Underlying: Common Stock · 2,083 shares

Expires 2028-11-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: One-fourth (1/4th) of the shares subject to the option vested on November 1, 2019 and one forty-eighth (1/48th) of the shares vest monthly thereafter.

SEC source: 0001209191-21-026167 · doc4.xml · derivative · entry 6

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 139,466

Underlying: Common Stock · 17,092 shares

Expires 2028-07-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: One forty-eighth (1/48th) of the shares subject to the option vested on August 2, 2018, and one forty-eighth (1/48th) of the shares subject to the option vest monthly thereafter.

SEC source: 0001209191-21-026167 · doc4.xml · nonDerivative · entry 5

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 213,719

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on May 28, 2020.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.83 to $19.83, inclusive.

SEC source: 0001209191-21-026167 · doc4.xml · nonDerivative · entry 4

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 213,764

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on May 28, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $18.81 to $19.80, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) and (3) to this Form 4.

SEC source: 0001209191-21-026167 · doc4.xml · nonDerivative · entry 3

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 236,019

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-026167 · doc4.xml · nonDerivative · entry 2

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 232,894

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-026167 · doc4.xml · nonDerivative · entry 1

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 230,811

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-022851 · doc4.xml · nonDerivative · entry 5

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 213,719

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on May 28, 2020.

SEC source: 0001209191-21-022851 · doc4.xml · nonDerivative · entry 4

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 227,519

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-022851 · doc4.xml · derivative · entry 7

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 156,558

Underlying: Common Stock · 13,800 shares

Expires 2028-07-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: One forty-eighth (1/48th) of the shares subject to the option vested on August 2, 2018, and one forty-eighth (1/48th) of the shares subject to the option vest monthly thereafter.

SEC source: 0001209191-21-022851 · doc4.xml · derivative · entry 6

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 170,358

Underlying: Common Stock · 30,000 shares

Expires 2028-07-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: One forty-eighth (1/48th) of the shares subject to the option vested on August 2, 2018, and one forty-eighth (1/48th) of the shares subject to the option vest monthly thereafter.

SEC source: 0001209191-21-022851 · doc4.xml · nonDerivative · entry 3

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 213,719

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on May 28, 2020.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $23.44 to $23.97, inclusive.

SEC source: 0001209191-21-022851 · doc4.xml · nonDerivative · entry 2

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 219,229

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on May 28, 2020.

F2 · price: The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $22.41 to $23.38 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) and (3) to this Form 4.

SEC source: 0001209191-21-022851 · doc4.xml · nonDerivative · entry 1

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 243,719

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-019607 · doc4.xml · derivative · entry 5

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 58,334

Underlying: Common Stock · 2,083 shares

Expires 2028-11-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: One-fourth (1/4th) of the shares subject to the option vested on November 1, 2019 and one forty-eighth (1/48th) of the shares vest monthly thereafter.

SEC source: 0001209191-21-019607 · doc4.xml · derivative · entry 4

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,358

Underlying: Common Stock · 17,092 shares

Expires 2028-07-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: One forty-eighth (1/48th) of the shares subject to the option vested on August 2, 2018, and one forty-eighth (1/48th) of the shares subject to the option vest monthly thereafter.

SEC source: 0001209191-21-019607 · doc4.xml · nonDerivative · entry 3

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 213,719

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on May 28, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $18.00 to $18.36, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-21-019607 · doc4.xml · nonDerivative · entry 2

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 232,894

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-019607 · doc4.xml · nonDerivative · entry 1

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 230,811

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-009765 · doc4.xml · derivative · entry 5

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,417

Underlying: Common Stock · 2,084 shares

Expires 2028-11-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: One-fourth (1/4th) of the shares subject to the option vested on November 1, 2019 and one forty-eighth (1/48th) of the shares vest monthly thereafter.

SEC source: 0001209191-21-009765 · doc4.xml · derivative · entry 4

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 217,450

Underlying: Common Stock · 17,091 shares

Expires 2028-07-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: One forty-eighth (1/48th) of the shares subject to the option vested on August 2, 2018, and one forty-eighth (1/48th) of the shares subject to the option vest monthly thereafter.

SEC source: 0001209191-21-009765 · doc4.xml · nonDerivative · entry 3

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 213,719

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on May 28, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $20.45 to $21.05, inclusive.

SEC source: 0001209191-21-009765 · doc4.xml · nonDerivative · entry 2

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 232,894

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-009765 · doc4.xml · nonDerivative · entry 1

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 230,810

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-005750 · doc4.xml · derivative · entry 10

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,501

Underlying: Common Stock · 4,166 shares

Expires 2028-11-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: One-fourth (1/4th) of the shares subject to the option vested on November 1, 2019 and one forty-eighth (1/48th) of the shares vest monthly thereafter.

SEC source: 0001209191-21-005750 · doc4.xml · derivative · entry 9

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 234,541

Underlying: Common Stock · 23,142 shares

Expires 2028-07-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: One forty-eighth (1/48th) of the shares subject to the option vested on August 2, 2018, and one forty-eighth (1/48th) of the shares subject to the option vest monthly thereafter.

SEC source: 0001209191-21-005750 · doc4.xml · nonDerivative · entry 6

Paul Robert · CIK 0001757964 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 213,719

F1 · kind: The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on May 28, 2020.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $18.00 to $18.055, inclusive.