AKBA

SEC source: 0001562180-23-004254 · primarydocument.xml · nonDerivative · entry 1

Burke Steven Keith · CIK 0001619834 · SVP, Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 530,487

F1 · shares: This sale was made automatically by the Issuer pursuant to the Issuer's previously adopted "sell-to-cover" policy to cover tax withholding obligations in connection with the vesting and settlement of 100% of the reporting person's restricted stock units granted on May 12, 2022.

SEC source: 0001562180-23-004253 · primarydocument.xml · nonDerivative · entry 1

Spellman David A · CIK 0001733204 · SVP, CFO and Treasurer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 446,483

F1 · shares: This sale was made automatically by the Issuer pursuant to the Issuer's previously adopted "sell-to-cover" policy to cover tax withholding obligations in connection with the vesting and settlement of 100% of the reporting person's restricted stock units granted on June 8, 2022.

SEC source: 0001562180-23-004168 · primarydocument.xml · nonDerivative · entry 1

Dahan Michel · CIK 0001669737 · SVP, Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 469,515

F1 · shares: The restricted stock units were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended. One third of the restricted stock units will vest on each of the first, second and third anniversaries of the grant date, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001562180-23-004169 · primarydocument.xml · nonDerivative · entry 1

Hadas Nicole R. · CIK 0001602396 · SVP, Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 387,530

F1 · shares: The restricted stock units were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended. One third of the restricted stock units will vest on each of the first, second and third anniversaries of the grant date, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001562180-23-002198 · primarydocument.xml · nonDerivative · entry 3

Dahan Michel · CIK 0001669737 · SVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 269,515

F3 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the performance-based restricted stock units that were previously reported for the Reporting Person on a Form 4 filed on March 18, 2021.

SEC source: 0001562180-23-002198 · primarydocument.xml · nonDerivative · entry 2

Dahan Michel · CIK 0001669737 · SVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 271,393

F2 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the reporting person's restricted stock units granted on February 28, 2020.

SEC source: 0001562180-23-002198 · primarydocument.xml · nonDerivative · entry 1

Dahan Michel · CIK 0001669737 · SVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 281,869

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the reporting person's restricted stock units granted on February 28, 2022.

SEC source: 0001562180-23-002201 · primarydocument.xml · nonDerivative · entry 3

Butler John P. · CIK 0001591467 · Director · CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,568,872

F3 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the performance-based restricted stock units that were previously reported for the Reporting Person on a Form 4 filed on March 18, 2021.

SEC source: 0001562180-23-002201 · primarydocument.xml · nonDerivative · entry 2

Butler John P. · CIK 0001591467 · Director · CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,575,242

F2 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the reporting person's restricted stock units granted on February 28, 2022.

SEC source: 0001562180-23-002201 · primarydocument.xml · nonDerivative · entry 1

Butler John P. · CIK 0001591467 · Director · CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,622,481

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the reporting person's restricted stock units granted on February 28, 2020.

SEC source: 0001562180-23-002200 · primarydocument.xml · nonDerivative · entry 3

Hadas Nicole R. · CIK 0001602396 · SVP, Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 287,530

F3 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the performance-based restricted stock units that were previously reported for the Reporting Person on a Form 4 filed on March 18, 2021.

SEC source: 0001562180-23-002200 · primarydocument.xml · nonDerivative · entry 2

Hadas Nicole R. · CIK 0001602396 · SVP, Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 288,618

F2 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the reporting person's restricted stock units granted on February 28, 2020.

SEC source: 0001562180-23-002200 · primarydocument.xml · nonDerivative · entry 1

Hadas Nicole R. · CIK 0001602396 · SVP, Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 295,231

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the reporting person's restricted stock units granted on February 28, 2022.

SEC source: 0001562180-23-002199 · primarydocument.xml · nonDerivative · entry 3

Burke Steven Keith · CIK 0001619834 · SVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 594,054

F3 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the performance-based restricted stock units that were previously reported for the Reporting Person on a Form 4 filed on March 18, 2021.

SEC source: 0001562180-23-002199 · primarydocument.xml · nonDerivative · entry 2

Burke Steven Keith · CIK 0001619834 · SVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 595,164

F2 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the reporting person's restricted stock units granted on February 28, 2022.

SEC source: 0001562180-23-002199 · primarydocument.xml · nonDerivative · entry 1

Burke Steven Keith · CIK 0001619834 · SVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 601,564

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the reporting person's restricted stock units granted on February 28, 2020.

SEC source: 0001562180-23-002197 · primarydocument.xml · nonDerivative · entry 2

Spellman David A · CIK 0001733204 · SVP, CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 510,050

F2 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the performance-based restricted stock units that were previously reported for the Reporting Person on a Form 4 filed on March 18, 2021.

SEC source: 0001562180-23-002197 · primarydocument.xml · nonDerivative · entry 1

Spellman David A · CIK 0001733204 · SVP, CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 510,860

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the reporting person's restricted stock units granted on February 28, 2022.

SEC source: 0001562180-23-002039 · primarydocument.xml · nonDerivative · entry 1

Dahan Michel · CIK 0001669737 · SVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 289,927

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the reporting person's restricted stock units granted on February 26, 2021.

F2 · balance_after: Includes 1,500 shares of the Issuers common stock purchased on June 30, 2022, and 1,500 shares of the Issuers common stock purchased on December 30, 2022, each under the Issuer's 2014 Amended and Restated Employee Stock Purchase Plan.

SEC source: 0001562180-23-002041 · primarydocument.xml · nonDerivative · entry 1

Butler John P. · CIK 0001591467 · Director · CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,660,740

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the reporting person's restricted stock units granted on February 26, 2021.

SEC source: 0001562180-23-002040 · primarydocument.xml · nonDerivative · entry 1

Burke Steven Keith · CIK 0001619834 · SVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 608,177

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the reporting person's restricted stock units granted on February 26, 2021.

SEC source: 0001562180-23-002038 · primarydocument.xml · nonDerivative · entry 1

Spellman David A · CIK 0001733204 · SVP, CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 517,260

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the reporting person's restricted stock units granted on February 26, 2021.

SEC source: 0001562180-23-002037 · primarydocument.xml · nonDerivative · entry 1

Hadas Nicole R. · CIK 0001602396 · SVP, Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 300,564

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the reporting person's restricted stock units granted on February 26, 2021.

F2 · balance_after: Includes 1,500 shares of the Issuers common stock purchased on June 30, 2022, and 1,500 shares of the Issuers common stock purchased on December 30, 2022, each under the Issuer's 2014 Amended and Restated Employee Stock Purchase Plan.

SEC source: 0001562180-23-000832 · primarydocument.xml · derivative · entry 7

Butler John P. · CIK 0001591467 · Director · CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 875,000

Underlying: Common Stock · 875,000 shares

Expires 2033-01-31

F4 · derivative.exercise_date: The options were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended. The options will vest over four years: 25% of the options will vest on the first anniversary of the grant date with the remaining 75% vesting in equal quarterly installments thereafter, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001562180-23-000832 · primarydocument.xml · derivative · entry 6

Butler John P. · CIK 0001591467 · Director · CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 635,313

Underlying: Common Stock · 635,313 shares

Expires 2033-01-31

F3 · derivative.exercise_date: The stock appreciation rights ("SARs") were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended. The SARs will vest over four years: 25% of the SARs will vest on the first anniversary of the grant date with the remaining 75% vesting in equal quarterly installments thereafter, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001562180-23-000832 · primarydocument.xml · nonDerivative · entry 1

Butler John P. · CIK 0001591467 · Director · CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,699,372

F1 · shares: The restricted stock units were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended. One third of the restricted stock units will vest on each of the first, second and third anniversaries of the grant date, subject to the reporting person's continued service with the Issuer on each vesting date.

F2 · balance_after: Includes 1,500 shares of the Issuer's common stock purchased on June 30, 2022 and 1,500 shares of the Issuer's common stock purchased on December 30, 2022, each under the Issuer's 2014 Amended and Restated Employee Stock Purchase Plan.

SEC source: 0001562180-23-000831 · primarydocument.xml · derivative · entry 2

Spellman David A · CIK 0001733204 · SVP, CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 294,300

Underlying: Common Stock · 294,300 shares

Expires 2033-01-31

F2 · derivative.exercise_date: The options were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended. The options will vest over four years: 25% of the options will vest on the first anniversary of the grant date with the remaining 75% vesting in equal quarterly installments thereafter, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001562180-23-000831 · primarydocument.xml · nonDerivative · entry 1

Spellman David A · CIK 0001733204 · SVP, CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 524,799

F1 · shares: The restricted stock units were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended. One third of the restricted stock units will vest on each of the first, second and third anniversaries of the grant date, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001562180-23-000830 · primarydocument.xml · derivative · entry 2

Burke Steven Keith · CIK 0001619834 · SVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 294,300

Underlying: Common Stock · 294,300 shares

Expires 2033-01-31

F3 · derivative.exercise_date: The options were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended. The options will vest over four years: 25% of the options will vest on the first anniversary of the grant date with the remaining 75% vesting in equal quarterly installments thereafter, subject to the reporting person's continued service with the Issuer on each vesting date.

SEC source: 0001562180-23-000830 · primarydocument.xml · nonDerivative · entry 1

Burke Steven Keith · CIK 0001619834 · SVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 615,716

F1 · shares: The restricted stock units were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended. One third of the restricted stock units will vest on each of the first, second and third anniversaries of the grant date, subject to the reporting person's continued service with the Issuer on each vesting date.

F2 · balance_after: Includes 1,500 shares of the Issuer's common stock purchased on December 30, 2022 under the Issuer's 2014 Amended and Restated Employee Stock Purchase Plan.

SEC source: 0001562180-22-006402 · primarydocument.xml · nonDerivative · entry 1

Burke Steven Keith · CIK 0001619834 · SVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 418,016

F1 · shares: This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the reporting person's restricted stock units granted on August 30, 2019.

F2 · balance_after: Includes 1,500 shares of the Issuer's common stock purchased on June 30, 2022, under the Issuer's 2014 Amended and Restated Employee Stock Purchase Plan.

SEC source: 0001562180-22-004978 · primarydocument.xml · derivative · entry 2

Wolf Myles · CIK 0001808317 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,100

Underlying: Common Stock · 20,100 shares

Expires 2032-06-08

F2 · shares: The option to purchase shares of the Issuer's common stock (the "Stock Option") was granted by the Issuer pursuant to the 2014 Plan, as provided by the Program. The Stock Option will vest and become exercisable in full (100%) on the first anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001562180-22-004978 · primarydocument.xml · nonDerivative · entry 1

Wolf Myles · CIK 0001808317 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,681

F1 · shares: The restricted stock units (the "RSUs") were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended (the "2014 Plan"), as provided by the Issuer's Amended and Restated Non-Employee Director Compensation Program (the "Program"). The RSUs will vest in full (100%) on the first anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001562180-22-004973 · primarydocument.xml · derivative · entry 2

ADAMS ADRIAN · CIK 0001248144 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,100

Underlying: Common Stock · 20,100 shares

Expires 2032-06-08

F2 · shares: The option to purchase shares of the Issuer's common stock (the "Stock Option") was granted by the Issuer pursuant to the 2014 Plan, as provided by the Program. The Stock Option will vest and become exercisable in full (100%) on the first anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001562180-22-004973 · primarydocument.xml · nonDerivative · entry 1

ADAMS ADRIAN · CIK 0001248144 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,800

F1 · shares: The restricted stock units (the "RSUs") were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended (the "2014 Plan"), as provided by the Issuer's Amended and Restated Non-Employee Director Compensation Program (the "Program"). The RSUs will vest in full (100%) on the first anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001562180-22-004976 · primarydocument.xml · derivative · entry 2

ROGERS MICHAEL W · CIK 0001244159 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,100

Underlying: Common Stock · 20,100 shares

Expires 2032-06-08

F2 · shares: The option to purchase shares of the Issuer's common stock (the "Stock Option") was granted by the Issuer pursuant to the 2014 Plan, as provided by the Program. The Stock Option will vest and become exercisable in full (100%) on the first anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001562180-22-004976 · primarydocument.xml · nonDerivative · entry 1

ROGERS MICHAEL W · CIK 0001244159 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 66,029

F1 · shares: The restricted stock units (the "RSUs") were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended (the "2014 Plan"), as provided by the Issuer's Amended and Restated Non-Employee Director Compensation Program (the "Program"). The RSUs will vest in full (100%) on the first anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001562180-22-004980 · primarydocument.xml · derivative · entry 2

ZUMWALT LEANNE M · CIK 0001204946 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,100

Underlying: Common Stock · 20,100 shares

Expires 2032-06-08

F2 · shares: The option to purchase shares of the Issuer's common stock (the "Stock Option") was granted by the Issuer pursuant to the 2014 Plan, as provided by the Program. The Stock Option will vest and become exercisable in full (100%) on the first anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001562180-22-004980 · primarydocument.xml · nonDerivative · entry 1

ZUMWALT LEANNE M · CIK 0001204946 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,700

F1 · shares: The restricted stock units (the "RSUs") were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended (the "2014 Plan"), as provided by the Issuer's Amended and Restated Non-Employee Director Compensation Program (the "Program"). The RSUs will vest in full (100%) on the first anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001562180-22-004975 · primarydocument.xml · derivative · entry 2

GILMAN STEVEN C · CIK 0001379970 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,100

Underlying: Common Stock · 20,100 shares

Expires 2032-06-08

F2 · shares: The option to purchase shares of the Issuer's common stock (the "Stock Option") was granted by the Issuer pursuant to the 2014 Plan, as provided by the Program. The Stock Option will vest and become exercisable in full (100%) on the first anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001562180-22-004975 · primarydocument.xml · nonDerivative · entry 1

GILMAN STEVEN C · CIK 0001379970 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 57,130

F1 · shares: The restricted stock units (the "RSUs") were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended (the "2014 Plan"), as provided by the Issuer's Amended and Restated Non-Employee Director Compensation Program (the "Program"). The RSUs will vest in full (100%) on the first anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001562180-22-004977 · primarydocument.xml · derivative · entry 2

Smith Cynthia · CIK 0001609480 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,100

Underlying: Common Stock · 20,100 shares

Expires 2032-06-08

F2 · shares: The option to purchase shares of the Issuer's common stock (the "Stock Option") was granted by the Issuer pursuant to the 2014 Plan, as provided by the Program. The Stock Option will vest and become exercisable in full (100%) on the first anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001562180-22-004977 · primarydocument.xml · nonDerivative · entry 1

Smith Cynthia · CIK 0001609480 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,233

F1 · shares: The restricted stock units (the "RSUs") were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended (the "2014 Plan"), as provided by the Issuer's Amended and Restated Non-Employee Director Compensation Program (the "Program"). The RSUs will vest in full (100%) on the first anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001562180-22-004974 · primarydocument.xml · derivative · entry 2

FRIESON RON · CIK 0001890219 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,100

Underlying: Common Stock · 20,100 shares

Expires 2032-06-08

F2 · shares: The option to purchase shares of the Issuer's common stock (the "Stock Option") was granted by the Issuer pursuant to the 2014 Plan, as provided by the Program. The Stock Option will vest and become exercisable in full (100%) on the first anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001562180-22-004974 · primarydocument.xml · nonDerivative · entry 1

FRIESON RON · CIK 0001890219 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,700

F1 · shares: The restricted stock units (the "RSUs") were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended (the "2014 Plan"), as provided by the Issuer's Amended and Restated Non-Employee Director Compensation Program (the "Program"). The RSUs will vest in full (100%) on the first anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001562180-22-005001 · primarydocument.xml · derivative · entry 2

Spellman David A · CIK 0001733204 · SVP, CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires 2032-06-08

F2 · derivative.exercise_date: The option to purchase shares of the Issuer's common stock ("the Stock Option") was granted by the Issuer pursuant to the 2014 Plan. The Stock Option will vest and become exercisable in full (100%) on May 12, 2023, subject to the Reporting Person's continued service with the Issuer on such vesting date.

SEC source: 0001562180-22-005001 · primarydocument.xml · nonDerivative · entry 1

Spellman David A · CIK 0001733204 · SVP, CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 328,599

F1 · shares: The restricted stock units (the "RSUs") were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended (the "2014 Plan"). The RSUs will vest in full (100%) on May 12, 2023, subject to the Reporting Person's continued service with the Issuer on such vesting date.

SEC source: 0001562180-22-004870 · primarydocument.xml · nonDerivative · entry 1

GILMAN STEVEN C · CIK 0001379970 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 43,430

F1 · kind: This sale was made pursuant to a 10b5-1 trading plan to cover tax withholding obligations in connection with the vesting and settlement of 100% of the Reporting Person's restricted stock units granted on June 2, 2021.

SEC source: 0001562180-22-004031 · primarydocument.xml · derivative · entry 2

Burke Steven Keith · CIK 0001619834 · SVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires 2032-05-12

F2 · derivative.exercise_date: The options were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended. The options will vest in full on the first anniversary of the grant date, subject to the reporting person's continued service with the Issuer on such vesting date.

SEC source: 0001562180-22-004031 · primarydocument.xml · nonDerivative · entry 1

Burke Steven Keith · CIK 0001619834 · SVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 417,663

F1 · shares: The restricted stock units were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended. The restricted stock units will vest in full on the first anniversary of the grant date, subject to the reporting person's continued service with the Issuer on such vesting date.