AGIO

SEC source: 0001209191-17-005946 · doc4.xml · derivative · entry 1

Schenkein David P · CIK 0001578200 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 136,363

Underlying: Common stock · 68,182 shares

Expires 2023-04-29

F1 · derivative.exercise_date: This option was originally granted on April 30, 2013 for the purchase of 136,363 shares of common stock. The option vests as to 50% of the underlying shares upon the achievement of a performance milestone, and as to the remaining 50% of upon the achievement of a second performance milestone. The Company's board of directors determined that the first performance milestone was achieved on December 3, 2015, resulting in the vesting of this option as to 68,181 shares. On January 26, 2017, the Company's board of directors determined that the second performance milestone was achieved, resulting in the vesting of this option as to the remaining 68,182 shares.

SEC source: 0001209191-17-005945 · doc4.xml · derivative · entry 1

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 54,090

Underlying: Common stock · 34,090 shares

Expires 2023-04-29

F1 · derivative.exercise_date: This option was originally granted on April 30, 2013 for the purchase of 68,181 shares of common stock. The option vests as to 50% of the underlying shares upon the achievement of a performance milestone, and as to the remaining 50% of upon the achievement of a second performance milestone. The Company's board of directors determined that the first performance milestone was achieved on December 3, 2015, resulting in the vesting of this option as to 34,091 shares. On January 26, 2017, the Company's board of directors determined that the second performance milestone was achieved, resulting in the vesting of this option as to the remaining 34,090 shares.

SEC source: 0001209191-17-001022 · doc4.xml · derivative · entry 1

CLARK IAN T · CIK 0001336504 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,000

Underlying: Common stock · 16,000 shares

Expires 2026-12-29

F1 · derivative.exercise_date: This option was granted on December 30, 2016. The shares underlying this option vest as to 25% of the underlying shares on December 30, 2017, with the remaining 75% vesting in 36 equal monthly installments thereafter.

SEC source: 0001209191-16-156556 · doc4.xml · nonDerivative · entry 1

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,470

F1 · kind: Represents shares donated by the reporting person to a charitable donor-advised fund.

SEC source: 0001209191-16-150568 · doc4.xml · derivative · entry 8

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,286

Underlying: Common stock · 6,520 shares

Expires 2024-03-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · kind: This exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F7 · derivative.exercise_date: This option was granted on March 5, 2014. The shares underlying this option vest as to 25% of the shares on March 5, 2015, with the remaining 75% vesting in 36 equal monthly installments thereafter.

SEC source: 0001209191-16-150568 · doc4.xml · derivative · entry 7

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common stock · 14,091 shares

Expires 2023-04-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · kind: This exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F6 · derivative.exercise_date: This option was originally granted on April 30, 2013 for the purchase of 68,181 shares of common stock. The option vests as to 50% of the underlying shares upon the achievement of a performance milestone, and as to an additional 50% upon the achievement of a second performance milestone. The Company's board of directors determined that the first performance milestone was achieved on December 3, 2015, resulting in the vesting of the option as to 34,091 shares. The second performance milestone has not yet been met.

SEC source: 0001209191-16-150568 · doc4.xml · derivative · entry 6

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,474

Underlying: Common stock · 6,889 shares

Expires 2020-12-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · kind: This exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F5 · derivative.exercise_date: This option was granted on December 7, 2010. The shares underlying this option vested as to 25% of the shares upon the achievement of a performance milestone, and as to the remaining 75% in 36 equal monthly installments thereafter. The performance criteria was met on June 23, 2015.

SEC source: 0001209191-16-150568 · doc4.xml · nonDerivative · entry 5

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,270

F4 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

SEC source: 0001209191-16-150568 · doc4.xml · nonDerivative · entry 4

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,770

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · kind: This exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

SEC source: 0001209191-16-150568 · doc4.xml · nonDerivative · entry 3

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 69,250

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · kind: This exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

SEC source: 0001209191-16-150568 · doc4.xml · nonDerivative · entry 2

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55,159

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · kind: This exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

SEC source: 0001209191-16-150568 · doc4.xml · nonDerivative · entry 1

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 6,000

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person's spouse.

F2 · ownership.nature: Shares held by a spousal lifetime access trust, of which the reporting person's wife is trustee.

SEC source: 0001209191-16-149900 · doc4.xml · nonDerivative · entry 2

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 11,000

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · ownership.nature: Shares held by a spousal lifetime access trust, of which the reporting person's wife is trustee.

SEC source: 0001209191-16-149900 · doc4.xml · nonDerivative · entry 1

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 13,128

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · ownership.nature: Shares held by a spousal lifetime access trust, of which the reporting person's wife is trustee.

SEC source: 0001209191-16-149075 · doc4.xml · derivative · entry 1

Alenson Carman · CIK 0001688865 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common stock · 15,000 shares

Expires 2026-11-06

F1 · derivative.exercise_date: This option was granted on November 7, 2016. The shares underlying this option vest as to 25% of the underlying shares on November 7, 2017, with the remaining 75% vesting in 36 equal monthly installments thereafter.

SEC source: 0001209191-16-147275 · doc4.xml · nonDerivative · entry 4

Cantley Lewis Clayton Jr. · CIK 0001581950 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 107,818

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $48.26 to $49.68. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Shares held by Vicki Lee Sato, who is the reporting person's spouse.

SEC source: 0001209191-16-147275 · doc4.xml · nonDerivative · entry 3

Cantley Lewis Clayton Jr. · CIK 0001581950 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 107,778

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $48.26 to $49.68. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-16-147275 · doc4.xml · nonDerivative · entry 2

Cantley Lewis Clayton Jr. · CIK 0001581950 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 108,443

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $48.49 to $49.45. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Shares held by Vicki Lee Sato, who is the reporting person's spouse.

SEC source: 0001209191-16-147275 · doc4.xml · nonDerivative · entry 1

Cantley Lewis Clayton Jr. · CIK 0001581950 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 108,405

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $48.49 to $49.45. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-16-145230 · doc4.xml · nonDerivative · entry 1

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 16,000

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · ownership.nature: Shares held by a spousal lifetime access trust, of which the reporting person's wife is trustee.

SEC source: 0001209191-16-143040 · doc4.xml · nonDerivative · entry 4

Cantley Lewis Clayton Jr. · CIK 0001581950 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 109,068

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $52.71 to $54.26. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Shares held by Vicki Lee Sato, who is the reporting person's spouse.

SEC source: 0001209191-16-143040 · doc4.xml · nonDerivative · entry 3

Cantley Lewis Clayton Jr. · CIK 0001581950 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 109,032

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $52.71 to $54.26. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-16-143040 · doc4.xml · nonDerivative · entry 2

Cantley Lewis Clayton Jr. · CIK 0001581950 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 109,693

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $53.63 to $54.56. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Shares held by Vicki Lee Sato, who is the reporting person's spouse.

SEC source: 0001209191-16-143040 · doc4.xml · nonDerivative · entry 1

Cantley Lewis Clayton Jr. · CIK 0001581950 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 109,659

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $53.63 to $54.56. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-16-142264 · doc4.xml · derivative · entry 1

Hirsch Andrew · CIK 0001586707 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common stock · 125,000 shares

Expires 2026-09-19

F1 · derivative.exercise_date: This option was granted on September 20, 2016. The shares underlying this option vest as to 25% of the underlying shares on September 19, 2017, with the remaining 75% vesting in 36 equal monthly installments thereafter.

SEC source: 0001209191-16-142475 · doc4.xml · nonDerivative · entry 1

Biller Scott · CIK 0001581956 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 21,000

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · ownership.nature: Shares held by a spousal lifetime access trust, of which the reporting person's wife is trustee.

SEC source: 0001012975-17-000157 · edgar.xml · nonDerivative · entry 8

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 109,230

F8 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration. Change from indirect to direct ownership of shares previously reported as beneficially owned by the reporting person.

F8 · price: Distribution of Common Stock held by a limited partnership to its partners for no consideration. Change from indirect to direct ownership of shares previously reported as beneficially owned by the reporting person.

SEC source: 0001012975-17-000157 · edgar.xml · nonDerivative · entry 7

NELSEN ROBERT · CIK 0001219042 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 73,078

F8 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration. Change from indirect to direct ownership of shares previously reported as beneficially owned by the reporting person.

F8 · price: Distribution of Common Stock held by a limited partnership to its partners for no consideration. Change from indirect to direct ownership of shares previously reported as beneficially owned by the reporting person.