ADXN

SEC source: 0001104659-26-105509 · tm2624769-5_4seq1.xml · derivative · entry 16

Teyssedou Lenaic Nathanael · CIK 0002123881 · PRINCIPAL ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 602,908

Underlying: Common Stock · 100,485 shares

Expires 2034-01-07

F2 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105509 · tm2624769-5_4seq1.xml · derivative · entry 15

Teyssedou Lenaic Nathanael · CIK 0002123881 · PRINCIPAL ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 502,423

Underlying: Common Stock · 100,485 shares

Expires 2034-01-07

F2 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105509 · tm2624769-5_4seq1.xml · derivative · entry 14

Teyssedou Lenaic Nathanael · CIK 0002123881 · PRINCIPAL ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 602,908

Underlying: Common Stock · 208,974 shares

Expires 2033-05-11

F2 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105509 · tm2624769-5_4seq1.xml · derivative · entry 13

Teyssedou Lenaic Nathanael · CIK 0002123881 · PRINCIPAL ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 393,934

Underlying: Common Stock · 208,974 shares

Expires 2033-05-11

F2 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105509 · tm2624769-5_4seq1.xml · derivative · entry 12

Teyssedou Lenaic Nathanael · CIK 0002123881 · PRINCIPAL ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 602,908

Underlying: Common Stock · 90,529 shares

Expires 2032-10-04

F2 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105509 · tm2624769-5_4seq1.xml · derivative · entry 11

Teyssedou Lenaic Nathanael · CIK 0002123881 · PRINCIPAL ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 512,379

Underlying: Common Stock · 90,529 shares

Expires 2032-10-04

F2 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105509 · tm2624769-5_4seq1.xml · derivative · entry 10

Teyssedou Lenaic Nathanael · CIK 0002123881 · PRINCIPAL ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 602,908

Underlying: Common Stock · 65,620 shares

Expires 2032-04-11

F2 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105509 · tm2624769-5_4seq1.xml · derivative · entry 9

Teyssedou Lenaic Nathanael · CIK 0002123881 · PRINCIPAL ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 537,288

Underlying: Common Stock · 65,620 shares

Expires 2032-04-11

F2 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105509 · tm2624769-5_4seq1.xml · derivative · entry 8

Teyssedou Lenaic Nathanael · CIK 0002123881 · PRINCIPAL ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 602,908

Underlying: Common Stock · 30,000 shares

Expires 2031-05-16

F2 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105509 · tm2624769-5_4seq1.xml · derivative · entry 7

Teyssedou Lenaic Nathanael · CIK 0002123881 · PRINCIPAL ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 572,908

Underlying: Common Stock · 30,000 shares

Expires 2031-05-16

F2 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105509 · tm2624769-5_4seq1.xml · derivative · entry 6

Teyssedou Lenaic Nathanael · CIK 0002123881 · PRINCIPAL ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 602,908

Underlying: Common Stock · 10,000 shares

Expires 2030-03-31

F2 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105509 · tm2624769-5_4seq1.xml · derivative · entry 5

Teyssedou Lenaic Nathanael · CIK 0002123881 · PRINCIPAL ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 592,908

Underlying: Common Stock · 10,000 shares

Expires 2030-03-31

F2 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105509 · tm2624769-5_4seq1.xml · derivative · entry 4

Teyssedou Lenaic Nathanael · CIK 0002123881 · PRINCIPAL ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 602,908

Underlying: Common Stock · 59,530 shares

Expires 2028-05-31

F2 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105509 · tm2624769-5_4seq1.xml · derivative · entry 3

Teyssedou Lenaic Nathanael · CIK 0002123881 · PRINCIPAL ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 543,378

Underlying: Common Stock · 59,530 shares

Expires 2028-05-31

F2 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105509 · tm2624769-5_4seq1.xml · derivative · entry 2

Teyssedou Lenaic Nathanael · CIK 0002123881 · PRINCIPAL ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 602,908

Underlying: Common Stock · 37,770 shares

Expires 2027-12-31

F2 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105509 · tm2624769-5_4seq1.xml · derivative · entry 1

Teyssedou Lenaic Nathanael · CIK 0002123881 · PRINCIPAL ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 565,138

Underlying: Common Stock · 37,770 shares

Expires 2027-12-31

F2 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105506 · tm2624769-9_4seq1.xml · derivative · entry 4

Kalinichev Mikhail · CIK 0002123907 · HEAD OF TRANSLATIONAL SCIENCE

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires 2034-01-07

F3 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F2 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105506 · tm2624769-9_4seq1.xml · derivative · entry 3

Kalinichev Mikhail · CIK 0002123907 · HEAD OF TRANSLATIONAL SCIENCE

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 200,000 shares

Expires 2034-01-07

F3 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F2 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105506 · tm2624769-9_4seq1.xml · nonDerivative · entry 2

Kalinichev Mikhail · CIK 0002123907 · HEAD OF TRANSLATIONAL SCIENCE

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 306,765

F1 · kind: Represents 306,765 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 179,171 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 127,594 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable. The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $ 1.2296 per CHF 1.00 as of September 2, 2026.

F1 · price: Represents 306,765 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 179,171 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 127,594 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable. The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $ 1.2296 per CHF 1.00 as of September 2, 2026.

SEC source: 0001104659-26-105506 · tm2624769-9_4seq1.xml · nonDerivative · entry 1

Kalinichev Mikhail · CIK 0002123907 · HEAD OF TRANSLATIONAL SCIENCE

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F1 · kind: Represents 306,765 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 179,171 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 127,594 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable. The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $ 1.2296 per CHF 1.00 as of September 2, 2026.

F1 · price: Represents 306,765 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 179,171 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 127,594 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable. The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $ 1.2296 per CHF 1.00 as of September 2, 2026.

SEC source: 0001104659-26-105501 · tm2624769-4_4seq1.xml · derivative · entry 4

Nunn Jason Raleigh · CIK 0001444319 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2034-01-07

F3 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F2 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of options was repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105501 · tm2624769-4_4seq1.xml · derivative · entry 3

Nunn Jason Raleigh · CIK 0001444319 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 50,000 shares

Expires 2034-01-07

F3 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F2 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of options was repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105501 · tm2624769-4_4seq1.xml · nonDerivative · entry 2

Nunn Jason Raleigh · CIK 0001444319 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 219,561

F1 · kind: Represents 219,561 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 128,238 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 91,323 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · price: Represents 219,561 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 128,238 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 91,323 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

SEC source: 0001104659-26-105501 · tm2624769-4_4seq1.xml · nonDerivative · entry 1

Nunn Jason Raleigh · CIK 0001444319 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F1 · kind: Represents 219,561 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 128,238 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 91,323 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · price: Represents 219,561 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 128,238 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 91,323 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

SEC source: 0001104659-26-105496 · tm2624769-7_4seq1.xml · derivative · entry 4

Mills Roger · CIK 0001368190 · Director · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2034-01-07

F3 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F2 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105496 · tm2624769-7_4seq1.xml · derivative · entry 3

Mills Roger · CIK 0001368190 · Director · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 50,000 shares

Expires 2034-01-07

F3 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F2 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105496 · tm2624769-7_4seq1.xml · nonDerivative · entry 2

Mills Roger · CIK 0001368190 · Director · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 785,976

F1 · kind: Represents 392,837 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 342,837 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 50,000 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable. The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026

F1 · price: Represents 392,837 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 342,837 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 50,000 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable. The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026

SEC source: 0001104659-26-105496 · tm2624769-7_4seq1.xml · nonDerivative · entry 1

Mills Roger · CIK 0001368190 · Director · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 393,139

F1 · kind: Represents 392,837 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 342,837 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 50,000 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable. The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026

F1 · price: Represents 392,837 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 342,837 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 50,000 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable. The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026

SEC source: 0001104659-26-105491 · tm2624769-3_4seq1.xml · derivative · entry 4

Manke Isaac · CIK 0001622769 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2034-01-07

F3 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F2 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of options was repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105491 · tm2624769-3_4seq1.xml · derivative · entry 3

Manke Isaac · CIK 0001622769 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 50,000 shares

Expires 2034-01-07

F3 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F2 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of options was repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105491 · tm2624769-3_4seq1.xml · nonDerivative · entry 2

Manke Isaac · CIK 0001622769 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 219,561

F1 · kind: Represents 219,561 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 128,238 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 91,323 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable. The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · price: Represents 219,561 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 128,238 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 91,323 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable. The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

SEC source: 0001104659-26-105491 · tm2624769-3_4seq1.xml · nonDerivative · entry 1

Manke Isaac · CIK 0001622769 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F1 · kind: Represents 219,561 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 128,238 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 91,323 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable. The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · price: Represents 219,561 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 128,238 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 91,323 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable. The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

SEC source: 0001104659-26-105489 · tm2624769-8_4seq1.xml · derivative · entry 4

Lawton Vincent Michael · CIK 0002123870 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 501,598

Underlying: Common Stock · 501,598 shares

Expires 2034-01-07

F3 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F2 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105489 · tm2624769-8_4seq1.xml · derivative · entry 3

Lawton Vincent Michael · CIK 0002123870 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 501,598 shares

Expires 2034-01-07

F3 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F2 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105489 · tm2624769-8_4seq1.xml · nonDerivative · entry 2

Lawton Vincent Michael · CIK 0002123870 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,507,987

F1 · kind: Represents 2,507,487 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 1,464,334 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 1,043,153 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · price: Represents 2,507,487 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 1,464,334 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 1,043,153 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

SEC source: 0001104659-26-105489 · tm2624769-8_4seq1.xml · nonDerivative · entry 1

Lawton Vincent Michael · CIK 0002123870 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 500

F1 · kind: Represents 2,507,487 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 1,464,334 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 1,043,153 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · price: Represents 2,507,487 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 1,464,334 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 1,043,153 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

SEC source: 0001104659-26-105484 · tm2624769-6_4seq1.xml · derivative · entry 4

Hill Raymond George · CIK 0002123864 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 273,107

Underlying: Common Stock · 273,107 shares

Expires 2034-01-07

F3 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F2 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105484 · tm2624769-6_4seq1.xml · derivative · entry 3

Hill Raymond George · CIK 0002123864 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 273,107 shares

Expires 2034-01-07

F3 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F2 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105484 · tm2624769-6_4seq1.xml · nonDerivative · entry 2

Hill Raymond George · CIK 0002123864 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,365,532

F1 · kind: Represents 1,365,532 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 797,563 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 567,969 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable. The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · price: Represents 1,365,532 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 797,563 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 567,969 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable. The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

SEC source: 0001104659-26-105484 · tm2624769-6_4seq1.xml · nonDerivative · entry 1

Hill Raymond George · CIK 0002123864 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F1 · kind: Represents 1,365,532 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 797,563 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 567,969 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable. The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · price: Represents 1,365,532 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 797,563 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 567,969 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable. The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

SEC source: 0001104659-26-105481 · tm2624769-2_4seq1.xml · derivative · entry 4

Dyer Timothy Mark · CIK 0001830908 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,369,796

Underlying: Common Stock · 3,369,796 shares

Expires 2034-01-07

F3 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F2 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105481 · tm2624769-2_4seq1.xml · derivative · entry 3

Dyer Timothy Mark · CIK 0001830908 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,369,796 shares

Expires 2034-01-07

F3 · derivative.exercise_price: The exercise price is reported in U.S. dollars and reflects the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F2 · kind: On September 2, 2026, following the implementation of the Remuneration Committee's decision, the exercise price of the options were repriced to $0.032. All of the other terms of the options remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable.

SEC source: 0001104659-26-105481 · tm2624769-2_4seq1.xml · nonDerivative · entry 2

Dyer Timothy Mark · CIK 0001830908 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,848,979

F1 · kind: Represents 16,413,787 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 9,405,754 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 7,008,033 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable. The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · price: Represents 16,413,787 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 9,405,754 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 7,008,033 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable. The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

SEC source: 0001104659-26-105481 · tm2624769-2_4seq1.xml · nonDerivative · entry 1

Dyer Timothy Mark · CIK 0001830908 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 435,192

F1 · kind: Represents 16,413,787 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 9,405,754 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 7,008,033 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable. The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.

F1 · price: Represents 16,413,787 shares of common Stock listed on SIX Swiss Exchange acquired following the exercise of options. Of these shares, 9,405,754 were acquired on October 26, 2022 under the deferred strike price payment plan with an initial strike price of $0.16 per share and 7,008,033 were acquired on November 27, 2023 with an initial strike price of $0.053 per share. On September 2, 2026, following the implementation of the Remuneration Committee's decision, the Strike price of all units was reduced to $0.032. All the other terms of the deferred strike price payment plan remain unchanged. Such transactions were exempt pursuant to Rule 16b-6(d) and Rule 16b-3 of the exchange act as applicable. The strike prices indicated in this section reflect the conversion from CHF to USD at an exchange rate of $1.2296 per CHF 1.00 as of September 2, 2026.