ACRS

SEC source: 0001415889-25-016247 · form4-06092025_040601.xml · nonDerivative · entry 1

Molineaux Christopher P. · CIK 0001654773 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 57,956

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

SEC source: 0001415889-25-016252 · form4-06092025_040612.xml · derivative · entry 4

SCHIFF ANDREW N · CIK 0001172252 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,580

Underlying: Common Stock · 11,580 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F5 · derivative.exercise_date: The shares underlying these restricted stock units will vest in one installment on June 5, 2026, subject to the Reporting Person's Continuous Service (as defined in the Plan) as of such date.

F5 · derivative.expiration_date: The shares underlying these restricted stock units will vest in one installment on June 5, 2026, subject to the Reporting Person's Continuous Service (as defined in the Plan) as of such date.

F4 · balance_after: This grant was made pursuant to the issuer's tenth amended and restated non-employee director compensation policy.

SEC source: 0001415889-25-016252 · form4-06092025_040612.xml · derivative · entry 3

SCHIFF ANDREW N · CIK 0001172252 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,350

Underlying: Common Stock · 42,350 shares

Expires 2035-06-04

F3 · derivative.exercise_date: The shares subject to this stock option will vest in twelve equal monthly installments commencing on July 5, 2025, subject to the Reporting Person's Continuous Service (as defined in the Plan) through each such vesting date.

F4 · balance_after: This grant was made pursuant to the issuer's tenth amended and restated non-employee director compensation policy.

SEC source: 0001415889-25-016249 · form4-06092025_040606.xml · derivative · entry 3

Humphries William D. · CIK 0001674278 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,580

Underlying: Common Stock · 11,580 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F4 · derivative.exercise_date: The shares underlying these restricted stock units will vest in one installment on June 5, 2026, subject to the Reporting Person's Continuous Service (as defined in the Plan) as of such date.

F4 · derivative.expiration_date: The shares underlying these restricted stock units will vest in one installment on June 5, 2026, subject to the Reporting Person's Continuous Service (as defined in the Plan) as of such date.

F3 · balance_after: This grant was made pursuant to the issuer's tenth amended and restated non-employee director compensation policy.

SEC source: 0001415889-25-016249 · form4-06092025_040606.xml · derivative · entry 2

Humphries William D. · CIK 0001674278 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,350

Underlying: Common Stock · 42,350 shares

Expires 2035-06-04

F2 · derivative.exercise_date: The shares subject to this stock option will vest in twelve equal monthly installments commencing on July 5, 2025, subject to the Reporting Person's Continuous Service (as defined in the Plan) through each such vesting date.

F3 · balance_after: This grant was made pursuant to the issuer's tenth amended and restated non-employee director compensation policy.

SEC source: 0001415889-25-016248 · form4-06092025_040604.xml · derivative · entry 3

GOWEN MAXINE · CIK 0001280044 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,580

Underlying: Common Stock · 11,580 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F4 · derivative.exercise_date: The shares underlying these restricted stock units will vest in one installment on June 5, 2026, subject to the Reporting Person's Continuous Service (as defined in the Plan) as of such date.

F4 · derivative.expiration_date: The shares underlying these restricted stock units will vest in one installment on June 5, 2026, subject to the Reporting Person's Continuous Service (as defined in the Plan) as of such date.

F3 · balance_after: This grant was made pursuant to the issuer's tenth amended and restated non-employee director compensation policy.

SEC source: 0001415889-25-016248 · form4-06092025_040604.xml · derivative · entry 2

GOWEN MAXINE · CIK 0001280044 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,350

Underlying: Common Stock · 42,350 shares

Expires 2035-06-04

F2 · derivative.exercise_date: The shares subject to this stock option will vest in twelve equal monthly installments commencing on July 5, 2025, subject to the Reporting Person's Continuous Service (as defined in the Plan) through each such vesting date.

F3 · balance_after: This grant was made pursuant to the issuer's tenth amended and restated non-employee director compensation policy.

SEC source: 0001415889-25-016251 · form4-06092025_040610.xml · derivative · entry 3

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,580

Underlying: Common Stock · 11,580 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F4 · derivative.exercise_date: The shares underlying these restricted stock units will vest in one installment on June 5, 2026, subject to the Reporting Person's Continuous Service (as defined in the Plan) as of such date.

F4 · derivative.expiration_date: The shares underlying these restricted stock units will vest in one installment on June 5, 2026, subject to the Reporting Person's Continuous Service (as defined in the Plan) as of such date.

F3 · balance_after: This grant was made pursuant to the issuer's tenth amended and restated non-employee director compensation policy.

SEC source: 0001415889-25-016251 · form4-06092025_040610.xml · derivative · entry 2

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,350

Underlying: Common Stock · 42,350 shares

Expires 2035-06-04

F2 · derivative.exercise_date: The shares subject to this stock option will vest in twelve equal monthly installments commencing on July 5, 2025, subject to the Reporting Person's Continuous Service (as defined in the Plan) through each such vesting date.

F3 · balance_after: This grant was made pursuant to the issuer's tenth amended and restated non-employee director compensation policy.

SEC source: 0001415889-25-016250 · form4-06092025_040608.xml · derivative · entry 3

Mehra Anand · CIK 0001590102 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,580

Underlying: Common Stock · 11,580 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F4 · derivative.exercise_date: The shares underlying these restricted stock units will vest in one installment on June 5, 2026, subject to the Reporting Person's Continuous Service (as defined in the Plan) as of such date.

F4 · derivative.expiration_date: The shares underlying these restricted stock units will vest in one installment on June 5, 2026, subject to the Reporting Person's Continuous Service (as defined in the Plan) as of such date.

F3 · balance_after: This grant was made pursuant to the issuer's tenth amended and restated non-employee director compensation policy.

SEC source: 0001415889-25-016250 · form4-06092025_040608.xml · derivative · entry 2

Mehra Anand · CIK 0001590102 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,350

Underlying: Common Stock · 42,350 shares

Expires 2035-06-04

F2 · derivative.exercise_date: The shares subject to this stock option will vest in twelve equal monthly installments commencing on July 5, 2025, subject to the Reporting Person's Continuous Service (as defined in the Plan) through each such vesting date.

F3 · balance_after: This grant was made pursuant to the issuer's tenth amended and restated non-employee director compensation policy.

SEC source: 0001415889-25-016247 · form4-06092025_040601.xml · derivative · entry 3

Molineaux Christopher P. · CIK 0001654773 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,580

Underlying: Common Stock · 11,580 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F4 · derivative.exercise_date: The shares underlying these restricted stock units will vest in one installment on June 5, 2026, subject to the Reporting Person's Continuous Service (as defined in the Plan) as of such date.

F4 · derivative.expiration_date: The shares underlying these restricted stock units will vest in one installment on June 5, 2026, subject to the Reporting Person's Continuous Service (as defined in the Plan) as of such date.

F3 · balance_after: This grant was made pursuant to the issuer's tenth amended and restated non-employee director compensation policy.

SEC source: 0001415889-25-016247 · form4-06092025_040601.xml · derivative · entry 2

Molineaux Christopher P. · CIK 0001654773 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,350

Underlying: Common Stock · 42,350 shares

Expires 2035-06-04

F2 · derivative.exercise_date: The shares subject to this stock option will vest in twelve equal monthly installments commencing on July 5, 2025, subject to the Reporting Person's Continuous Service (as defined in the Plan) through each such vesting date.

F3 · balance_after: This grant was made pursuant to the issuer's tenth amended and restated non-employee director compensation policy.

SEC source: 0001415889-25-011966 · form4-05052025_080553.xml · derivative · entry 2

Hall Jesse Wayne · CIK 0002065269 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 510,000

Underlying: Common Stock · 510,000 shares

Expires 2035-04-30

F3 · derivative.exercise_date: Exercisable with respect to 25% of the shares subject to the option vesting in four equal installments on the first, second, third and fourth anniversaries of May 1, 2025, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

SEC source: 0001415889-25-011966 · form4-05052025_080553.xml · derivative · entry 1

Hall Jesse Wayne · CIK 0002065269 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 145,500

Underlying: Common Stock · 145,500 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

F2 · derivative.exercise_date: The shares underlying these restricted stock units vest in four equal installments on the first, second, third and fourth anniversaries of May 1, 2025, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

F2 · derivative.expiration_date: The shares underlying these restricted stock units vest in four equal installments on the first, second, third and fourth anniversaries of May 1, 2025, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

SEC source: 0001415889-25-011955 · form4-05052025_040501.xml · derivative · entry 3

Walker Neal · CIK 0001604457 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 9,467 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

F3 · derivative.exercise_date: The shares vest in equal monthly installments over 15 months beginning March 1, 2024, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as the Interim CEO to the Company as of each such vesting date, provided that in the event he ceases to be Interim CEO but continues to provide Continuous Service in any capacity, such awards will continue to vest in the event that the Issuer's Board of Directors determines in its sole discretion that he achieved the Performance Goals (as defined in his letter agreement of employment as Interim CEO) prior to the cessation of his employment as Interim CEO.

F3 · derivative.expiration_date: The shares vest in equal monthly installments over 15 months beginning March 1, 2024, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as the Interim CEO to the Company as of each such vesting date, provided that in the event he ceases to be Interim CEO but continues to provide Continuous Service in any capacity, such awards will continue to vest in the event that the Issuer's Board of Directors determines in its sole discretion that he achieved the Performance Goals (as defined in his letter agreement of employment as Interim CEO) prior to the cessation of his employment as Interim CEO.

SEC source: 0001415889-25-011955 · form4-05052025_040501.xml · nonDerivative · entry 2

Walker Neal · CIK 0001604457 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,479,824

F2 · kind: The transaction reported represents the withholding of shares by the issuer to satisfy the Reporting Person's tax withholding obligations in connection with the vesting and settlement of restricted stock units described in this Form 4.

SEC source: 0001415889-25-011955 · form4-05052025_040501.xml · nonDerivative · entry 1

Walker Neal · CIK 0001604457 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,482,799

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

SEC source: 0001415889-25-009937 · form4-04032025_040410.xml · derivative · entry 3

Walker Neal · CIK 0001604457 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,467

Underlying: Common Stock · 9,467 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

F3 · derivative.exercise_date: The shares vest in equal monthly installments over 15 months beginning March 1, 2024, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as the Interim CEO to the Company as of each such vesting date, provided that in the event he ceases to be Interim CEO but continues to provide Continuous Service in any capacity, such awards will continue to vest in the event that the Issuer's Board of Directors determines in its sole discretion that he achieved the Performance Goals (as defined in his letter agreement of employment as Interim CEO) prior to the cessation of his employment as Interim CEO.

F3 · derivative.expiration_date: The shares vest in equal monthly installments over 15 months beginning March 1, 2024, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as the Interim CEO to the Company as of each such vesting date, provided that in the event he ceases to be Interim CEO but continues to provide Continuous Service in any capacity, such awards will continue to vest in the event that the Issuer's Board of Directors determines in its sole discretion that he achieved the Performance Goals (as defined in his letter agreement of employment as Interim CEO) prior to the cessation of his employment as Interim CEO.

SEC source: 0001415889-25-009937 · form4-04032025_040410.xml · nonDerivative · entry 2

Walker Neal · CIK 0001604457 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,473,332

F2 · kind: The transaction reported represents the withholding of shares by the issuer to satisfy the Reporting Person's tax withholding obligations in connection with the vesting and settlement of restricted stock units described in this Form 4.

SEC source: 0001415889-25-009937 · form4-04032025_040410.xml · nonDerivative · entry 1

Walker Neal · CIK 0001604457 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,476,374

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

SEC source: 0001415889-25-006495 · form4-03042025_040310.xml · derivative · entry 6

Monahan Joseph · CIK 0001861790 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,925

Underlying: Common Stock · 10,925 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F4 · derivative.exercise_date: The shares underlying these restricted stock units vest in four equal annual installments beginning on March 1, 2023, subject to the Continuous Service of the Reporting Person (as defined in the Plan) as of each such date.

F4 · derivative.expiration_date: The shares underlying these restricted stock units vest in four equal annual installments beginning on March 1, 2023, subject to the Continuous Service of the Reporting Person (as defined in the Plan) as of each such date.

SEC source: 0001415889-25-006495 · form4-03042025_040310.xml · derivative · entry 5

Monahan Joseph · CIK 0001861790 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 50,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F3 · derivative.exercise_date: The shares underlying these restricted stock units vest in four equal annual installments beginning on March 1, 2022, subject to the Continuous Service of the Reporting Person (as defined in the Plan) as of each such date.

F3 · derivative.expiration_date: The shares underlying these restricted stock units vest in four equal annual installments beginning on March 1, 2022, subject to the Continuous Service of the Reporting Person (as defined in the Plan) as of each such date.

SEC source: 0001415889-25-006495 · form4-03042025_040310.xml · nonDerivative · entry 3

Monahan Joseph · CIK 0001861790 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 265,662

F2 · kind: The transaction reported represents the withholding of shares by the issuer to satisfy the Reporting Person's tax withholding obligations in connection with the vesting and settlement of restricted stock units described in this Form 4.

SEC source: 0001415889-25-006495 · form4-03042025_040310.xml · nonDerivative · entry 2

Monahan Joseph · CIK 0001861790 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 292,920

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

SEC source: 0001415889-25-006495 · form4-03042025_040310.xml · nonDerivative · entry 1

Monahan Joseph · CIK 0001861790 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 281,995

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

SEC source: 0001415889-25-006494 · form4-03042025_040308.xml · derivative · entry 5

Balthaser Kevin · CIK 0001957554 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,375

Underlying: Common Stock · 2,375 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F4 · derivative.exercise_date: The shares underlying these restricted stock units vest in four equal annual installments beginning on March 1, 2023, subject to the Continuous Service of the Reporting Person (as defined in the Plan) as of the applicable vesting date.

F4 · derivative.expiration_date: The shares underlying these restricted stock units vest in four equal annual installments beginning on March 1, 2023, subject to the Continuous Service of the Reporting Person (as defined in the Plan) as of the applicable vesting date.

SEC source: 0001415889-25-006494 · form4-03042025_040308.xml · derivative · entry 4

Balthaser Kevin · CIK 0001957554 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,100 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F3 · derivative.exercise_date: The shares underlying these restricted stock units vest over a period of three years, with one-third of the shares vesting on each of March 1, 2023, March 1, 2024 and March 1, 2025, subject to the Continuous Service of the Reporting Person (as defined in the Plan) as of each such date.

F3 · derivative.expiration_date: The shares underlying these restricted stock units vest over a period of three years, with one-third of the shares vesting on each of March 1, 2023, March 1, 2024 and March 1, 2025, subject to the Continuous Service of the Reporting Person (as defined in the Plan) as of each such date.

SEC source: 0001415889-25-006494 · form4-03042025_040308.xml · nonDerivative · entry 3

Balthaser Kevin · CIK 0001957554 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 92,608

F2 · kind: The transaction reported represents the withholding of shares by the issuer to satisfy the Reporting Person's tax withholding obligations in connection with the vesting and settlement of restricted stock units described in this Form 4.

SEC source: 0001415889-25-006494 · form4-03042025_040308.xml · nonDerivative · entry 2

Balthaser Kevin · CIK 0001957554 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 93,335

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

SEC source: 0001415889-25-006494 · form4-03042025_040308.xml · nonDerivative · entry 1

Balthaser Kevin · CIK 0001957554 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 90,960

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

SEC source: 0001415889-25-006496 · form4-03042025_040312.xml · derivative · entry 3

Walker Neal · CIK 0001604457 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,934

Underlying: Common Stock · 9,466 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

F3 · derivative.exercise_date: The shares vest in equal monthly installments over 15 months beginning March 1, 2024, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as the Interim CEO to the Company as of each such vesting date, provided that in the event he ceases to be Interim CEO but continues to provide Continuous Service in any capacity, such awards will continue to vest in the event that the Issuer's Board of Directors determines in its sole discretion that he achieved the Performance Goals (as defined in his letter agreement of employment as Interim CEO) prior to the cessation of his employment as Interim CEO.

F3 · derivative.expiration_date: The shares vest in equal monthly installments over 15 months beginning March 1, 2024, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as the Interim CEO to the Company as of each such vesting date, provided that in the event he ceases to be Interim CEO but continues to provide Continuous Service in any capacity, such awards will continue to vest in the event that the Issuer's Board of Directors determines in its sole discretion that he achieved the Performance Goals (as defined in his letter agreement of employment as Interim CEO) prior to the cessation of his employment as Interim CEO.

SEC source: 0001415889-25-006496 · form4-03042025_040312.xml · nonDerivative · entry 2

Walker Neal · CIK 0001604457 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,466,907

F2 · kind: The transaction reported represents the withholding of shares by the issuer to satisfy the Reporting Person's tax withholding obligations in connection with the vesting and settlement of restricted stock units described in this Form 4.

SEC source: 0001415889-25-006496 · form4-03042025_040312.xml · nonDerivative · entry 1

Walker Neal · CIK 0001604457 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,470,184

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

SEC source: 0001415889-25-002942 · form4-02042025_040211.xml · derivative · entry 2

Davis Hugh M. · CIK 0002045027 · Director · President and COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 261,600

Underlying: Common Stock · 261,600 shares

Expires 2035-02-02

F3 · derivative.exercise_date: Exercisable with respect to 25% of the shares subject to the option vesting in four equal installments on the first, second, third and fourth anniversaries of February 3, 2025, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

SEC source: 0001415889-25-002942 · form4-02042025_040211.xml · derivative · entry 1

Davis Hugh M. · CIK 0002045027 · Director · President and COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 74,700

Underlying: Common Stock · 74,700 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

F2 · derivative.exercise_date: The shares underlying these restricted stock units vest in four equal installments on the first, second, third and fourth anniversaries of February 3, 2025, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

F2 · derivative.expiration_date: The shares underlying these restricted stock units vest in four equal installments on the first, second, third and fourth anniversaries of February 3, 2025, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

SEC source: 0001415889-25-002940 · form4-02042025_040206.xml · derivative · entry 8

Monahan Joseph · CIK 0001861790 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 293,500

Underlying: Common Stock · 293,500 shares

Expires 2035-02-02

F6 · derivative.exercise_date: Exercisable with respect to 25% of the shares subject to the option vesting in four equal installments on the first, second, third and fourth anniversaries of February 3, 2025, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

SEC source: 0001415889-25-002940 · form4-02042025_040206.xml · derivative · entry 7

Monahan Joseph · CIK 0001861790 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 83,900

Underlying: Common Stock · 83,900 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F5 · derivative.exercise_date: The shares underlying these restricted stock units vest in four equal installments on the first, second, third and fourth anniversaries of February 3, 2025, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

F5 · derivative.expiration_date: The shares underlying these restricted stock units vest in four equal installments on the first, second, third and fourth anniversaries of February 3, 2025, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

SEC source: 0001415889-25-002938 · form4-02042025_040201.xml · derivative · entry 9

Loerop James · CIK 0001781549 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 292,300

Underlying: Common Stock · 292,300 shares

Expires 2035-02-02

F7 · derivative.exercise_date: Exercisable with respect to 25% of the shares subject to the option vesting in four equal installments on the first, second, third and fourth anniversaries of February 3, 2025, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

SEC source: 0001415889-25-002938 · form4-02042025_040201.xml · derivative · entry 8

Loerop James · CIK 0001781549 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 83,500

Underlying: Common Stock · 83,500 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F6 · derivative.exercise_date: The shares underlying these restricted stock units vest in four equal installments on the first, second, third and fourth anniversaries of February 3, 2025, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

F6 · derivative.expiration_date: The shares underlying these restricted stock units vest in four equal installments on the first, second, third and fourth anniversaries of February 3, 2025, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

SEC source: 0001415889-25-002941 · form4-02042025_040208.xml · derivative · entry 5

Walker Neal · CIK 0001604457 · Director · INTERIM CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 888,800

Underlying: Common Stock · 888,800 shares

Expires 2035-02-02

F5 · derivative.exercise_date: Exercisable with respect to 25% of the shares subject to the option vesting in four equal installments on the first, second, third and fourth anniversaries of February 3, 2025, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

SEC source: 0001415889-25-002941 · form4-02042025_040208.xml · derivative · entry 4

Walker Neal · CIK 0001604457 · Director · INTERIM CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 253,900

Underlying: Common Stock · 253,900 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

F4 · derivative.exercise_date: The shares underlying these restricted stock units vest in four equal installments on the first, second, third and fourth anniversaries of February 3, 2025, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

F4 · derivative.expiration_date: The shares underlying these restricted stock units vest in four equal installments on the first, second, third and fourth anniversaries of February 3, 2025, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

SEC source: 0001415889-25-002939 · form4-02042025_040204.xml · derivative · entry 5

Balthaser Kevin · CIK 0001957554 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 308,200

Underlying: Common Stock · 308,200 shares

Expires 2035-02-02

F5 · derivative.exercise_date: Exercisable with respect to 25% of the shares subject to the option vesting in four equal installments on the first, second, third and fourth anniversaries of February 3, 2025, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

SEC source: 0001415889-25-002939 · form4-02042025_040204.xml · derivative · entry 4

Balthaser Kevin · CIK 0001957554 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 88,100

Underlying: Common Stock · 88,100 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F4 · derivative.exercise_date: The shares underlying these restricted stock units vest in four equal installments on the first, second, third and fourth anniversaries of February 3, 2025, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

F4 · derivative.expiration_date: The shares underlying these restricted stock units vest in four equal installments on the first, second, third and fourth anniversaries of February 3, 2025, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

SEC source: 0001415889-25-002940 · form4-02042025_040206.xml · derivative · entry 6

Monahan Joseph · CIK 0001861790 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 44,250

Underlying: Common Stock · 14,750 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F4 · derivative.exercise_date: The shares underlying these restricted stock units vest in four equal installments on the first, second, third and fourth anniversaries of February 1, 2024, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

F4 · derivative.expiration_date: The shares underlying these restricted stock units vest in four equal installments on the first, second, third and fourth anniversaries of February 1, 2024, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

SEC source: 0001415889-25-002940 · form4-02042025_040206.xml · derivative · entry 5

Monahan Joseph · CIK 0001861790 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 7,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F3 · derivative.exercise_date: The shares underlying these restricted stock units vest in four equal installments on the first, second, third and fourth anniversaries of February 1, 2023, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

F3 · derivative.expiration_date: The shares underlying these restricted stock units vest in four equal installments on the first, second, third and fourth anniversaries of February 1, 2023, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

SEC source: 0001415889-25-002940 · form4-02042025_040206.xml · nonDerivative · entry 3

Monahan Joseph · CIK 0001861790 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 231,995

F2 · kind: The transaction reported represents the withholding of shares by the issuer to satisfy the Reporting Person's tax withholding obligations in connection with the vesting and settlement of restricted stock units described in this Form 4.

SEC source: 0001415889-25-002940 · form4-02042025_040206.xml · nonDerivative · entry 2

Monahan Joseph · CIK 0001861790 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 243,312

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

SEC source: 0001415889-25-002940 · form4-02042025_040206.xml · nonDerivative · entry 1

Monahan Joseph · CIK 0001861790 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 228,562

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

SEC source: 0001415889-25-002938 · form4-02042025_040201.xml · derivative · entry 7

Loerop James · CIK 0001781549 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 44,250

Underlying: Common Stock · 14,750 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F5 · derivative.exercise_date: The shares underlying these restricted stock units vest in four equal installments on the first, second, third and fourth anniversaries of February 1, 2024, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.

F5 · derivative.expiration_date: The shares underlying these restricted stock units vest in four equal installments on the first, second, third and fourth anniversaries of February 1, 2024, subject to the Continuous Service (as defined in the Plan) of the Reporting Person as of each such date.