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Cramer Pamela J.

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66515
SEC CIK
0001873517

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CompanyLast reported asReport datePublished
RHYTHM PHARMACEUTICALS, INC.RYTM · Entity 3693Chief Human Resources OfficerFebruary 11, 2026February 13, 2026

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

RHYTHM PHARMACEUTICALS, INC.

Report date February 11, 2026 · Filed February 13, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Restricted Stock UnitsSEC Table II · derivative / convertible securityDirect11,650 Reported balance After 2026-02-11 transaction · row 1 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 1 · 2026-02-11 · Grant · Acquired 11,650 · Balance 11,650

F1: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F2: The restricted stock units vest as to 25% of the total shares on each of February 1, 2027, February 1, 2028, February 1, 2029 and February 1, 2030. The restricted stock units have no expiration date.

Stock Options (Right to Buy)SEC Table II · derivative / convertible security · Conversion / exercise price $98.47 · Expires 2036-02-10Direct17,500 Reported balance After 2026-02-11 transaction · row 2 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 2 · 2026-02-11 · Grant · Acquired 17,500 · Balance 17,500

F3: The stock options were granted on February 11, 2026. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Filing footnotes · ownership attribution and instrument terms

F1: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F2: The restricted stock units vest as to 25% of the total shares on each of February 1, 2027, February 1, 2028, February 1, 2029 and February 1, 2030. The restricted stock units have no expiration date.

F3: The stock options were granted on February 11, 2026. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Transaction history

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateCompanyActivity / securityShares / unitsReported priceReported valueDetails
February 11, 2026 Filed Feb 13, 2026 22:45 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 GrantStock Options (Right to Buy) · Derivative 17,500 $0.00 Strike: $98.47 $0.00
Disclosure

SEC source: 0001104659-26-015396 · tm266366-1_4seq1.xml · derivative · entry 2

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires 2036-02-10

F3 · derivative.exercise_date: The stock options were granted on February 11, 2026. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Read SEC document
February 11, 2026 Filed Feb 13, 2026 22:45 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 GrantRestricted Stock Units · Derivative 11,650 $0.00 $0.00
Disclosure

SEC source: 0001104659-26-015396 · tm266366-1_4seq1.xml · derivative · entry 1

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,650

Underlying: Common Stock · 11,650 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F2 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 1, 2027, February 1, 2028, February 1, 2029 and February 1, 2030. The restricted stock units have no expiration date.

F2 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 1, 2027, February 1, 2028, February 1, 2029 and February 1, 2030. The restricted stock units have no expiration date.

Read SEC document
February 01, 2026 Filed Feb 3, 2026 21:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 5,000 $0.00 $0.00
Disclosure

SEC source: 0001104659-26-009758 · tm264963-1_4seq1.xml · derivative · entry 6

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 5,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F6 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 1, 2026, February 1, 2027, February 1, 2028 and February 1, 2029. The restricted stock units have no expiration date.

F6 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 1, 2026, February 1, 2027, February 1, 2028 and February 1, 2029. The restricted stock units have no expiration date.

Read SEC document
February 01, 2026 Filed Feb 3, 2026 21:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 3,300 $0.00 $0.00
Disclosure

SEC source: 0001104659-26-009758 · tm264963-1_4seq1.xml · derivative · entry 5

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,600

Underlying: Common Stock · 3,300 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F5 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 16, 2025, February 1, 2026, February 1, 2027 and February 1, 2028. The restricted stock units have no expiration date.

F5 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 16, 2025, February 1, 2026, February 1, 2027 and February 1, 2028. The restricted stock units have no expiration date.

Read SEC document
February 01, 2026 Filed Feb 3, 2026 21:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 2,650 $0.00 $0.00
Disclosure

SEC source: 0001104659-26-009758 · tm264963-1_4seq1.xml · derivative · entry 4

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,650

Underlying: Common Stock · 2,650 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F4 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 1, 2024, February 1, 2025, February 1, 2026 and February 1, 2027. The restricted stock units have no expiration date.

F4 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 1, 2024, February 1, 2025, February 1, 2026 and February 1, 2027. The restricted stock units have no expiration date.

Read SEC document
February 01, 2026 Filed Feb 3, 2026 21:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 2,343 $0.00 $0.00
Disclosure

SEC source: 0001104659-26-009758 · tm264963-1_4seq1.xml · derivative · entry 3

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,343 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 9, 2023, February 9, 2024, February 9, 2025 and February 1, 2026. The restricted stock units have no expiration date.

F3 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 9, 2023, February 9, 2024, February 9, 2025 and February 1, 2026. The restricted stock units have no expiration date.

Read SEC document
February 01, 2026 Filed Feb 3, 2026 21:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Tax withholdingCommon Stock 4,731 $108.99 $515,631.69
Disclosure

SEC source: 0001104659-26-009758 · tm264963-1_4seq1.xml · nonDerivative · entry 2

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,376

F2 · kind: These shares were withheld for payment of the withholding taxes upon the vesting of the restricted stock units reported herein.

Read SEC document
February 01, 2026 Filed Feb 3, 2026 21:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 13,293 Not disclosed Not disclosed
Disclosure

SEC source: 0001104659-26-009758 · tm264963-1_4seq1.xml · nonDerivative · entry 1

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,107

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

Read SEC document
December 11, 2025 Filed Dec 15, 2025 21:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 3,350 $0.00 Strike: $27.35 $0.00
Disclosure

SEC source: 0001104659-25-121181 · tm2533512-1_4seq1.xml · derivative · entry 3

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,375

Underlying: Common Stock · 3,350 shares

Expires 2033-01-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock options were granted on February 1, 2023. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Read SEC document
December 11, 2025 Filed Dec 15, 2025 21:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 3,350 $111.00 $371,850.00
Disclosure

SEC source: 0001104659-25-121181 · tm2533512-1_4seq1.xml · nonDerivative · entry 2

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,814

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 7, 2025.

Read SEC document
December 11, 2025 Filed Dec 15, 2025 21:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 3,350 $27.35 $91,622.50
Disclosure

SEC source: 0001104659-25-121181 · tm2533512-1_4seq1.xml · nonDerivative · entry 1

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,164

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 20, 2025 Filed Nov 24, 2025 21:15 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 3,350 $0.00 Strike: $27.35 $0.00
Disclosure

SEC source: 0001104659-25-115421 · tm2531966d1_4seq1.xml · derivative · entry 3

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,725

Underlying: Common Stock · 3,350 shares

Expires 2033-01-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock options were granted on February 1, 2023. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Read SEC document
November 20, 2025 Filed Nov 24, 2025 21:15 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 3,350 $105.00 $351,750.00
Disclosure

SEC source: 0001104659-25-115421 · tm2531966d1_4seq1.xml · nonDerivative · entry 2

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,814

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 7, 2025.

Read SEC document
November 20, 2025 Filed Nov 24, 2025 21:15 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 3,350 $27.35 $91,622.50
Disclosure

SEC source: 0001104659-25-115421 · tm2531966d1_4seq1.xml · nonDerivative · entry 1

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,164

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 10, 2025 Filed Nov 12, 2025 21:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 3,515 $0.00 Strike: $6.80 $0.00
Disclosure

SEC source: 0001104659-25-110430 · tm2530920-1_4seq1.xml · derivative · entry 8

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,520

Underlying: Common Stock · 3,515 shares

Expires 2032-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Read SEC document
November 10, 2025 Filed Nov 12, 2025 21:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 3,515 $100.00 $351,500.00
Disclosure

SEC source: 0001104659-25-110430 · tm2530920-1_4seq1.xml · nonDerivative · entry 5

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,814

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 7, 2025.

Read SEC document
November 10, 2025 Filed Nov 12, 2025 21:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 3,515 $6.80 $23,902.00
Disclosure

SEC source: 0001104659-25-110430 · tm2530920-1_4seq1.xml · nonDerivative · entry 4

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,329

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 07, 2025 Filed Nov 12, 2025 21:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 10,546 $0.00 Strike: $6.80 $0.00
Disclosure

SEC source: 0001104659-25-110430 · tm2530920-1_4seq1.xml · derivative · entry 7

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,035

Underlying: Common Stock · 10,546 shares

Expires 2032-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Read SEC document
November 07, 2025 Filed Nov 12, 2025 21:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 8,805 $0.00 Strike: $19.02 $0.00
Disclosure

SEC source: 0001104659-25-110430 · tm2530920-1_4seq1.xml · derivative · entry 6

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,257

Underlying: Common Stock · 8,805 shares

Expires 2031-07-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock option is fully vested.

Read SEC document
November 07, 2025 Filed Nov 12, 2025 21:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 19,351 $98.82 $1,912,325.81
Disclosure

SEC source: 0001104659-25-110430 · tm2530920-1_4seq1.xml · nonDerivative · entry 3

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,814

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 7, 2025.

Read SEC document
November 07, 2025 Filed Nov 12, 2025 21:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 10,546 $6.80 $71,712.80
Disclosure

SEC source: 0001104659-25-110430 · tm2530920-1_4seq1.xml · nonDerivative · entry 2

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 40,165

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 07, 2025 Filed Nov 12, 2025 21:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 8,805 $19.02 $167,471.10
Disclosure

SEC source: 0001104659-25-110430 · tm2530920-1_4seq1.xml · nonDerivative · entry 1

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 29,619

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
July 29, 2025 Filed Jul 29, 2025 22:56 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 1,520 $85.93 $130,613.60
Disclosure

SEC source: 0001104659-25-071849 · tm2522015-1_4seq1.xml · nonDerivative · entry 2

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,814

F2 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 instruction adopted prior to February 27, 2023 solely with the intent to cover withholding taxes in connection with the vesting of certain previously reported restricted stock units.

Read SEC document
July 26, 2025 Filed Jul 29, 2025 22:56 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 3,125 $0.00 $0.00
Disclosure

SEC source: 0001104659-25-071849 · tm2522015-1_4seq1.xml · derivative · entry 3

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,125 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of July 26, 2022, July 26, 2023, July 26, 2024 and July 26, 2025. The restricted stock units have no expiration date.

F3 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of July 26, 2022, July 26, 2023, July 26, 2024 and July 26, 2025. The restricted stock units have no expiration date.

Read SEC document
July 26, 2025 Filed Jul 29, 2025 22:56 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 3,125 Not disclosed Not disclosed
Disclosure

SEC source: 0001104659-25-071849 · tm2522015-1_4seq1.xml · nonDerivative · entry 1

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,334

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

Read SEC document
July 09, 2025 Filed Jul 11, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 5,025 $0.00 Strike: $27.35 $0.00
Disclosure

SEC source: 0001104659-25-067427 · tm2520691-1_4seq1.xml · derivative · entry 7

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,075

Underlying: Common Stock · 5,025 shares

Expires 2033-01-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The stock options were granted on February 1, 2023. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Read SEC document
July 09, 2025 Filed Jul 11, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 10,547 $0.00 Strike: $6.80 $0.00
Disclosure

SEC source: 0001104659-25-067427 · tm2520691-1_4seq1.xml · derivative · entry 6

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 17,581

Underlying: Common Stock · 10,547 shares

Expires 2032-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Read SEC document
July 09, 2025 Filed Jul 11, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 3,516 $80.00 $281,280.00
Disclosure

SEC source: 0001104659-25-067427 · tm2520691-1_4seq1.xml · nonDerivative · entry 5

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,209

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 16, 2024.

Read SEC document
July 09, 2025 Filed Jul 11, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 7,831 $76.69 $600,564.87
Disclosure

SEC source: 0001104659-25-067427 · tm2520691-1_4seq1.xml · nonDerivative · entry 4

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,725

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 16, 2024.

F3 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $76.17 to $76.75 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
July 09, 2025 Filed Jul 11, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 4,225 $75.55 $319,217.34
Disclosure

SEC source: 0001104659-25-067427 · tm2520691-1_4seq1.xml · nonDerivative · entry 3

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 30,556

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 16, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $75.08 to $75.98 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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July 09, 2025 Filed Jul 11, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 5,025 $27.35 $137,433.75
Disclosure

SEC source: 0001104659-25-067427 · tm2520691-1_4seq1.xml · nonDerivative · entry 2

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 34,781

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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July 09, 2025 Filed Jul 11, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 10,547 $6.80 $71,719.60
Disclosure

SEC source: 0001104659-25-067427 · tm2520691-1_4seq1.xml · nonDerivative · entry 1

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 29,756

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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June 06, 2025 Filed Jun 10, 2025 20:45 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 7,031 $0.00 Strike: $6.80 $0.00
Disclosure

SEC source: 0001104659-25-058188 · tm2517539-1_4seq1.xml · derivative · entry 3

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 28,128

Underlying: Common Stock · 7,031 shares

Expires 2032-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

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June 06, 2025 Filed Jun 10, 2025 20:45 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 7,031 $68.05 $478,434.94
Disclosure

SEC source: 0001104659-25-058188 · tm2517539-1_4seq1.xml · nonDerivative · entry 2

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,209

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 16, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $68.00 to $68.18 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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June 06, 2025 Filed Jun 10, 2025 20:45 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 7,031 $6.80 $47,810.80
Disclosure

SEC source: 0001104659-25-058188 · tm2517539-1_4seq1.xml · nonDerivative · entry 1

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,240

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
April 29, 2025 Filed May 1, 2025 20:53 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 7,031 $0.00 Strike: $6.80 $0.00
Disclosure

SEC source: 0001104659-25-043557 · tm2513769-2_4seq1.xml · derivative · entry 3

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 35,159

Underlying: Common Stock · 7,031 shares

Expires 2032-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

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April 29, 2025 Filed May 1, 2025 20:53 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 7,031 $65.09 $457,663.26
Disclosure

SEC source: 0001104659-25-043557 · tm2513769-2_4seq1.xml · nonDerivative · entry 2

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,209

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 16, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $65 to $65.42 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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April 29, 2025 Filed May 1, 2025 20:53 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 7,031 $6.80 $47,810.80
Disclosure

SEC source: 0001104659-25-043557 · tm2513769-2_4seq1.xml · nonDerivative · entry 1

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,240

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
April 08, 2025 Filed Apr 10, 2025 21:17 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 6,700 $0.00 Strike: $27.35 $0.00
Disclosure

SEC source: 0001104659-25-033821 · tm2512047-2_4seq1.xml · derivative · entry 8

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,100

Underlying: Common Stock · 6,700 shares

Expires 2033-01-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The stock options were granted on February 1, 2023. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

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April 08, 2025 Filed Apr 10, 2025 21:17 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 14,060 $0.00 Strike: $6.80 $0.00
Disclosure

SEC source: 0001104659-25-033821 · tm2512047-2_4seq1.xml · derivative · entry 7

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 42,190

Underlying: Common Stock · 14,060 shares

Expires 2032-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

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April 08, 2025 Filed Apr 10, 2025 21:17 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 7,030 $62.00 $435,860.00
Disclosure

SEC source: 0001104659-25-033821 · tm2512047-2_4seq1.xml · nonDerivative · entry 6

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,209

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 16, 2024.

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April 08, 2025 Filed Apr 10, 2025 21:17 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 6,700 $60.00 $402,000.00
Disclosure

SEC source: 0001104659-25-033821 · tm2512047-2_4seq1.xml · nonDerivative · entry 5

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,239

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 16, 2024.

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April 08, 2025 Filed Apr 10, 2025 21:17 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 600 $59.00 $35,400.00
Disclosure

SEC source: 0001104659-25-033821 · tm2512047-2_4seq1.xml · nonDerivative · entry 4

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 32,939

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 16, 2024.

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April 08, 2025 Filed Apr 10, 2025 21:17 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 6,430 $58.36 $375,230.37
Disclosure

SEC source: 0001104659-25-033821 · tm2512047-2_4seq1.xml · nonDerivative · entry 3

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 33,539

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 16, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $58.00 to $58.735 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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April 08, 2025 Filed Apr 10, 2025 21:17 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 6,700 $27.35 $183,245.00
Disclosure

SEC source: 0001104659-25-033821 · tm2512047-2_4seq1.xml · nonDerivative · entry 2

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 39,969

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
April 08, 2025 Filed Apr 10, 2025 21:17 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 14,060 $6.80 $95,608.00
Disclosure

SEC source: 0001104659-25-033821 · tm2512047-2_4seq1.xml · nonDerivative · entry 1

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 33,269

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 19, 2025 Filed Feb 20, 2025 02:43 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 982 $57.22 $56,190.04
Disclosure

SEC source: 0001104659-25-015317 · tm257103-1_4seq1.xml · nonDerivative · entry 2

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,209

F2 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 instruction adopted prior to February 27, 2023 solely with the intent to cover withholding taxes in connection with the vesting of certain previously reported restricted stock units.

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February 16, 2025 Filed Feb 20, 2025 02:43 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 3,300 $0.00 $0.00
Disclosure

SEC source: 0001104659-25-015317 · tm257103-1_4seq1.xml · derivative · entry 5

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 9,900

Underlying: Common Stock · 3,300 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F5 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 16, 2025, February 16, 2026, February 16, 2027 and February 16, 2028. The restricted stock units have no expiration date.

F5 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 16, 2025, February 16, 2026, February 16, 2027 and February 16, 2028. The restricted stock units have no expiration date.

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February 16, 2025 Filed Feb 20, 2025 02:43 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 3,300 Not disclosed Not disclosed
Disclosure

SEC source: 0001104659-25-015317 · tm257103-1_4seq1.xml · nonDerivative · entry 1

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,191

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

Read SEC document
February 14, 2025 Filed Feb 20, 2025 02:43 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 GrantStock Options (Right to Buy) · Derivative 30,000 $0.00 Strike: $56.69 $0.00
Disclosure

SEC source: 0001104659-25-015317 · tm257103-1_4seq1.xml · derivative · entry 4

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2035-02-13

F4 · derivative.exercise_date: The stock options were granted on February 14, 2025. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.