Abel Robert Lorne

SEC source: 0001798179-26-000005 · wk-form4_1772835958.xml · nonDerivative · entry 1

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,897

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 25, 2025, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units ("RSUs"). The sale does not represent a discretionary trade by the reporting person.

F2 · balance_after: Includes 49,824 unvested RSUs.

SEC source: 0001798179-26-000004 · wk-form4_1772573439.xml · derivative · entry 3

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,250

Underlying: Common Stock · 34,250 shares

Expires 2036-03-02

F4 · derivative.exercise_date: The option was granted on March 2, 2026. The shares underlying the option are scheduled to vest with respect to 25% of the shares on March 2, 2027 and the remainder are scheduled to vest in equal monthly installments through March 2, 2030, subject to the reporting person's continued service with the company.

SEC source: 0001798179-26-000004 · wk-form4_1772573439.xml · nonDerivative · entry 2

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 57,197

F2 · kind: Represents portion of the performance-based restricted stock units ("PRSUs") previously granted to the reporting person on March 4, 2024 and March 21, 2024, for which the compensation committee of the Issuer's board of directors certified on March 2, 2026 the level of achievement of the performance metrics for the PRSUs. The PRSUs will vest upon the filing of the Issuer's Annual Report on Form 10-K for the year ended December 31, 2026, subject to the reporting person's continued service with the company.

F3 · balance_after: Includes an aggregate of 52,949 unvested RSUs.

SEC source: 0001798179-26-000004 · wk-form4_1772573439.xml · nonDerivative · entry 1

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,515

F1 · security: Grant of restricted stock units ("RSUs") under the Issuer's 2022 Equity Incentive Plan, as amended. Each RSU represents a contingent right to receive one share of common stock of the Issuer. The RSUs were granted on March 2, 2026 and will vest in equal installments on each of March 9, 2027, 2028, 2029 and 2030, subject to the reporting person's continued service with the company.

SEC source: 0001798179-26-000002 · wk-form4_1770850833.xml · nonDerivative · entry 1

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,385

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 13, 2023, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units ("RSUs"). The sale does not represent a discretionary trade by the reporting person.

F2 · balance_after: Includes 15,137 unvested RSUs.

SEC source: 0001490978-25-000015 · wk-form4_1741127151.xml · derivative · entry 2

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2035-03-03

F3 · derivative.exercise_date: The option was granted on March 3, 2025. The shares underlying the option are scheduled to vest with respect to 25% of the shares on March 3, 2026 and the remainder are scheduled to vest in equal monthly installments through March 3, 2029.

SEC source: 0001490978-25-000015 · wk-form4_1741127151.xml · nonDerivative · entry 1

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,615

F1 · security: Grant of restricted stock units ("RSUs") under the Issuer's 2022 Equity Incentive Plan, as amended. Each RSU represents a contingent right to receive one share of common stock of the Issuer. The RSUs were granted on March 3, 2025 and will vest in equal installments on each of March 4, 2026, 2027, 2028 and 2029, subject to the Reporting Person's continued service with the company.

F2 · balance_after: Includes 17,773 unvested RSUs.

SEC source: 0001490978-25-000005 · wk-form4_1739394536.xml · nonDerivative · entry 1

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,115

F1 · kind: This sale was effected pursuant to a durable automatic sale instruction under Rule 10b5-1 adopted by the reporting person on June 13, 2023, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units ("RSUs"). The sale does not represent a discretionary trade by the reporting person.

F2 · balance_after: Includes 5,273 unvested RSUs.

SEC source: 0001490978-24-000024 · wk-form4_1711139131.xml · derivative · entry 1

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2034-03-21

F1 · derivative.exercise_date: The option was granted on March 21, 2024. The shares underlying the option are scheduled to vest with respect to 25% of the shares on March 4, 2025 and the remainder are scheduled to vest in equal monthly installments through March 4, 2028.

SEC source: 0001628280-24-008948 · wk-form4_1709674728.xml · derivative · entry 1

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Stock · 60,000 shares

Expires 2034-03-04

F1 · derivative.exercise_date: The option was granted on March 4, 2024. The shares underlying the option are scheduled to vest with respect to 25% of the shares on March 4, 2025 and the remainder are scheduled to vest in equal monthly installments through March 4, 2028.

SEC source: 0001490978-24-000006 · wk-form4_1707871058.xml · nonDerivative · entry 1

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 9,340

F1 · kind: This sale was effected pursuant to a durable automatic sale instruction under Rule 10b5-1 adopted by the reporting person on June 13, 2023, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units ("RSUs"). The sale does not represent a discretionary trade by the reporting person.

F2 · balance_after: Includes 7,909 unvested RSUs.

SEC source: 0001490978-23-000010 · wf-form4_167606634889763.xml · derivative · entry 2

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 63,270

Underlying: Common Stock · 63,270 shares

Expires 2033-02-09

F3 · derivative.exercise_date: The option was granted on February 9, 2023. The shares underlying the option are scheduled to vest with respect to 25% of the shares on February 9, 2024 and the remainder are scheduled to vest in equal monthly installments through February 9, 2027.

SEC source: 0001490978-23-000010 · wf-form4_167606634889763.xml · nonDerivative · entry 1

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,545

F1 · security: Grant of restricted stock units ("RSUs") under the Issuer's 2022 Equity Incentive Plan. Each RSU represents a contingent right to receive one share of common stock of the Issuer. The RSUs were granted on February 9, 2023 and will vest in equal installments on each of February 9, 2024, 2025, 2026 and 2027, subject to the Reporting Person's continued service with the company.

F2 · balance_after: Includes 10,545 unvested RSUs.

SEC source: 0001209191-22-008273 · doc4.xml · derivative · entry 1

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,000

Underlying: Common Stock · 70,000 shares

Expires 2032-02-09

F1 · derivative.exercise_date: The option was granted on February 9, 2022. The shares underlying the option are scheduled to vest with respect to 25% of the shares on February 9, 2023 and the remainder are scheduled to vest in equal monthly installments through February 9, 2026.

SEC source: 0001209191-21-069493 · doc4.xml · derivative · entry 4

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,756

Underlying: Common Stock · 15,601 shares

Expires 2030-02-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

F4 · derivative.exercise_date: This option was granted on February 5, 2020. The shares underlying the option vested with respect to 25% of the shares on February 5, 2021 and the remainder are scheduled to vest in equal monthly installments through February 5, 2024.

SEC source: 0001209191-21-069493 · doc4.xml · nonDerivative · entry 3

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $36.78 to $36.99, inclusive.

SEC source: 0001209191-21-069493 · doc4.xml · nonDerivative · entry 2

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,900

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $35.77 to $36.73, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) through (3) of this Form 4.

SEC source: 0001209191-21-069493 · doc4.xml · nonDerivative · entry 1

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,601

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

SEC source: 0001209191-21-055953 · doc4.xml · derivative · entry 4

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 110,357

Underlying: Common Stock · 15,602 shares

Expires 2030-02-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

F4 · derivative.exercise_date: This option was granted on February 5, 2020. The shares underlying the option vested with respect to 25% of the shares on February 5, 2021 and the remainder are scheduled to vest in equal monthly installments through February 5, 2024.

SEC source: 0001209191-21-055953 · doc4.xml · nonDerivative · entry 3

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $61.73 to $62.63, inclusive.

SEC source: 0001209191-21-055953 · doc4.xml · nonDerivative · entry 2

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,782

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $60.65 to $61.58, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) through (3) of this Form 4.

SEC source: 0001209191-21-055953 · doc4.xml · nonDerivative · entry 1

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,602

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

SEC source: 0001209191-21-042424 · doc4.xml · derivative · entry 7

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 125,959

Underlying: Common Stock · 7,814 shares

Expires 2030-02-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

F4 · derivative.exercise_date: This option was granted on February 5, 2020. The shares underlying the option vested with respect to 25% of the shares on February 5, 2021 and the remainder are scheduled to vest in equal monthly installments through February 5, 2024.

SEC source: 0001209191-21-042424 · doc4.xml · derivative · entry 6

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,148

Underlying: Common Stock · 5,574 shares

Expires 2028-11-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

F3 · derivative.exercise_date: This option was granted on November 29, 2018. The shares underlying the option vested with respect to 25% of the shares on December 31, 2019 and the remainder are scheduled to vest in equal monthly installments through December 31, 2022.

SEC source: 0001209191-21-042424 · doc4.xml · derivative · entry 5

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,214 shares

Expires 2027-06-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

F2 · derivative.exercise_date: The option was granted on June 1, 2017 and is fully vested.

SEC source: 0001209191-21-042424 · doc4.xml · nonDerivative · entry 4

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

SEC source: 0001209191-21-042424 · doc4.xml · nonDerivative · entry 3

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,602

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

SEC source: 0001209191-21-042424 · doc4.xml · nonDerivative · entry 2

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,388

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

SEC source: 0001209191-21-042424 · doc4.xml · nonDerivative · entry 1

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,814

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

SEC source: 0001209191-21-030962 · doc4.xml · derivative · entry 7

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,496 shares

Expires 2025-07-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 17, 2020.

F6 · derivative.exercise_date: The option was granted on July 20, 2015 and is fully vested.

SEC source: 0001209191-21-030962 · doc4.xml · derivative · entry 6

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 13,377 shares

Expires 2024-05-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 17, 2020.

F5 · derivative.exercise_date: This option was granted on May 19, 2014 and is fully vested.

SEC source: 0001209191-21-030962 · doc4.xml · nonDerivative · entry 5

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 17, 2020.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $70.61 to $71.17, inclusive.

SEC source: 0001209191-21-030962 · doc4.xml · nonDerivative · entry 4

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 954

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 17, 2020.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $69.51 to $70.36, inclusive.

SEC source: 0001209191-21-030962 · doc4.xml · nonDerivative · entry 3

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,444

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 17, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $68.50 to $69.47, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) through (4) of this Form 4.

SEC source: 0001209191-21-030962 · doc4.xml · nonDerivative · entry 2

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,873

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 17, 2020.

SEC source: 0001209191-21-030962 · doc4.xml · nonDerivative · entry 1

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,377

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 17, 2020.

SEC source: 0001209191-21-016109 · doc4.xml · derivative · entry 1

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Stock · 80,000 shares

Expires 2031-02-27

F1 · derivative.exercise_date: The option was granted on February 27, 2021. The shares underlying the option are scheduled to vest with respect to 25% of the shares on February 27, 2022 and the remainder are scheduled to vest in equal monthly installments through February 27, 2025.

SEC source: 0001209191-21-008501 · doc4.xml · derivative · entry 7

Abel Robert Lorne · CIK 0001798179 · EVP, Science

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,496

Underlying: Common Stock · 10,881 shares

Expires 2025-07-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 17, 2020.

F6 · derivative.exercise_date: The option was granted on July 20, 2015 and is fully vested.

SEC source: 0001209191-21-008501 · doc4.xml · derivative · entry 6

Abel Robert Lorne · CIK 0001798179 · EVP, Science

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,214

Underlying: Common Stock · 4,992 shares

Expires 2027-06-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 17, 2020.

F5 · derivative.exercise_date: The option was granted on June 1, 2017 and is fully vested.

SEC source: 0001209191-21-008501 · doc4.xml · nonDerivative · entry 5

Abel Robert Lorne · CIK 0001798179 · EVP, Science

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 17, 2020.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $99.22 to $100.16, inclusive.

SEC source: 0001209191-21-008501 · doc4.xml · nonDerivative · entry 4

Abel Robert Lorne · CIK 0001798179 · EVP, Science

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,687

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 17, 2020.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $98.22 to $99.21, inclusive.

SEC source: 0001209191-21-008501 · doc4.xml · nonDerivative · entry 3

Abel Robert Lorne · CIK 0001798179 · EVP, Science

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,765

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 17, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $97.16 to $98.1, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) through (4) of this Form 4.

SEC source: 0001209191-21-008501 · doc4.xml · nonDerivative · entry 2

Abel Robert Lorne · CIK 0001798179 · EVP, Science

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,873

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 17, 2020.

SEC source: 0001209191-21-008501 · doc4.xml · nonDerivative · entry 1

Abel Robert Lorne · CIK 0001798179 · EVP, Science

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,992

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 17, 2020.

SEC source: 0000899243-20-033893 · doc4.xml · derivative · entry 11

Abel Robert Lorne · CIK 0001798179 · EVP, Science

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,206

Underlying: Common Stock · 1,649 shares

Expires 2027-06-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 17, 2020.

F10 · derivative.exercise_date: The option was granted on June 1, 2017. The shares underlying the option are scheduled to vest in equal yearly installments from January 1, 2017 through January 1, 2021.

SEC source: 0000899243-20-033893 · doc4.xml · derivative · entry 10

Abel Robert Lorne · CIK 0001798179 · EVP, Science

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 14,224 shares

Expires 2026-05-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 17, 2020.

F9 · derivative.exercise_date: The option was granted on May 11, 2016 and is fully vested.

SEC source: 0000899243-20-033893 · doc4.xml · nonDerivative · entry 9

Abel Robert Lorne · CIK 0001798179 · EVP, Science

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 17, 2020.

F8 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $73.96 to $74.05, inclusive.

SEC source: 0000899243-20-033893 · doc4.xml · nonDerivative · entry 8

Abel Robert Lorne · CIK 0001798179 · EVP, Science

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,782

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 17, 2020.

F7 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $72.83 to $73.79, inclusive.

SEC source: 0000899243-20-033893 · doc4.xml · nonDerivative · entry 7

Abel Robert Lorne · CIK 0001798179 · EVP, Science

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,925

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 17, 2020.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $71.64 to $72.59, inclusive.

SEC source: 0000899243-20-033893 · doc4.xml · nonDerivative · entry 6

Abel Robert Lorne · CIK 0001798179 · EVP, Science

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,043

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 17, 2020.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $70.45 to $71.20, inclusive.