Essex Woodlands IX, LLC

SEC source: 0001193125-26-128987 · ownership.xml · derivative · entry 3

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 3, 5, 7 and 8

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 3, 5, 7 and 8

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner · See footnotes 3, 5, 7 and 8

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner · See footnotes 3, 5, 7 and 8

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: Not disclosed

Underlying: Common Stock · 195,777 shares

Expires not disclosed

F6 · derivative.exercise_price: The secured subordinated convertible notes in the aggregate principal (including payment-in-kind interest) plus accrued and unpaid interest (calculated through March 25, 2026) amount of $2,694,091.31 (the "Notes") are convertible at any time into an aggregate 195,777 shares of Common Stock at a conversion rate of 72.6691 shares of Common Stock for each $1,000.00 principal amount of Notes.

F1 · price: Pursuant to a Securities Purchase Agreement (the "SPA"), dated March 26, 2026, by and among EW Healthcare Partners, L.P. ("EWHP"), EW Healthcare Partners-A, L.P. ("EWHP-A" and, together with EWHP, the "EWHP Funds"), Madryn Health Partners, LP, Madryn Health Partners (Cayman Master), LP (together, "Madryn"), and the other parties thereto, the EWHP Funds sold to Madryn the securities reported herein, for an aggregate sale price of $2,600,000.

F6 · derivative.exercise_date: The secured subordinated convertible notes in the aggregate principal (including payment-in-kind interest) plus accrued and unpaid interest (calculated through March 25, 2026) amount of $2,694,091.31 (the "Notes") are convertible at any time into an aggregate 195,777 shares of Common Stock at a conversion rate of 72.6691 shares of Common Stock for each $1,000.00 principal amount of Notes.

F6 · derivative.expiration_date: The secured subordinated convertible notes in the aggregate principal (including payment-in-kind interest) plus accrued and unpaid interest (calculated through March 25, 2026) amount of $2,694,091.31 (the "Notes") are convertible at any time into an aggregate 195,777 shares of Common Stock at a conversion rate of 72.6691 shares of Common Stock for each $1,000.00 principal amount of Notes.

F7 · ownership.nature: The amount shown above is the aggregate principal and interest amount of Notes sold by EWHP and EWHP-A pursuant to the SPA. EWHP sold $2,589,895.67 of the principal and interest amount shown above and EWHP-A sold $104,195.64 of the principal and interest amount shown above.

F8 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of the EWHP Funds. Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the securities held by each of the EW Funds. The managers of the General Partner are Martin P. Sutter, R. Scott Barry, Ronald Eastman, Petri Vainio and Steve Wiggins (collectively, the "Managers") and may exercise voting and investment control over the securities only by majority action of the Managers. Each individual Manager, EW Fund IX GP and the General Partner disclaims ownership over the securities except to the extent of his or its respective pecuniary interest therein.

SEC source: 0001193125-26-128987 · ownership.xml · derivative · entry 2

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 3, 5, 7 and 8

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 3, 5, 7 and 8

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner · See footnotes 3, 5, 7 and 8

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner · See footnotes 3, 5, 7 and 8

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 0

Underlying: Common Stock · 382,022 shares

Expires not disclosed

F1 · price: Pursuant to a Securities Purchase Agreement (the "SPA"), dated March 26, 2026, by and among EW Healthcare Partners, L.P. ("EWHP"), EW Healthcare Partners-A, L.P. ("EWHP-A" and, together with EWHP, the "EWHP Funds"), Madryn Health Partners, LP, Madryn Health Partners (Cayman Master), LP (together, "Madryn"), and the other parties thereto, the EWHP Funds sold to Madryn the securities reported herein, for an aggregate sale price of $2,600,000.

F4 · derivative.exercise_date: The shares of Senior Convertible Preferred Stock are convertible into shares of Common Stock at a ratio of 0.2424 shares of Common Stock for each share of Senior Convertible Preferred Stock at the option of the holder at any time or by the Issuer under certain conditions.

F4 · derivative.expiration_date: The shares of Senior Convertible Preferred Stock are convertible into shares of Common Stock at a ratio of 0.2424 shares of Common Stock for each share of Senior Convertible Preferred Stock at the option of the holder at any time or by the Issuer under certain conditions.

F5 · ownership.nature: The share total shown above is the aggregate amount of shares of Senior Convertible Preferred Stock sold by EWHP and EWHP-A pursuant to the SPA. EWHP sold 1,514,864 shares of the amount shown above and EWHP-A sold 60,946 shares of the amount shown above.

F8 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of the EWHP Funds. Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the securities held by each of the EW Funds. The managers of the General Partner are Martin P. Sutter, R. Scott Barry, Ronald Eastman, Petri Vainio and Steve Wiggins (collectively, the "Managers") and may exercise voting and investment control over the securities only by majority action of the Managers. Each individual Manager, EW Fund IX GP and the General Partner disclaims ownership over the securities except to the extent of his or its respective pecuniary interest therein.

SEC source: 0001193125-26-128987 · ownership.xml · derivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 3, 5, 7 and 8

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 3, 5, 7 and 8

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner · See footnotes 3, 5, 7 and 8

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner · See footnotes 3, 5, 7 and 8

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 0

Underlying: Common Stock · 90,913 shares

Expires not disclosed

F1 · price: Pursuant to a Securities Purchase Agreement (the "SPA"), dated March 26, 2026, by and among EW Healthcare Partners, L.P. ("EWHP"), EW Healthcare Partners-A, L.P. ("EWHP-A" and, together with EWHP, the "EWHP Funds"), Madryn Health Partners, LP, Madryn Health Partners (Cayman Master), LP (together, "Madryn"), and the other parties thereto, the EWHP Funds sold to Madryn the securities reported herein, for an aggregate sale price of $2,600,000.

F2 · derivative.exercise_date: The shares of Junior Convertible Preferred Stock are convertible into shares of Common Stock at a ratio of 0.0606 shares of Common Stock for each share of Junior Convertible Preferred Stock at the option of the holder at any time or by the Issuer under certain conditions.

F2 · derivative.expiration_date: The shares of Junior Convertible Preferred Stock are convertible into shares of Common Stock at a ratio of 0.0606 shares of Common Stock for each share of Junior Convertible Preferred Stock at the option of the holder at any time or by the Issuer under certain conditions.

F3 · ownership.nature: The share total shown above is the aggregate amount of shares of Junior Convertible Preferred Stock sold by EWHP and EWHP-A pursuant to the SPA. EWHP sold 1,441,983 shares of the amount shown above and EWHP-A sold 58,017 shares of the amount shown above.

F8 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of the EWHP Funds. Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the securities held by each of the EW Funds. The managers of the General Partner are Martin P. Sutter, R. Scott Barry, Ronald Eastman, Petri Vainio and Steve Wiggins (collectively, the "Managers") and may exercise voting and investment control over the securities only by majority action of the Managers. Each individual Manager, EW Fund IX GP and the General Partner disclaims ownership over the securities except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000950170-24-005774 · ownership.xml · derivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 2

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: Not disclosed

Underlying: Common Stock · 1,598,722 shares

Expires 2025-12-09

F1 · derivative.exercise_price: The secured subordinated convertible notes in the aggregate principal amount of $2,000,000.00 (the "Notes") are convertible at any time into an aggregate 1,598,722 shares of common stock, $0.0001 par value per share ("Common Stock"), of Venus Concept Inc., at a conversion rate of 799.3605 shares of Common Stock for each $1,000.00 principal amount of Notes, 1,536,890 of which are held by EW Healthcare Partners, L.P. ("EWHP"), and 61,832 of which are held by EW Healthcare Partners-A, L.P. ("EWHP-A" and, together with EWHP, the "EWHP Funds").

F1 · reported_value: The secured subordinated convertible notes in the aggregate principal amount of $2,000,000.00 (the "Notes") are convertible at any time into an aggregate 1,598,722 shares of common stock, $0.0001 par value per share ("Common Stock"), of Venus Concept Inc., at a conversion rate of 799.3605 shares of Common Stock for each $1,000.00 principal amount of Notes, 1,536,890 of which are held by EW Healthcare Partners, L.P. ("EWHP"), and 61,832 of which are held by EW Healthcare Partners-A, L.P. ("EWHP-A" and, together with EWHP, the "EWHP Funds").

F1 · price: The secured subordinated convertible notes in the aggregate principal amount of $2,000,000.00 (the "Notes") are convertible at any time into an aggregate 1,598,722 shares of common stock, $0.0001 par value per share ("Common Stock"), of Venus Concept Inc., at a conversion rate of 799.3605 shares of Common Stock for each $1,000.00 principal amount of Notes, 1,536,890 of which are held by EW Healthcare Partners, L.P. ("EWHP"), and 61,832 of which are held by EW Healthcare Partners-A, L.P. ("EWHP-A" and, together with EWHP, the "EWHP Funds").

F1 · derivative.underlying_shares: The secured subordinated convertible notes in the aggregate principal amount of $2,000,000.00 (the "Notes") are convertible at any time into an aggregate 1,598,722 shares of common stock, $0.0001 par value per share ("Common Stock"), of Venus Concept Inc., at a conversion rate of 799.3605 shares of Common Stock for each $1,000.00 principal amount of Notes, 1,536,890 of which are held by EW Healthcare Partners, L.P. ("EWHP"), and 61,832 of which are held by EW Healthcare Partners-A, L.P. ("EWHP-A" and, together with EWHP, the "EWHP Funds").

F1 · valueOwnedAfter: The secured subordinated convertible notes in the aggregate principal amount of $2,000,000.00 (the "Notes") are convertible at any time into an aggregate 1,598,722 shares of common stock, $0.0001 par value per share ("Common Stock"), of Venus Concept Inc., at a conversion rate of 799.3605 shares of Common Stock for each $1,000.00 principal amount of Notes, 1,536,890 of which are held by EW Healthcare Partners, L.P. ("EWHP"), and 61,832 of which are held by EW Healthcare Partners-A, L.P. ("EWHP-A" and, together with EWHP, the "EWHP Funds").

F2 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of the EWHP Funds. Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares"). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the "Managers") and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, EW Fund IX GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-020011 · doc4.xml · derivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 2 and 3

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 2 and 3

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner · See footnotes 2 and 3

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner · See footnotes 2 and 3

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · I

Disclosed balance after: 1,575,810

Underlying: Common Stock · 1,340,051 shares

Expires not disclosed

F2 · shares: The share total shown above is the aggregate amount of shares of Senior Convertible Preferred Stock purchased by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the date set forth above. EWHP purchased 483,078 shares of the amount shown above and EWHP-A purchased 19,435 shares of the amount shown above. EWHP now holds a total of 1,514,864 shares of Senior Convertible Preferred Stock (convertible into 4,039,688 shares of Common Stock) of the Issuer and EWHP-A now holds a total of 60,946 shares of Senior Convertible Preferred Stock (convertible into 162,525 shares of Common Stock) of the Issuer.

F1 · derivative.exercise_date: The shares of Senior Convertible Preferred Stock are convertible into shares of Common Stock at a ratio of 2.6667 shares of Common Stock for each share of Senior Convertible Preferred Stock at the option of the holder at any time or by the Issuer under certain conditions.

F1 · derivative.expiration_date: The shares of Senior Convertible Preferred Stock are convertible into shares of Common Stock at a ratio of 2.6667 shares of Common Stock for each share of Senior Convertible Preferred Stock at the option of the holder at any time or by the Issuer under certain conditions.

F2 · ownership.direct: The share total shown above is the aggregate amount of shares of Senior Convertible Preferred Stock purchased by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the date set forth above. EWHP purchased 483,078 shares of the amount shown above and EWHP-A purchased 19,435 shares of the amount shown above. EWHP now holds a total of 1,514,864 shares of Senior Convertible Preferred Stock (convertible into 4,039,688 shares of Common Stock) of the Issuer and EWHP-A now holds a total of 60,946 shares of Senior Convertible Preferred Stock (convertible into 162,525 shares of Common Stock) of the Issuer.

F3 · ownership.direct: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Fund IX GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

F2 · ownership.nature: The share total shown above is the aggregate amount of shares of Senior Convertible Preferred Stock purchased by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the date set forth above. EWHP purchased 483,078 shares of the amount shown above and EWHP-A purchased 19,435 shares of the amount shown above. EWHP now holds a total of 1,514,864 shares of Senior Convertible Preferred Stock (convertible into 4,039,688 shares of Common Stock) of the Issuer and EWHP-A now holds a total of 60,946 shares of Senior Convertible Preferred Stock (convertible into 162,525 shares of Common Stock) of the Issuer.

F3 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Fund IX GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018735 · doc4.xml · derivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 2 and 3

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 2 and 3

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · I

Disclosed balance after: 1,073,297

Underlying: Common Stock · 779,737 shares

Expires not disclosed

F2 · shares: The share total shown above is the aggregate amount of shares of Senior Convertible Preferred Stock purchased by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the date set forth above. EWHP purchased 281,089 shares of the amount shown above and EWHP-A purchased 11,309 shares of the amount shown above. EWHP now holds a total of 1,031,786 shares of Senior Convertible Preferred Stock (convertible into 2,751,463 shares of Common Stock) of the Issuer and EWHP-A now holds a total of 41,511 shares of Senior Convertible Preferred Stock (convertible into 110,697 shares of Common Stock) of the Issuer.

F1 · derivative.exercise_date: The shares of Senior Convertible Preferred Stock are convertible into shares of Common Stock at a ratio of 2.6667 shares of Common Stock for each share of Senior Convertible Preferred Stock at the option of the holder at any time or by the Issuer under certain conditions.

F1 · derivative.expiration_date: The shares of Senior Convertible Preferred Stock are convertible into shares of Common Stock at a ratio of 2.6667 shares of Common Stock for each share of Senior Convertible Preferred Stock at the option of the holder at any time or by the Issuer under certain conditions.

F2 · ownership.direct: The share total shown above is the aggregate amount of shares of Senior Convertible Preferred Stock purchased by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the date set forth above. EWHP purchased 281,089 shares of the amount shown above and EWHP-A purchased 11,309 shares of the amount shown above. EWHP now holds a total of 1,031,786 shares of Senior Convertible Preferred Stock (convertible into 2,751,463 shares of Common Stock) of the Issuer and EWHP-A now holds a total of 41,511 shares of Senior Convertible Preferred Stock (convertible into 110,697 shares of Common Stock) of the Issuer.

F3 · ownership.direct: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Fund IX GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

F2 · ownership.nature: The share total shown above is the aggregate amount of shares of Senior Convertible Preferred Stock purchased by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the date set forth above. EWHP purchased 281,089 shares of the amount shown above and EWHP-A purchased 11,309 shares of the amount shown above. EWHP now holds a total of 1,031,786 shares of Senior Convertible Preferred Stock (convertible into 2,751,463 shares of Common Stock) of the Issuer and EWHP-A now holds a total of 41,511 shares of Senior Convertible Preferred Stock (convertible into 110,697 shares of Common Stock) of the Issuer.

F3 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Fund IX GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018661 · doc4a.xml · nonDerivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 3

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 3

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,490,921

F2 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $9.73 to $10.11. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F1 · ownership.nature: The share total shown above is the aggregate amount of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the date set forth above. EWHP sold 19,226 shares of the amount shown above, and EWHP-A sold 774 shares of the amount shown above. EWHP now holds a total of 3,355,921 shares of Common Stock of the Issuer and EWHP-A now holds a total of 135,000 shares of Common Stock of the Issuer.

F3 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EWHP Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Fund IX GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018658 · doc4.xml · nonDerivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 3

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 3

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,490,921

F2 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $9.73 to $10.11. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F1 · ownership.nature: The share total shown above is the aggregate amount of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the date set forth above. EWHP sold 19,226 shares of the amount shown above, and EWHP-A sold 774 shares of the amount shown above. EWHP now holds a total of 3,355,921 shares of Common Stock of the Issuer and EWHP-A now holds a total of 135,000 shares of Common Stock of the Issuer.

F3 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EWHP Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Fund IX GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018636 · doc4.xml · nonDerivative · entry 4

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 6

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 6

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,510,921

F5 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $10.84 to $11.23. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 58,616 shares and 75,457 shares of the amounts shown above on August 30, 2023 and August 31, 2023, respectively, and EWHP-A sold 2,360 shares and 3,038 shares of the amounts shown above on August 30, 2023 and August 31, 2023, respectively. EWHP now holds a total of 3,375,147 shares of Common Stock of the Issuer and EWHP-A now holds a total of 135,774 shares of Common Stock of the Issuer.

F6 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EWHP Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Fund IX GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018636 · doc4.xml · nonDerivative · entry 3

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 6

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 6

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,517,938

F4 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $9.83 to $10.76. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 58,616 shares and 75,457 shares of the amounts shown above on August 30, 2023 and August 31, 2023, respectively, and EWHP-A sold 2,360 shares and 3,038 shares of the amounts shown above on August 30, 2023 and August 31, 2023, respectively. EWHP now holds a total of 3,375,147 shares of Common Stock of the Issuer and EWHP-A now holds a total of 135,774 shares of Common Stock of the Issuer.

F6 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EWHP Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Fund IX GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018636 · doc4.xml · nonDerivative · entry 2

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 6

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 6

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,589,416

F3 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $11.35 to $11.37. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 58,616 shares and 75,457 shares of the amounts shown above on August 30, 2023 and August 31, 2023, respectively, and EWHP-A sold 2,360 shares and 3,038 shares of the amounts shown above on August 30, 2023 and August 31, 2023, respectively. EWHP now holds a total of 3,375,147 shares of Common Stock of the Issuer and EWHP-A now holds a total of 135,774 shares of Common Stock of the Issuer.

F6 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EWHP Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Fund IX GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018636 · doc4.xml · nonDerivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 6

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 6

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,589,743

F2 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $10.32 to $11.29. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 58,616 shares and 75,457 shares of the amounts shown above on August 30, 2023 and August 31, 2023, respectively, and EWHP-A sold 2,360 shares and 3,038 shares of the amounts shown above on August 30, 2023 and August 31, 2023, respectively. EWHP now holds a total of 3,375,147 shares of Common Stock of the Issuer and EWHP-A now holds a total of 135,774 shares of Common Stock of the Issuer.

F6 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EWHP Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Fund IX GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018610 · doc4.xml · nonDerivative · entry 3

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 4

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 4

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 3,650,392

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 58,503 shares and 84,454 shares of the amounts shown above on August 28, 2023 and August 29, 2023, respectively, and EWHP-A sold 2,355 shares and 3,400 shares of the amounts shown above on August 28, 2023 and August 29, 2023, respectively. EWHP now holds a total of 3,509,220 shares of Common Stock of the Issuer and EWHP-A now holds a total of 141,172 shares of Common Stock of the Issuer.

F4 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018610 · doc4.xml · nonDerivative · entry 2

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 4

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 4

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 3,650,957

F3 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $10.30 to $11.29. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 58,503 shares and 84,454 shares of the amounts shown above on August 28, 2023 and August 29, 2023, respectively, and EWHP-A sold 2,355 shares and 3,400 shares of the amounts shown above on August 28, 2023 and August 29, 2023, respectively. EWHP now holds a total of 3,509,220 shares of Common Stock of the Issuer and EWHP-A now holds a total of 141,172 shares of Common Stock of the Issuer.

F4 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018610 · doc4.xml · nonDerivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 4

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 4

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 3,738,246

F2 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $11.28 to $12.00. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 58,503 shares and 84,454 shares of the amounts shown above on August 28, 2023 and August 29, 2023, respectively, and EWHP-A sold 2,355 shares and 3,400 shares of the amounts shown above on August 28, 2023 and August 29, 2023, respectively. EWHP now holds a total of 3,509,220 shares of Common Stock of the Issuer and EWHP-A now holds a total of 141,172 shares of Common Stock of the Issuer.

F4 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000950170-23-044843 · ownership.xml · nonDerivative · entry 3

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 2

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 2

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 3,799,104

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 133,890 shares and 81,380 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively, and EWHP-A sold 5,390 shares and 3,276 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively. EWHP now holds a total of 3,652,177 shares of Common Stock of the Issuer and EWHP-A now holds a total of 146,927 shares of Common Stock of the Issuer.

F2 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000950170-23-044843 · ownership.xml · nonDerivative · entry 2

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 2

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 2

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 3,853,760

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 133,890 shares and 81,380 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively, and EWHP-A sold 5,390 shares and 3,276 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively. EWHP now holds a total of 3,652,177 shares of Common Stock of the Issuer and EWHP-A now holds a total of 146,927 shares of Common Stock of the Issuer.

F2 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018606 · doc4a.xml · nonDerivative · entry 4

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 6

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 6

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,799,104

F5 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $10.36 to $10.50. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F7 · price: This Amended Form 4 is being filed to correct an administrative error in reporting the weighted average prices at which shares were sold on August 24, 2023 and August 25, 2023 from that reported in the original Form 4 to the prices shown in this Amended Form 4.

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 133,890 shares and 81,380 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively, and EWHP-A sold 5,390 shares and 3,276 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively. EWHP now holds a total of 3,652,177 shares of Common Stock of the Issuer and EWHP-A now holds a total of 146,927 shares of Common Stock of the Issuer.

F6 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018606 · doc4a.xml · nonDerivative · entry 3

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 6

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 6

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,810,835

F4 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $10.5001 to $11.50. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F7 · price: This Amended Form 4 is being filed to correct an administrative error in reporting the weighted average prices at which shares were sold on August 24, 2023 and August 25, 2023 from that reported in the original Form 4 to the prices shown in this Amended Form 4.

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 133,890 shares and 81,380 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively, and EWHP-A sold 5,390 shares and 3,276 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively. EWHP now holds a total of 3,652,177 shares of Common Stock of the Issuer and EWHP-A now holds a total of 146,927 shares of Common Stock of the Issuer.

F6 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000950170-23-044843 · ownership.xml · nonDerivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 2

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 2

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 3,883,760

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 133,890 shares and 81,380 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively, and EWHP-A sold 5,390 shares and 3,276 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively. EWHP now holds a total of 3,652,177 shares of Common Stock of the Issuer and EWHP-A now holds a total of 146,927 shares of Common Stock of the Issuer.

F2 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018606 · doc4a.xml · nonDerivative · entry 2

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 6

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 6

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,883,760

F3 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $10.11 to $11.04. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F7 · price: This Amended Form 4 is being filed to correct an administrative error in reporting the weighted average prices at which shares were sold on August 24, 2023 and August 25, 2023 from that reported in the original Form 4 to the prices shown in this Amended Form 4.

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 133,890 shares and 81,380 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively, and EWHP-A sold 5,390 shares and 3,276 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively. EWHP now holds a total of 3,652,177 shares of Common Stock of the Issuer and EWHP-A now holds a total of 146,927 shares of Common Stock of the Issuer.

F6 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018606 · doc4a.xml · nonDerivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 6

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 6

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,935,940

F2 · price: Price is the volume weighted average selling price of all sales by the Reporting Persons on the transaction date within a one dollar range. Actual prices ranged from $11.05 to $12.04. The Reporting Persons hereby undertake to provide upon request of the Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F7 · price: This Amended Form 4 is being filed to correct an administrative error in reporting the weighted average prices at which shares were sold on August 24, 2023 and August 25, 2023 from that reported in the original Form 4 to the prices shown in this Amended Form 4.

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 133,890 shares and 81,380 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively, and EWHP-A sold 5,390 shares and 3,276 shares of the amounts shown above on August 24, 2023 and August 25, 2023, respectively. EWHP now holds a total of 3,652,177 shares of Common Stock of the Issuer and EWHP-A now holds a total of 146,927 shares of Common Stock of the Issuer.

F6 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Steve Wiggins (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018380 · doc4.xml · nonDerivative · entry 2

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 2

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 2

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 4,023,040

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 44,968 shares and 116,416 shares of the amounts shown above on August 22, 2023 and August 23, 2023, respectively, and EWHP-A sold 1,810 shares and 4,687 shares of the amounts shown above on August 22, 2023 and August 23, 2023, respectively. EWHP now holds a total of 3,867,447 shares of Common Stock of the Issuer and EWHP-A now holds a total of 155,593 shares of Common Stock of the Issuer.

F2 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EWHP Funds (the "Shares"). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Scott Wiggins (collectively, the "Managers") and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-018380 · doc4.xml · nonDerivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 1 and 2

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 1 and 2

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 4,144,143

F1 · ownership.nature: The share totals shown above are the aggregate amounts of shares of Common Stock sold by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the dates set forth above. EWHP sold 44,968 shares and 116,416 shares of the amounts shown above on August 22, 2023 and August 23, 2023, respectively, and EWHP-A sold 1,810 shares and 4,687 shares of the amounts shown above on August 22, 2023 and August 23, 2023, respectively. EWHP now holds a total of 3,867,447 shares of Common Stock of the Issuer and EWHP-A now holds a total of 155,593 shares of Common Stock of the Issuer.

F2 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EWHP Funds (the "Shares"). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, Petri Vainio and Scott Wiggins (collectively, the "Managers") and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-017388 · doc4.xml · derivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 2 and 3

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 2 and 3

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · I

Disclosed balance after: 780,899

Underlying: Common Stock · 1,333,350 shares

Expires not disclosed

F2 · shares: The share total shown above is the aggregate amount of shares of Senior Convertible Preferred Stock purchased by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the date set forth above. EWHP purchased 480,662 shares of the amount shown above and EWHP-A purchased 19,338 shares of the amount shown above. EWHP now holds a total of 750,697 shares of Senior Convertible Preferred Stock (convertible into 2,001,883 shares of Common Stock) of the Issuer and EWHP-A now holds a total of 30,202 shares of Senior Convertible Preferred Stock (convertible into 80,540 shares of Common Stock) of the Issuer.

F1 · derivative.exercise_date: The shares of Senior Convertible Preferred Stock are convertible into shares of Common Stock at a ratio of 2.6667 shares of Common Stock for each share of Senior Convertible Preferred Stock at the option of the holder at any time or at the option of the Issuer under certain conditions.

F1 · derivative.expiration_date: The shares of Senior Convertible Preferred Stock are convertible into shares of Common Stock at a ratio of 2.6667 shares of Common Stock for each share of Senior Convertible Preferred Stock at the option of the holder at any time or at the option of the Issuer under certain conditions.

F2 · ownership.direct: The share total shown above is the aggregate amount of shares of Senior Convertible Preferred Stock purchased by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the date set forth above. EWHP purchased 480,662 shares of the amount shown above and EWHP-A purchased 19,338 shares of the amount shown above. EWHP now holds a total of 750,697 shares of Senior Convertible Preferred Stock (convertible into 2,001,883 shares of Common Stock) of the Issuer and EWHP-A now holds a total of 30,202 shares of Senior Convertible Preferred Stock (convertible into 80,540 shares of Common Stock) of the Issuer.

F3 · ownership.direct: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, and Petri Vainio (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

F2 · ownership.nature: The share total shown above is the aggregate amount of shares of Senior Convertible Preferred Stock purchased by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the date set forth above. EWHP purchased 480,662 shares of the amount shown above and EWHP-A purchased 19,338 shares of the amount shown above. EWHP now holds a total of 750,697 shares of Senior Convertible Preferred Stock (convertible into 2,001,883 shares of Common Stock) of the Issuer and EWHP-A now holds a total of 30,202 shares of Senior Convertible Preferred Stock (convertible into 80,540 shares of Common Stock) of the Issuer.

F3 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, and Petri Vainio (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-23-013130 · doc4.xml · derivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner · See footnotes 2 and 3

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner · See footnotes 2 and 3

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · I

Disclosed balance after: 280,899

Underlying: Common Stock · 749,073 shares

Expires not disclosed

F2 · shares: The share total shown above is the aggregate amount of shares of Senior Convertible Preferred Stock purchased by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the date set forth above. EWHP purchased 270,035 shares of the amount shown above and EWHP-A purchased 10,864 shares of the amount shown above.

F1 · derivative.exercise_date: The shares of Senior Convertible Preferred Stock are convertible into shares of Common Stock at a ratio of 2.6667 shares of Common Stock for each share of Senior Convertible Preferred Stock at the option of the holder at any time or at the option of the Issuer under certain conditions. The Senior Convertible Preferred Stock do not expire.

F1 · derivative.expiration_date: The shares of Senior Convertible Preferred Stock are convertible into shares of Common Stock at a ratio of 2.6667 shares of Common Stock for each share of Senior Convertible Preferred Stock at the option of the holder at any time or at the option of the Issuer under certain conditions. The Senior Convertible Preferred Stock do not expire.

F2 · ownership.direct: The share total shown above is the aggregate amount of shares of Senior Convertible Preferred Stock purchased by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the date set forth above. EWHP purchased 270,035 shares of the amount shown above and EWHP-A purchased 10,864 shares of the amount shown above.

F3 · ownership.direct: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, and Petri Vainio (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

F2 · ownership.nature: The share total shown above is the aggregate amount of shares of Senior Convertible Preferred Stock purchased by EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A") on the date set forth above. EWHP purchased 270,035 shares of the amount shown above and EWHP-A purchased 10,864 shares of the amount shown above.

F3 · ownership.nature: Essex Woodlands Fund IX-GP, L.P. (the "EW Fund IX GP"), is the general partner of each of EW Healthcare Partners, L.P. ("EWHP") and EW Healthcare Partners-A, L.P. ("EWHP-A" and together with EWHP, the "EWHP Funds"). Essex Woodlands IX, LLC (the "General Partner") is the general partner of EW Fund IX GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Scott Barry, Ron Eastman, and Petri Vainio (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.

SEC source: 0000899243-22-036815 · doc4a.xml · derivative · entry 2

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · EW Healthcare Partners-A, LP

Disclosed balance after: 58,015

Underlying: Common Stock · 580,150 shares

Expires not disclosed

F1 · derivative.exercise_price: The Voting Convertible Preferred Stock will convert into shares of Common Stock on a one for ten basis (i) at the option the holder or (ii) at the option of the Company within 30 days following the occurrence of certain events. The Voting Convertible Preferred Convertible Stock votes with the Common Stock on an as-converted basis. The Voting Convertible Preferred Stock does not expire.

F1 · deemedExecutionDate: The Voting Convertible Preferred Stock will convert into shares of Common Stock on a one for ten basis (i) at the option the holder or (ii) at the option of the Company within 30 days following the occurrence of certain events. The Voting Convertible Preferred Convertible Stock votes with the Common Stock on an as-converted basis. The Voting Convertible Preferred Stock does not expire.

F1 · derivative.expiration_date: The Voting Convertible Preferred Stock will convert into shares of Common Stock on a one for ten basis (i) at the option the holder or (ii) at the option of the Company within 30 days following the occurrence of certain events. The Voting Convertible Preferred Convertible Stock votes with the Common Stock on an as-converted basis. The Voting Convertible Preferred Stock does not expire.

F2 · ownership.nature: Held by EW Healthcare Partners L.P. ("EWHP"). Essex Woodlands Fund IX-GP, L.P. ("EW Fund IX GP") is the general partner of EWHP and EWHP-A (as defined below). Essex Woodlands IX, LLC ("Essex IX General Partner") is the general partner of Essex IX Fund GP. Martin P. Sutter, R. Scott Barry, Ronald W. Eastman, Petri Vainio and Steve Wiggins are each a Manager of Essex IX General Partner (the "Managers"). Each of the Managers may be deemed to exercise shared voting and investment power with respect to such shares. Each of EW Fund IX GP, Essex IX General Partner and the Managers, including Mr. Barry who is a member of the Issuer's board of directors, disclaims beneficial ownership of the shares held by EWHP and EWHP-A, except to the extent of any pecuniary interests therein.

F3 · ownership.nature: Held by EW Healthcare Partners-A.L.P. ("EWHP-A").

SEC source: 0000899243-22-036815 · doc4a.xml · derivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · EW Healthcare Partners, LP

Disclosed balance after: 1,441,985

Underlying: Common Stock · 14,419,850 shares

Expires not disclosed

F1 · derivative.exercise_price: The Voting Convertible Preferred Stock will convert into shares of Common Stock on a one for ten basis (i) at the option the holder or (ii) at the option of the Company within 30 days following the occurrence of certain events. The Voting Convertible Preferred Convertible Stock votes with the Common Stock on an as-converted basis. The Voting Convertible Preferred Stock does not expire.

F1 · deemedExecutionDate: The Voting Convertible Preferred Stock will convert into shares of Common Stock on a one for ten basis (i) at the option the holder or (ii) at the option of the Company within 30 days following the occurrence of certain events. The Voting Convertible Preferred Convertible Stock votes with the Common Stock on an as-converted basis. The Voting Convertible Preferred Stock does not expire.

F1 · derivative.expiration_date: The Voting Convertible Preferred Stock will convert into shares of Common Stock on a one for ten basis (i) at the option the holder or (ii) at the option of the Company within 30 days following the occurrence of certain events. The Voting Convertible Preferred Convertible Stock votes with the Common Stock on an as-converted basis. The Voting Convertible Preferred Stock does not expire.

F4 · derivative.underlying_shares: This Amended Form 4 is filed only to correct the Amount of Securities Underlying Derivative Security set forth in Box 7 of Table II in the original Form 4 filed on November 22, 2022 shown for EW Healthcare Partners, LP. from 14,410,850 to 14,419,850, and to correct the Suite number for the Reporting Persons' address to Suite 225. No other changes has been made to the original Form 4 filed on November 22, 2022 relating to the trade made on November 18, 2022.

F2 · ownership.nature: Held by EW Healthcare Partners L.P. ("EWHP"). Essex Woodlands Fund IX-GP, L.P. ("EW Fund IX GP") is the general partner of EWHP and EWHP-A (as defined below). Essex Woodlands IX, LLC ("Essex IX General Partner") is the general partner of Essex IX Fund GP. Martin P. Sutter, R. Scott Barry, Ronald W. Eastman, Petri Vainio and Steve Wiggins are each a Manager of Essex IX General Partner (the "Managers"). Each of the Managers may be deemed to exercise shared voting and investment power with respect to such shares. Each of EW Fund IX GP, Essex IX General Partner and the Managers, including Mr. Barry who is a member of the Issuer's board of directors, disclaims beneficial ownership of the shares held by EWHP and EWHP-A, except to the extent of any pecuniary interests therein.

SEC source: 0000899243-22-036684 · doc4.xml · derivative · entry 2

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · EW Healthcare Partners-A, LP

Disclosed balance after: 58,015

Underlying: Common Stock · 580,150 shares

Expires not disclosed

F1 · derivative.exercise_price: The Voting Convertible Preferred Stock will convert into shares of Common Stock on a one for ten basis (i) at the option the holder or (ii) at the option of the Company within 30 days following the occurrence of certain events. The Voting Convertible Preferred Convertible Stock votes with the Common Stock on an as-converted basis. The Voting Convertible Preferred Stock does not expire.

F1 · deemedExecutionDate: The Voting Convertible Preferred Stock will convert into shares of Common Stock on a one for ten basis (i) at the option the holder or (ii) at the option of the Company within 30 days following the occurrence of certain events. The Voting Convertible Preferred Convertible Stock votes with the Common Stock on an as-converted basis. The Voting Convertible Preferred Stock does not expire.

F1 · derivative.expiration_date: The Voting Convertible Preferred Stock will convert into shares of Common Stock on a one for ten basis (i) at the option the holder or (ii) at the option of the Company within 30 days following the occurrence of certain events. The Voting Convertible Preferred Convertible Stock votes with the Common Stock on an as-converted basis. The Voting Convertible Preferred Stock does not expire.

F2 · ownership.nature: Held by EW Healthcare Partners L.P. ("EWHP"). Essex Woodlands Fund IX-GP, L.P. ("EW Fund IX GP") is the general partner of EWHP and EWHP-A (as defined below). Essex Woodlands IX, LLC ("Essex IX General Partner") is the general partner of Essex IX Fund GP. Martin P. Sutter, R. Scott Barry, Ronald W. Eastman, Petri Vainio and Steve Wiggins are each a Manager of Essex IX General Partner (the "Managers"). Each of the Managers may be deemed to exercise shared voting and investment power with respect to such shares. Each of EW Fund IX GP, Essex IX General Partner and the Managers, including Mr. Barry who is a member of the Issuer's board of directors, disclaims beneficial ownership of the shares held by EWHP and EWHP-A, except to the extent of any pecuniary interests therein.

F3 · ownership.nature: Held by EW Healthcare Partners-A.L.P. ("EWHP-A").

SEC source: 0000899243-22-036684 · doc4.xml · derivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · EW Healthcare Partners, LP

Disclosed balance after: 1,441,985

Underlying: Common Stock · 14,410,850 shares

Expires not disclosed

F1 · derivative.exercise_price: The Voting Convertible Preferred Stock will convert into shares of Common Stock on a one for ten basis (i) at the option the holder or (ii) at the option of the Company within 30 days following the occurrence of certain events. The Voting Convertible Preferred Convertible Stock votes with the Common Stock on an as-converted basis. The Voting Convertible Preferred Stock does not expire.

F1 · deemedExecutionDate: The Voting Convertible Preferred Stock will convert into shares of Common Stock on a one for ten basis (i) at the option the holder or (ii) at the option of the Company within 30 days following the occurrence of certain events. The Voting Convertible Preferred Convertible Stock votes with the Common Stock on an as-converted basis. The Voting Convertible Preferred Stock does not expire.

F1 · derivative.expiration_date: The Voting Convertible Preferred Stock will convert into shares of Common Stock on a one for ten basis (i) at the option the holder or (ii) at the option of the Company within 30 days following the occurrence of certain events. The Voting Convertible Preferred Convertible Stock votes with the Common Stock on an as-converted basis. The Voting Convertible Preferred Stock does not expire.

F2 · ownership.nature: Held by EW Healthcare Partners L.P. ("EWHP"). Essex Woodlands Fund IX-GP, L.P. ("EW Fund IX GP") is the general partner of EWHP and EWHP-A (as defined below). Essex Woodlands IX, LLC ("Essex IX General Partner") is the general partner of Essex IX Fund GP. Martin P. Sutter, R. Scott Barry, Ronald W. Eastman, Petri Vainio and Steve Wiggins are each a Manager of Essex IX General Partner (the "Managers"). Each of the Managers may be deemed to exercise shared voting and investment power with respect to such shares. Each of EW Fund IX GP, Essex IX General Partner and the Managers, including Mr. Barry who is a member of the Issuer's board of directors, disclaims beneficial ownership of the shares held by EWHP and EWHP-A, except to the extent of any pecuniary interests therein.

SEC source: 0001140361-21-042316 · form4.xml · nonDerivative · entry 2

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 16,337,856

F1 · ownership.nature: Held by EW Healthcare Partners-A L.P. ("EWHP-A"). EWHP-A is an affiliated fund of EW Healthcare Partners L.P. ("EWHP"). Essex Woodlands Fund IX-GP, L.P. ("EW Fund IX GP") is the general partner of EWHP and EWHP-A. Essex Woodlands IX, LLC ("Essex IX General Partner") is the general partner of Essex IX Fund GP. Martin P. Sutter, R. Scott Barry, Ronald W. Eastman, Petri Vainio and Steve Wiggins are each a Manager of Essex IX General Partner (the "Managers"). Each of the Managers may be deemed to exercise shared voting and investment power with respect to such shares. Each of EW Fund IX GP, Essex IX General Partner and the Managers, including Mr. Barry who is a member of the Issuer's board of directors, disclaims beneficial ownership of the shares held by EWHP and EWHP-A, except to the extent of any pecuniary interests therein.

SEC source: 0001140361-21-042316 · form4.xml · nonDerivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,705,966

SEC source: 0001612343-20-000002 · edgar.xml · derivative · entry 4

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

Underlying: Common Stock · 208,853 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: The shares of Series A Preferred Stock were originally purchased from the Issuer at a purchase price of $2.50 per unit (consisting of one-tenth of one share of Series A Preferred Stock and 0.75 of a Warrant, with each whole Warrant exercisable for one share of Common Stock, at an exercise price of $3.50 per share). Each share of Series A Preferred Stock converted into ten shares of Common Stock for no additional consideration.

F3 · derivative.expiration_date: The Series A Preferred Stock had no expiration date.

F2 · ownership.nature: Held by EW Healthcare Partners-A L.P. ("EWHP-A"). EWHP-A is an affiliated fund of EW Healthcare Partners L.P. ("EWHP"). Essex Woodlands Fund IX-GP, L.P. ("EW Fund IX GP") is the general partner of EWHP and EWHP-A. Essex Woodlands IX, LLC ("Essex IX General Partner") is the general partner of Essex IX Fund GP. Martin P. Sutter, R. Scott Barry, Ronald W. Eastman, Petri Vainio and Steve Wiggins are each a Manager of Essex IX General Partner (the "Managers"). Each of the Managers may be deemed to exercise shared voting and investment power with respect to such shares. Each of EW Fund IX GP, Essex IX General Partner and the Managers, including Mr. Barry who is a member of the Issuer's board of directors, disclaims beneficial ownership of the shares held by EWHP and EWHP-A, except to the extent of any pecuniary interests therein.

SEC source: 0001612343-20-000002 · edgar.xml · derivative · entry 3

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 5,191,147 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: The shares of Series A Preferred Stock were originally purchased from the Issuer at a purchase price of $2.50 per unit (consisting of one-tenth of one share of Series A Preferred Stock and 0.75 of a Warrant, with each whole Warrant exercisable for one share of Common Stock, at an exercise price of $3.50 per share). Each share of Series A Preferred Stock converted into ten shares of Common Stock for no additional consideration.

F3 · derivative.expiration_date: The Series A Preferred Stock had no expiration date.

SEC source: 0001612343-20-000002 · edgar.xml · nonDerivative · entry 2

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 12,417,856

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The shares of Series A Preferred Stock were originally purchased from the Issuer at a purchase price of $2.50 per unit (consisting of one-tenth of one share of Series A Preferred Stock and 0.75 of a Warrant, with each whole Warrant exercisable for one share of Common Stock, at an exercise price of $3.50 per share). Each share of Series A Preferred Stock converted into ten shares of Common Stock for no additional consideration.

F2 · ownership.nature: Held by EW Healthcare Partners-A L.P. ("EWHP-A"). EWHP-A is an affiliated fund of EW Healthcare Partners L.P. ("EWHP"). Essex Woodlands Fund IX-GP, L.P. ("EW Fund IX GP") is the general partner of EWHP and EWHP-A. Essex Woodlands IX, LLC ("Essex IX General Partner") is the general partner of Essex IX Fund GP. Martin P. Sutter, R. Scott Barry, Ronald W. Eastman, Petri Vainio and Steve Wiggins are each a Manager of Essex IX General Partner (the "Managers"). Each of the Managers may be deemed to exercise shared voting and investment power with respect to such shares. Each of EW Fund IX GP, Essex IX General Partner and the Managers, including Mr. Barry who is a member of the Issuer's board of directors, disclaims beneficial ownership of the shares held by EWHP and EWHP-A, except to the extent of any pecuniary interests therein.

SEC source: 0001612343-20-000002 · edgar.xml · nonDerivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,209,003

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The shares of Series A Preferred Stock were originally purchased from the Issuer at a purchase price of $2.50 per unit (consisting of one-tenth of one share of Series A Preferred Stock and 0.75 of a Warrant, with each whole Warrant exercisable for one share of Common Stock, at an exercise price of $3.50 per share). Each share of Series A Preferred Stock converted into ten shares of Common Stock for no additional consideration.

SEC source: 0000899243-20-009104 · doc4.xml · derivative · entry 4

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 156,640

Underlying: Common Stock · 156,640 shares

Expires not disclosed

F3 · price: These securities were purchased from the Issuer at a purchase price of $2.50 per unit (consisting of one-tenth of one share of Series A Preferred Stock and 0.75 of a Warrant, with each whole Warrant exercisable for one share of Common Stock, at an exercise price of $3.50 per share).

F4 · derivative.exercise_date: The Warrants have a five-year term and are exercisable beginning 181 days after their issue date.

F4 · derivative.expiration_date: The Warrants have a five-year term and are exercisable beginning 181 days after their issue date.

F5 · ownership.nature: Held by EW Healthcare Partners-A L.P. ("EWHP-A"). EWHP-A is an affiliated fund of EW Healthcare Partners L.P. ("EWHP"). Essex Woodlands Fund IX-GP, L.P. ("EW Fund IX GP") is the general partner of EWHP and EWHP-A. Essex Woodlands IX, LLC ("Essex IX General Partner") is the general partner of Essex IX Fund GP. Martin P. Sutter, R. Scott Barry, Ronald W. Eastman, Petri Vainio and Steve Wiggins are each a Manager of Essex IX General Partner (the "Managers"). Each of the Managers may be deemed to exercise shared voting and investment power with respect to such shares. Each of EW Fund IX GP, Essex IX General Partner and the Managers, including Mr. Barry who is a member of the Issuer's board of directors, disclaims beneficial ownership of the shares held by EWHP and EWHP-A, except to the extent of any pecuniary interests therein.

SEC source: 0000899243-20-009104 · doc4.xml · derivative · entry 3

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 20,885.3

Underlying: Common Stock · 208,853 shares

Expires not disclosed

F1 · derivative.exercise_price: Each share of Series A Preferred Stock converts into ten shares of Common Stock for no additional consideration.

F3 · price: These securities were purchased from the Issuer at a purchase price of $2.50 per unit (consisting of one-tenth of one share of Series A Preferred Stock and 0.75 of a Warrant, with each whole Warrant exercisable for one share of Common Stock, at an exercise price of $3.50 per share).

F2 · derivative.exercise_date: The Series A Preferred Stock is convertible into common stock at any time, upon approval of the stockholders, and has no expiration date.

F2 · derivative.expiration_date: The Series A Preferred Stock is convertible into common stock at any time, upon approval of the stockholders, and has no expiration date.

F5 · ownership.nature: Held by EW Healthcare Partners-A L.P. ("EWHP-A"). EWHP-A is an affiliated fund of EW Healthcare Partners L.P. ("EWHP"). Essex Woodlands Fund IX-GP, L.P. ("EW Fund IX GP") is the general partner of EWHP and EWHP-A. Essex Woodlands IX, LLC ("Essex IX General Partner") is the general partner of Essex IX Fund GP. Martin P. Sutter, R. Scott Barry, Ronald W. Eastman, Petri Vainio and Steve Wiggins are each a Manager of Essex IX General Partner (the "Managers"). Each of the Managers may be deemed to exercise shared voting and investment power with respect to such shares. Each of EW Fund IX GP, Essex IX General Partner and the Managers, including Mr. Barry who is a member of the Issuer's board of directors, disclaims beneficial ownership of the shares held by EWHP and EWHP-A, except to the extent of any pecuniary interests therein.

SEC source: 0000899243-20-009104 · doc4.xml · derivative · entry 2

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,893,360

Underlying: Common Stock · 3,893,360 shares

Expires not disclosed

F3 · price: These securities were purchased from the Issuer at a purchase price of $2.50 per unit (consisting of one-tenth of one share of Series A Preferred Stock and 0.75 of a Warrant, with each whole Warrant exercisable for one share of Common Stock, at an exercise price of $3.50 per share).

F4 · derivative.exercise_date: The Warrants have a five-year term and are exercisable beginning 181 days after their issue date.

F4 · derivative.expiration_date: The Warrants have a five-year term and are exercisable beginning 181 days after their issue date.

SEC source: 0000899243-20-009104 · doc4.xml · derivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 519,114.7

Underlying: Common Stock · 5,191,147 shares

Expires not disclosed

F1 · derivative.exercise_price: Each share of Series A Preferred Stock converts into ten shares of Common Stock for no additional consideration.

F3 · price: These securities were purchased from the Issuer at a purchase price of $2.50 per unit (consisting of one-tenth of one share of Series A Preferred Stock and 0.75 of a Warrant, with each whole Warrant exercisable for one share of Common Stock, at an exercise price of $3.50 per share).

F2 · derivative.exercise_date: The Series A Preferred Stock is convertible into common stock at any time, upon approval of the stockholders, and has no expiration date.

F2 · derivative.expiration_date: The Series A Preferred Stock is convertible into common stock at any time, upon approval of the stockholders, and has no expiration date.

SEC source: 0000899243-19-026973 · doc4.xml · derivative · entry 9

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 57,911

Underlying: Common Stock · 28,955.5 shares

Expires 2024-11-07

F7 · shares: These securities were purchased from the Issuer at a purchase price of $3.75 per unit, consisting of one share of Common Stock and a warrant exercisable for 0.5 shares of Common Stock, with two warrants exercisable for one share of Common Stock at an exercise price of $6.00 per share.

F7 · price: These securities were purchased from the Issuer at a purchase price of $3.75 per unit, consisting of one share of Common Stock and a warrant exercisable for 0.5 shares of Common Stock, with two warrants exercisable for one share of Common Stock at an exercise price of $6.00 per share.

F7 · derivative.underlying_shares: These securities were purchased from the Issuer at a purchase price of $3.75 per unit, consisting of one share of Common Stock and a warrant exercisable for 0.5 shares of Common Stock, with two warrants exercisable for one share of Common Stock at an exercise price of $6.00 per share.

F7 · balance_after: These securities were purchased from the Issuer at a purchase price of $3.75 per unit, consisting of one share of Common Stock and a warrant exercisable for 0.5 shares of Common Stock, with two warrants exercisable for one share of Common Stock at an exercise price of $6.00 per share.

F4 · ownership.nature: Held by EW Healthcare Partners-A L.P. ("EWHP-A").

SEC source: 0000899243-19-026973 · doc4.xml · derivative · entry 8

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,439,437

Underlying: Common Stock · 719,718.5 shares

Expires 2024-11-07

F7 · shares: These securities were purchased from the Issuer at a purchase price of $3.75 per unit, consisting of one share of Common Stock and a warrant exercisable for 0.5 shares of Common Stock, with two warrants exercisable for one share of Common Stock at an exercise price of $6.00 per share.

F7 · price: These securities were purchased from the Issuer at a purchase price of $3.75 per unit, consisting of one share of Common Stock and a warrant exercisable for 0.5 shares of Common Stock, with two warrants exercisable for one share of Common Stock at an exercise price of $6.00 per share.

F7 · derivative.underlying_shares: These securities were purchased from the Issuer at a purchase price of $3.75 per unit, consisting of one share of Common Stock and a warrant exercisable for 0.5 shares of Common Stock, with two warrants exercisable for one share of Common Stock at an exercise price of $6.00 per share.

F7 · balance_after: These securities were purchased from the Issuer at a purchase price of $3.75 per unit, consisting of one share of Common Stock and a warrant exercisable for 0.5 shares of Common Stock, with two warrants exercisable for one share of Common Stock at an exercise price of $6.00 per share.

F2 · ownership.direct: Held by EW Healthcare Partners L.P. ("EWHP"). Essex Woodlands Fund IX-GP, L.P. ("EW Fund IX GP") is the general partner of EWHP and EWHP-A (as defined below). Essex Woodlands IX, LLC ("Essex IX General Partner") is the general partner of Essex IX Fund GP. Martin P. Sutter, R. Scott Barry, Ronald W. Eastman, Petri Vainio and Steve Wiggins are each a Manager of Essex IX General Partner (the "Managers"). Each of the Managers may be deemed to exercise shared voting and investment power with respect to such shares. Each of EW Fund IX GP, Essex IX General Partner and the Managers, including Mr. Barry who is a member of the Issuer's board of directors, disclaims beneficial ownership of the shares held by EWHP and EWHP-A, except to the extent of any pecuniary interests therein.

SEC source: 0000899243-19-026973 · doc4.xml · derivative · entry 7

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,301

Underlying: Common Stock · 17,301 shares

Expires 2027-11-08

F9 · price: Received, in connection with the Merger in exchange for an employee stock option to acquire 30,000 Venus Concept Ltd. ordinary shares with an original exercise price of $4.00 per share.

F8 · derivative.exercise_date: As of the Transaction Date, 8,285 of these options to acquire Common Stock of the Issuer are fully vested and exercisable. Of the remaining balance, 361 options vest and become exercisable monthly from November 8, 2019 through November 8, 2021.

F2 · ownership.direct: Held by EW Healthcare Partners L.P. ("EWHP"). Essex Woodlands Fund IX-GP, L.P. ("EW Fund IX GP") is the general partner of EWHP and EWHP-A (as defined below). Essex Woodlands IX, LLC ("Essex IX General Partner") is the general partner of Essex IX Fund GP. Martin P. Sutter, R. Scott Barry, Ronald W. Eastman, Petri Vainio and Steve Wiggins are each a Manager of Essex IX General Partner (the "Managers"). Each of the Managers may be deemed to exercise shared voting and investment power with respect to such shares. Each of EW Fund IX GP, Essex IX General Partner and the Managers, including Mr. Barry who is a member of the Issuer's board of directors, disclaims beneficial ownership of the shares held by EWHP and EWHP-A, except to the extent of any pecuniary interests therein.

SEC source: 0000899243-19-026973 · doc4.xml · nonDerivative · entry 6

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 7,017,856

F7 · price: These securities were purchased from the Issuer at a purchase price of $3.75 per unit, consisting of one share of Common Stock and a warrant exercisable for 0.5 shares of Common Stock, with two warrants exercisable for one share of Common Stock at an exercise price of $6.00 per share.

F4 · ownership.nature: Held by EW Healthcare Partners-A L.P. ("EWHP-A").

SEC source: 0000899243-19-026973 · doc4.xml · nonDerivative · entry 5

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,959,945

F7 · price: These securities were purchased from the Issuer at a purchase price of $3.75 per unit, consisting of one share of Common Stock and a warrant exercisable for 0.5 shares of Common Stock, with two warrants exercisable for one share of Common Stock at an exercise price of $6.00 per share.

F2 · ownership.direct: Held by EW Healthcare Partners L.P. ("EWHP"). Essex Woodlands Fund IX-GP, L.P. ("EW Fund IX GP") is the general partner of EWHP and EWHP-A (as defined below). Essex Woodlands IX, LLC ("Essex IX General Partner") is the general partner of Essex IX Fund GP. Martin P. Sutter, R. Scott Barry, Ronald W. Eastman, Petri Vainio and Steve Wiggins are each a Manager of Essex IX General Partner (the "Managers"). Each of the Managers may be deemed to exercise shared voting and investment power with respect to such shares. Each of EW Fund IX GP, Essex IX General Partner and the Managers, including Mr. Barry who is a member of the Issuer's board of directors, disclaims beneficial ownership of the shares held by EWHP and EWHP-A, except to the extent of any pecuniary interests therein.

SEC source: 0000899243-19-026973 · doc4.xml · nonDerivative · entry 4

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 5,520,508

F6 · price: Received, in connection with the Merger, upon the conversion of the outstanding principal and any accrued and unpaid interest of three 8% Convertible Promissory Notes issued by Venus Concept Ltd., dated as of June 25, 2019, August 14, 2019 and August 21, 2019, in the original principal amounts of $193,382.50, $76,248.03 and $310,517.37, respectively.

F4 · ownership.nature: Held by EW Healthcare Partners-A L.P. ("EWHP-A").

SEC source: 0000899243-19-026973 · doc4.xml · nonDerivative · entry 3

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,435,821

F5 · price: Received, in connection with the Merger, upon the conversion of the outstanding principal and any accrued and unpaid interest of three 8% Convertible Promissory Notes issued by Venus Concept Ltd., dated as of June 25, 2019, August 14, 2019 and August 21, 2019, in the original principal amounts of $4,806,617.66, $1,895,180.45 and $7,718,054.15, respectively.

F2 · ownership.direct: Held by EW Healthcare Partners L.P. ("EWHP"). Essex Woodlands Fund IX-GP, L.P. ("EW Fund IX GP") is the general partner of EWHP and EWHP-A (as defined below). Essex Woodlands IX, LLC ("Essex IX General Partner") is the general partner of Essex IX Fund GP. Martin P. Sutter, R. Scott Barry, Ronald W. Eastman, Petri Vainio and Steve Wiggins are each a Manager of Essex IX General Partner (the "Managers"). Each of the Managers may be deemed to exercise shared voting and investment power with respect to such shares. Each of EW Fund IX GP, Essex IX General Partner and the Managers, including Mr. Barry who is a member of the Issuer's board of directors, disclaims beneficial ownership of the shares held by EWHP and EWHP-A, except to the extent of any pecuniary interests therein.

SEC source: 0000899243-19-026973 · doc4.xml · nonDerivative · entry 2

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 3,330,880

F3 · price: Received, in connection with the Merger, in exchange for 194,896 shares and 28,488 shares of Series C Preferred Stock and Series D Preferred Stock of Venus Concept Ltd., respectively.

F4 · ownership.nature: Held by EW Healthcare Partners-A L.P. ("EWHP-A").

SEC source: 0000899243-19-026973 · doc4.xml · nonDerivative · entry 1

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,202,053

F1 · price: Received, in connection with the merger of a wholly-owned subsidiary of Restoration Robotics, Inc. with and into Venus Concept Ltd. (the "Merger"), in exchange for 4,844,231 shares and 708,078 shares of Series C Preferred Stock and Series D Preferred Stock of Venus Concept Ltd., respectively.

F2 · ownership.direct: Held by EW Healthcare Partners L.P. ("EWHP"). Essex Woodlands Fund IX-GP, L.P. ("EW Fund IX GP") is the general partner of EWHP and EWHP-A (as defined below). Essex Woodlands IX, LLC ("Essex IX General Partner") is the general partner of Essex IX Fund GP. Martin P. Sutter, R. Scott Barry, Ronald W. Eastman, Petri Vainio and Steve Wiggins are each a Manager of Essex IX General Partner (the "Managers"). Each of the Managers may be deemed to exercise shared voting and investment power with respect to such shares. Each of EW Fund IX GP, Essex IX General Partner and the Managers, including Mr. Barry who is a member of the Issuer's board of directors, disclaims beneficial ownership of the shares held by EWHP and EWHP-A, except to the extent of any pecuniary interests therein.

SEC source: 0000899243-19-003415 · doc5.xml · nonDerivative · entry 2

EW Healthcare Partners, L.P. · CIK 0001612343 · 10% owner

EW Healthcare Partners-A, L.P. · CIK 0001736240 · 10% owner

Essex Woodlands Fund IX-GP, L.P. · CIK 0001652285 · 10% owner

Essex Woodlands IX, LLC · CIK 0001652286 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · EW Healthcare Partners-A L.P.

Disclosed balance after: 41,903,956

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 40,283,255 shares held by EW Healthcare Partners L.P. ("EWHP") and 1,620,701 shares held by EW Healthcare Partners-A L.P. ("EWHP-A"). Essex Woodlands Fund IX-GP, L.P. ("Fund IX-GP") is the general partner of EWHP and EWHP-A, respectively. Essex Woodlands IX, LLC (the "General Partner") is the general partner of Fund IX-GP. The General Partner holds sole voting and dispositive power over the shares held by EWHP and EWHP-A. The managers of the General Partner are Martin P. Sutter, R. Scott Barry, Ronald Eastman (also a member of the Issuer's board of directors) and Petri Vainio (collectively, the "Managers"), and may exercise voting and investment control over the shares only by the majority action of the Managers.

F1 · ownership.direct: Includes 40,283,255 shares held by EW Healthcare Partners L.P. ("EWHP") and 1,620,701 shares held by EW Healthcare Partners-A L.P. ("EWHP-A"). Essex Woodlands Fund IX-GP, L.P. ("Fund IX-GP") is the general partner of EWHP and EWHP-A, respectively. Essex Woodlands IX, LLC (the "General Partner") is the general partner of Fund IX-GP. The General Partner holds sole voting and dispositive power over the shares held by EWHP and EWHP-A. The managers of the General Partner are Martin P. Sutter, R. Scott Barry, Ronald Eastman (also a member of the Issuer's board of directors) and Petri Vainio (collectively, the "Managers"), and may exercise voting and investment control over the shares only by the majority action of the Managers.