Aftab Dana

SEC source: 0000939767-26-000070 · wk-form4_1780007115.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · EVP, Research and Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 594,741

F1 · balance_after: Includes 405,966 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"), and the performance-based restricted stock unit award granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000064 · wk-form4_1779231503.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · EVP, Research and Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 638,192

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units ("RSUs") awarded on March 4, 2022, April 3, 2023, February 23, 2024, and February 26, 2025.

F2 · balance_after: Includes 405,966 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of RSUs, the performance-based restricted stock unit award granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs") and 646 shares of Common Stock acquired on April 30, 2026, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan. Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000037 · wk-form4_1772499575.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · EVP, Research and Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 668,124

F1 · date: Represents shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon the vesting of restricted stock units ("RSUs"). The RSUs were granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 1/4th of the original number of shares subject to the RSU award on May 15, 2027 and thereafter as to 1/4th of the original number of shares subject to the RSU award on each May 15th until fully vested.

F1 · shares: Represents shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon the vesting of restricted stock units ("RSUs"). The RSUs were granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 1/4th of the original number of shares subject to the RSU award on May 15, 2027 and thereafter as to 1/4th of the original number of shares subject to the RSU award on each May 15th until fully vested.

F2 · balance_after: Includes 466,061 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs and the performance-based restricted stock unit award granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000032 · wk-form4_1772149294.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · EVP, Research and Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 616,106

F1 · balance_after: Includes 414,043 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and PSUs granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000031 · wk-form4_1771890600.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · EVP, Research and Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 664,024

F1 · balance_after: Includes 414,043 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and PSUs granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000024 · wk-form4_1771465741.xml · nonDerivative · entry 2

Aftab Dana · CIK 0001959132 · EVP, Research and Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 693,897

F3 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of RSUs awarded on January 5, 2023.

F2 · balance_after: Includes 414,043 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and PSUs granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000024 · wk-form4_1771465741.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · EVP, Research and Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 706,617

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of performance-based restricted stock units awarded on March 4, 2022, for which the Compensation Committee certified that Exelixis, Inc. had achieved certain performance criteria on January 16, 2025.

F2 · balance_after: Includes 414,043 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and PSUs granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000006 · wk-form4_1768608171.xml · nonDerivative · entry 2

Aftab Dana · CIK 0001959132 · EVP, Research and Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 733,102

F4 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of the PSUs awarded on April 3, 2023, for which the Committee certified that Exelixis, Inc. had achieved certain performance criteria on January 15, 2026.

F3 · balance_after: Includes 491,096 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and PSUs granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-26-000006 · wk-form4_1768608171.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · EVP, Research and Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 760,356

F1 · date: On April 3, 2023, the Reporting Person was granted a performance-based restricted stock unit award ("PSU") under the Exelixis, Inc. 2017 Equity Incentive Plan covering 68,331 shares of common stock (such shares, the "Target Shares"). The PSU generally vests as follows: (i) 50% of the eligible Target Shares vest upon the Compensation Committee's (the "Committee") certification of achievement of certain performance criteria; and (ii) 50% of the eligible Target Shares vest on the first quarterly PSU vesting date (i.e. February 15th, May 15th, August 15th and November 15th) following the one-year anniversary of the Committee's certification. In addition, the PSU provides for vesting of up to a maximum of 175% of the Target Shares depending on the timing and level of achievement of the performance criteria provided for under the PSU.

F2 · shares: On January 15, 2026, the Committee determined that certain performance criteria had been achieved, resulting in the Reporting Person's eligibility to vest up to 175% of the Target Shares subject to the PSU (such shares, the "Achieved Shares"). Accordingly, the Committee's certification on January 15, 2026 resulted in the immediate vesting of 50% of the Achieved Shares, and the remaining 50% of the Achieved Shares will vest on February 15, 2027, subject to the Reporting Person's continuous service through that date.

F3 · balance_after: Includes 491,096 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and PSUs granted to the Reporting Person on March 31, 2025 ("One-Time Award PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each One-Time Award PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000139 · wk-form4_1764031668.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · EVP, Research and Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 640,778

F1 · kind: On November 21, 2025, the Reporting Person gifted 24,000 shares of Exelixis Inc. common stock ("Common Stock") to a donor-advised fund.

F2 · balance_after: Includes 431,306 shares of Common Stock that will be issued to the Reporting Person upon vesting of restricted stock units ("RSU") and performance-based restricted stock units ("PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000135 · wk-form4_1763079156.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · EVP, Research and Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 664,778

F1 · price: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $42.50 to $42.58. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 1 to this Form 4.

F2 · balance_after: Includes 431,306 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSU"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-25-000118 · wk-form4_1760137034.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · EVP, Research & Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 713,161

F1 · date: Represents shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon the vesting of restricted stock units ("RSUs"). The RSUs were granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 1/4th of the original number of shares subject to the RSU award on November 15, 2026 and thereafter as to 1/4th of the original number of shares subject to the RSU award on each November 15th until fully vested.

F1 · shares: Represents shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon the vesting of restricted stock units ("RSUs"). The RSUs were granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 1/4th of the original number of shares subject to the RSU award on November 15, 2026 and thereafter as to 1/4th of the original number of shares subject to the RSU award on each November 15th until fully vested.

F2 · balance_after: Includes 431,306 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000939767-25-000082 · wk-form4_1747443488.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 662,488

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units ("RSUs") awarded on March 4, 2021, March 4, 2022, April 3, 2023, and February 23, 2024.

F2 · balance_after: Includes 380,633 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of RSUs and performance-based restricted stock units ("PSUs"). Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000064 · wk-form4_1746486720.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 693,181

F1 · balance_after: Includes 441,071 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs") and performance-based restricted stock units ("PSUs") and 753 shares of Common Stock acquired on April 30, 2025, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan. Each RSU is the economic equivalent of one share of Common Stock and each PSU represents a contingent right to receive one share of Common Stock.

SEC source: 0000939767-25-000053 · wk-form4_1743464596.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 693,936

F1 · shares: Represents an award of performance-based restricted stock units (each, a "PSU") that was granted to the Reporting Person on the Transaction Date pursuant to the 2017 Equity Incentive Plan. Each PSU represents a contingent right to receive one share of Exelixis, Inc. common stock ("Common Stock"). The PSUs vest upon satisfaction of both (i) a performance-based condition requiring the volume-weighted average closing price of the Common Stock to equal or exceed $60 per share for any consecutive 90-calendar-day period during a five-year performance period, and (ii) a service-based condition requiring employment through the fifth anniversary of the grant date (except in the event of certain qualifying terminations of employment).

F2 · balance_after: Includes 441,071 shares of Common Stock that will be issued to the Reporting Person upon the vesting of restricted stock units (each, an "RSU") and the PSUs. Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-25-000043 · wk-form4_1740792922.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 561,117

F1 · security: Represents shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

F2 · date: The RSUs were granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The RSUs will vest as to 1/4th of the original number of shares subject to the RSU award on May 15, 2026 and thereafter as to 1/4th of the original number of shares subject to the RSU award on each May 15th until fully vested.

F3 · balance_after: Includes 308,252 shares of Common Stock that will be issued to the Reporting Person upon vesting of RSUs.

SEC source: 0000939767-25-000035 · wk-form4_1740618043.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 511,908

F1 · balance_after: Includes 259,043 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-25-000023 · wk-form4_1740015090.xml · nonDerivative · entry 2

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 538,895

F3 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of RSUs awarded January 5, 2023.

F2 · balance_after: Includes 259,043 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-25-000023 · wk-form4_1740015090.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 551,590

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of performance-based restricted stock units awarded on March 4, 2021, for which the Compensation Committee certified that Exelixis, Inc. had achieved certain performance criteria on January 11, 2024.

F2 · balance_after: Includes 259,043 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-25-000006 · wk-form4_1737168301.xml · nonDerivative · entry 2

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 567,643

F4 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of PSU awarded on March 4, 2022, for which the Committee certified that Exelixis, Inc. had achieved certain performance criteria on January 16, 2025.

F3 · balance_after: Includes 315,655 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-25-000006 · wk-form4_1737168301.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 590,213

F1 · date: On March 4, 2022, the Reporting Person was granted a performance-based restricted stock unit award ("PSU") under the Exelixis, Inc. 2017 Equity Incentive Plan covering 59,490 shares of common stock (such shares, the "Target Shares"). The PSU generally vests as follows: (i) 50% of the eligible Target Shares vest upon the Compensation Committee's (the "Committee") certification of achievement of certain performance criteria; and (ii) 50% of the eligible Target Shares vest on the first quarterly PSU vesting date (i.e. February 15th, May 15th, August 15th and November 15th) following the one-year anniversary of the Committee's certification. In addition, the PSU provides for vesting of up to a maximum of 175% of the Target Shares depending on the timing and level of achievement of the performance criteria provided for under the PSU.

F2 · shares: On January 16, 2025, the Committee determined that certain performance criteria had been achieved, resulting in the Reporting Person's eligibility to vest up to 175% of the Target Shares subject to the PSU (such shares, the "Achieved Shares"). Accordingly, the Committee's certification on January 16, 2025 resulted in the immediate vesting of 50% of the Achieved Shares, and 50% of the Achieved Shares will vest on February 15, 2026, subject to the Reporting Person's continuous service through that date.

F3 · balance_after: Includes 315,655 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-24-000159 · wk-form4_1732064563.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 486,107

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of performance-based restricted stock units awarded on September 11, 2020, for which the Compensation Committee certified that Exelixis, Inc. had achieved certain performance criteria on September 6, 2023.

F2 · balance_after: Includes 263,602 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-24-000157 · wk-form4_1731026361.xml · derivative · entry 4

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 96,986 shares

Expires 2025-09-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option, representing the right to purchase a total of 96,986 shares of Common Stock, became fully exercisable on September 10, 2022.

SEC source: 0000939767-24-000157 · wk-form4_1731026361.xml · nonDerivative · entry 2

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 498,945

F2 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 25, 2023.

F1 · balance_after: Includes 288,932 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-24-000157 · wk-form4_1731026361.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 595,931

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 288,932 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-24-000153 · wk-form4_1730501025.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 498,945

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 25, 2023.

F2 · balance_after: Includes 288,932 shares of Exelixis, Inc. common stock ("Common Stock") that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Common Stock.

SEC source: 0000939767-24-000128 · wk-form4_1723677152.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 500,107

F1 · price: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $27.05 to $27.09. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 1 to this Form 4.

F2 · balance_after: Includes 288,932 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units ("RSUs"). Each RSU is the economic equivalent of one share of Exelixis, Inc. common stock.

SEC source: 0000939767-24-000126 · wk-form4_1723246333.xml · derivative · entry 4

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 95,000 shares

Expires 2024-10-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option, representing the right to purchase a total of 95,000 shares of Exelixis, Inc. common stock became fully exercisable on October 3, 2021.

SEC source: 0000939767-24-000126 · wk-form4_1723246333.xml · nonDerivative · entry 2

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 520,990

F2 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 25, 2023.

F1 · balance_after: Includes 288,932 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000126 · wk-form4_1723246333.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 615,990

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 288,932 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000070 · wk-form4_1715990289.xml · nonDerivative · entry 3

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 520,990

F4 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units awarded April 3, 2023.

F2 · balance_after: Includes 288,932 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units and 1,214 shares of Exelixis, Inc. common stock acquired on April 30, 2024, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan.

SEC source: 0000939767-24-000070 · wk-form4_1715990289.xml · nonDerivative · entry 2

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 529,648

F3 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units awarded March 4, 2022.

F2 · balance_after: Includes 288,932 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units and 1,214 shares of Exelixis, Inc. common stock acquired on April 30, 2024, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan.

SEC source: 0000939767-24-000070 · wk-form4_1715990289.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 537,186

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units awarded March 4, 2021.

F2 · balance_after: Includes 288,932 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units and 1,214 shares of Exelixis, Inc. common stock acquired on April 30, 2024, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan.

SEC source: 0000939767-24-000034 · wk-form4_1709078327.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 542,381

F1 · security: Represents shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units. Each restricted stock unit is the economic equivalent of one share of Exelixis, Inc. common stock.

F2 · date: The restricted stock units were granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The restricted stock units will vest as to 1/4th of the original number of shares subject to the restricted stock unit award on May 15, 2025 and thereafter as to 1/4th of the original number of shares subject to the restricted stock unit award on each May 15th until fully vested.

F3 · balance_after: Includes 333,531 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000029 · wk-form4_1708129256.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 479,031

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units awarded January 5, 2023.

F2 · balance_after: Includes 270,181 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000016 · wk-form4_1705456195.xml · nonDerivative · entry 2

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 489,661

F4 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of certain restricted stock units earned on January 11, 2024.

F3 · balance_after: Includes 295,181 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-24-000016 · wk-form4_1705456195.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 501,267

F1 · date: On March 4, 2021, the Reporting Person was granted a performance-based restricted stock unit award ("PSU") under the Exelixis, Inc. 2017 Equity Incentive Plan covering 50,580 shares of common stock (such shares, the "Target Shares"). The PSU generally vests as follows: (i) 50% of the eligible Target Shares vest upon the Compensation Committee's (the "Committee") certification of achievement of certain performance criteria; and (ii) 50% of the eligible Target Shares vest on the first quarterly PSU vesting date (i.e. February 15th, May 15th, August 15th and November 15th) following the one-year anniversary of the Committee's certification. In addition, the PSU provides for vesting of up to a maximum of 200% of the Target Shares depending on the timing and level of achievement of the performance criteria provided for under the PSU.

F2 · shares: On January 11, 2024, the Committee determined that certain performance criteria had been achieved, resulting in the Reporting Person's eligibility to vest up to 125% of the Target Shares subject to the PSU (such shares, the "Achieved Shares"). Accordingly, the Committee's certification on January 11, 2024 resulted in the immediate vesting of 50% of the Achieved Shares, and 50% of the Achieved Shares will vest on February 15, 2025, subject to the Reporting Person's continuous service through that date.

F3 · balance_after: Includes 295,181 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-23-000105 · wk-form4_1694222728.xml · nonDerivative · entry 2

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 438,043

F4 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of certain restricted stock units earned on September 6, 2023.

F3 · balance_after: Includes 263,569 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-23-000105 · wk-form4_1694222728.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 450,603

F1 · date: On September 11, 2020, the Reporting Person was granted a performance-based restricted stock unit award ("PSU") under the Exelixis, Inc. 2017 Equity Incentive Plan covering 50,660 shares of common stock (such shares, the "Target Shares"). The PSU generally vests as follows: (i) 50% of the eligible Target Shares vest upon the Compensation Committee's (the "Committee") certification of achievement of certain performance criteria; and (ii) 50% of the eligible Target Shares vest on the first quarterly PSU vesting date (i.e. February 15th, May 15th, August 15th and November 15th) following the one-year anniversary of the Committee's certification. In addition, the PSU provides for vesting of up to a maximum of 200% of the Target Shares depending on the timing and level of achievement of the performance criteria provided for under the PSU.

F2 · shares: On September 6, 2023, the Committee determined that certain performance criteria had been achieved, resulting in the Reporting Person's eligibility to vest up to 150% of the Target Shares subject to the PSU (such shares, the "Achieved Shares"). The Reporting Person had already vested 1/3 of the Achieved Shares as a result of the Committee's certification that certain performance criteria had been achieved on August 3, 2022 and continuous service through August 15, 2023. Accordingly, the Committee's certification on September 6, 2023 resulted in the immediate vesting of 1/3 of the Achieved Shares, and 1/3 of the Achieved Shares will vest on November 15, 2024, subject to the Reporting Person's continuous service through that date. The Reporting Person remains eligible for additional vesting depending on the level and timing of achievement of the performance criteria through December 31, 2024.

F3 · balance_after: Includes 263,569 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-23-000101 · wk-form4_1693613697.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 399,943

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 25, 2023.

F2 · price: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $22.40 to $22.52. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 2 to this Form 4.

F3 · balance_after: Includes 238,239 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-23-000086 · wk-form4_1692317673.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 404,543

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of performance-based restricted stock units awarded on September 11, 2020, for which the Compensation Committee certified that Exelixis, Inc. had achieved certain performance criteria on August 3, 2022.

F2 · balance_after: Includes 238,239 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-23-000050 · wf-form4_168436869987997.xml · nonDerivative · entry 2

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 410,823

F3 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units awarded March 4, 2022.

SEC source: 0000939767-23-000050 · wf-form4_168436869987997.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 416,938

F1 · shares: Shares withheld by Exelixis, Inc. to satisfy taxes payable in connection with the vesting of restricted stock units awarded March 4, 2021.

F2 · balance_after: Includes 250,904 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units and 1,508 shares of Exelixis, Inc. common stock acquired on April 28, 2023, pursuant to the Exelixis, Inc. 2000 Employee Stock Purchase Plan.

SEC source: 0000939767-23-000039 · wf-form4_168074082916477.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 419,803

F1 · security: Represents shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units. Each restricted stock unit is the economic equivalent of one share of Exelixis, Inc. common stock.

F2 · date: The restricted stock units were granted to the Reporting Person on the Transaction Date pursuant to the Exelixis, Inc. 2017 Equity Incentive Plan. The restricted stock units will vest as to 1/4th of the original number of shares subject to the restricted stock unit award on May 15, 2024 and thereafter as to 1/4th of the original number of shares subject to the restricted stock unit award on each May 15th until fully vested.

F3 · balance_after: Includes 278,421 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.

SEC source: 0000939767-23-000029 · wf-form4_167771857999028.xml · derivative · entry 7

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 82,490 shares

Expires 2023-09-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000939767-23-000029 · wf-form4_167771857999028.xml · nonDerivative · entry 4

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 351,472

F2 · price: Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $17.50 to $17.51. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 2 to this Form 4.

SEC source: 0000939767-23-000029 · wf-form4_167771857999028.xml · nonDerivative · entry 3

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 433,962

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000939767-23-000029 · wf-form4_167771857999028.xml · derivative · entry 6

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 82,490

Underlying: Common Stock · 10 shares

Expires 2023-09-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000939767-23-000029 · wf-form4_167771857999028.xml · nonDerivative · entry 2

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 351,472

SEC source: 0000939767-23-000029 · wf-form4_167771857999028.xml · nonDerivative · entry 1

Aftab Dana · CIK 0001959132 · CSO/EVP Disc & Trans Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 351,482

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 210,090 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.