POWELL MICHAEL

SEC source: 0001144204-19-026681 · tv521648_4.xml · nonDerivative · entry 2

Sofinnova Venture Partners IX, L.P. · CIK 0001612133 · 10% owner

Sofinnova Management IX, L.L.C. · CIK 0001612134 · 10% owner

HEALY JAMES · CIK 0001245624 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 743,358

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The reported securities automatically converted into shares of Common Stock on a 1-for-8.0338 basis upon the closing of the Issuer's initial public offering and had no expiration date.

F2 · ownership.direct: The shares are held directly by Sofinnova Venture Partners IX, L.P. ("SVP IX"). Sofinnova Management IX, L.L.C. ("SM IX") is the general partner of SVP IX and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by SVP IX. Dr. James I. Healy, Michael F. Powell, Ph.D., and Dr. Anand Mehra are the managing members of SM IX and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by SVP IX. Each of the reporting persons disclaims beneficial ownership of such securities, except to the extent of his, her or its proportionate pecuniary interest therein.

SEC source: 0001144204-19-026681 · tv521648_4.xml · nonDerivative · entry 1

Sofinnova Venture Partners IX, L.P. · CIK 0001612133 · 10% owner

Sofinnova Management IX, L.L.C. · CIK 0001612134 · 10% owner

HEALY JAMES · CIK 0001245624 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 278,759

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The reported securities automatically converted into shares of Common Stock on a 1-for-8.0338 basis upon the closing of the Issuer's initial public offering and had no expiration date.

F2 · ownership.direct: The shares are held directly by Sofinnova Venture Partners IX, L.P. ("SVP IX"). Sofinnova Management IX, L.L.C. ("SM IX") is the general partner of SVP IX and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by SVP IX. Dr. James I. Healy, Michael F. Powell, Ph.D., and Dr. Anand Mehra are the managing members of SM IX and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by SVP IX. Each of the reporting persons disclaims beneficial ownership of such securities, except to the extent of his, her or its proportionate pecuniary interest therein.

SEC source: 0001209191-18-053539 · doc4.xml · derivative · entry 5

Sofinnova Venture Partners IX, L.P. · CIK 0001612133 · 10% owner

Sofinnova Management IX, L.L.C. · CIK 0001612134 · 10% owner

HEALY JAMES · CIK 0001245624 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 458,425 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Series B-1 Tranche A Convertible Preferred Stock and Series B-1 Tranche B Convertible Preferred Stock (collectively, the "Preferred Stock") automatically converted into Common Stock on a 20.728-for-one basis upon the closing of the Issuer's initial public offering. The Preferred Stock had no expiration date.

F1 · derivative.exercise_date: Each share of Series B-1 Tranche A Convertible Preferred Stock and Series B-1 Tranche B Convertible Preferred Stock (collectively, the "Preferred Stock") automatically converted into Common Stock on a 20.728-for-one basis upon the closing of the Issuer's initial public offering. The Preferred Stock had no expiration date.

F1 · derivative.expiration_date: Each share of Series B-1 Tranche A Convertible Preferred Stock and Series B-1 Tranche B Convertible Preferred Stock (collectively, the "Preferred Stock") automatically converted into Common Stock on a 20.728-for-one basis upon the closing of the Issuer's initial public offering. The Preferred Stock had no expiration date.

F1 · derivative.underlying_shares: Each share of Series B-1 Tranche A Convertible Preferred Stock and Series B-1 Tranche B Convertible Preferred Stock (collectively, the "Preferred Stock") automatically converted into Common Stock on a 20.728-for-one basis upon the closing of the Issuer's initial public offering. The Preferred Stock had no expiration date.

F2 · ownership.direct: The reportable shares are held of record by Sofinnova Venture Partners IX, L.P. ("SVP IX"). Sofinnova Management IX, L.L.C. ("SM IX") is the general partner of SVP IX. The individual managing members of SM IX are Michael Powell, James Healy and Anand Mehra, and they may be deemed to share voting and dispositive power over the shares held by SVP IX. Such persons and entities disclaim beneficial ownership over the shares held by SVP IX except to the extent of any pecuniary interest therein.

SEC source: 0001209191-18-053539 · doc4.xml · derivative · entry 4

Sofinnova Venture Partners IX, L.P. · CIK 0001612133 · 10% owner

Sofinnova Management IX, L.L.C. · CIK 0001612134 · 10% owner

HEALY JAMES · CIK 0001245624 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 359,267 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Series B-1 Tranche A Convertible Preferred Stock and Series B-1 Tranche B Convertible Preferred Stock (collectively, the "Preferred Stock") automatically converted into Common Stock on a 20.728-for-one basis upon the closing of the Issuer's initial public offering. The Preferred Stock had no expiration date.

F1 · derivative.exercise_date: Each share of Series B-1 Tranche A Convertible Preferred Stock and Series B-1 Tranche B Convertible Preferred Stock (collectively, the "Preferred Stock") automatically converted into Common Stock on a 20.728-for-one basis upon the closing of the Issuer's initial public offering. The Preferred Stock had no expiration date.

F1 · derivative.expiration_date: Each share of Series B-1 Tranche A Convertible Preferred Stock and Series B-1 Tranche B Convertible Preferred Stock (collectively, the "Preferred Stock") automatically converted into Common Stock on a 20.728-for-one basis upon the closing of the Issuer's initial public offering. The Preferred Stock had no expiration date.

F1 · derivative.underlying_shares: Each share of Series B-1 Tranche A Convertible Preferred Stock and Series B-1 Tranche B Convertible Preferred Stock (collectively, the "Preferred Stock") automatically converted into Common Stock on a 20.728-for-one basis upon the closing of the Issuer's initial public offering. The Preferred Stock had no expiration date.

F2 · ownership.direct: The reportable shares are held of record by Sofinnova Venture Partners IX, L.P. ("SVP IX"). Sofinnova Management IX, L.L.C. ("SM IX") is the general partner of SVP IX. The individual managing members of SM IX are Michael Powell, James Healy and Anand Mehra, and they may be deemed to share voting and dispositive power over the shares held by SVP IX. Such persons and entities disclaim beneficial ownership over the shares held by SVP IX except to the extent of any pecuniary interest therein.

SEC source: 0001209191-18-053539 · doc4.xml · nonDerivative · entry 3

Sofinnova Venture Partners IX, L.P. · CIK 0001612133 · 10% owner

Sofinnova Management IX, L.L.C. · CIK 0001612134 · 10% owner

HEALY JAMES · CIK 0001245624 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,180,178

F2 · ownership.direct: The reportable shares are held of record by Sofinnova Venture Partners IX, L.P. ("SVP IX"). Sofinnova Management IX, L.L.C. ("SM IX") is the general partner of SVP IX. The individual managing members of SM IX are Michael Powell, James Healy and Anand Mehra, and they may be deemed to share voting and dispositive power over the shares held by SVP IX. Such persons and entities disclaim beneficial ownership over the shares held by SVP IX except to the extent of any pecuniary interest therein.

SEC source: 0001209191-18-053539 · doc4.xml · nonDerivative · entry 2

Sofinnova Venture Partners IX, L.P. · CIK 0001612133 · 10% owner

Sofinnova Management IX, L.L.C. · CIK 0001612134 · 10% owner

HEALY JAMES · CIK 0001245624 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 842,454

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Series B-1 Tranche A Convertible Preferred Stock and Series B-1 Tranche B Convertible Preferred Stock (collectively, the "Preferred Stock") automatically converted into Common Stock on a 20.728-for-one basis upon the closing of the Issuer's initial public offering. The Preferred Stock had no expiration date.

F3 · balance_after: This number includes an aggregate of 24,762 shares of Common Stock received upon the conversion of the Issuer's Preferred Stock as payment of the accrued dividends through September 27, 2018. No dividends will accrue after September 27, 2018.

F2 · ownership.direct: The reportable shares are held of record by Sofinnova Venture Partners IX, L.P. ("SVP IX"). Sofinnova Management IX, L.L.C. ("SM IX") is the general partner of SVP IX. The individual managing members of SM IX are Michael Powell, James Healy and Anand Mehra, and they may be deemed to share voting and dispositive power over the shares held by SVP IX. Such persons and entities disclaim beneficial ownership over the shares held by SVP IX except to the extent of any pecuniary interest therein.

SEC source: 0001209191-18-053539 · doc4.xml · nonDerivative · entry 1

Sofinnova Venture Partners IX, L.P. · CIK 0001612133 · 10% owner

Sofinnova Management IX, L.L.C. · CIK 0001612134 · 10% owner

HEALY JAMES · CIK 0001245624 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 359,267

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Series B-1 Tranche A Convertible Preferred Stock and Series B-1 Tranche B Convertible Preferred Stock (collectively, the "Preferred Stock") automatically converted into Common Stock on a 20.728-for-one basis upon the closing of the Issuer's initial public offering. The Preferred Stock had no expiration date.

F2 · ownership.direct: The reportable shares are held of record by Sofinnova Venture Partners IX, L.P. ("SVP IX"). Sofinnova Management IX, L.L.C. ("SM IX") is the general partner of SVP IX. The individual managing members of SM IX are Michael Powell, James Healy and Anand Mehra, and they may be deemed to share voting and dispositive power over the shares held by SVP IX. Such persons and entities disclaim beneficial ownership over the shares held by SVP IX except to the extent of any pecuniary interest therein.

SEC source: 0001209191-18-051838 · doc4.xml · derivative · entry 9

Sofinnova Venture Partners VIII, L.P. · CIK 0001524064 · 10% owner

Sofinnova Management VIII, L.L.C. · CIK 0001559565 · 10% owner

HEALY JAMES · CIK 0001245624 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 167,537 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each share of the Series C Preferred Stock converted immediately upon the closing of the Issuer's initial public offering of its common stock into 1 share of the Issuer's common stock.

F5 · price: Each share of the Series C Preferred Stock converted immediately upon the closing of the Issuer's initial public offering of its common stock into 1 share of the Issuer's common stock.

F5 · derivative.exercise_date: Each share of the Series C Preferred Stock converted immediately upon the closing of the Issuer's initial public offering of its common stock into 1 share of the Issuer's common stock.

F5 · derivative.expiration_date: Each share of the Series C Preferred Stock converted immediately upon the closing of the Issuer's initial public offering of its common stock into 1 share of the Issuer's common stock.

F2 · ownership.direct: The shares are held of record by Sofinnova Venture Partners VIII, L.P. ("SVP VIII"). Sofinnova Management VIII, L.L.C. ("SM VIII") is the general partner of SVP VIII. The individual managing members of SM VIII are Michael Powell, James Healy and Anand Mehra, and they may be deemed to share voting and dispositive power over the shares held by SVP VIII. Such persons and entities disclaim beneficial ownership over the shares held by SVP VIII except to the extent of any pecuniary interest therein.

SEC source: 0001209191-18-051838 · doc4.xml · derivative · entry 8

Sofinnova Venture Partners VIII, L.P. · CIK 0001524064 · 10% owner

Sofinnova Management VIII, L.L.C. · CIK 0001559565 · 10% owner

HEALY JAMES · CIK 0001245624 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 453,954 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each share of the Series B-3 Preferred Stock converted immediately upon the closing of the Issuer's initial public offering of its common stock into 1 share of the Issuer's common stock.

F4 · price: Each share of the Series B-3 Preferred Stock converted immediately upon the closing of the Issuer's initial public offering of its common stock into 1 share of the Issuer's common stock.

F4 · derivative.exercise_date: Each share of the Series B-3 Preferred Stock converted immediately upon the closing of the Issuer's initial public offering of its common stock into 1 share of the Issuer's common stock.

F4 · derivative.expiration_date: Each share of the Series B-3 Preferred Stock converted immediately upon the closing of the Issuer's initial public offering of its common stock into 1 share of the Issuer's common stock.

F2 · ownership.direct: The shares are held of record by Sofinnova Venture Partners VIII, L.P. ("SVP VIII"). Sofinnova Management VIII, L.L.C. ("SM VIII") is the general partner of SVP VIII. The individual managing members of SM VIII are Michael Powell, James Healy and Anand Mehra, and they may be deemed to share voting and dispositive power over the shares held by SVP VIII. Such persons and entities disclaim beneficial ownership over the shares held by SVP VIII except to the extent of any pecuniary interest therein.

SEC source: 0001209191-18-051838 · doc4.xml · derivative · entry 7

Sofinnova Venture Partners VIII, L.P. · CIK 0001524064 · 10% owner

Sofinnova Management VIII, L.L.C. · CIK 0001559565 · 10% owner

HEALY JAMES · CIK 0001245624 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 521,235 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each share of the Series B-2 Preferred Stock converted immediately upon the closing of the Issuer's initial public offering of its common stock into 1 share of the Issuer's common stock.

F3 · price: Each share of the Series B-2 Preferred Stock converted immediately upon the closing of the Issuer's initial public offering of its common stock into 1 share of the Issuer's common stock.

F3 · derivative.exercise_date: Each share of the Series B-2 Preferred Stock converted immediately upon the closing of the Issuer's initial public offering of its common stock into 1 share of the Issuer's common stock.

F3 · derivative.expiration_date: Each share of the Series B-2 Preferred Stock converted immediately upon the closing of the Issuer's initial public offering of its common stock into 1 share of the Issuer's common stock.

F2 · ownership.direct: The shares are held of record by Sofinnova Venture Partners VIII, L.P. ("SVP VIII"). Sofinnova Management VIII, L.L.C. ("SM VIII") is the general partner of SVP VIII. The individual managing members of SM VIII are Michael Powell, James Healy and Anand Mehra, and they may be deemed to share voting and dispositive power over the shares held by SVP VIII. Such persons and entities disclaim beneficial ownership over the shares held by SVP VIII except to the extent of any pecuniary interest therein.

SEC source: 0001209191-18-051838 · doc4.xml · derivative · entry 6

Sofinnova Venture Partners VIII, L.P. · CIK 0001524064 · 10% owner

Sofinnova Management VIII, L.L.C. · CIK 0001559565 · 10% owner

HEALY JAMES · CIK 0001245624 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 625,482 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of the Series B-1 Preferred Stock converted immediately upon the closing of the Issuer's initial public offering of its common stock into 1 share of the Issuer's common stock.

F1 · price: Each share of the Series B-1 Preferred Stock converted immediately upon the closing of the Issuer's initial public offering of its common stock into 1 share of the Issuer's common stock.

F1 · derivative.exercise_date: Each share of the Series B-1 Preferred Stock converted immediately upon the closing of the Issuer's initial public offering of its common stock into 1 share of the Issuer's common stock.

F1 · derivative.expiration_date: Each share of the Series B-1 Preferred Stock converted immediately upon the closing of the Issuer's initial public offering of its common stock into 1 share of the Issuer's common stock.

F2 · ownership.direct: The shares are held of record by Sofinnova Venture Partners VIII, L.P. ("SVP VIII"). Sofinnova Management VIII, L.L.C. ("SM VIII") is the general partner of SVP VIII. The individual managing members of SM VIII are Michael Powell, James Healy and Anand Mehra, and they may be deemed to share voting and dispositive power over the shares held by SVP VIII. Such persons and entities disclaim beneficial ownership over the shares held by SVP VIII except to the extent of any pecuniary interest therein.

SEC source: 0001209191-18-051838 · doc4.xml · nonDerivative · entry 5

Sofinnova Venture Partners VIII, L.P. · CIK 0001524064 · 10% owner

Sofinnova Management VIII, L.L.C. · CIK 0001559565 · 10% owner

HEALY JAMES · CIK 0001245624 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,038,208

F2 · ownership.direct: The shares are held of record by Sofinnova Venture Partners VIII, L.P. ("SVP VIII"). Sofinnova Management VIII, L.L.C. ("SM VIII") is the general partner of SVP VIII. The individual managing members of SM VIII are Michael Powell, James Healy and Anand Mehra, and they may be deemed to share voting and dispositive power over the shares held by SVP VIII. Such persons and entities disclaim beneficial ownership over the shares held by SVP VIII except to the extent of any pecuniary interest therein.

SEC source: 0001209191-18-051838 · doc4.xml · nonDerivative · entry 4

Sofinnova Venture Partners VIII, L.P. · CIK 0001524064 · 10% owner

Sofinnova Management VIII, L.L.C. · CIK 0001559565 · 10% owner

HEALY JAMES · CIK 0001245624 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,768,208

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · price: Each share of the Series C Preferred Stock converted immediately upon the closing of the Issuer's initial public offering of its common stock into 1 share of the Issuer's common stock.

F2 · ownership.direct: The shares are held of record by Sofinnova Venture Partners VIII, L.P. ("SVP VIII"). Sofinnova Management VIII, L.L.C. ("SM VIII") is the general partner of SVP VIII. The individual managing members of SM VIII are Michael Powell, James Healy and Anand Mehra, and they may be deemed to share voting and dispositive power over the shares held by SVP VIII. Such persons and entities disclaim beneficial ownership over the shares held by SVP VIII except to the extent of any pecuniary interest therein.

SEC source: 0001209191-18-051838 · doc4.xml · nonDerivative · entry 3

Sofinnova Venture Partners VIII, L.P. · CIK 0001524064 · 10% owner

Sofinnova Management VIII, L.L.C. · CIK 0001559565 · 10% owner

HEALY JAMES · CIK 0001245624 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,600,671

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · price: Each share of the Series B-3 Preferred Stock converted immediately upon the closing of the Issuer's initial public offering of its common stock into 1 share of the Issuer's common stock.

F2 · ownership.direct: The shares are held of record by Sofinnova Venture Partners VIII, L.P. ("SVP VIII"). Sofinnova Management VIII, L.L.C. ("SM VIII") is the general partner of SVP VIII. The individual managing members of SM VIII are Michael Powell, James Healy and Anand Mehra, and they may be deemed to share voting and dispositive power over the shares held by SVP VIII. Such persons and entities disclaim beneficial ownership over the shares held by SVP VIII except to the extent of any pecuniary interest therein.

SEC source: 0001209191-18-051838 · doc4.xml · nonDerivative · entry 2

Sofinnova Venture Partners VIII, L.P. · CIK 0001524064 · 10% owner

Sofinnova Management VIII, L.L.C. · CIK 0001559565 · 10% owner

HEALY JAMES · CIK 0001245624 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,146,717

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: Each share of the Series B-2 Preferred Stock converted immediately upon the closing of the Issuer's initial public offering of its common stock into 1 share of the Issuer's common stock.

F2 · ownership.direct: The shares are held of record by Sofinnova Venture Partners VIII, L.P. ("SVP VIII"). Sofinnova Management VIII, L.L.C. ("SM VIII") is the general partner of SVP VIII. The individual managing members of SM VIII are Michael Powell, James Healy and Anand Mehra, and they may be deemed to share voting and dispositive power over the shares held by SVP VIII. Such persons and entities disclaim beneficial ownership over the shares held by SVP VIII except to the extent of any pecuniary interest therein.

SEC source: 0001209191-18-051838 · doc4.xml · nonDerivative · entry 1

Sofinnova Venture Partners VIII, L.P. · CIK 0001524064 · 10% owner

Sofinnova Management VIII, L.L.C. · CIK 0001559565 · 10% owner

HEALY JAMES · CIK 0001245624 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 625,482

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of the Series B-1 Preferred Stock converted immediately upon the closing of the Issuer's initial public offering of its common stock into 1 share of the Issuer's common stock.

F2 · ownership.direct: The shares are held of record by Sofinnova Venture Partners VIII, L.P. ("SVP VIII"). Sofinnova Management VIII, L.L.C. ("SM VIII") is the general partner of SVP VIII. The individual managing members of SM VIII are Michael Powell, James Healy and Anand Mehra, and they may be deemed to share voting and dispositive power over the shares held by SVP VIII. Such persons and entities disclaim beneficial ownership over the shares held by SVP VIII except to the extent of any pecuniary interest therein.

SEC source: 0000899243-18-016591 · doc4.xml · derivative · entry 1

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2028-06-13

F1 · derivative.exercise_date: The option vests and becomes exercisable in full on the earlier of (A) the first anniversary of the date of grant or (B) immediately prior to the next annual meeting of the Corporation's stockholders after the date of grant, subject in each case to the reporting person's continued service as a director of the Corporation.

SEC source: 0001144204-18-031803 · tv495514_form4.xml · derivative · entry 7

Sofinnova Venture Partners IX, L.P. · CIK 0001612133 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Sofinnova Management IX, L.L.C. · CIK 0001612134 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 229,660 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: The Series B-2 Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F4 · derivative.exercise_date: The Series B-2 Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F5 · derivative.expiration_date: Not applicable.

F2 · ownership.direct: These shares are held directly by Sofinnova Venture Partners IX, L.P. (the "Fund"). The general partner of the Fund is Sofinnova Management IX, L.L.C. (the "GP") and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by the Fund. Dr. James I. Healy, Michael F. Powell, Ph.D., and Dr. Anand Mehra are the managing members of the GP and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by the Fund. Each of the reporting persons disclaims beneficial ownership of such shares, except to the extent of his, her or its proportionate pecuniary interest therein, if any.

SEC source: 0001144204-18-031803 · tv495514_form4.xml · derivative · entry 6

Sofinnova Venture Partners IX, L.P. · CIK 0001612133 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Sofinnova Management IX, L.L.C. · CIK 0001612134 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 275,446 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: The Series B-1 Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F3 · derivative.exercise_date: The Series B-1 Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F5 · derivative.expiration_date: Not applicable.

F2 · ownership.direct: These shares are held directly by Sofinnova Venture Partners IX, L.P. (the "Fund"). The general partner of the Fund is Sofinnova Management IX, L.L.C. (the "GP") and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by the Fund. Dr. James I. Healy, Michael F. Powell, Ph.D., and Dr. Anand Mehra are the managing members of the GP and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by the Fund. Each of the reporting persons disclaims beneficial ownership of such shares, except to the extent of his, her or its proportionate pecuniary interest therein, if any.

SEC source: 0001144204-18-031803 · tv495514_form4.xml · derivative · entry 5

Sofinnova Venture Partners IX, L.P. · CIK 0001612133 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Sofinnova Management IX, L.L.C. · CIK 0001612134 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 721,408 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: The Series A Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F1 · derivative.exercise_date: The Series A Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F5 · derivative.expiration_date: Not applicable.

F2 · ownership.direct: These shares are held directly by Sofinnova Venture Partners IX, L.P. (the "Fund"). The general partner of the Fund is Sofinnova Management IX, L.L.C. (the "GP") and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by the Fund. Dr. James I. Healy, Michael F. Powell, Ph.D., and Dr. Anand Mehra are the managing members of the GP and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by the Fund. Each of the reporting persons disclaims beneficial ownership of such shares, except to the extent of his, her or its proportionate pecuniary interest therein, if any.

SEC source: 0001144204-18-031803 · tv495514_form4.xml · nonDerivative · entry 4

Sofinnova Venture Partners IX, L.P. · CIK 0001612133 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Sofinnova Management IX, L.L.C. · CIK 0001612134 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,726,514

F2 · ownership.direct: These shares are held directly by Sofinnova Venture Partners IX, L.P. (the "Fund"). The general partner of the Fund is Sofinnova Management IX, L.L.C. (the "GP") and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by the Fund. Dr. James I. Healy, Michael F. Powell, Ph.D., and Dr. Anand Mehra are the managing members of the GP and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by the Fund. Each of the reporting persons disclaims beneficial ownership of such shares, except to the extent of his, her or its proportionate pecuniary interest therein, if any.

SEC source: 0001144204-18-031803 · tv495514_form4.xml · nonDerivative · entry 3

Sofinnova Venture Partners IX, L.P. · CIK 0001612133 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Sofinnova Management IX, L.L.C. · CIK 0001612134 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,226,514

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · price: The Series B-2 Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F2 · ownership.direct: These shares are held directly by Sofinnova Venture Partners IX, L.P. (the "Fund"). The general partner of the Fund is Sofinnova Management IX, L.L.C. (the "GP") and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by the Fund. Dr. James I. Healy, Michael F. Powell, Ph.D., and Dr. Anand Mehra are the managing members of the GP and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by the Fund. Each of the reporting persons disclaims beneficial ownership of such shares, except to the extent of his, her or its proportionate pecuniary interest therein, if any.

SEC source: 0001144204-18-031803 · tv495514_form4.xml · nonDerivative · entry 2

Sofinnova Venture Partners IX, L.P. · CIK 0001612133 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Sofinnova Management IX, L.L.C. · CIK 0001612134 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 996,854

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: The Series B-1 Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F2 · ownership.direct: These shares are held directly by Sofinnova Venture Partners IX, L.P. (the "Fund"). The general partner of the Fund is Sofinnova Management IX, L.L.C. (the "GP") and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by the Fund. Dr. James I. Healy, Michael F. Powell, Ph.D., and Dr. Anand Mehra are the managing members of the GP and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by the Fund. Each of the reporting persons disclaims beneficial ownership of such shares, except to the extent of his, her or its proportionate pecuniary interest therein, if any.

SEC source: 0001144204-18-031803 · tv495514_form4.xml · nonDerivative · entry 1

Sofinnova Venture Partners IX, L.P. · CIK 0001612133 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Sofinnova Management IX, L.L.C. · CIK 0001612134 · 10% owner

Mehra Anand · CIK 0001590102 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 721,408

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The Series A Preferred Shares automatically converted into Ordinary Shares of the Issuer on a 1-to-1 basis upon closing of the initial public offering of the Issuer.

F2 · ownership.direct: These shares are held directly by Sofinnova Venture Partners IX, L.P. (the "Fund"). The general partner of the Fund is Sofinnova Management IX, L.L.C. (the "GP") and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by the Fund. Dr. James I. Healy, Michael F. Powell, Ph.D., and Dr. Anand Mehra are the managing members of the GP and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by the Fund. Each of the reporting persons disclaims beneficial ownership of such shares, except to the extent of his, her or its proportionate pecuniary interest therein, if any.

SEC source: 0000899243-18-002261 · doc4.xml · nonDerivative · entry 1

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 574,972

F1 · ownership.nature: The shares are held by Sofinnova Venture Partners VIII, L.P. ("SVP VIII"). Sofinnova Management VIII, L.L.C. ("SM VIII") is the general partner of SVP VIII. The individual managing members of SVP VIII are Michael Powell, James Healy and Anand Mehra. The managing members share voting and dispositive power with regard to the shares held directly by SVP VIII. Such persons and entities disclaim beneficial ownership over the shares owned by SVP VIII except to the extent of any pecuniary interest therein.

SEC source: 0000899243-18-000275 · doc4.xml · derivative · entry 1

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,572

Underlying: Common Stock · 18,572 shares

Expires 2027-12-29

F1 · derivative.exercise_date: The options vest and become exercisable in substantially equal installments on each of the first three anniversaries of August 28, 2017 subject to the Reporting Person continuing to provide services to the Issuer through each such vesting date.

SEC source: 0000899243-17-021254 · doc4.xml · derivative · entry 1

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,428

Underlying: Common Stock · 1,428 shares

Expires 2027-08-28

F1 · derivative.exercise_date: The option vests and become exercisable in full on the earlier of (A) August 28, 2018 or (B) immediately prior to the next annual meeting of the Issuer's stockholders, subject to the Reporting Person continuing to provide services to the Issuer through such vesting date.

SEC source: 0001144204-16-141985 · v455976_form4.xml · nonDerivative · entry 10

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 14,328

F10 · acquired: Shares acquired by SV LLC in connection with the distributions reported above.

F11 · ownership.nature: Shares are held by SV LLC. SV LLC is the general partner of each of SV VI, SV KG, and SV A, and Healy, Powell, Azan and Buatois, the managing members of SV LLC, may be deemed to share voting and dispositive power over the shares held by such entities.

SEC source: 0001144204-16-141985 · v455976_form4.xml · nonDerivative · entry 9

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

F9 · acquired: Represents a pro-rata in-kind distribution of Common Stock of the Issuer by SV A without consideration to its partners.

F3 · ownership.nature: Shares are held by Sofinnova Venture Affiliates VI, L.P. ("SV A"). SV LLC is the general partner of SV A, and Healy, Powell, Azan and Buatois, the managing members of SV LLC, may be deemed to share voting and dispositive power over the shares held by such entities.

SEC source: 0001144204-16-141985 · v455976_form4.xml · nonDerivative · entry 8

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

F8 · acquired: Represents a pro-rata in-kind distribution of Common Stock of the Issuer by SV KG without consideration to its partners.

F2 · ownership.nature: Shares are held by Sofinnova Venture Partners VI GmbH & Co. KG ("SV KG"). SV LLC is the managing limited partner of SV KG, and Healy, Powell, Azan and Buatois, the managing members of SV LLC, may be deemed to share voting and dispositive power over the shares held by such entities.

SEC source: 0001144204-16-141985 · v455976_form4.xml · nonDerivative · entry 7

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

F7 · acquired: Represents a pro-rata in-kind distribution of Common Stock of the Issuer by SV VI without consideration to its partners.

F1 · ownership.nature: Shares are held by Sofinnova Venture Partners VI, L.P. ("SV VI"). Sofinnova Management VI, L.L.C. ("SV LLC") is the general partner of SV VI and Michael F. Powell ("Powell"), a director of the Issuer, James I. Healy ("Healy"), Alain L. Azan ("Azan") and Eric P. Buatois ("Buatois"), the managing members of SV LLC, may be deemed to share voting and dispositive power over the shares held by such entities.

SEC source: 0001144204-16-129201 · v450997_4.xml · nonDerivative · entry 3

Mehra Anand · CIK 0001590102 · 10% owner

SOFINNOVA VENTURE PARTNERS VI L P · CIK 0001211465 · 10% owner

Sofinnova Venture Partners VI GmbH & Co. KG · CIK 0001397189 · 10% owner

Sofinnova Venture Affiliates VI LP · CIK 0001312272 · 10% owner

Sofinnova Management VI, L.L.C. · CIK 0001397188 · 10% owner

Buatois Eric · CIK 0001362314 · 10% owner

HEALY JAMES · CIK 0001245624 · 10% owner

Azan Alain · CIK 0001294340 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 15,470

F3 · ownership.nature: Shares are held by Sofinnova Venture Affiliates VI, L.P. ("SVA VI"). SM VI is the general partner of SVA VI, and Healy, Powell, Azan and Buatois, the managing members of SM VI, and Mehra, a former director of the Issuer, may be deemed to share voting and dispositive power over the shares held by such entities.

SEC source: 0001144204-16-129201 · v450997_4.xml · nonDerivative · entry 2

Mehra Anand · CIK 0001590102 · 10% owner

SOFINNOVA VENTURE PARTNERS VI L P · CIK 0001211465 · 10% owner

Sofinnova Venture Partners VI GmbH & Co. KG · CIK 0001397189 · 10% owner

Sofinnova Venture Affiliates VI LP · CIK 0001312272 · 10% owner

Sofinnova Management VI, L.L.C. · CIK 0001397188 · 10% owner

Buatois Eric · CIK 0001362314 · 10% owner

HEALY JAMES · CIK 0001245624 · 10% owner

Azan Alain · CIK 0001294340 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 224,845

F2 · ownership.nature: Shares are held by Sofinnova Venture Partners VI GmbH & Co. KG ("SVP KG"). SM VI is the managing limited partner of SVP KG, and Healy, Powell, Azan and Buatois, the managing members of SM VI, and Mehra, a former director of the Issuer, may be deemed to share voting and dispositive power over the shares held by such entities.

SEC source: 0001144204-16-129201 · v450997_4.xml · nonDerivative · entry 1

Mehra Anand · CIK 0001590102 · 10% owner

SOFINNOVA VENTURE PARTNERS VI L P · CIK 0001211465 · 10% owner

Sofinnova Venture Partners VI GmbH & Co. KG · CIK 0001397189 · 10% owner

Sofinnova Venture Affiliates VI LP · CIK 0001312272 · 10% owner

Sofinnova Management VI, L.L.C. · CIK 0001397188 · 10% owner

Buatois Eric · CIK 0001362314 · 10% owner

HEALY JAMES · CIK 0001245624 · 10% owner

Azan Alain · CIK 0001294340 · 10% owner

POWELL MICHAEL · CIK 0001202793 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,134,851

F1 · ownership.nature: Shares are held by Sofinnova Venture Partners VI, L.P. ("SVP VI"). Sofinnova Management VI, L.L.C. ("SM VI") is the general partner of SVP VI and James I. Healy ("Healy"), Michael F. Powell ("Powell"), Alain L. Azan ("Azan") and Eric P. Buatois ("Buatois"), the managing members of SM VI, and Anand Mehra ("Mehra"), a former director of the Issuer, may be deemed to share voting and dispositive power over the shares held by such entities.

SEC source: 0001144204-16-141985 · v455976_form4.xml · derivative · entry 16

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 125 shares

Expires 2019-10-01

F3 · ownership.nature: Shares are held by Sofinnova Venture Affiliates VI, L.P. ("SV A"). SV LLC is the general partner of SV A, and Healy, Powell, Azan and Buatois, the managing members of SV LLC, may be deemed to share voting and dispositive power over the shares held by such entities.

SEC source: 0001144204-16-141985 · v455976_form4.xml · derivative · entry 15

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 125 shares

Expires 2012-03-30

F3 · ownership.nature: Shares are held by Sofinnova Venture Affiliates VI, L.P. ("SV A"). SV LLC is the general partner of SV A, and Healy, Powell, Azan and Buatois, the managing members of SV LLC, may be deemed to share voting and dispositive power over the shares held by such entities.

SEC source: 0001144204-16-141985 · v455976_form4.xml · derivative · entry 14

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 1,820 shares

Expires 2019-10-01

F2 · ownership.nature: Shares are held by Sofinnova Venture Partners VI GmbH & Co. KG ("SV KG"). SV LLC is the managing limited partner of SV KG, and Healy, Powell, Azan and Buatois, the managing members of SV LLC, may be deemed to share voting and dispositive power over the shares held by such entities.

SEC source: 0001144204-16-141985 · v455976_form4.xml · derivative · entry 13

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 1,820 shares

Expires 2019-03-30

F2 · ownership.nature: Shares are held by Sofinnova Venture Partners VI GmbH & Co. KG ("SV KG"). SV LLC is the managing limited partner of SV KG, and Healy, Powell, Azan and Buatois, the managing members of SV LLC, may be deemed to share voting and dispositive power over the shares held by such entities.

SEC source: 0001144204-16-141985 · v455976_form4.xml · derivative · entry 12

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 9,187 shares

Expires 2019-10-01

F1 · ownership.nature: Shares are held by Sofinnova Venture Partners VI, L.P. ("SV VI"). Sofinnova Management VI, L.L.C. ("SV LLC") is the general partner of SV VI and Michael F. Powell ("Powell"), a director of the Issuer, James I. Healy ("Healy"), Alain L. Azan ("Azan") and Eric P. Buatois ("Buatois"), the managing members of SV LLC, may be deemed to share voting and dispositive power over the shares held by such entities.

SEC source: 0001144204-16-141985 · v455976_form4.xml · derivative · entry 11

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 9,187 shares

Expires 2019-03-30

F1 · ownership.nature: Shares are held by Sofinnova Venture Partners VI, L.P. ("SV VI"). Sofinnova Management VI, L.L.C. ("SV LLC") is the general partner of SV VI and Michael F. Powell ("Powell"), a director of the Issuer, James I. Healy ("Healy"), Alain L. Azan ("Azan") and Eric P. Buatois ("Buatois"), the managing members of SV LLC, may be deemed to share voting and dispositive power over the shares held by such entities.

SEC source: 0001144204-16-141985 · v455976_form4.xml · nonDerivative · entry 6

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 9,540

F6 · acquired: On September 12, 2016, the holder exercised warrants to purchase 250 shares of OCRX common stock for $0.67 a share. The holder paid the exercise price on a cashless basis, resulting in OCRX's withholding of 74 of the warrant shares to pay the exercise price and issuing to the holder the remaining 176 shares.

F3 · ownership.nature: Shares are held by Sofinnova Venture Affiliates VI, L.P. ("SV A"). SV LLC is the general partner of SV A, and Healy, Powell, Azan and Buatois, the managing members of SV LLC, may be deemed to share voting and dispositive power over the shares held by such entities.

SEC source: 0001144204-16-141985 · v455976_form4.xml · nonDerivative · entry 5

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 138,686

F5 · acquired: On September 12, 2016, the holder exercised warrants to purchase 3,640 shares of OCRX common stock for $0.67 a share. The holder paid the exercise price on a cashless basis, resulting in OCRX's withholding of 1,066 of the warrant shares to pay the exercise price and issuing to the holder the remaining 2,574 shares.

F2 · ownership.nature: Shares are held by Sofinnova Venture Partners VI GmbH & Co. KG ("SV KG"). SV LLC is the managing limited partner of SV KG, and Healy, Powell, Azan and Buatois, the managing members of SV LLC, may be deemed to share voting and dispositive power over the shares held by such entities.

SEC source: 0001144204-16-141985 · v455976_form4.xml · nonDerivative · entry 4

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 699,996

F4 · acquired: On September 12, 2016, the holder exercised warrants to purchase 18,374 shares of OCRX common stock for $0.67 a share. The holder paid the exercise price on a cashless basis, resulting in OCRX's withholding of 5,372 of the warrant shares to pay the exercise price and issuing to the holder the remaining 13,002 shares.

F1 · ownership.nature: Shares are held by Sofinnova Venture Partners VI, L.P. ("SV VI"). Sofinnova Management VI, L.L.C. ("SV LLC") is the general partner of SV VI and Michael F. Powell ("Powell"), a director of the Issuer, James I. Healy ("Healy"), Alain L. Azan ("Azan") and Eric P. Buatois ("Buatois"), the managing members of SV LLC, may be deemed to share voting and dispositive power over the shares held by such entities.

SEC source: 0001144204-16-141985 · v455976_form4.xml · nonDerivative · entry 3

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 9,614

F3 · ownership.nature: Shares are held by Sofinnova Venture Affiliates VI, L.P. ("SV A"). SV LLC is the general partner of SV A, and Healy, Powell, Azan and Buatois, the managing members of SV LLC, may be deemed to share voting and dispositive power over the shares held by such entities.

SEC source: 0001144204-16-141985 · v455976_form4.xml · nonDerivative · entry 2

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 139,752

F2 · ownership.nature: Shares are held by Sofinnova Venture Partners VI GmbH & Co. KG ("SV KG"). SV LLC is the managing limited partner of SV KG, and Healy, Powell, Azan and Buatois, the managing members of SV LLC, may be deemed to share voting and dispositive power over the shares held by such entities.

SEC source: 0001144204-16-141985 · v455976_form4.xml · nonDerivative · entry 1

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 705,368

F1 · ownership.nature: Shares are held by Sofinnova Venture Partners VI, L.P. ("SV VI"). Sofinnova Management VI, L.L.C. ("SV LLC") is the general partner of SV VI and Michael F. Powell ("Powell"), a director of the Issuer, James I. Healy ("Healy"), Alain L. Azan ("Azan") and Eric P. Buatois ("Buatois"), the managing members of SV LLC, may be deemed to share voting and dispositive power over the shares held by such entities.

SEC source: 0001274644-17-000005 · wf-form5_148676095579836.xml · nonDerivative · entry 1

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These shares were issued upon the Reporting Person's exercise of a stock option on July 11, 2016 that was reported on a Form 4 filed on July 13, 2016. The cash proceeds from this sale of the shares were donated by the Reporting Person to Washington University in St. Louis on August 17, 2016.

F1 · shares: These shares were issued upon the Reporting Person's exercise of a stock option on July 11, 2016 that was reported on a Form 4 filed on July 13, 2016. The cash proceeds from this sale of the shares were donated by the Reporting Person to Washington University in St. Louis on August 17, 2016.

SEC source: 0001140361-16-078998 · doc1.xml · derivative · entry 1

POWELL MICHAEL · CIK 0001202793 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2026-06-29

F1 · derivative.exercise_date: The option vests and become exercisable in full on the earlier of (A) June 29, 2017 or (B) immediately prior to the next annual meeting of the Issuer's stockholders, subject to the Reporting Person continuing to provide services to the Issuer through such vesting date.