Hoppenot Herve

SEC source: 0001596492-26-000007 · form4-06102026_080650.xml · derivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,000

Underlying: Common Stock · 18,000 shares

Expires 2036-06-07

F1 · derivative.exercise_date: The option shall vest and be fully exercisable on the earlier of (i) the date of the issuer's 2027 annual stockholders meeting or (ii) June 8, 2027, subject to the reporting person's continued service to the issuer on the vesting date.

SEC source: 0001596492-26-000002 · form4-01062026_080107.xml · derivative · entry 2

Hoppenot Herve · CIK 0001596492 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,065

Underlying: Ordinary Shares · 6,065 shares

Expires 2036-01-02

F3 · derivative.exercise_date: This option shall vest in four equal installments on March 15, 2026, June 15, 2026, September 15, 2026 and December 15, 2026.

SEC source: 0001596492-26-000002 · form4-01062026_080107.xml · nonDerivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,532

F1 · shares: Represents a restricted share unit ("RSU") award. The RSUs shall vest in four equal installments on March 15, 2026, June 15, 2026, September 15, 2026 and December 15, 2026.

F2 · price: Each RSU represents a contingent right to receive one ordinary share.

SEC source: 0001596492-25-000010 · wk-form4_1765400799.xml · nonDerivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 326,803

F1 · shares: Represents shares withheld automatically by the Issuer to satisfy tax withholding obligations due at settlement of RSUs or earned performance shares previously reported in Table I as common stock.

F2 · balance_after: This includes an aggregate of 70,643 shares of common stock issuable pursuant to previously reported RSUs and earned performance shares that have not vested.

SEC source: 0001596492-25-000008 · wk-form4_1762981583.xml · nonDerivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 329,646

F1 · balance_after: This includes an aggregate of 73,486 shares of common stock issuable pursuant to previously reported RSUs and earned performance shares that have not vested.

SEC source: 0001596492-25-000006 · form4-10072025_081023.xml · derivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,000

Underlying: Common Stock · 36,000 shares

Expires 2035-10-05

F1 · derivative.exercise_date: The option shall vest as to 1/36th of the total award monthly, with the first tranche vesting on November 6, 2025, and each subsequent tranche vesting on the monthly anniversary thereof, subject to the reporting person's continued service to the Issuer on each vesting date.

SEC source: 0001415889-25-024100 · form4-09102025_080931.xml · derivative · entry 2

Hoppenot Herve · CIK 0001596492 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Ordinary Shares · 25,000 shares

Expires 2035-09-08

F3 · derivative.exercise_date: This option will vest in three equal installments on each of September 8, 2026, September 8, 2027 and September 8, 2028.

SEC source: 0001415889-25-024100 · form4-09102025_080931.xml · nonDerivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,500

F1 · shares: Represents a restricted share unit ("RSU") award. The RSUs will vest in three equal installments on each of September 8, 2026, September 8, 2027 and September 8, 2028.

F2 · price: Each RSU represents a contingent right to receive one ordinary share.

SEC source: 0000879169-25-000079 · wk-form4_1752696081.xml · nonDerivative · entry 2

Hoppenot Herve · CIK 0001596492 · Director · Special Advisor to the CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 517,146

F1 · shares: Represents shares withheld automatically by the Issuer to satisfy tax withholding obligations due at settlement of RSUs or earned performance shares previously reported in Table I as common stock.

F2 · balance_after: This includes an aggregate of 73,486 shares of common stock issuable pursuant to previously reported RSUs and earned performance shares that have not vested.

SEC source: 0000879169-25-000079 · wk-form4_1752696081.xml · nonDerivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director · Special Advisor to the CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 521,859

F1 · shares: Represents shares withheld automatically by the Issuer to satisfy tax withholding obligations due at settlement of RSUs or earned performance shares previously reported in Table I as common stock.

SEC source: 0000879169-25-000071 · wk-form4_1751920928.xml · nonDerivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director · Special Advisor to the CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 526,820

F1 · shares: Represents shares withheld automatically by the Issuer to satisfy tax withholding obligations due at settlement of RSUs or earned performance shares previously reported in Table I as common stock.

F2 · balance_after: This includes an aggregate of 94,538 shares of common stock issuable pursuant to previously reported RSUs and earned performance shares that have not vested.

SEC source: 0001628280-25-033513 · wk-form4_1751315517.xml · derivative · entry 3

Hoppenot Herve · CIK 0001596492 · Director · Special Advisor to the CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,050

Underlying: Common Stock · 18,050 shares

Expires 2028-06-26

F4 · derivative.exercise_price: Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ('TSR') over a three-year performance period beginning on January 1, 2025 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date.

F4 · derivative.exercise_date: Each performance share represents the right to receive up to 200% of one share of common stock. Such shares may be earned based upon the issuer's relative total shareholder return ('TSR') over a three-year performance period beginning on January 1, 2025 as compared to the TSR of companies in a fixed peer group, as set forth in the Performance Share Award Agreement. The earned shares will vest on the third anniversary of the grant date.

SEC source: 0001628280-25-033513 · wk-form4_1751315517.xml · derivative · entry 2

Hoppenot Herve · CIK 0001596492 · Director · Special Advisor to the CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,438

Underlying: Common Stock · 18,438 shares

Expires 2035-06-25

F3 · derivative.exercise_date: The June 26, 2025 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years.

SEC source: 0001628280-25-033513 · wk-form4_1751315517.xml · nonDerivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director · Special Advisor to the CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 569,589

F1 · shares: Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years. The RSUs may be settled only for shares of common stock on a one-for-one basis.

F2 · balance_after: Including the June 26, 2025 grant, this includes an aggregate of 187,611 shares of common stock issuable pursuant to previously reported RSUs and earned performance shares that have not vested.

SEC source: 0001628280-25-016570 · wk-form4_1743713353.xml · nonDerivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 563,573

F1 · shares: Represents the shares of common stock underlying performance shares earned upon the achievement of performance criteria determined to be satisfied on April 1, 2025. The earned shares will vest on the third anniversary of the July 2, 2022 grant date, subject to the Reporting Persons continued service with the Issuer. Each performance share represents the right to receive one or more shares of common stock based on, and subject to, specified development, revenue and market-based (relative total shareholder returns compared to the Nasdaq Biotechnology Index) performance goals determined by the Issuers Compensation Committee in January 2022 as set forth in the Performance Share Award Agreement. The number of shares of common stock that the Reporting Person is entitled to receive over the three year performance period ranges from 0% to 150% of the number of performance shares awarded.

F2 · balance_after: This includes an aggregate of 181,595 shares of common stock issuable pursuant to previously reported RSUs and earned performance shares that have not vested.

SEC source: 0000879169-25-000037 · wk-form4_1737580084.xml · derivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,510

Underlying: Common Stock · 55,510 shares

Expires 2035-01-16

F1 · derivative.exercise_date: Beginning January 17, 2025, options become exercisable in 37 installments, with the first 25% vesting on July 15, 2025 and the remainder vesting monthly over three years.

SEC source: 0000879169-24-000133 · wk-form4_1721233641.xml · derivative · entry 3

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 61,189

Underlying: Common Stock · 61,189 shares

Expires 2034-07-14

F4 · derivative.exercise_date: The July 15, 2024 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years.

SEC source: 0000879169-24-000133 · wk-form4_1721233641.xml · nonDerivative · entry 2

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 496,674

F2 · shares: Represents shares withheld automatically by the Issuer to satisfy tax withholding obligations due at settlement of RSUs or earned performance shares previously reported in Table I as common stock.

F3 · balance_after: Including the July 15, 2024 grant, this includes an aggregate of 114,696 shares of common stock issuable pursuant to previously reported RSUs and earned performance shares that have not vested.

SEC source: 0000879169-24-000133 · wk-form4_1721233641.xml · nonDerivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 501,635

F1 · shares: Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years, subject to the employee's continued service with the issuer through the applicable vesting dates. The RSUs may be settled only for shares of common stock on a one-for-one basis.

SEC source: 0000879169-24-000116 · wk-form4_1720023594.xml · nonDerivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 460,610

F1 · shares: Represents shares withheld automatically by the Issuer to satisfy tax withholding obligations due at settlement of RSUs or earned performance shares previously reported in Table I as common stock.

F2 · balance_after: This includes an aggregate of 84,467 shares of common stock issuable pursuant to previously reported RSUs and earned performance shares that have not vested.

SEC source: 0000879169-24-000060 · wk-form4_1708105819.xml · nonDerivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 502,333

F1 · shares: Represents shares of common stock underlying performance shares earned upon the achievement of performance criteria determined to be satisfied on February 14, 2024. The earned shares will vest on the third anniversary of the July 2, 2021 grant date, subject to the Reporting Persons continued service with the Issuer. Each performance share represents the right to receive one or more shares of common stock based on, and subject to, the achievement of specified financial and development performance criteria determined by the Issuers Compensation Committee in January 2021 as set forth in the Performance Share Award Agreement. The number of shares of common stock that the Reporting Person is entitled to receive over the three year performance period ranges from 0% to 150% of the number of performance shares awarded.

F2 · balance_after: This includes an aggregate of 175,262 shares of common stock issuable pursuant to previously reported RSUs and earned performance shares that have not vested.

F3 · balance_after: On June 15, 2018, the reporting person contributed 103,033 shares to a grantor retained annuity trust (GRAT). On June 17, 2019, 20,407 shares were distributed by the GRAT to the reporting person in accordance with the terms of the GRAT and continue to be reported in this Form 4 as directly owned. In addition, on June 2, 2020 an additional 16,392 shares were distributed by the GRAT to the reporting person in accordance with the terms of the GRAT and continue to be reported in this Form 4 as directly owned. On June 22, 2021 an additional 19,033 shares were distributed by the GRAT to the reporting person in accordance with the terms of the GRAT and continue to be reported in this Form 4 as directly owned.

F4 · balance_after: On June 29, 2022 an additional 21,301 shares were distributed by the GRAT to the reporting person in accordance with the terms of the GRAT and continue to be reported in this Form 4 as directly owned. On November 17 , 2023 the remaining 25,900 shares were distributed by the GRAT to the reporting person in accordance with the terms of the GRAT and will be reported in this Form 4 as directly owned.

SEC source: 0000879169-24-000026 · wk-form4_1705946423.xml · derivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 97,566

Underlying: Common Stock · 97,566 shares

Expires 2034-01-17

F1 · derivative.exercise_date: Beginning January 18, 2024, options become exercisable in 37 installments, with the first 25% vesting on July 14, 2024 and the remainder vesting monthly over three years.

SEC source: 0001209191-23-042547 · doc4.xml · derivative · entry 3

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 90,563

Underlying: Common Stock · 90,563 shares

Expires 2033-07-13

F3 · derivative.exercise_date: The July 14, 2023 options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years.

SEC source: 0001209191-23-042547 · doc4.xml · nonDerivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 434,856

F1 · shares: Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years, subject to Herve Hoppenot's continued service with the Issuer through the applicable vesting dates. The RSUs may be settled only for shares of common stock on a one-for-one basis.

F2 · balance_after: Including the July 14, 2023 RSU Grant, this includes an aggregate of 133,685 shares of common stock issuable pursuant to previously reported RSUs and earned performance shares that have not vested.

SEC source: 0001209191-23-041510 · doc4.xml · nonDerivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 391,672

F1 · shares: Represents shares withheld automatically by the Issuer to satisfy tax withholding obligations due at settlement of RSUs or performance shares previously reported in Table I as common stock.

F2 · balance_after: This includes an aggregate of 90,501 shares of common stock issuable pursuant to previously reported RSUs and earned performance shares that have not vested.

SEC source: 0001209191-23-004564 · doc4.xml · derivative · entry 3

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,449

Underlying: Common Stock · 86,449 shares

Expires 2033-01-19

F4 · derivative.exercise_date: Beginning January 20, 2023, options become exercisable in 37 installments, with the first 25% vesting on July 2, 2023 and the remainder vesting monthly over three years.

SEC source: 0001209191-23-004564 · doc4.xml · nonDerivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 435,139

F1 · shares: Represents shares of common stock underlying performance shares earned upon the achievement of performance criteria determined to be satisfied on January 20, 2023. The earned shares will vest on the third anniversary of the July 2, 2020 grant date, subject to the Reporting Persons continued service with the Issuer. Each performance share represents the right to receive one or more shares of common stock based on, and subject to, the achievement of specified financial and development performance criteria determined by the Issuers Compensation Committee in January 2020 as set forth in the Performance Share Award Agreement. The number of shares of common stock that the Reporting Person is entitled to receive over the three year performance period ranges from 0% to 175% of the number of performance shares awarded.

F2 · balance_after: This includes an aggregate of 276,741 shares of common stock issuable pursuant to previously reported restricted stock units and earned performance stock units that have not vested. The aggregate amount also includes the additional Performance Stock Units earned on January 20, 2023.

SEC source: 0001209191-22-041071 · doc4.xml · nonDerivative · entry 2

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 405,943

F2 · shares: Represents shares withheld automatically by the Issuer to satisfy tax withholding obligations due at settlement of RSUs or performance shares previously reported in Table I as common stock.

F3 · balance_after: Including the July 2, 2022 RSU Grant, this includes an aggregate of 95,461 shares of common stock issuable pursuant to previously reported RSUs and earned performance shares that have not vested.

SEC source: 0001209191-22-041071 · doc4.xml · derivative · entry 4

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 81,885

Underlying: Common Stock · 81,885 shares

Expires 2032-07-01

F5 · derivative.exercise_date: Beginning July 2, 2022, options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years.

SEC source: 0001209191-22-041071 · doc4.xml · nonDerivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 427,117

F1 · shares: Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years, subject to Herve Hoppenot's continued service with the Issuer through the applicable vesting dates. The RSUs may be settled only for shares of common stock on a one-for-one basis.

SEC source: 0001209191-22-004404 · doc4.xml · derivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 84,852

Underlying: Common Stock · 84,852 shares

Expires 2032-01-18

F1 · derivative.exercise_date: Beginning January 19, 2022, options become exercisable in 37 installments, with the first 25.00% vesting on July 2, 2022 and the remainder vesting monthly over three years.

SEC source: 0001209191-21-066406 · doc4.xml · nonDerivative · entry 2

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 345,383

F2 · shares: Represents shares of common stock underlying performance shares earned upon the interim achievement of performance criteria determined to be satisfied on November 19, 2021. The earned shares will vest on the third anniversary of the July 2, 2021 grant date, subject to the Reporting Persons continued service with the Issuer. Each performance share represents the right to receive one or more shares of common stock based on, and subject to, the achievement of specified financial and development performance criteria determined by the Issuers Compensation Committee in February 2021 as set forth in the Performance Share Award Agreement. The number of shares of common stock that the Reporting Person is entitled to receive over the three year performance period ranges from 0% to 150% of the number of performance shares awarded.

F3 · balance_after: Including the Performance Stock Units earned on November 19, 2021 this includes an aggregate of 141,536 shares of common stock issuable pursuant to previously reported restricted stock units and earned performance shares that have not vested.

SEC source: 0001209191-21-066406 · doc4.xml · nonDerivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 332,104

F1 · shares: Represents shares of common stock underlying performance shares earned upon the interim achievement of performance criteria determined to be satisfied on November 19, 2021. The earned shares will vest on the third anniversary of the July 2, 2020 grant date, subject to the Reporting Persons continued service with the Issuer. Each performance share represents the right to receive one or more shares of common stock based on, and subject to, the achievement of specified financial and development performance criteria determined by the Issuers Compensation Committee in January 2020 as set forth in the Performance Share Award Agreement. The number of shares of common stock that the Reporting Person is entitled to receive over the three year performance period ranges from 0% to 175% of the number of performance shares awarded.

SEC source: 0001209191-21-045789 · doc4.xml · nonDerivative · entry 5

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 329,877

F2 · shares: Represents shares withheld automatically by the Issuer to satisfy tax withholding obligations due at settlement of restricted stock units or performance shares previously reported in Table I as common stock.

F3 · balance_after: Including the July 2, 2021 Restricted Stock Unit Grant, this includes an aggregate of 126,030 shares of common stock issuable pursuant to previously reported restricted stock units and earned performance shares that have not vested.

SEC source: 0001209191-21-045789 · doc4.xml · derivative · entry 7

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 84,851

Underlying: Common Stock · 84,851 shares

Expires 2031-07-01

F5 · derivative.exercise_date: Beginning July 2, 2021, options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years.

SEC source: 0001209191-21-045789 · doc4.xml · nonDerivative · entry 3

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 331,439

F2 · shares: Represents shares withheld automatically by the Issuer to satisfy tax withholding obligations due at settlement of restricted stock units or performance shares previously reported in Table I as common stock.

SEC source: 0001209191-21-045789 · doc4.xml · nonDerivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 347,528

F1 · shares: Represents award of restricted stock units ("RSUs") that will vest 25% annually over four years, subject to Herve Hoppenot's continued service with the Issuer through the applicable vesting dates. The RSUs may be settled only for shares of common stock on a one-for-one basis.

SEC source: 0001209191-21-013261 · doc4.xml · nonDerivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 284,231

F1 · balance_after: This includes an aggregate of 120,195 shares of common stock issuable pursuant to previously reported restricted stock units and earned performance shares that have not vested.

SEC source: 0001209191-21-004324 · doc4.xml · derivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 74,720

Underlying: Common Stock · 74,720 shares

Expires 2031-01-14

F1 · derivative.exercise_date: Beginning January 15, 2021, options become exercisable in 37 installments, with the first 25.00% vesting on July 2, 2021 and the remainder vesting monthly over three years.

SEC source: 0001209191-20-059104 · doc4.xml · nonDerivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 271,306

F1 · shares: Represents shares of common stock underlying performance shares earned upon the interim achievement of performance criteria determined to be satisfied on November 16, 2020. The earned shares will vest on the third anniversary of the July 2, 2020 grant date, subject to the Reporting Persons continued service with the Issuer. Each performance share represents the right to receive one or more shares of common stock based on, and subject to, the achievement of specified financial and development performance criteria determined by the Issuers Compensation Committee in January 2020 as set forth in the Performance Share Award Agreement. The number of shares of common stock that the Reporting Person is entitled to receive over the three year performance period ranges from 0% to 175% of the number of performance shares awarded.

F2 · balance_after: Including the Performance Stock Units earned on November 16, 2020 this includes an aggregate of 120,195 shares of common stock issuable pursuant to previously reported restricted stock units and earned performance shares that have not vested.

SEC source: 0001209191-20-042798 · doc4.xml · nonDerivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 264,081

F1 · shares: Represents shares withheld automatically by the Issuer to satisfy tax withholding obligations due at settlement of restricted stock units or performance shares previously reported in Table I as common stock.

F2 · balance_after: This includes an aggregate of 112,970 shares of common stock issuable pursuant to previously reported restricted stock units and earned performance shares that have not vested.

SEC source: 0001209191-20-041557 · doc4.xml · derivative · entry 17

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 88,406 shares

Expires 2022-01-07

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · derivative.exercise_date: Beginning January 8, 2015, options become exercisable in 25 installments, with the first 33.33% vesting after one year and the remainder vesting monthly over two years.

SEC source: 0001209191-20-041557 · doc4.xml · derivative · entry 16

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,365 shares

Expires 2022-01-07

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · derivative.exercise_date: Beginning January 8, 2015, options become exercisable in 25 installments, with the first 33.33% vesting after one year and the remainder vesting monthly over two years.

SEC source: 0001209191-20-041557 · doc4.xml · nonDerivative · entry 13

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 266,501

F3 · price: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by reporting person.

F4 · balance_after: Including the July 2, 2020 Restricted Stock Unit Grant, this includes an aggregate of 118,371 shares of common stock issuable pursuant to previously reported restricted stock units and earned performance shares that have not vested.

SEC source: 0001209191-20-041557 · doc4.xml · nonDerivative · entry 11

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 354,907

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-20-041557 · doc4.xml · nonDerivative · entry 9

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 266,501

F3 · price: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by reporting person.

SEC source: 0001209191-20-041557 · doc4.xml · nonDerivative · entry 7

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 267,866

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-20-041557 · doc4.xml · nonDerivative · entry 5

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 266,501

F2 · shares: Represents shares withheld automatically by the Issuer to satisfy tax withholding obligations due at settlement of restricted stock units or performance shares previously reported in Table I as common stock.

SEC source: 0001209191-20-041557 · doc4.xml · derivative · entry 15

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 74,720

Underlying: Common Stock · 74,720 shares

Expires 2030-07-01

F6 · derivative.exercise_date: Beginning July 2, 2020, options become exercisable in 37 installments, with the first 25% vesting after one year and the remainder vesting monthly over three years.

SEC source: 0001209191-20-041557 · doc4.xml · nonDerivative · entry 3

Hoppenot Herve · CIK 0001596492 · Director · Chairman / CEO · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 268,060

F2 · shares: Represents shares withheld automatically by the Issuer to satisfy tax withholding obligations due at settlement of restricted stock units or performance shares previously reported in Table I as common stock.