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person · Reporting owner

LOSCALZO JOSEPH

Disclosed activity across 2 companies

Tapewire entity
32406
SEC CIK
0001276128

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Reported relationships

Latest disclosed role at each company.

CompanyLast reported asReport datePublished
CYPHERPUNK TECHNOLOGIES INC.CYPH · Entity 6392DirectorMarch 13, 2026March 17, 2026
IONIS PHARMACEUTICALS INCIONS · Entity 1182DirectorJuly 01, 2026July 06, 2026

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

CYPHERPUNK TECHNOLOGIES INC.

Report date March 13, 2026 · Filed March 17, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Common StockSEC Table I · non-derivativeDirect168,750 Ending reported balance After 2026-03-13 transaction · row 2
2 source rows · reconciled sequence

Row 1 · 2026-03-13 · Exercise / conversion · Acquired 74,700 · Balance 74,700

F1: 74,700 Restricted Stock Units ("RSUs") previously granted by Cypherpunk Technologies Inc. (the "Company") to the reporting person on November 11, 2025 pursuant to the Company's 2022 Equity Incentive Plan for no consideration (the "November 2025 RSUs") were settled on March 13, 2026 on a 1 for 1 basis for shares of the Company's common stock, par value $0.001 per share ("Common Stock").

Row 2 · 2026-03-13 · Exercise / conversion · Acquired 94,050 · Balance 168,750

F2: 94,050 RSUs previously granted by the Company to the reporting person on December 23, 2025 pursuant to the Company's 2025 Equity Incentive Plan for no consideration (the "December 2025 RSUs") were settled on March 13, 2026 on a 1 for 1 basis for shares of Common Stock.

Restricted Stock UnitsSEC Table II · derivative / convertible security · Conversion / exercise price $0.00Direct0 Reported balance After 2026-03-13 transaction · row 3 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 3 · 2026-03-13 · Exercise / conversion · Disposed 74,700 · Balance 0

F1: 74,700 Restricted Stock Units ("RSUs") previously granted by Cypherpunk Technologies Inc. (the "Company") to the reporting person on November 11, 2025 pursuant to the Company's 2022 Equity Incentive Plan for no consideration (the "November 2025 RSUs") were settled on March 13, 2026 on a 1 for 1 basis for shares of the Company's common stock, par value $0.001 per share ("Common Stock").

F3: The November 2025 RSUs vested at issuance on their grant date.

Restricted Stock UnitsSEC Table II · derivative / convertible security · Conversion / exercise price $0.00Direct0 Reported balance After 2026-03-13 transaction · row 4 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 4 · 2026-03-13 · Exercise / conversion · Disposed 94,050 · Balance 0

F2: 94,050 RSUs previously granted by the Company to the reporting person on December 23, 2025 pursuant to the Company's 2025 Equity Incentive Plan for no consideration (the "December 2025 RSUs") were settled on March 13, 2026 on a 1 for 1 basis for shares of Common Stock.

F4: The December 2025 RSUs vested at issuance on their grant date.

Filing footnotes · ownership attribution and instrument terms

F1: 74,700 Restricted Stock Units ("RSUs") previously granted by Cypherpunk Technologies Inc. (the "Company") to the reporting person on November 11, 2025 pursuant to the Company's 2022 Equity Incentive Plan for no consideration (the "November 2025 RSUs") were settled on March 13, 2026 on a 1 for 1 basis for shares of the Company's common stock, par value $0.001 per share ("Common Stock").

F2: 94,050 RSUs previously granted by the Company to the reporting person on December 23, 2025 pursuant to the Company's 2025 Equity Incentive Plan for no consideration (the "December 2025 RSUs") were settled on March 13, 2026 on a 1 for 1 basis for shares of Common Stock.

F3: The November 2025 RSUs vested at issuance on their grant date.

F4: The December 2025 RSUs vested at issuance on their grant date.

IONIS PHARMACEUTICALS INC

Report date July 01, 2026 · Filed July 06, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Non-Qualified Stock Option (right to buy)SEC Table II · derivative / convertible security · Conversion / exercise price $79.19 · Expires 2036-06-30Direct5,369 Reported balance After 2026-07-01 transaction · row 1 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 1 · 2026-07-01 · Grant · Acquired 5,369 · Balance 5,369

F1: Pursuant to the Company's Non-Employee Director Compensation Policy, these grants were adjusted downward such that the non-employee Director's annual equity compensation in 2026 totals no more than $400,000 based on the aggregate grant date fair value as determined in accordance with FASB Topic ASC 718.

F2: Grant on July 1, 2026 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. 100% of the shares subject to the option vest and become exercisable on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier. The option is exercisable to 0 shares on July 1, 2026.

Restricted Stock UnitSEC Table II · derivative / convertible security · Conversion / exercise price $0.00Direct7,521 Reported balance After 2026-07-01 transaction · row 2 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 2 · 2026-07-01 · Grant · Acquired 2,301 · Balance 7,521

F3: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F1: Pursuant to the Company's Non-Employee Director Compensation Policy, these grants were adjusted downward such that the non-employee Director's annual equity compensation in 2026 totals no more than $400,000 based on the aggregate grant date fair value as determined in accordance with FASB Topic ASC 718.

F4: Grant on July 1, 2026 to reporting person of Restricted Stock Unit award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. These Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and will be delivered to the reporting person on the July 15th following the vesting date. The Restricted Stock Unit is vested as to 0 shares on July 1, 2026.

Filing footnotes · ownership attribution and instrument terms

F1: Pursuant to the Company's Non-Employee Director Compensation Policy, these grants were adjusted downward such that the non-employee Director's annual equity compensation in 2026 totals no more than $400,000 based on the aggregate grant date fair value as determined in accordance with FASB Topic ASC 718.

F2: Grant on July 1, 2026 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. 100% of the shares subject to the option vest and become exercisable on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier. The option is exercisable to 0 shares on July 1, 2026.

F3: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F4: Grant on July 1, 2026 to reporting person of Restricted Stock Unit award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. These Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and will be delivered to the reporting person on the July 15th following the vesting date. The Restricted Stock Unit is vested as to 0 shares on July 1, 2026.

Transaction history

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateCompanyActivity / securityShares / unitsReported priceReported valueDetails
July 03, 2023 Filed Jul 6, 2023 21:14 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantRestricted Stock Unit · Derivative 4,677 $0.00 Strike: $0.00 $0.00
Disclosure

SEC source: 0000874015-23-000159 · edgardoc.xml · derivative · entry 2

LOSCALZO JOSEPH · CIK 0001276128 · Director · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,787

Underlying: Common Stock · 4,677 shares

Expires not disclosed

F3 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F1 · shares: Pursuant to the Company's Non-Employee Director Compensation Policy, these grants were adjusted downward such that the non-employee Director's annual equity compensation in 2023 totals no more than $450,000 based on the aggregate grant date fair value as determined in accordance with FASB Topic ASC 718.

F4 · derivative.exercise_date: Grant on July 3, 2023 to reporting person of Restricted Stock Unit award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. These Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and will be delivered to the reporting person on the July 15th following the vesting date. The Restricted Stock Unit is vested as to 0 shares on July 3, 2023.

F4 · derivative.expiration_date: Grant on July 3, 2023 to reporting person of Restricted Stock Unit award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. These Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and will be delivered to the reporting person on the July 15th following the vesting date. The Restricted Stock Unit is vested as to 0 shares on July 3, 2023.

Read SEC document
July 03, 2023 Filed Jul 6, 2023 21:14 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantNon-Qualified Stock Option (right to buy) · Derivative 10,321 $0.00 Strike: $41.08 $0.00
Disclosure

SEC source: 0000874015-23-000159 · edgardoc.xml · derivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,321

Underlying: Common Stock · 10,321 shares

Expires 2033-07-02

F1 · shares: Pursuant to the Company's Non-Employee Director Compensation Policy, these grants were adjusted downward such that the non-employee Director's annual equity compensation in 2023 totals no more than $450,000 based on the aggregate grant date fair value as determined in accordance with FASB Topic ASC 718.

F2 · derivative.exercise_date: Grant on July 3, 2023 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. 100% of the shares subject to the option vest and become exercisable on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier. The option is exercisable to 0 shares on July 3, 2023.

F2 · derivative.expiration_date: Grant on July 3, 2023 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. 100% of the shares subject to the option vest and become exercisable on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier. The option is exercisable to 0 shares on July 3, 2023.

Read SEC document
March 31, 2023 Filed Apr 5, 2023 00:15 UTC CYPHERPUNK TECHNOLOGIES INC. LPTX · Entity 6392 GrantStock Option (Right to Buy) · Derivative 150,000 $0.00 Strike: $0.34 $0.00
Disclosure

SEC source: 0001104659-23-041751 · tm2311741-10_4seq1.xml · derivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common Stock · 150,000 shares

Expires 2033-03-31

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2022 Equity Incentive Plan. By its terms, the Option shall vest and become exercisable for the shares underlying the Option in a series of 4 quarterly installments on each of March 31, 2023, June 30, 2023, September 30, 2023, and December 31, 2023 for so long as the reporting person continues to be a director, consultant or service provider of the Company until the Option is fully vested.

Read SEC document
September 01, 2022 Filed Sep 3, 2022 01:22 UTC CYPHERPUNK TECHNOLOGIES INC. LPTX · Entity 6392 GrantStock Option (Right to Buy) · Derivative 25,000 $0.00 Strike: $1.43 $0.00
Disclosure

SEC source: 0001104659-22-097614 · tm2225099-2_4seq1.xml · derivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2032-08-31

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2022 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of September 1, 2022, the Vesting Start Date.

Read SEC document
July 15, 2022 Filed Jul 19, 2022 23:21 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Unit · Derivative 2,665 $0.00 Strike: $0.00 $0.00
Disclosure

SEC source: 0000874015-22-000141 · edgardoc.xml · derivative · entry 4

LOSCALZO JOSEPH · CIK 0001276128 · Director · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,110

Underlying: Common Stock · 2,665 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F5 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.

F5 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 15, 2022 Filed Jul 19, 2022 23:21 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Unit · Derivative 5,333 $0.00 Strike: $0.00 $0.00
Disclosure

SEC source: 0000874015-22-000141 · edgardoc.xml · derivative · entry 3

LOSCALZO JOSEPH · CIK 0001276128 · Director · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,775

Underlying: Common Stock · 5,333 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F4 · derivative.exercise_date: Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.

F4 · derivative.expiration_date: Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 15, 2022 Filed Jul 19, 2022 23:21 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 2,665 $0.00 $0.00
Disclosure

SEC source: 0000874015-22-000141 · edgardoc.xml · nonDerivative · entry 2

LOSCALZO JOSEPH · CIK 0001276128 · Director · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,972

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · kind: Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards.

F2 · shares: Acquired pursuant to vesting and release of shares in accordance with Restricted Stock Unit awards.

Read SEC document
July 15, 2022 Filed Jul 19, 2022 23:21 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 5,333 $0.00 $0.00
Disclosure

SEC source: 0000874015-22-000141 · edgardoc.xml · nonDerivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,307

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award.

F1 · shares: Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award.

Read SEC document
July 01, 2022 Filed Jul 6, 2022 21:25 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantRestricted Stock Unit · Derivative 5,333 $0.00 Strike: $0.00 $0.00
Disclosure

SEC source: 0000874015-22-000123 · edgardoc.xml · derivative · entry 2

LOSCALZO JOSEPH · CIK 0001276128 · Director · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,108

Underlying: Common Stock · 5,333 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F3 · derivative.exercise_date: Grant on July 1, 2022 to reporting person of Restricted Stock Unit award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. These Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and will be delivered to the reporting person on the July 15th following the vesting date. The Restricted Stock Unit is vested as to 0 shares on July 1, 2022.

F3 · derivative.expiration_date: Grant on July 1, 2022 to reporting person of Restricted Stock Unit award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. These Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and will be delivered to the reporting person on the July 15th following the vesting date. The Restricted Stock Unit is vested as to 0 shares on July 1, 2022.

Read SEC document
July 01, 2022 Filed Jul 6, 2022 21:25 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantNon-Qualified Stock Option (right to buy) · Derivative 12,000 $0.00 Strike: $38.06 $0.00
Disclosure

SEC source: 0000874015-22-000123 · edgardoc.xml · derivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,000

Underlying: Common Stock · 12,000 shares

Expires 2032-06-30

F1 · derivative.exercise_date: Grant on July 1, 2022 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. 100% of the shares subject to the option vest and become exercisable on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier. The option is exercisable to 0 shares on July 1, 2022.

F1 · derivative.expiration_date: Grant on July 1, 2022 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. 100% of the shares subject to the option vest and become exercisable on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier. The option is exercisable to 0 shares on July 1, 2022.

Read SEC document
January 31, 2022 Filed Feb 3, 2022 02:50 UTC CYPHERPUNK TECHNOLOGIES INC. LPTX · Entity 6392 GrantStock Option (Right to Buy) · Derivative 55,000 $0.00 Strike: $1.94 $0.00
Disclosure

SEC source: 0001104659-22-011059 · tm225302-11_4seq1.xml · derivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55,000

Underlying: Common Stock · 55,000 shares

Expires 2032-01-30

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2022, the Vesting Start Date.

Read SEC document
July 15, 2021 Filed Jul 20, 2021 00:14 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Unit · Derivative 1,778 $0.00 Strike: $0.00 $0.00
Disclosure

SEC source: 0000874015-21-000137 · edgardoc.xml · derivative · entry 8

LOSCALZO JOSEPH · CIK 0001276128 · Director · Chairman of Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,775

Underlying: Common Stock · 1,778 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F4 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.

F4 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 15, 2021 Filed Jul 20, 2021 00:14 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Unit · Derivative 666 $0.00 Strike: $0.00 $0.00
Disclosure

SEC source: 0000874015-21-000137 · edgardoc.xml · derivative · entry 7

LOSCALZO JOSEPH · CIK 0001276128 · Director · Chairman of Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,553

Underlying: Common Stock · 666 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F4 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.

F4 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 15, 2021 Filed Jul 20, 2021 00:14 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Unit · Derivative 889 $0.00 Strike: $0.00 $0.00
Disclosure

SEC source: 0000874015-21-000137 · edgardoc.xml · derivative · entry 6

LOSCALZO JOSEPH · CIK 0001276128 · Director · Chairman of Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,219

Underlying: Common Stock · 889 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F4 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.

F4 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 15, 2021 Filed Jul 20, 2021 00:14 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Unit · Derivative 5,333 $0.00 Strike: $0.00 $0.00
Disclosure

SEC source: 0000874015-21-000137 · edgardoc.xml · derivative · entry 5

LOSCALZO JOSEPH · CIK 0001276128 · Director · Chairman of Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,108

Underlying: Common Stock · 5,333 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F3 · derivative.exercise_date: Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.

F3 · derivative.expiration_date: Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and are delivered to the reporting person on the July 15th following the vesting date. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 15, 2021 Filed Jul 20, 2021 00:14 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 1,778 $0.00 $0.00
Disclosure

SEC source: 0000874015-21-000137 · edgardoc.xml · nonDerivative · entry 4

LOSCALZO JOSEPH · CIK 0001276128 · Director · Chairman of Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,974

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to a Restricted Stock Unit Award.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to a Restricted Stock Unit Award.

Read SEC document
July 15, 2021 Filed Jul 20, 2021 00:14 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 666 $0.00 $0.00
Disclosure

SEC source: 0000874015-21-000137 · edgardoc.xml · nonDerivative · entry 3

LOSCALZO JOSEPH · CIK 0001276128 · Director · Chairman of Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,196

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to a Restricted Stock Unit Award.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to a Restricted Stock Unit Award.

Read SEC document
July 15, 2021 Filed Jul 20, 2021 00:14 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 889 $0.00 $0.00
Disclosure

SEC source: 0000874015-21-000137 · edgardoc.xml · nonDerivative · entry 2

LOSCALZO JOSEPH · CIK 0001276128 · Director · Chairman of Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,530

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to a Restricted Stock Unit Award.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to a Restricted Stock Unit Award.

Read SEC document
July 15, 2021 Filed Jul 20, 2021 00:14 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 5,333 $0.00 $0.00
Disclosure

SEC source: 0000874015-21-000137 · edgardoc.xml · nonDerivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director · Chairman of Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,641

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to a Restricted Stock Unit Award.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to a Restricted Stock Unit Award.

Read SEC document
July 01, 2021 Filed Jul 6, 2021 21:51 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantRestricted Stock Unit · Derivative 5,333 $0.00 Strike: $0.00 $0.00
Disclosure

SEC source: 0000874015-21-000115 · edgardoc.xml · derivative · entry 2

LOSCALZO JOSEPH · CIK 0001276128 · Director · Chairman of Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,441

Underlying: Common Stock · 5,333 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F3 · derivative.exercise_date: Grant of July 1, 2021 to reporting person of Restricted Stock Unit award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. These Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and will be delivered to the reporting person on the July 15th following the vesting date. The Restricted Stock Unit is vested as to 0 shares on July 1, 2021.

F3 · derivative.expiration_date: Grant of July 1, 2021 to reporting person of Restricted Stock Unit award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. These Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and will be delivered to the reporting person on the July 15th following the vesting date. The Restricted Stock Unit is vested as to 0 shares on July 1, 2021.

Read SEC document
July 01, 2021 Filed Jul 6, 2021 21:51 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantNon-Qualified Stock Option (right to buy) · Derivative 12,000 $0.00 Strike: $40.05 $0.00
Disclosure

SEC source: 0000874015-21-000115 · edgardoc.xml · derivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director · Chairman of Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,000

Underlying: Common Stock · 12,000 shares

Expires 2031-06-30

F1 · derivative.exercise_date: Grant of July 1, 2021 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. 100% of the shares subject to the option vest and become exercisable on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier. The option is exercisable to 0 shares on July 1, 2021.

F1 · derivative.expiration_date: Grant of July 1, 2021 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. 100% of the shares subject to the option vest and become exercisable on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier. The option is exercisable to 0 shares on July 1, 2021.

Read SEC document
January 04, 2021 Filed Jan 7, 2021 00:02 UTC CYPHERPUNK TECHNOLOGIES INC. LPTX · Entity 6392 GrantStock Option (Right to Buy) · Derivative 32,300 $0.00 Strike: $2.18 $0.00
Disclosure

SEC source: 0001104659-21-001644 · tm211724-1_4seq1.xml · derivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,300

Underlying: Common Stock · 32,300 shares

Expires 2031-01-03

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2021, the Vesting Start Date.

Read SEC document
August 10, 2020 Filed Aug 13, 2020 01:18 UTC CYPHERPUNK TECHNOLOGIES INC. LPTX · Entity 6392 GrantStock Option (Right to Buy) · Derivative 10,000 $0.00 Strike: $1.97 $0.00
Disclosure

SEC source: 0001104659-20-094197 · a4.xml · derivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2030-08-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three month anniversary of August 10, 2020, the Vesting Start Date.

Read SEC document
July 06, 2020 Filed Jul 6, 2020 21:49 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 667 $0.00 $0.00
Disclosure

SEC source: 0000874015-20-000105 · edgar.xml · derivative · entry 8

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 666

Underlying: Common Stock · 667 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F3 · derivative.exercise_date: These Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F3 · derivative.expiration_date: These Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 06, 2020 Filed Jul 6, 2020 21:49 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 667 $0.00 $0.00
Disclosure

SEC source: 0000874015-20-000105 · edgar.xml · nonDerivative · entry 4

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,308

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
July 02, 2020 Filed Jul 6, 2020 21:49 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 889 $0.00 $0.00
Disclosure

SEC source: 0000874015-20-000105 · edgar.xml · derivative · entry 7

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,777

Underlying: Common Stock · 889 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F3 · derivative.exercise_date: These Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F3 · derivative.expiration_date: These Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 02, 2020 Filed Jul 6, 2020 21:49 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 889 $0.00 $0.00
Disclosure

SEC source: 0000874015-20-000105 · edgar.xml · nonDerivative · entry 3

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,641

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
July 01, 2020 Filed Jul 6, 2020 21:49 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantDirector Stock Option (right to buy) · Derivative 12,000 $0.00 Strike: $60.20 $0.00
Disclosure

SEC source: 0000874015-20-000105 · edgar.xml · derivative · entry 10

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,000

Underlying: Common Stock · 12,000 shares

Expires 2030-06-30

F5 · derivative.exercise_date: Grant of July 1, 2020 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. 100% of the shares subject to the option vest and become exercisable on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier. The option is exercisable to 0 shares on July 1, 2020.

F5 · derivative.expiration_date: Grant of July 1, 2020 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. 100% of the shares subject to the option vest and become exercisable on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier. The option is exercisable to 0 shares on July 1, 2020.

Read SEC document
July 01, 2020 Filed Jul 6, 2020 21:49 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantRestricted Stock Units · Derivative 5,333 $0.00 Strike: $0.00 $0.00
Disclosure

SEC source: 0000874015-20-000105 · edgar.xml · derivative · entry 9

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,333

Underlying: Common Stock · 5,333 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F4 · derivative.exercise_date: Grant of July 1, 2020 to reporting person of Restricted Stock Unit award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. These Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and will be delivered to the reporting person on the July 15th following the vesting date. The Restricted Stock Unit is vested as to 0 shares on July 1, 2020.

F4 · derivative.expiration_date: Grant of July 1, 2020 to reporting person of Restricted Stock Unit award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. These Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and will be delivered to the reporting person on the July 15th following the vesting date. The Restricted Stock Unit is vested as to 0 shares on July 1, 2020.

Read SEC document
July 01, 2020 Filed Jul 6, 2020 21:49 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 1,778 $0.00 $0.00
Disclosure

SEC source: 0000874015-20-000105 · edgar.xml · derivative · entry 6

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,332

Underlying: Common Stock · 1,778 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F3 · derivative.exercise_date: These Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F3 · derivative.expiration_date: These Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 01, 2020 Filed Jul 6, 2020 21:49 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 666 $0.00 $0.00
Disclosure

SEC source: 0000874015-20-000105 · edgar.xml · derivative · entry 5

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 666 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F3 · derivative.exercise_date: These Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F3 · derivative.expiration_date: These Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 01, 2020 Filed Jul 6, 2020 21:49 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 1,778 $0.00 $0.00
Disclosure

SEC source: 0000874015-20-000105 · edgar.xml · nonDerivative · entry 2

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,752

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
July 01, 2020 Filed Jul 6, 2020 21:49 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 666 $0.00 $0.00
Disclosure

SEC source: 0000874015-20-000105 · edgar.xml · nonDerivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,974

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
April 09, 2020 Filed Apr 14, 2020 00:20 UTC CYPHERPUNK TECHNOLOGIES INC. LPTX · Entity 6392 GrantStock Option (Right to Buy) · Derivative 10,000 $0.00 Strike: $1.69 $0.00
Disclosure

SEC source: 0001104659-20-046074 · a4.xml · derivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2030-04-09

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of April 9, 2020, the Vesting Start Date.

Read SEC document
March 02, 2020 Filed Mar 4, 2020 22:08 UTC CYPHERPUNK TECHNOLOGIES INC. LPTX · Entity 6392 GrantStock Option (Right to Buy) · Derivative 20,000 $0.00 Strike: $2.94 $0.00
Disclosure

SEC source: 0001104659-20-029241 · a4.xml · derivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2030-03-01

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2020, the Vesting Start Date.

Read SEC document
July 03, 2019 Filed Jul 3, 2019 22:39 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 667 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000097 · edgar.xml · derivative · entry 8

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,333

Underlying: Common Stock · 667 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F3 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F3 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 03, 2019 Filed Jul 3, 2019 22:39 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 667 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000097 · edgar.xml · nonDerivative · entry 4

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,308

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
July 02, 2019 Filed Jul 3, 2019 22:39 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 889 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000097 · edgar.xml · derivative · entry 7

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,666

Underlying: Common Stock · 889 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F3 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F3 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 02, 2019 Filed Jul 3, 2019 22:39 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 889 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000097 · edgar.xml · nonDerivative · entry 3

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,641

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
July 01, 2019 Filed Jul 3, 2019 22:39 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantDirector Stock Option (right to buy) · Derivative 16,000 $0.00 Strike: $64.80 $0.00
Disclosure

SEC source: 0000874015-19-000097 · edgar.xml · derivative · entry 10

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,000

Underlying: Common Stock · 16,000 shares

Expires 2029-06-30

F5 · derivative.exercise_date: Grant of July 1, 2019 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vesting on July 1, 2020. The option shall be fully vested and exercisable on July 1, 2023. The option is exercisable to 0 shares on July 1, 2019.

F5 · derivative.expiration_date: Grant of July 1, 2019 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vesting on July 1, 2020. The option shall be fully vested and exercisable on July 1, 2023. The option is exercisable to 0 shares on July 1, 2019.

Read SEC document
July 01, 2019 Filed Jul 3, 2019 22:39 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantRestricted Stock Units · Derivative 7,110 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000097 · edgar.xml · derivative · entry 9

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,110

Underlying: Common Stock · 7,110 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F4 · derivative.exercise_date: Grant of July 1, 2019 to reporting person of Restricted Stock Unit Award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. Restricted Stock Units vest in four equal annual installments, the first installment vesting on July 1, 2020. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on July 1, 2023. The RSU is vested as to 0 shares on July 1, 2019.

F4 · derivative.expiration_date: Grant of July 1, 2019 to reporting person of Restricted Stock Unit Award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. Restricted Stock Units vest in four equal annual installments, the first installment vesting on July 1, 2020. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on July 1, 2023. The RSU is vested as to 0 shares on July 1, 2019.

Read SEC document
July 01, 2019 Filed Jul 3, 2019 22:39 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 667 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000097 · edgar.xml · derivative · entry 6

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 666

Underlying: Common Stock · 667 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F3 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F3 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 01, 2019 Filed Jul 3, 2019 22:39 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 666 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000097 · edgar.xml · derivative · entry 5

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 666 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F3 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F3 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
July 01, 2019 Filed Jul 3, 2019 22:39 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 667 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000097 · edgar.xml · nonDerivative · entry 2

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,752

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
July 01, 2019 Filed Jul 3, 2019 22:39 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 666 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000097 · edgar.xml · nonDerivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,085

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
June 11, 2019 Filed Jun 12, 2019 20:46 UTC CYPHERPUNK TECHNOLOGIES INC. LPTX · Entity 6392 GrantStock Option (Right to Buy) · Derivative 10,000 $0.00 Strike: $1.39 $0.00
Disclosure

SEC source: 0001104659-19-035081 · a4.xml · derivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2029-06-10

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of June 11, 2019, the Vesting Start Date.

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January 01, 2019 Filed Jan 3, 2019 21:33 UTC CYPHERPUNK TECHNOLOGIES INC. LPTX · Entity 6392 GrantStock Option (Right to Buy) · Derivative 7,500 $0.00 Strike: $2.00 $0.00
Disclosure

SEC source: 0001104659-19-000506 · a4.xml · derivative · entry 1

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Common Stock · 7,500 shares

Expires 2028-12-31

F1 · derivative.exercise_date: The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 4 quarterly installments until the Option is fully vested, with the first such quarterly installment vesting on the three-month anniversary of January 1, 2019, the Vesting Start Date.

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July 03, 2018 Filed Jul 3, 2018 19:20 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 667 $0.00 $0.00
Disclosure

SEC source: 0000874015-18-000087 · edgar.xml · derivative · entry 4

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,000

Underlying: Common Stock · 667 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F3 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F3 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

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July 03, 2018 Filed Jul 3, 2018 19:20 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 667 $0.00 $0.00
Disclosure

SEC source: 0000874015-18-000087 · edgar.xml · nonDerivative · entry 2

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,419

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

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July 02, 2018 Filed Jul 3, 2018 19:20 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantDirector Stock Option (right to buy) · Derivative 16,000 $0.00 Strike: $42.88 $0.00
Disclosure

SEC source: 0000874015-18-000087 · edgar.xml · derivative · entry 6

LOSCALZO JOSEPH · CIK 0001276128 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,000

Underlying: Common Stock · 16,000 shares

Expires 2028-07-01

F5 · derivative.exercise_date: Grant of July 2, 2018 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vesting on July 2, 2019. The option shall be fully vested and exercisable on July 2, 2022. The option is exercisable to 0 shares on July 2, 2018.

F5 · derivative.expiration_date: Grant of July 2, 2018 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vesting on July 2, 2019. The option shall be fully vested and exercisable on July 2, 2022. The option is exercisable to 0 shares on July 2, 2018.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.