Zhen Marianne

SEC source: 0001193125-26-363611 · ownership.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,389

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001193125-26-236907 · ownership.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 57,516

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001193125-26-209007 · ownership.xml · derivative · entry 2

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,500

Underlying: Common Stock · 31,500 shares

Expires 2036-05-03

F1 · derivative.exercise_date: The Reporting Person was conditionally granted time-vested restricted stock units ("RSUs") and non-statutory stock options ("Options"). The RSUs and Options were granted subject to stockholder approval of the Issuer's 2026 Equity Incentive Plan at the Issuer's 2026 annual meeting of stockholders on May 4, 2026, as disclosed in the Issuer's Schedule 14A filed with the Securities and Exchange Commission ("SEC") on March 24, 2026.

F2 · derivative.exercise_date: Twenty-five percent of each of the RSUs and Options vest on February 20, 2027 and the balance will vest in twelve (12) substantially equal installments thereafter on each three (3) month anniversary of the initial vesting date, in each case, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date, with accelerated vesting (i) with respect to the Options, in the event of a "change in control" (as defined in the Issuer's 2026 Equity Incentive Plan) in which the options are not assumed or replaced, provided that the Reporting Person has not experienced a termination prior to such "change in control," or (ii) with respect to the Options and the RSUs, in the event that the Reporting Person experiences an "involuntary termination" of employment within 24 months following a "change in control" where such awards are assumed or substituted, subject to an effective release of claims.

SEC source: 0001193125-26-209007 · ownership.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 58,643

F1 · shares: The Reporting Person was conditionally granted time-vested restricted stock units ("RSUs") and non-statutory stock options ("Options"). The RSUs and Options were granted subject to stockholder approval of the Issuer's 2026 Equity Incentive Plan at the Issuer's 2026 annual meeting of stockholders on May 4, 2026, as disclosed in the Issuer's Schedule 14A filed with the Securities and Exchange Commission ("SEC") on March 24, 2026.

F2 · shares: Twenty-five percent of each of the RSUs and Options vest on February 20, 2027 and the balance will vest in twelve (12) substantially equal installments thereafter on each three (3) month anniversary of the initial vesting date, in each case, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date, with accelerated vesting (i) with respect to the Options, in the event of a "change in control" (as defined in the Issuer's 2026 Equity Incentive Plan) in which the options are not assumed or replaced, provided that the Reporting Person has not experienced a termination prior to such "change in control," or (ii) with respect to the Options and the RSUs, in the event that the Reporting Person experiences an "involuntary termination" of employment within 24 months following a "change in control" where such awards are assumed or substituted, subject to an effective release of claims.

SEC source: 0001193125-26-067022 · ownership.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,877

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001104659-25-115425 · tm2531942-1_4seq1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,337

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001104659-25-081888 · tm2524111-1_4seq1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,329

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001104659-25-052002 · tm2515701-7_4seq1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,320

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0000899140-25-000474 · form4.xml · derivative · entry 2

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 93,322

Underlying: Common Stock · 30,300 shares

Expires 2034-03-05

F2 · derivative.exercise_date: Twenty-five percent of the options vest on February 20, 2026 and the balance will vest in twelve (12) substantially equal installments thereafter on each three (3) month anniversary of the initial vesting date, in each case, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date, with accelerated vesting (i) in the event of a "change in control" (as defined in the Issuer's 2012 Equity Incentive Plan) in which the options are not assumed or replaced, or (ii) in the event that the Reporting Person experiences an "involuntary termination" of employment within 24 months following a "change in control," subject to an effective release of claims. The grant was approved by the Compensation Committee of the Board of Directors of the Company.

SEC source: 0000899140-25-000474 · form4.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,312

F1 · shares: The Reporting Person was granted a time-vested restricted stock unit ("RSU"). Twenty-five percent of the shares subject to the RSU vest on February 20, 2026 and the balance will vest in twelve (12) substantially equal installments thereafter on each three (3) month anniversary of the initial vesting date, in each case, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date, with accelerated vesting (i) in the event of a "change in control" (as defined in the Issuer's 2012 Equity Incentive Plan) in which the RSU is not assumed or replaced, or (ii) in the event that the Reporting Person experiences an "involuntary termination" of employment within 24 months following a "change in control," subject to an effective release of claims. The grant was approved by the Compensation Committee of the Board of Directors of the Company.

SEC source: 0000899140-25-000361 · form4.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,374

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001104659-24-122107 · tm2429169-1_4seq1.xml · nonDerivative · entry 2

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 44,939

F2 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001104659-24-122107 · tm2429169-1_4seq1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,915

F1 · shares: Includes 300 shares of common stock acquired under the Innoviva, Inc. Employee Stock Purchase Plan on November 15, 2024.

SEC source: 0001104659-24-091987 · tm2422388-1_4seq1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,615

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0000899140-24-000627 · form4.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,590

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001104659-24-032001 · tm248180-1_4seq1.xml · derivative · entry 2

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 63,022

Underlying: Common Stock · 23,022 shares

Expires 2034-03-05

F2 · derivative.exercise_date: 25% of the options will vest on February 20, 2025 and the balance will vest in twelve (12) substantially equal installments thereafter on each three (3) month anniversary of the initial vesting date, in each case, subject to Ms. Zhen's continuous service through the applicable vesting date, with accelerated vesting (i) in the event of a "change in control" (as defined in the Issuer's 2012 Equity Incentive Plan) in which the options are not assumed or replaced, or (ii) in the event that Ms. Zhen experiences a termination of employment by the Innoviva, Inc. without "cause" or by Ms. Zhen for "good reason" (each as defined in Ms. Zhen's employment agreement) within 24 months following a "change in control," subject to an effective release of claims.

SEC source: 0001104659-24-032001 · tm248180-1_4seq1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,566

F1 · shares: The Reporting Person was granted a one time-based restricted stock unit ("RSU"). Twenty-five percent of the shares subject to the RSU shall vest on February 20, 2025, 6.25% on May 20, 2025, and an additional 6.25% on the final day of each 3-month period thereafter, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date. The grant was approved by the Compensation Committee of the Board of Directors of the Company.

SEC source: 0001104659-24-026714 · tm246891-1_4seq1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,814

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0000899140-23-001120 · form4.xml · nonDerivative · entry 2

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,676

F2 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0000899140-23-001112 · form4.xml · nonDerivative · entry 2

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,158

SEC source: 0000899140-23-001112 · form4.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,563

SEC source: 0000899140-23-001120 · form4.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,460

F1 · shares: Includes 302 shares of common stock acquired under the Innoviva, Inc. Employee Stock Purchase Plan on November 15, 2023.

SEC source: 0000899140-23-000929 · form4.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,152

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0000899140-23-000678 · form4.xml · nonDerivative · entry 2

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,937

F2 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0000899140-23-000678 · form4.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 52,721

F1 · shares: Includes 1,576 shares of common stock acquired under the Innoviva, Inc. Employee Stock Purchase Plan on May 15, 2023.

SEC source: 0000899140-23-000540 · form4.xml · derivative · entry 2

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 20,000 shares

Expires 2033-04-12

F2 · derivative.exercise_date: The Reporting Person was granted options. Twenty-five percent of the options shall vest on February 20, 2024, 6.25% on May 20, 2024, and an additional 6.25% on the final day of each 3-month period thereafter, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date. The grant was approved by the Compensation Committee of the Board of Directors of the Company.

SEC source: 0000899140-23-000540 · form4.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,145

F1 · shares: The Reporting Person was granted a one time-based restricted stock unit ("RSU"). Twenty-five percent of the shares subject to the RSU shall vest on February 20, 2024, 6.25% on May 20, 2024, and an additional 6.25% on the final day of each 3-month period thereafter, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date. The grant was approved by the Compensation Committee of the Board of Directors of the Company.

SEC source: 0001567619-23-003505 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,801

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001567619-22-020775 · doc1.xml · nonDerivative · entry 2

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,653

F2 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001567619-22-020775 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,481

F1 · shares: Includes 433 shares of common stock acquired under the Innoviva, Inc. Employee Stock Purchase Plan on November 15, 2022.

SEC source: 0001567619-22-016563 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,048

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001567619-22-011518 · doc1.xml · nonDerivative · entry 2

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,878

F2 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001567619-22-011518 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,706

F1 · shares: Includes 1,834 shares of common stock acquired under the Innoviva, Inc. Employee Stock Purchase Plan on May 13, 2022.

SEC source: 0001567619-22-006130 · doc1.xml · derivative · entry 2

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 15,000 shares

Expires 2032-02-28

F2 · derivative.exercise_date: The Reporting Person was granted options. Twenty-five percent of the options shall vest on February 20, 2023, 6.25% on May 20, 2023, and an additional 6.25% on the final day of each 3-month period thereafter, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date. The grant was approved by the Compensation Committee of the Board of Directors of the Company.

SEC source: 0001567619-22-006130 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,872

F1 · shares: The Reporting Person was granted a time-based restricted stock award ("RSA"). Twenty-five percent of the shares subject to the RSA shall vest on February 20, 2023, 6.25% on May 20, 2023, and an additional 6.25% on the final day of each 3-month period thereafter, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date. The grant was approved by the Compensation Committee of the Board of Directors of the Company.

SEC source: 0001567619-22-005277 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,181

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001567619-21-020984 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,458

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

F2 · balance_after: Includes 612 shares of common stock acquired under the Innoviva, Inc. Employee Stock Purchase Plan on November 15, 2021.

SEC source: 0001567619-21-016236 · doc1.xml · nonDerivative · entry 3

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,604

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001567619-21-016236 · doc1.xml · nonDerivative · entry 2

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,364

SEC source: 0001567619-21-016263 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,364

F1 · acquired: The Form 4 of the Reporting Person filed with the Securities and Exchange Commission on August 23, 2021 inadvertently indicated in Column 4 of Table I that the sale by the Reporting Person of 1,129 shares of Common Stock of the Issuer on August 20, 2021 was an acquisition "(A)" rather than a disposition "(D)". For the avoidance of doubt, such sale transaction was a disposition "(D)".

SEC source: 0001567619-21-016236 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,493

SEC source: 0001567619-21-011058 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,295

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

F2 · balance_after: Includes 1,655 shares of common stock acquired under the Innoviva, Inc. Employee Stock Purchase Plan on May 15, 2021.

SEC source: 0001567619-21-007207 · doc1.xml · derivative · entry 2

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2031-03-29

F2 · derivative.exercise_date: The Reporting Person was granted options. Twenty-five percent of the options shall vest on February 20, 2022, 6.25% on May 20, 2022, and an additional 6.25% on the final day of each 3-month period thereafter, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date. The grant was approved by the Compensation Committee of the Board of Directors of the Company.

SEC source: 0001567619-21-007207 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,399

F1 · shares: The Reporting Person was granted a time-based restricted stock award ("RSA"). Twenty-five percent of the shares subject to the RSA shall vest on February 20, 2022, 6.25% on May 20, 2022, and an additional 6.25% on the final day of each 3-month period thereafter, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date. The grant was approved by the Compensation Committee of the Board of Directors of the Company.

SEC source: 0001567619-21-004617 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,094

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001567619-20-020225 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,202

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

F2 · balance_after: Includes 757 shares of common stock acquired under the Innoviva, Inc. Employee Stock Purchase Plan (ESPP) on November 15, 2020.

SEC source: 0001567619-20-015897 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,243

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

SEC source: 0001567619-20-011000 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,040

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.

F2 · balance_after: Includes 1,252 shares of common stock acquired under the Innoviva, Inc. Employee Stock Purchase Plan (ESPP) on May 15, 2020.

SEC source: 0001567619-20-004695 · doc1.xml · nonDerivative · entry 2

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,913

F2 · shares: This sale was effected for tax planning purposes.

SEC source: 0001567619-20-004695 · doc1.xml · nonDerivative · entry 1

Zhen Marianne · CIK 0001750085 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,867

F1 · shares: The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants.