Fridriksdottir Hafrun

SEC source: 0001209191-20-009879 · doc4.xml · nonDerivative · entry 2

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,532.514

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

SEC source: 0001209191-20-009879 · doc4.xml · nonDerivative · entry 1

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,682.514

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

SEC source: 0001209191-20-009049 · doc4.xml · derivative · entry 1

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,850

Underlying: Ordinary Shares · 17,850 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

F2 · derivative.exercise_date: Represents restricted share units received upon satisfaction of performance criteria of performance share units. These units remain subject to time-based vesting and will vest on February 14, 2020.

F2 · derivative.expiration_date: Represents restricted share units received upon satisfaction of performance criteria of performance share units. These units remain subject to time-based vesting and will vest on February 14, 2020.

F3 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001209191-20-008164 · doc4.xml · nonDerivative · entry 2

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,329.514

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F3 · kind: The transaction reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · shares: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of the restricted share units listed in Table II.

SEC source: 0001209191-20-008164 · doc4.xml · derivative · entry 3

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,241

Underlying: Ordinary Shares · 16,120 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

F5 · derivative.exercise_date: Restricted share units were granted on February 9, 2018, with 16,120 vesting on each of February 9, 2020 and February 9, 2021 and 16,121 vesting on February 9, 2022.

F5 · derivative.expiration_date: Restricted share units were granted on February 9, 2018, with 16,120 vesting on each of February 9, 2020 and February 9, 2021 and 16,121 vesting on February 9, 2022.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001209191-20-008164 · doc4.xml · nonDerivative · entry 1

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,873.514

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

SEC source: 0001209191-20-000005 · doc4.xml · derivative · entry 3

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 4,640 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

F6 · derivative.exercise_date: Restricted share units were granted on July 1, 2014, with 4,640 vesting on each of December 31, 2018 and December 31, 2019.

F6 · derivative.expiration_date: Restricted share units were granted on July 1, 2014, with 4,640 vesting on each of December 31, 2018 and December 31, 2019.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001209191-20-000005 · doc4.xml · nonDerivative · entry 2

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,753.514

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F3 · kind: The transaction reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · shares: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of the restricted share units listed in Table II.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $9.92 to $9.9238, inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or any security holder of the issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-20-000005 · doc4.xml · nonDerivative · entry 1

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,212.514

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

SEC source: 0001209191-19-058620 · doc4.xml · nonDerivative · entry 2

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,572.514

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F3 · kind: The transaction reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · shares: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of the restricted share units listed in Table II.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.490 to $10.495, inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or any security holder of the issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-19-058620 · doc4.xml · derivative · entry 3

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 8,133 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

F6 · derivative.exercise_date: Restricted share units were granted on November 30, 2016, with 2,711 vesting on November 30, 2018 and 8,133 vesting on November 30, 2019.

F6 · derivative.expiration_date: Restricted share units were granted on November 30, 2016, with 2,711 vesting on November 30, 2018 and 8,133 vesting on November 30, 2019.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001209191-19-058620 · doc4.xml · nonDerivative · entry 1

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,882.514

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

SEC source: 0001209191-19-020157 · doc4.xml · nonDerivative · entry 4

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,749.514

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F3 · kind: The transaction reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · shares: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of the restricted share units listed in Table II.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.5800 to $16.6800, inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or any security holder of the issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-19-020157 · doc4.xml · nonDerivative · entry 3

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,842.514

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F3 · kind: The transaction reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · shares: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of the restricted share units listed in Table II.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.5800 to $16.6800, inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or any security holder of the issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-19-020157 · doc4.xml · derivative · entry 6

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 266

Underlying: Ordinary Shares · 265 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

F7 · derivative.exercise_date: Restricted share units were granted on September 9, 2016, with 265 vesting on each of March 17, 2018 and March 17, 2019 and 266 vesting on March 17, 2020.

F7 · derivative.expiration_date: Restricted share units were granted on September 9, 2016, with 265 vesting on each of March 17, 2018 and March 17, 2019 and 266 vesting on March 17, 2020.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001209191-19-020157 · doc4.xml · derivative · entry 5

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 748

Underlying: Ordinary Shares · 747 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

F6 · derivative.exercise_date: Restricted share units were granted on August 2, 2016, with 747 vesting on each of March 17, 2018 and March 17, 2019 and 748 vesting on March 17, 2020.

F6 · derivative.expiration_date: Restricted share units were granted on August 2, 2016, with 747 vesting on each of March 17, 2018 and March 17, 2019 and 748 vesting on March 17, 2020.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001209191-19-020157 · doc4.xml · nonDerivative · entry 2

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,105.514

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

SEC source: 0001209191-19-020157 · doc4.xml · nonDerivative · entry 1

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,840.514

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

SEC source: 0001209191-19-016085 · doc4.xml · derivative · entry 3

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 1,165 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

F6 · derivative.exercise_date: Restricted share units were granted on March 4, 2015, with 1,165 vesting on each of March 4, 2018 and March 4, 2019.

F6 · derivative.expiration_date: Restricted share units were granted on March 4, 2015, with 1,165 vesting on each of March 4, 2018 and March 4, 2019.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001209191-19-016085 · doc4.xml · nonDerivative · entry 2

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,093.514

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F3 · kind: The transaction reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · shares: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of the restricted share units listed in Table II.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.755 to $17.130, inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or any security holder of the issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-19-016085 · doc4.xml · nonDerivative · entry 1

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,502.514

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

SEC source: 0001209191-19-017230 · doc4.xml · derivative · entry 1

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,716

Underlying: Ordinary Shares · 56,716 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

F2 · derivative.exercise_date: Restricted share units were granted on March 4, 2019, with 18,905 vesting on each of March 4, 2021 and March 4, 2022 and 18,906 vesting on March 4, 2023.

F2 · derivative.expiration_date: Restricted share units were granted on March 4, 2019, with 18,905 vesting on each of March 4, 2021 and March 4, 2022 and 18,906 vesting on March 4, 2023.

F3 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001209191-19-010837 · doc4.xml · derivative · entry 3

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,708

Underlying: Ordinary Shares · 5,353 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

F6 · derivative.exercise_date: Restricted share units were granted on February 14, 2017, with 5,353 vesting on each of February 14, 2019 and February 14, 2020 and 5,355 vesting on February 14, 2021.

F6 · derivative.expiration_date: Restricted share units were granted on February 14, 2017, with 5,353 vesting on each of February 14, 2019 and February 14, 2020 and 5,355 vesting on February 14, 2021.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001209191-19-010837 · doc4.xml · nonDerivative · entry 2

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,337.514

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F3 · kind: The transaction reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · shares: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of the restricted share units listed in Table II.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $17.66 to $17.675, inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or any security holder of the issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-19-010837 · doc4.xml · nonDerivative · entry 1

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,178.514

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

SEC source: 0001209191-19-000609 · doc4.xml · nonDerivative · entry 2

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,825.514

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F3 · kind: The transaction reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · shares: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of the restricted share units listed in Table II.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $15.7 to $15.705, inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or any security holder of the issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-19-000609 · doc4.xml · derivative · entry 3

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,640

Underlying: Ordinary Shares · 4,640 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

F6 · derivative.exercise_date: Restricted share units were granted on July 1, 2014, with 4,640 vesting on each of December 31, 2018 and December 31, 2019.

F6 · derivative.expiration_date: Restricted share units were granted on July 1, 2014, with 4,640 vesting on each of December 31, 2018 and December 31, 2019.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001209191-19-000609 · doc4.xml · nonDerivative · entry 1

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,468.514

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

SEC source: 0001209191-18-060707 · doc4.xml · derivative · entry 3

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,133

Underlying: Ordinary Shares · 2,711 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

F5 · derivative.exercise_date: Restricted share units were granted on November 30, 2016, with 2,711 vesting on November 30, 2018 and 8,133 vesting on November 30, 2019.

F5 · derivative.expiration_date: Restricted share units were granted on November 30, 2016, with 2,711 vesting on November 30, 2018 and 8,133 vesting on November 30, 2019.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001209191-18-060707 · doc4.xml · nonDerivative · entry 2

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,828.514

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F3 · kind: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of the restricted share units listed in Table II.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $21.7600 to $21.7638, inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or any security holder of the issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-18-060707 · doc4.xml · nonDerivative · entry 1

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,761.514

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

SEC source: 0001209191-18-020859 · doc4.xml · nonDerivative · entry 4

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,050.514

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F3 · kind: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of the restricted share units listed in Table II.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $17.83 to $17.925, inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or any security holder of the issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-18-020859 · doc4.xml · nonDerivative · entry 3

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,141.514

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F3 · kind: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of the restricted share units listed in Table II.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $17.83 to $17.925, inclusive. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or any security holder of the issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001209191-18-020859 · doc4.xml · derivative · entry 6

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 531

Underlying: Ordinary Shares · 265 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

F6 · derivative.exercise_date: Restricted share units were granted on September 9, 2016, with 265 vesting on each of March 17, 2018 and March 17, 2019 and 266 vesting on March 17, 2020.

F6 · derivative.expiration_date: Restricted share units were granted on September 9, 2016, with 265 vesting on each of March 17, 2018 and March 17, 2019 and 266 vesting on March 17, 2020.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001209191-18-020859 · doc4.xml · derivative · entry 5

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,495

Underlying: Ordinary Shares · 747 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

F5 · derivative.exercise_date: Restricted share units were granted on August 2, 2016, with 747 vesting on each of March 17, 2018 and March 17, 2019 and 748 vesting on March 17, 2020.

F5 · derivative.expiration_date: Restricted share units were granted on August 2, 2016, with 747 vesting on each of March 17, 2018 and March 17, 2019 and 748 vesting on March 17, 2020.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001209191-18-020859 · doc4.xml · nonDerivative · entry 2

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,398.514

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

SEC source: 0001209191-18-020859 · doc4.xml · nonDerivative · entry 1

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,133.514

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

SEC source: 0001209191-18-017207 · doc4.xml · derivative · entry 6

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 3,432 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

F4 · derivative.exercise_date: Restricted share units were granted on May 8, 2014 and vest on March 5, 2018.

F4 · derivative.expiration_date: Restricted share units were granted on May 8, 2014 and vest on March 5, 2018.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001209191-18-017207 · doc4.xml · nonDerivative · entry 4

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,386.514

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001209191-18-017207 · doc4.xml · nonDerivative · entry 3

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,541.514

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001209191-18-017207 · doc4.xml · nonDerivative · entry 2

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,941.514

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

SEC source: 0001209191-18-017207 · doc4.xml · derivative · entry 5

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,165

Underlying: Ordinary Shares · 1,165 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

F3 · derivative.exercise_date: Restricted share units were granted on March 4, 2015, with 1,165 vesting on each of March 4, 2018 and March 4, 2019.

F3 · derivative.expiration_date: Restricted share units were granted on March 4, 2015, with 1,165 vesting on each of March 4, 2018 and March 4, 2019.

F1 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001209191-18-017207 · doc4.xml · nonDerivative · entry 1

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,509.514

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

F2 · price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

SEC source: 0001209191-18-009186 · doc4.xml · derivative · entry 2

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,361

Underlying: Ordinary Shares · 48,361 shares

Expires not disclosed

F3 · derivative.exercise_price: Each restricted share unit represents a contingent right to receive, at settlement, one ordinary share or, at the option of the Human Resources and Compensation Committee, the cash value of one ordinary share.

F4 · derivative.exercise_date: Restricted share units were granted on February 9, 2018, with 16,120 vesting on each of February 9, 2020 and February 9, 2021 and 16,121 vesting on February 9, 2022.

F4 · derivative.expiration_date: Restricted share units were granted on February 9, 2018, with 16,120 vesting on each of February 9, 2020 and February 9, 2021 and 16,121 vesting on February 9, 2022.

F2 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.

SEC source: 0001209191-18-009186 · doc4.xml · derivative · entry 1

Fridriksdottir Hafrun · CIK 0001561458 · Executive VP, Global R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 123,288

Underlying: Ordinary Shares · 123,288 shares

Expires 2028-02-08

F1 · derivative.exercise_date: Stock options were granted on February 9, 2018, with 41,096 vesting on each of February 9, 2020, February 9, 2021 and February 9, 2022.

F2 · derivative.underlying: The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.