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person · Reporting owner

O'NEIL PATRICK R.

Disclosed activity across 1 company

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1184
SEC CIK
0001564926

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Reported relationships

Latest disclosed role at each company.

CompanyLast reported asReport datePublished
IONIS PHARMACEUTICALS INCIONS · Entity 1182EVP CLO & General CounselAugust 31, 2026September 03, 2026

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

IONIS PHARMACEUTICALS INC

Report date August 31, 2026 · Filed September 03, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Common StockSEC Table I · non-derivativeDirect59,205 Reported balance After 2026-08-31 transaction · row 1
1 source row

Row 1 · 2026-08-31 · Other · Acquired 63 · Balance 59,205

F1: Reporting shares purchased under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on August 31, 2026. These shares may not be sold until February 28, 2027.

Filing footnotes · ownership attribution and instrument terms

F1: Reporting shares purchased under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on August 31, 2026. These shares may not be sold until February 28, 2027.

Transaction history

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateCompanyActivity / securityShares / unitsReported priceReported valueDetails
February 05, 2019 Filed Feb 5, 2019 23:05 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionEmployee Stock Option (right to buy) · Derivative 15,600 $0.00 Strike: $39.87 $0.00
Disclosure

SEC source: 0000874015-19-000034 · edgar.xml · derivative · entry 6

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,275

Underlying: Common Stock · 15,600 shares

Expires 2021-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 05, 2019 Filed Feb 5, 2019 23:05 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 SaleCommon Stock 15,600 $59.50 $928,200.00
Disclosure

SEC source: 0000874015-19-000034 · edgar.xml · nonDerivative · entry 4

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,673

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F1 · price: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

Read SEC document
February 05, 2019 Filed Feb 5, 2019 23:05 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 15,600 $39.87 $621,972.00
Disclosure

SEC source: 0000874015-19-000034 · edgar.xml · nonDerivative · entry 3

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,273

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

Read SEC document
February 01, 2019 Filed Feb 5, 2019 23:05 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionEmployee Stock Option (right to buy) · Derivative 4,000 $0.00 Strike: $39.87 $0.00
Disclosure

SEC source: 0000874015-19-000034 · edgar.xml · derivative · entry 5

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,875

Underlying: Common Stock · 4,000 shares

Expires 2021-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 01, 2019 Filed Feb 5, 2019 23:05 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 SaleCommon Stock 4,000 $58.29 $233,160.00
Disclosure

SEC source: 0000874015-19-000034 · edgar.xml · nonDerivative · entry 2

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,673

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F1 · price: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

Read SEC document
February 01, 2019 Filed Feb 5, 2019 23:05 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 4,000 $39.87 $159,480.00
Disclosure

SEC source: 0000874015-19-000034 · edgar.xml · nonDerivative · entry 1

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,673

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 8/29/2018.

Read SEC document
January 15, 2019 Filed Jan 18, 2019 00:24 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 7,823 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000020 · edgar.xml · derivative · entry 4

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,466

Underlying: Common Stock · 7,823 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F5 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F5 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
January 15, 2019 Filed Jan 18, 2019 00:24 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantRestricted Stock Units · Derivative 22,131 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000020 · edgar.xml · derivative · entry 3

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,131

Underlying: Common Stock · 22,131 shares

Expires not disclosed

F3 · derivative.exercise_price: Grant to reporting person of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan.

F4 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F5 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F5 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

Read SEC document
January 15, 2019 Filed Jan 18, 2019 00:24 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Tax withholdingCommon Stock 2,734 $58.26 $159,282.84
Disclosure

SEC source: 0000874015-19-000020 · edgar.xml · nonDerivative · entry 2

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,607

F2 · kind: Shares withheld to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice.

F2 · shares: Shares withheld to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice.

Read SEC document
January 15, 2019 Filed Jan 18, 2019 00:24 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 7,823 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000020 · edgar.xml · nonDerivative · entry 1

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,341

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
January 03, 2019 Filed Jan 4, 2019 00:50 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionEmployee Stock Option (right to buy) · Derivative 4,000 $0.00 Strike: $39.87 $0.00
Disclosure

SEC source: 0000874015-19-000014 · edgar.xml · derivative · entry 8

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,875

Underlying: Common Stock · 4,000 shares

Expires 2021-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 03, 2019 Filed Jan 4, 2019 00:50 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionEmpoyee Stock Option (right to buy) · Derivative 400 $0.00 Strike: $10.82 $0.00
Disclosure

SEC source: 0000874015-19-000014 · edgar.xml · derivative · entry 7

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 400 shares

Expires 2020-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 03, 2019 Filed Jan 4, 2019 00:50 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 SaleCommon Stock 4,000 $54.80 $219,200.00
Disclosure

SEC source: 0000874015-19-000014 · edgar.xml · nonDerivative · entry 5

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,584

F3 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 08/29/18.

F3 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 08/29/18.

Read SEC document
January 03, 2019 Filed Jan 4, 2019 00:50 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 4,000 $39.87 $159,480.00
Disclosure

SEC source: 0000874015-19-000014 · edgar.xml · nonDerivative · entry 4

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,584

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 08/29/18.

F3 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 08/29/18.

Read SEC document
January 03, 2019 Filed Jan 4, 2019 00:50 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 SaleCommon Stock 400 $54.80 $21,920.00
Disclosure

SEC source: 0000874015-19-000014 · edgar.xml · nonDerivative · entry 3

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,584

F3 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 08/29/18.

F3 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 08/29/18.

Read SEC document
January 03, 2019 Filed Jan 4, 2019 00:50 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 400 $10.82 $4,328.00
Disclosure

SEC source: 0000874015-19-000014 · edgar.xml · nonDerivative · entry 2

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,984

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 08/29/18.

F3 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 08/29/18.

Read SEC document
January 02, 2019 Filed Jan 4, 2019 00:50 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantEmployee Stock Option (right to buy) · Derivative 49,800 $0.00 Strike: $53.77 $0.00
Disclosure

SEC source: 0000874015-19-000014 · edgar.xml · derivative · entry 6

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 49,800

Underlying: Common Stock · 49,800 shares

Expires 2026-01-01

F2 · derivative.exercise_date: Grant of 01/02/2019 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan. 25% of the shares subject to the option vest and become exercisable on 01/02/2020. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments over the next 3 years. Following this transaction, the option was exercisable as to 0 on 01/02/2019.

Read SEC document
January 01, 2019 Filed Jan 4, 2019 00:50 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 OtherCommon Stock 66 $36.45 $2,405.57
Disclosure

SEC source: 0000874015-19-000014 · edgar.xml · nonDerivative · entry 1

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,584

F1 · kind: Reporting shares acquired under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on January 1, 2019. These shares may not be sold until July 2, 2019.

F1 · shares: Reporting shares acquired under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on January 1, 2019. These shares may not be sold until July 2, 2019.

Read SEC document
July 01, 2018 Filed Jul 3, 2018 19:28 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 OtherCommon Stock 66 $35.42 $2,337.69
Disclosure

SEC source: 0000874015-18-000089 · edgar.xml · nonDerivative · entry 1

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,518

F1 · kind: Reporting 66 shares acquired under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on July 1, 2018. These 66 shares may not be sold until January 2, 2019.

F1 · shares: Reporting 66 shares acquired under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on July 1, 2018. These 66 shares may not be sold until January 2, 2019.

Read SEC document
March 12, 2018 Filed Mar 14, 2018 01:14 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionEmployee Stock Option (right to buy) · Derivative 1,000 $0.00 Strike: $10.82 $0.00
Disclosure

SEC source: 0000874015-18-000051 · edgar.xml · derivative · entry 3

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 400

Underlying: Common Stock · 1,000 shares

Expires 2020-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
March 12, 2018 Filed Mar 14, 2018 01:14 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 SaleCommon Stock 1,000 $55.00 $55,000.00
Disclosure

SEC source: 0000874015-18-000051 · edgar.xml · nonDerivative · entry 2

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,452

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

Read SEC document
March 12, 2018 Filed Mar 14, 2018 01:14 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 1,000 $10.82 $10,820.00
Disclosure

SEC source: 0000874015-18-000051 · edgar.xml · nonDerivative · entry 1

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,452

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

Read SEC document
January 29, 2018 Filed Jan 31, 2018 21:16 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionEmployee Stock Option (right to buy) · Derivative 300 $0.00 Strike: $10.82 $0.00
Disclosure

SEC source: 0000874015-18-000034 · edgar.xml · derivative · entry 6

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,400

Underlying: Common Stock · 300 shares

Expires 2020-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 29, 2018 Filed Jan 31, 2018 21:16 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionEmployee Stock Option (right to buy) · Derivative 55 $0.00 Strike: $10.82 $0.00
Disclosure

SEC source: 0000874015-18-000034 · edgar.xml · derivative · entry 5

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 55 shares

Expires 2020-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 29, 2018 Filed Jan 31, 2018 21:16 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 SaleCommon Stock 300 $55.00 $16,500.00
Disclosure

SEC source: 0000874015-18-000034 · edgar.xml · nonDerivative · entry 4

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,452

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

Read SEC document
January 29, 2018 Filed Jan 31, 2018 21:16 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 300 $10.82 $3,246.00
Disclosure

SEC source: 0000874015-18-000034 · edgar.xml · nonDerivative · entry 3

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,752

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

Read SEC document
January 29, 2018 Filed Jan 31, 2018 21:16 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 SaleCommon Stock 55 $55.00 $3,025.00
Disclosure

SEC source: 0000874015-18-000034 · edgar.xml · nonDerivative · entry 2

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,452

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

Read SEC document
January 29, 2018 Filed Jan 31, 2018 21:16 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 55 $10.82 $595.10
Disclosure

SEC source: 0000874015-18-000034 · edgar.xml · nonDerivative · entry 1

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,507

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

Read SEC document
January 25, 2018 Filed Jan 29, 2018 21:08 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionEmployee Stock Option (right to buy) · Derivative 645 $0.00 Strike: $10.82 $0.00
Disclosure

SEC source: 0000874015-18-000029 · edgar.xml · derivative · entry 3

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55

Underlying: Common Stock · 645 shares

Expires 2020-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 25, 2018 Filed Jan 29, 2018 21:08 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 SaleCommon Stock 645 $55.00 $35,475.00
Disclosure

SEC source: 0000874015-18-000029 · edgar.xml · nonDerivative · entry 2

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,452

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

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January 25, 2018 Filed Jan 29, 2018 21:08 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 645 $10.82 $6,978.90
Disclosure

SEC source: 0000874015-18-000029 · edgar.xml · nonDerivative · entry 1

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,097

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

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January 16, 2018 Filed Jan 18, 2018 02:25 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 SaleCommon Stock 2,697 $51.76 $139,596.72
Disclosure

SEC source: 0000874015-18-000021 · edgar.xml · nonDerivative · entry 2

O'NEIL PATRICK R. · CIK 0001564926 · SVP, Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,452

F2 · kind: The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice.

F2 · shares: The sale was made pursuant to an automatic sale to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $51.759 to $51.761, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) on this Form 4.

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January 15, 2018 Filed Jan 18, 2018 02:25 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionRestricted Stock Units · Derivative 6,663 $0.00 $0.00
Disclosure

SEC source: 0000874015-18-000021 · edgar.xml · derivative · entry 4

O'NEIL PATRICK R. · CIK 0001564926 · SVP, Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,148

Underlying: Common Stock · 6,663 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F5 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F5 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

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January 15, 2018 Filed Jan 18, 2018 02:25 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantRestricted Stock Units · Derivative 12,141 $0.00 $0.00
Disclosure

SEC source: 0000874015-18-000021 · edgar.xml · derivative · entry 3

O'NEIL PATRICK R. · CIK 0001564926 · SVP, Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,141

Underlying: Common Stock · 12,141 shares

Expires not disclosed

F4 · derivative.exercise_price: Grant to reporting person of Restricted Stock Units under the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan.

F6 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F5 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F5 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

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January 15, 2018 Filed Jan 18, 2018 02:25 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 6,663 $0.00 $0.00
Disclosure

SEC source: 0000874015-18-000021 · edgar.xml · nonDerivative · entry 1

O'NEIL PATRICK R. · CIK 0001564926 · SVP, Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,149

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

Read SEC document
January 02, 2018 Filed Jan 3, 2018 01:50 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 GrantEmployee Stock Option (right to buy) · Derivative 54,638 $0.00 Strike: $49.25 $0.00
Disclosure

SEC source: 0000874015-18-000008 · edgar.xml · derivative · entry 2

O'NEIL PATRICK R. · CIK 0001564926 · SVP, Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 54,638

Underlying: Common Stock · 54,638 shares

Expires 2025-01-01

F2 · derivative.exercise_date: Grant of 1/2/2018 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan. 25% of the shares subject to the option vest and become exercisable on 1/2/2019. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 13,660 shares per year. Following this transaction, the option was exercisable as to 0 on 1/2/2018.

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January 01, 2018 Filed Jan 3, 2018 01:50 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 OtherCommon Stock 53 $42.76 $2,266.02
Disclosure

SEC source: 0000874015-18-000008 · edgar.xml · nonDerivative · entry 1

O'NEIL PATRICK R. · CIK 0001564926 · SVP, Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,486

F1 · kind: Reporting 53 shares acquired under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on January 1, 2018. These 53 shares may not be sold until July 2, 2018.

F1 · shares: Reporting 53 shares acquired under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on January 1, 2018. These 53 shares may not be sold until July 2, 2018.

Read SEC document
December 01, 2017 Filed Dec 2, 2017 00:03 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionEmployee Stock Option (right to buy) · Derivative 1,000 $0.00 Strike: $10.82 $0.00
Disclosure

SEC source: 0000874015-17-000069 · edgar.xml · derivative · entry 3

O'NEIL PATRICK R. · CIK 0001564926 · SVP, Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 700

Underlying: Common Stock · 1,000 shares

Expires 2020-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 01, 2017 Filed Dec 2, 2017 00:03 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 SaleCommon Stock 1,000 $55.50 $55,500.00
Disclosure

SEC source: 0000874015-17-000069 · edgar.xml · nonDerivative · entry 2

O'NEIL PATRICK R. · CIK 0001564926 · SVP, Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,433

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $55.45 to $55.55, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.

Read SEC document
December 01, 2017 Filed Dec 2, 2017 00:03 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 1,000 $10.82 $10,820.00
Disclosure

SEC source: 0000874015-17-000069 · edgar.xml · nonDerivative · entry 1

O'NEIL PATRICK R. · CIK 0001564926 · SVP, Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,433

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

Read SEC document
November 01, 2017 Filed Nov 3, 2017 21:20 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionEmployee Stock Option (right to buy) · Derivative 1,000 $0.00 Strike: $10.82 $0.00
Disclosure

SEC source: 0000874015-17-000065 · edgar.xml · derivative · entry 3

O'NEIL PATRICK R. · CIK 0001564926 · SVP, Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,700

Underlying: Common Stock · 1,000 shares

Expires 2020-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 01, 2017 Filed Nov 3, 2017 21:20 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 SaleCommon Stock 1,000 $58.35 $58,350.00
Disclosure

SEC source: 0000874015-17-000065 · edgar.xml · nonDerivative · entry 2

O'NEIL PATRICK R. · CIK 0001564926 · SVP, Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,433

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $58.20 to $58.50, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.

Read SEC document
November 01, 2017 Filed Nov 3, 2017 21:20 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 1,000 $10.82 $10,820.00
Disclosure

SEC source: 0000874015-17-000065 · edgar.xml · nonDerivative · entry 1

O'NEIL PATRICK R. · CIK 0001564926 · SVP, Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,433

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

Read SEC document
October 05, 2017 Filed Oct 6, 2017 20:41 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionEmployee Stock Option (right to buy) · Derivative 800 $0.00 Strike: $10.82 $0.00
Disclosure

SEC source: 0000874015-17-000060 · edgar.xml · derivative · entry 6

O'NEIL PATRICK R. · CIK 0001564926 · SVP, Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,700

Underlying: Common Stock · 800 shares

Expires 2020-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
October 05, 2017 Filed Oct 6, 2017 20:41 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionEmployee Stock Option (right to buy) · Derivative 200 $0.00 Strike: $7.25 $0.00
Disclosure

SEC source: 0000874015-17-000060 · edgar.xml · derivative · entry 5

O'NEIL PATRICK R. · CIK 0001564926 · SVP, Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 200 shares

Expires 2019-01-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
October 05, 2017 Filed Oct 6, 2017 20:41 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 SaleCommon Stock 800 $55.00 $44,000.00
Disclosure

SEC source: 0000874015-17-000060 · edgar.xml · nonDerivative · entry 4

O'NEIL PATRICK R. · CIK 0001564926 · SVP, Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,433

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

Read SEC document
October 05, 2017 Filed Oct 6, 2017 20:41 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 800 $10.82 $8,656.00
Disclosure

SEC source: 0000874015-17-000060 · edgar.xml · nonDerivative · entry 3

O'NEIL PATRICK R. · CIK 0001564926 · SVP, Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,233

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

Read SEC document
October 05, 2017 Filed Oct 6, 2017 20:41 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 SaleCommon Stock 200 $55.00 $11,000.00
Disclosure

SEC source: 0000874015-17-000060 · edgar.xml · nonDerivative · entry 2

O'NEIL PATRICK R. · CIK 0001564926 · SVP, Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,433

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

Read SEC document
October 05, 2017 Filed Oct 6, 2017 20:41 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionCommon Stock 200 $7.25 $1,450.00
Disclosure

SEC source: 0000874015-17-000060 · edgar.xml · nonDerivative · entry 1

O'NEIL PATRICK R. · CIK 0001564926 · SVP, Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,633

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 6/30/2017.

Read SEC document
September 06, 2017 Filed Sep 8, 2017 00:23 UTC IONIS PHARMACEUTICALS INC IONS · Entity 1182 Exercise / conversionEmployee Stock Option (right to buy) · Derivative 800 $0.00 Strike: $7.25 $0.00
Disclosure

SEC source: 0001140361-17-034864 · form4.xml · derivative · entry 6

O'NEIL PATRICK R. · CIK 0001564926 · SVP, Legal and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200

Underlying: CommonStock · 800 shares

Expires 2019-01-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.