tapewire.
TapewireAll managers ↗

Institutional portfolios / 13F

5AM Venture Management, LLC

A closer look at the portfolio, one quarter at a time.

Export portfolio ↓ Export quarterly changes ↓

Portfolio snapshot

Q2 2026

Reported portfolio value
$287,891,952
As of June 30, 2026
Positions
16
Across disclosed securities
Top 5 weight
52.1%
Share of reported value

View SEC filing · Published 2026-08-14 20:56 UTC

Inside the portfolio

Reported holdings

By portfolio value ↓

Quarterly comparison unavailable: complete reports and corporate-action evidence are required. Reported holdings remain available below.

SecurityShares / principalReported valueWeightAdjusted quarterly change
MAPLIGHT THERAPEUTICS INCCOM · MPLT
Holding details

Reported CUSIP: 56565P103

Issuer filings on SEC

Reported row 8 · 0001799883-26-000003

Quarterly change unavailable. Security identity or split coverage is incomplete.

 950,011 SH $34,048,394 11.83%11.83% —Comparison unavailable
TYRA BIOSCIENCES INCCOM · TYRA
Holding details

Reported CUSIP: 90240B106

Issuer filings on SEC

Reported row 15 · 0001799883-26-000003

Quarterly change unavailable. Security identity or split coverage is incomplete.

 1,029,298 SH $32,875,778 11.42%11.42% —Comparison unavailable
ENTRADA THERAPEUTICS INCCOM · TRDA
Holding details

Reported CUSIP: 29384C108

Issuer filings on SEC

Reported row 6 · 0001799883-26-000003

Quarterly change unavailable. Security identity or split coverage is incomplete.

 4,056,379 SH $29,854,949 10.37%10.37% —Comparison unavailable
PHARVARIS N VCOM · PHVS
Holding details

Reported CUSIP: N69605108

Issuer filings on SEC

Reported row 9 · 0001799883-26-000003

Quarterly change unavailable. Security identity or split coverage is incomplete.

 797,600 SH $27,581,008 9.58%9.58% —Comparison unavailable
CAMP4 THERAPEUTICS CORPCOM · CAMP
Holding details

Reported CUSIP: 13463J101

Issuer filings on SEC

Reported row 4 · 0001799883-26-000003

Quarterly change unavailable. Security identity or split coverage is incomplete.

 5,869,091 SH $25,647,928 8.91%8.91% —Comparison unavailable
ARTIVA BIOTHERAPEUTICS INCCOM · ARTV
Holding details

Reported CUSIP: 04317A107

Issuer filings on SEC

Reported row 2 · 0001799883-26-000003

Quarterly change unavailable. Security identity or split coverage is incomplete.

 2,353,304 SH $22,827,049 7.93%7.93% —Comparison unavailable
TECTONIC THERAPEUTIC INCCOM · TECX
Holding details

Reported CUSIP: 878972108

Issuer filings on SEC

Reported row 14 · 0001799883-26-000003

Quarterly change unavailable. Security identity or split coverage is incomplete.

 606,660 SH $20,853,938 7.24%7.24% —Comparison unavailable
ZENTALIS PHARMACEUTICALS INCCOM · ZNTL
Holding details

Reported CUSIP: 98943L107

Issuer filings on SEC

Reported row 16 · 0001799883-26-000003

Quarterly change unavailable. Security identity or split coverage is incomplete.

 3,947,913 SH $19,147,378 6.65%6.65% —Comparison unavailable
CELLDEX THERAPEUTICS INC NEWCOM NEW · CLDX
Holding details

Reported CUSIP: 15117B202

Issuer filings on SEC

Reported row 5 · 0001799883-26-000003

Quarterly change unavailable. Security identity or split coverage is incomplete.

 497,270 SH $18,503,417 6.43%6.43% —Comparison unavailable
EYEPOINT INCCOM NEW · EYPT
Holding details

Reported CUSIP: 30233G209

Issuer filings on SEC

Reported row 7 · 0001799883-26-000003

Quarterly change unavailable. Security identity or split coverage is incomplete.

 1,050,000 SH $15,015,000 5.22%5.22% —Comparison unavailable
BIOHAVEN LTDCOM · BHVN
Holding details

Reported CUSIP: G1110E107

Issuer filings on SEC

Reported row 3 · 0001799883-26-000003

Quarterly change unavailable. Security identity or split coverage is incomplete.

 738,972 SH $10,995,903 3.82%3.82% —Comparison unavailable
SURROZEN INCCOM NEW · SRZN
Holding details

Reported CUSIP: 86889P208

Issuer filings on SEC

Reported row 13 · 0001799883-26-000003

Quarterly change unavailable. Security identity or split coverage is incomplete.

 271,250 SH $7,038,938 2.44%2.44% —Comparison unavailable
SKYE BIOSCIENCE INCCOM NEW · SKYE
Holding details

Reported CUSIP: 83086J200

Issuer filings on SEC

Reported row 12 · 0001799883-26-000003

Quarterly change unavailable. Security identity or split coverage is incomplete.

 9,681,763 SH $6,712,366 2.33%2.33% —Comparison unavailable
ALX ONCOLOGY HLDGS INCCOM · ALXO
Holding details

Reported CUSIP: 00166B105

Issuer filings on SEC

Reported row 1 · 0001799883-26-000003

Quarterly change unavailable. Security identity or split coverage is incomplete.

 3,057,325 SH $6,328,663 2.20%2.20% —Comparison unavailable
PROTARA THERAPEUTICS INCCOM STK · TARA
Holding details

Reported CUSIP: 74365U107

Issuer filings on SEC

Reported row 10 · 0001799883-26-000003

Quarterly change unavailable. Security identity or split coverage is incomplete.

 1,369,782 SH $5,232,567 1.82%1.82% —Comparison unavailable
SILENCE THERAPEUTICS PLCADS · SLN
Holding details

Reported CUSIP: 82686Q101

Issuer filings on SEC

Reported row 11 · 0001799883-26-000003

Quarterly change unavailable. Security identity or split coverage is incomplete.

 476,200 SH $5,228,676 1.82%1.82% —Comparison unavailable