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Nasdaq · USD

ZYME

Zymeworks Inc.

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Tapewire entity
4458
SEC CIK
0001937653
Parsed reports
119

Last 12 months

Inside the activity.

0 purchase rows · 11 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202500
Dec 202501
Jan 202609
Feb 202600
Mar 202600
Apr 202600
May 202600
Jun 202600
Jul 202600
Aug 202600
Sep 202600
Oct 202601

Latest available

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
October 09, 2026 Filed Oct 9, 2026 22:28 UTC
Schayowitz AdamEVP, Head of R&D
Exercise / conversionRestricted Stock Unit · Derivative 37,037 $0.00 $0.00
Disclosure

SEC source: 0002127119-26-000006 · wk-form4_1791584905.xml · derivative · entry 3

Schayowitz Adam · CIK 0002127119 · EVP, Head of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 74,074

Underlying: Common Stock · 37,037 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of common stock.

F5 · derivative.exercise_date: Restricted stock units ("RSUs") granted October 9, 2025; vest in three equal annual installments beginning October 9, 2026.

F5 · derivative.expiration_date: Restricted stock units ("RSUs") granted October 9, 2025; vest in three equal annual installments beginning October 9, 2026.

Read SEC document
October 09, 2026 Filed Oct 9, 2026 22:28 UTC
Schayowitz AdamEVP, Head of R&D
SaleCommon Stock 13,832 $25.85 $357,557.20
Disclosure

SEC source: 0002127119-26-000006 · wk-form4_1791584905.xml · nonDerivative · entry 2

Schayowitz Adam · CIK 0002127119 · EVP, Head of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,205

F2 · kind: Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $25.85 to $25.88, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

Read SEC document
October 09, 2026 Filed Oct 9, 2026 22:28 UTC
Schayowitz AdamEVP, Head of R&D
Exercise / conversionCommon Stock 37,037 $0.00 $0.00
Disclosure

SEC source: 0002127119-26-000006 · wk-form4_1791584905.xml · nonDerivative · entry 1

Schayowitz Adam · CIK 0002127119 · EVP, Head of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,037

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Represents shares of common stock issued upon vesting of one third of the restricted stock units ("RSUs") granted on October 9, 2025.

Read SEC document
July 06, 2026 Filed Jul 6, 2026 21:29 UTC
Hollywood MarkEVP & Chief Operating Officer
GrantCommon Stock 939 $22.22 $20,864.58
Disclosure

SEC source: 0002104446-26-000009 · wk-form4_1783373362.xml · nonDerivative · entry 1

Hollywood Mark · CIK 0002104446 · EVP & Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 133,852

F1 · kind: The shares were acquired under the Issuer's Employee Stock Purchase Plan (the "ESPP") for the ESPP purchase period of January 1, 2026 to June 30, 2026.

F2 · price: The purchase price reflects a 15% discount to the closing price of the Issuer's Common Stock on June 30, 2026 pursuant to the provisions of the ESPP.

Read SEC document
May 13, 2026 Filed May 15, 2026 21:00 UTC
Schneider Paul REVP, General Counsel
GrantRestricted Stock Unit · Derivative 119,000 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-227140 · ownership.xml · derivative · entry 2

Schneider Paul R · CIK 0001455484 · EVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 119,000

Underlying: Common Stock · 119,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F3 · derivative.exercise_date: RSUs vest in four equal annual installments beginning on first anniversary of grant date.

F3 · derivative.expiration_date: RSUs vest in four equal annual installments beginning on first anniversary of grant date.

Read SEC document
May 13, 2026 Filed May 15, 2026 21:00 UTC
Schneider Paul REVP, General Counsel
GrantStock Option (Right to Buy) · Derivative 178,000 $0.00 Strike: $24.57 $0.00
Disclosure

SEC source: 0001193125-26-227140 · ownership.xml · derivative · entry 1

Schneider Paul R · CIK 0001455484 · EVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 178,000

Underlying: Common Stock · 178,000 shares

Expires 2036-05-12

F1 · derivative.exercise_date: Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date.

Read SEC document
April 09, 2026 Filed Apr 10, 2026 20:10 UTC
Platshon ScottEVP, Chief Business Officer
GrantPerformance Stock Unit · Derivative 76,000 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-151264 · ownership.xml · derivative · entry 3

Platshon Scott · CIK 0001816539 · EVP, Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 76,000

Underlying: Common Stock · 76,000 shares

Expires not disclosed

F4 · derivative.exercise_price: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return ("TSR") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 38,000 PSUs ("Target Number") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index.

F5 · derivative.exercise_price: (Continued from footnote 4) The PSUs will only vest at the end of the three-year performance period if the Reporting Person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals, except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control).

F4 · derivative.exercise_date: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return ("TSR") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 38,000 PSUs ("Target Number") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index.

F5 · derivative.exercise_date: (Continued from footnote 4) The PSUs will only vest at the end of the three-year performance period if the Reporting Person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals, except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control).

F4 · derivative.expiration_date: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return ("TSR") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 38,000 PSUs ("Target Number") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index.

F5 · derivative.expiration_date: (Continued from footnote 4) The PSUs will only vest at the end of the three-year performance period if the Reporting Person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals, except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control).

Read SEC document
April 09, 2026 Filed Apr 10, 2026 20:10 UTC
Platshon ScottEVP, Chief Business Officer
GrantRestricted Stock Unit · Derivative 47,000 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-151264 · ownership.xml · derivative · entry 2

Platshon Scott · CIK 0001816539 · EVP, Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,000

Underlying: Common Stock · 47,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F3 · derivative.exercise_date: RSUs vest in four equal annual installments beginning on first anniversary of grant date.

F3 · derivative.expiration_date: RSUs vest in four equal annual installments beginning on first anniversary of grant date.

Read SEC document
April 09, 2026 Filed Apr 10, 2026 20:10 UTC
Platshon ScottEVP, Chief Business Officer
GrantStock Option (Right to Buy) · Derivative 70,000 $0.00 Strike: $27.35 $0.00
Disclosure

SEC source: 0001193125-26-151264 · ownership.xml · derivative · entry 1

Platshon Scott · CIK 0001816539 · EVP, Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,000

Underlying: Common Stock · 70,000 shares

Expires 2036-04-08

F1 · derivative.exercise_date: Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date.

Read SEC document
April 09, 2026 Filed Apr 10, 2026 20:10 UTC
Schayowitz AdamSee Remarks
GrantPerformance Stock Unit · Derivative 76,000 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-151265 · ownership.xml · derivative · entry 3

Schayowitz Adam · CIK 0002127119 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 76,000

Underlying: Common Stock · 76,000 shares

Expires not disclosed

F4 · derivative.exercise_price: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return ("TSR") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 38,000 PSUs ("Target Number") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index.

F5 · derivative.exercise_price: (Continued from footnote 1) The PSUs will only vest at the end of the three-year performance period if the Reporting Person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals, except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control).

F4 · derivative.exercise_date: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return ("TSR") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 38,000 PSUs ("Target Number") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index.

F5 · derivative.exercise_date: (Continued from footnote 1) The PSUs will only vest at the end of the three-year performance period if the Reporting Person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals, except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control).

F4 · derivative.expiration_date: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return ("TSR") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 38,000 PSUs ("Target Number") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index.

F5 · derivative.expiration_date: (Continued from footnote 1) The PSUs will only vest at the end of the three-year performance period if the Reporting Person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals, except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control).

Read SEC document
April 09, 2026 Filed Apr 10, 2026 20:10 UTC
Schayowitz AdamSee Remarks
GrantRestricted Stock Unit · Derivative 47,000 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-151265 · ownership.xml · derivative · entry 2

Schayowitz Adam · CIK 0002127119 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,000

Underlying: Common Stock · 47,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F3 · derivative.exercise_date: RSUs vest in four equal annual installments beginning on first anniversary of grant date.

F3 · derivative.expiration_date: RSUs vest in four equal annual installments beginning on first anniversary of grant date.

Read SEC document
April 09, 2026 Filed Apr 10, 2026 20:10 UTC
Schayowitz AdamSee Remarks
GrantStock Option (Right to Buy) · Derivative 70,000 $0.00 Strike: $27.35 $0.00
Disclosure

SEC source: 0001193125-26-151265 · ownership.xml · derivative · entry 1

Schayowitz Adam · CIK 0002127119 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,000

Underlying: Common Stock · 70,000 shares

Expires 2036-04-08

F1 · derivative.exercise_date: Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date.

Read SEC document
April 06, 2026 Filed Apr 7, 2026 18:24 UTC
Stafford KristinEVP, Chief Financial Officer
GrantRestricted Stock Unit · Derivative 50,000 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-145305 · ownership.xml · derivative · entry 3

Stafford Kristin · CIK 0001970438 · EVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F4 · derivative.exercise_date: RSUs vest in three equal annual installments beginning on first anniversary of grant date.

F4 · derivative.expiration_date: RSUs vest in three equal annual installments beginning on first anniversary of grant date.

Read SEC document
April 06, 2026 Filed Apr 7, 2026 18:24 UTC
Stafford KristinEVP, Chief Financial Officer
GrantRestricted Stock Unit · Derivative 119,000 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-145305 · ownership.xml · derivative · entry 2

Stafford Kristin · CIK 0001970438 · EVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 119,000

Underlying: Common Stock · 119,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F3 · derivative.exercise_date: RSUs vest in four equal annual installments beginning on first anniversary of grant date.

F3 · derivative.expiration_date: RSUs vest in four equal annual installments beginning on first anniversary of grant date.

Read SEC document
April 06, 2026 Filed Apr 7, 2026 18:24 UTC
Stafford KristinEVP, Chief Financial Officer
GrantStock Option (Right to Buy) · Derivative 178,000 $0.00 Strike: $25.84 $0.00
Disclosure

SEC source: 0001193125-26-145305 · ownership.xml · derivative · entry 1

Stafford Kristin · CIK 0001970438 · EVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 178,000

Underlying: Common Stock · 178,000 shares

Expires 2036-04-05

F1 · derivative.exercise_date: Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 01:59 UTC GrantRestricted Stock Unit · Derivative 7,700 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-010864 · ownership.xml · derivative · entry 2

Ciongoli Gregory Austin · CIK 0002023732 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,700

Underlying: Common Stock · 7,700 shares

Expires 2027-01-12

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of common stock.

F3 · derivative.exercise_date: RSUs vest on January 12, 2027.

F3 · derivative.expiration_date: RSUs vest on January 12, 2027.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 01:59 UTC GrantStock Option (Right to Buy) · Derivative 11,500 $0.00 Strike: $23.16 $0.00
Disclosure

SEC source: 0001193125-26-010864 · ownership.xml · derivative · entry 1

Ciongoli Gregory Austin · CIK 0002023732 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,500

Underlying: Common Stock · 11,500 shares

Expires 2036-01-11

F1 · derivative.exercise_date: Stock options vest on January 12, 2027.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 01:42 UTC
Mahony SusanDirector
GrantRestricted Stock Unit · Derivative 7,700 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-010843 · ownership.xml · derivative · entry 2

Mahony Susan · CIK 0001463321 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,700

Underlying: Common Stock · 7,700 shares

Expires 2027-01-12

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of common stock.

F3 · derivative.exercise_date: RSUs vest on January 12, 2027.

F3 · derivative.expiration_date: RSUs vest on January 12, 2027.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 01:42 UTC
Mahony SusanDirector
GrantStock Option (Right to Buy) · Derivative 11,500 $0.00 Strike: $23.16 $0.00
Disclosure

SEC source: 0001193125-26-010843 · ownership.xml · derivative · entry 1

Mahony Susan · CIK 0001463321 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,500

Underlying: Common Stock · 11,500 shares

Expires 2036-01-11

F1 · derivative.exercise_date: Stock options vest on January 12, 2027.

Read SEC document
January 12, 2026 Filed Jan 12, 2026 20:56 UTC
Neu KelvinDirector
GrantRestricted Stock Unit · Derivative 7,700 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-010860 · ownership.xml · derivative · entry 2

Neu Kelvin · CIK 0001554699 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,700

Underlying: Common Stock · 7,700 shares

Expires 2027-01-12

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of common stock.

F3 · derivative.exercise_date: RSUs vest on January 12, 2027.

F3 · derivative.expiration_date: RSUs vest on January 12, 2027.

Read SEC document
January 12, 2026 Filed Jan 12, 2026 20:56 UTC
Neu KelvinDirector
GrantStock Option (Right to Buy) · Derivative 11,500 $0.00 Strike: $23.16 $0.00
Disclosure

SEC source: 0001193125-26-010860 · ownership.xml · derivative · entry 1

Neu Kelvin · CIK 0001554699 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,500

Underlying: Common Stock · 11,500 shares

Expires 2036-01-11

F1 · derivative.exercise_date: Stock options vest on January 12, 2027.

Read SEC document
January 12, 2026 Filed Jan 12, 2026 19:07 UTC
Galbraith KennethDirector · Chair & CEO
GrantPerformance Stock Unit · Derivative 222,000 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-010790 · ownership.xml · derivative · entry 6

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 222,000

Underlying: Common Stock · 222,000 shares

Expires not disclosed

F8 · derivative.exercise_price: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return ("TSR") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 111,000 PSUs ("Target Number") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index. The PSUs will only vest at the end of the three-year performance period if the reporting person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals,

F9 · derivative.exercise_price: (Continued from footnote 8) except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control).

F8 · derivative.exercise_date: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return ("TSR") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 111,000 PSUs ("Target Number") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index. The PSUs will only vest at the end of the three-year performance period if the reporting person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals,

F9 · derivative.exercise_date: (Continued from footnote 8) except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control).

F8 · derivative.expiration_date: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return ("TSR") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 111,000 PSUs ("Target Number") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index. The PSUs will only vest at the end of the three-year performance period if the reporting person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals,

F9 · derivative.expiration_date: (Continued from footnote 8) except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control).

Read SEC document
January 12, 2026 Filed Jan 12, 2026 19:07 UTC
Galbraith KennethDirector · Chair & CEO
GrantRestricted Stock Unit · Derivative 144,000 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-010790 · ownership.xml · derivative · entry 5

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 144,000

Underlying: Common Stock · 144,000 shares

Expires not disclosed

F4 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of common stock.

F7 · derivative.exercise_date: RSUs vest in four equal annual installments beginning on first anniversary of grant date.

F7 · derivative.expiration_date: RSUs vest in four equal annual installments beginning on first anniversary of grant date.

Read SEC document
January 12, 2026 Filed Jan 12, 2026 19:07 UTC
Galbraith KennethDirector · Chair & CEO
GrantStock Option (Right to Buy) · Derivative 216,000 $0.00 Strike: $23.16 $0.00
Disclosure

SEC source: 0001193125-26-010790 · ownership.xml · derivative · entry 4

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 216,000

Underlying: Common Stock · 216,000 shares

Expires 2036-01-11

F6 · derivative.exercise_date: Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date.

Read SEC document
January 12, 2026 Filed Jan 12, 2026 19:07 UTC
Galbraith KennethDirector · Chair & CEO
Exercise / conversionRestricted Stock Unit · Derivative 64,000 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-010790 · ownership.xml · derivative · entry 3

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 128,000

Underlying: Common Stock · 64,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of common stock.

F5 · derivative.exercise_date: The RSUs were granted on January 10, 2025 and vest in three equal annual installments beginning on the first anniversary of grant date.

F5 · derivative.expiration_date: The RSUs were granted on January 10, 2025 and vest in three equal annual installments beginning on the first anniversary of grant date.

Read SEC document
January 12, 2026 Filed Jan 12, 2026 19:07 UTC
Galbraith KennethDirector · Chair & CEO
SaleCommon Stock 30,424 $22.67 $689,818.56
Disclosure

SEC source: 0001193125-26-010790 · ownership.xml · nonDerivative · entry 2

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 226,842

F2 · kind: Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $22.49 to $23.05, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

Read SEC document
January 12, 2026 Filed Jan 12, 2026 19:07 UTC
Galbraith KennethDirector · Chair & CEO
Exercise / conversionCommon Stock 64,000 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-010790 · ownership.xml · nonDerivative · entry 1

Galbraith Kenneth · CIK 0001567045 · Director · Chair & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 257,266

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Represents shares of common stock issued upon vesting of one third of the restricted stock units ("RSUs") granted on January 10, 2025.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 01:56 UTC GrantRestricted Stock Unit · Derivative 7,700 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-010859 · ownership.xml · derivative · entry 2

Landry Robert E · CIK 0001585160 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,700

Underlying: Common Stock · 7,700 shares

Expires 2027-01-12

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of common stock.

F3 · derivative.exercise_date: RSUs vest on January 12, 2027.

F3 · derivative.expiration_date: RSUs vest on January 12, 2027.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 01:56 UTC GrantStock Option (Right to Buy) · Derivative 11,500 $0.00 Strike: $23.16 $0.00
Disclosure

SEC source: 0001193125-26-010859 · ownership.xml · derivative · entry 1

Landry Robert E · CIK 0001585160 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,500

Underlying: Common Stock · 11,500 shares

Expires 2036-01-11

F1 · derivative.exercise_date: Stock options vest on January 12, 2027.

Read SEC document
January 12, 2026 Filed Jan 12, 2026 21:00 UTC
Smith Jeffrey T LEVP & Chief Medical Officer
Exercise / conversionRestricted Stock Unit · Derivative 17,666 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-010865 · ownership.xml · derivative · entry 3

Smith Jeffrey T L · CIK 0001604800 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,334

Underlying: Common Stock · 17,666 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F5 · derivative.exercise_date: The RSUs were granted on January 10, 2025 and vest in three equal annual installments beginning on the first anniversary of grant date.

F5 · derivative.expiration_date: The RSUs were granted on January 10, 2025 and vest in three equal annual installments beginning on the first anniversary of grant date.

Read SEC document
January 12, 2026 Filed Jan 12, 2026 21:00 UTC
Smith Jeffrey T LEVP & Chief Medical Officer
SaleCommon Stock 9,310 $22.67 $211,090.29
Disclosure

SEC source: 0001193125-26-010865 · ownership.xml · nonDerivative · entry 2

Smith Jeffrey T L · CIK 0001604800 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,708

F2 · kind: Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $22.49 to $23.05, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

Read SEC document
January 12, 2026 Filed Jan 12, 2026 21:00 UTC
Smith Jeffrey T LEVP & Chief Medical Officer
Exercise / conversionCommon Stock 17,666 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-010865 · ownership.xml · nonDerivative · entry 1

Smith Jeffrey T L · CIK 0001604800 · EVP & Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,018

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Represents shares of common stock issued upon vesting of one third of the restricted stock units ("RSUs") granted on January 10, 2025.

Read SEC document
January 12, 2026 Filed Jan 12, 2026 20:50 UTC GrantRestricted Stock Unit · Derivative 7,700 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-010852 · ownership.xml · derivative · entry 2

Campoy Carlos · CIK 0001761518 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,700

Underlying: Common Stock · 7,700 shares

Expires 2027-01-12

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of common stock.

F3 · derivative.exercise_date: RSUs vest on January 12, 2027.

F3 · derivative.expiration_date: RSUs vest on January 12, 2027.

Read SEC document
January 12, 2026 Filed Jan 12, 2026 20:50 UTC GrantStock Option (Right to Buy) · Derivative 11,500 $0.00 Strike: $23.16 $0.00
Disclosure

SEC source: 0001193125-26-010852 · ownership.xml · derivative · entry 1

Campoy Carlos · CIK 0001761518 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,500

Underlying: Common Stock · 11,500 shares

Expires 2036-01-11

F1 · derivative.exercise_date: Stock options vest on January 12, 2027.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 01:54 UTC GrantRestricted Stock Unit · Derivative 7,700 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-010856 · ownership.xml · derivative · entry 2

Cesano Alessandra · CIK 0001827015 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,700

Underlying: Common Stock · 7,700 shares

Expires 2027-01-12

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of common stock.

F3 · derivative.exercise_date: RSUs vest on January 12, 2027.

F3 · derivative.expiration_date: RSUs vest on January 12, 2027.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 01:54 UTC GrantStock Option (Right to Buy) · Derivative 11,500 $0.00 Strike: $23.16 $0.00
Disclosure

SEC source: 0001193125-26-010856 · ownership.xml · derivative · entry 1

Cesano Alessandra · CIK 0001827015 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,500

Underlying: Common Stock · 11,500 shares

Expires 2036-01-11

F1 · derivative.exercise_date: Stock options vest on January 12, 2027.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 01:32 UTC
Moore Paul AndrewChief Scientific Officer
GrantPerformance Stock Unit · Derivative 66,000 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-010834 · ownership.xml · derivative · entry 6

Moore Paul Andrew · CIK 0001938192 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 66,000

Underlying: Common Stock · 66,000 shares

Expires not disclosed

F8 · derivative.exercise_price: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return ("TSR") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 33,000 PSUs ("Target Number") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index. The PSUs will only vest at the end of the three-year performance period if the Reporting Person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals,

F9 · derivative.exercise_price: (Continued from footnote 8) except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control).

F8 · derivative.exercise_date: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return ("TSR") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 33,000 PSUs ("Target Number") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index. The PSUs will only vest at the end of the three-year performance period if the Reporting Person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals,

F9 · derivative.exercise_date: (Continued from footnote 8) except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control).

F8 · derivative.expiration_date: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return ("TSR") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 33,000 PSUs ("Target Number") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index. The PSUs will only vest at the end of the three-year performance period if the Reporting Person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals,

F9 · derivative.expiration_date: (Continued from footnote 8) except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control).

Read SEC document
January 12, 2026 Filed Jan 13, 2026 01:32 UTC
Moore Paul AndrewChief Scientific Officer
GrantRestricted Stock Unit · Derivative 47,000 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-010834 · ownership.xml · derivative · entry 5

Moore Paul Andrew · CIK 0001938192 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,000

Underlying: Common Stock · 47,000 shares

Expires not disclosed

F4 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F7 · derivative.exercise_date: RSUs vest in four equal annual installments beginning on first anniversary of grant date.

F7 · derivative.expiration_date: RSUs vest in four equal annual installments beginning on first anniversary of grant date.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 01:32 UTC
Moore Paul AndrewChief Scientific Officer
GrantStock Option (Right to Buy) · Derivative 70,000 $0.00 Strike: $23.16 $0.00
Disclosure

SEC source: 0001193125-26-010834 · ownership.xml · derivative · entry 4

Moore Paul Andrew · CIK 0001938192 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,000

Underlying: Common Stock · 70,000 shares

Expires 2036-01-11

F6 · derivative.exercise_date: Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 01:32 UTC
Moore Paul AndrewChief Scientific Officer
Exercise / conversionRestricted Stock Unit · Derivative 17,666 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-010834 · ownership.xml · derivative · entry 3

Moore Paul Andrew · CIK 0001938192 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,334

Underlying: Common Stock · 17,666 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F5 · derivative.exercise_date: The RSUs were granted on January 10, 2025 and vest in three equal annual installments beginning on the first anniversary of grant date.

F5 · derivative.expiration_date: The RSUs were granted on January 10, 2025 and vest in three equal annual installments beginning on the first anniversary of grant date.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 01:32 UTC
Moore Paul AndrewChief Scientific Officer
SaleCommon Stock 9,560 $22.67 $216,758.66
Disclosure

SEC source: 0001193125-26-010834 · ownership.xml · nonDerivative · entry 2

Moore Paul Andrew · CIK 0001938192 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,497

F2 · kind: Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $22.49 to $23.05, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 01:32 UTC
Moore Paul AndrewChief Scientific Officer
Exercise / conversionCommon Stock 17,666 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-010834 · ownership.xml · nonDerivative · entry 1

Moore Paul Andrew · CIK 0001938192 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 58,057

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Represents shares of common stock issued upon vesting of one third of the restricted stock units ("RSUs") granted on January 10, 2025.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 21:30 UTC GrantRestricted Stock Unit · Derivative 15,400 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-011793 · ownership.xml · derivative · entry 2

Cherry Brian N · CIK 0001290922 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,400

Underlying: Common Stock · 15,400 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of common stock.

F3 · derivative.exercise_date: RSUs vest in three equal annual installments beginning on first anniversary of grant date.

F3 · derivative.expiration_date: RSUs vest in three equal annual installments beginning on first anniversary of grant date.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 21:30 UTC GrantStock Option (Right to Buy) · Derivative 23,000 $0.00 Strike: $23.16 $0.00
Disclosure

SEC source: 0001193125-26-011793 · ownership.xml · derivative · entry 1

Cherry Brian N · CIK 0001290922 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,000

Underlying: Common Stock · 23,000 shares

Expires 2036-01-11

F1 · derivative.exercise_date: Stock options vest in 36 equal monthly installments starting one month after grant date of January 12, 2026.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 22:11 UTC
Hollywood MarkEVP & Chief Operating Officer
GrantPerformance Stock Unit · Derivative 66,000 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-011885 · ownership.xml · derivative · entry 6

Hollywood Mark · CIK 0002104446 · EVP & Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 66,000

Underlying: Common Stock · 66,000 shares

Expires not disclosed

F8 · derivative.exercise_price: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return ("TSR") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 33,000 PSUs ("Target Number") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index.

F9 · derivative.exercise_price: (Continued from footnote 8) The PSUs will only vest at the end of the three-year performance period if the Reporting Person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals, except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control).

F8 · derivative.exercise_date: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return ("TSR") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 33,000 PSUs ("Target Number") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index.

F9 · derivative.exercise_date: (Continued from footnote 8) The PSUs will only vest at the end of the three-year performance period if the Reporting Person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals, except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control).

F8 · derivative.expiration_date: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of common stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain cumulative total shareholder return ("TSR") goals over a three-year performance period ending on January 12, 2029 (or in some cases at earlier times). Between 50% and 200% of the target number of 33,000 PSUs ("Target Number") may be earned upon achievement of such TSR goals. 50% of the Target Number may be earned upon achievement of relative TSR goals if the Company's TSR for the performance period equals or exceeds a prespecified percentile for the Nasdaq Biotech Index.

F9 · derivative.expiration_date: (Continued from footnote 8) The PSUs will only vest at the end of the three-year performance period if the Reporting Person's service to the Company continues through such time that the board of directors of the Company certifies the achievement of TSR goals, except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change of control).

Read SEC document
January 12, 2026 Filed Jan 13, 2026 22:11 UTC
Hollywood MarkEVP & Chief Operating Officer
GrantRestricted Stock Unit · Derivative 47,000 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-011885 · ownership.xml · derivative · entry 5

Hollywood Mark · CIK 0002104446 · EVP & Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,000

Underlying: Common Stock · 47,000 shares

Expires not disclosed

F4 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F7 · derivative.exercise_date: RSUs vest in four equal annual installments beginning on first anniversary of grant date.

F7 · derivative.expiration_date: RSUs vest in four equal annual installments beginning on first anniversary of grant date.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 22:11 UTC
Hollywood MarkEVP & Chief Operating Officer
GrantStock Option (Right to Buy) · Derivative 70,000 $0.00 Strike: $23.16 $0.00
Disclosure

SEC source: 0001193125-26-011885 · ownership.xml · derivative · entry 4

Hollywood Mark · CIK 0002104446 · EVP & Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,000

Underlying: Common Stock · 70,000 shares

Expires 2036-01-11

F6 · derivative.exercise_date: Stock options vest as follows: (i) 25% of underlying shares of common stock on first anniversary of grant date and (ii) remainder of underlying shares of common stock in 36 equal monthly installments on last day of month following first anniversary of grant date.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 22:11 UTC
Hollywood MarkEVP & Chief Operating Officer
Exercise / conversionRestricted Stock Unit · Derivative 17,666 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-011885 · ownership.xml · derivative · entry 3

Hollywood Mark · CIK 0002104446 · EVP & Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,334

Underlying: Common Stock · 17,666 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock.

F5 · derivative.exercise_date: The RSUs were granted on January 10, 2025 and vest in three equal annual installments beginning on the first anniversary of grant date.

F5 · derivative.expiration_date: The RSUs were granted on January 10, 2025 and vest in three equal annual installments beginning on the first anniversary of grant date.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 22:11 UTC
Hollywood MarkEVP & Chief Operating Officer
SaleCommon Stock 6,120 $22.67 $138,761.82
Disclosure

SEC source: 0001193125-26-011885 · ownership.xml · nonDerivative · entry 2

Hollywood Mark · CIK 0002104446 · EVP & Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 132,913

F2 · kind: Represents shares of common stock sold to cover tax withholding obligations and other applicable fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the Reporting Person's applicable RSU grant agreement, and does not represent a discretionary sale by the Reporting Person. The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $22.49 to $23.05, inclusive. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 22:11 UTC
Hollywood MarkEVP & Chief Operating Officer
Exercise / conversionCommon Stock 17,666 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-011885 · ownership.xml · nonDerivative · entry 1

Hollywood Mark · CIK 0002104446 · EVP & Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 139,033

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Represents shares of common stock issued upon vesting of one third of the restricted stock units ("RSUs") granted on January 10, 2025.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.