ZLAB

SEC source: 0001567619-21-011217 · doc1.xml · derivative · entry 5

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 76,000

Underlying: Ordinary Shares · 8,000 shares

Expires 2028-03-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · derivative.exercise_date: The options vest in equal annual installments over five years beginning on 03/28/2019, the first anniversary of the date of grant.

SEC source: 0001567619-21-011217 · doc1.xml · nonDerivative · entry 2

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-011217 · doc1.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-009234 · doc1.xml · nonDerivative · entry 1

DIEKMAN JOHN D · CIK 0001240357 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,852

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 31, 2021, may terminate on May 5, 2022 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 25

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 786,430

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 24

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 786,484

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F25 · price: Reflects a weighted average sale price of $168.95 per share, at prices ranging from $168.69 to $169.15 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 23

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 786,831

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F24 · price: Reflects a weighted average sale price of $167.86 per share, at prices ranging from $167.65 to $168.27 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 22

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 787,071

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F23 · price: Reflects a weighted average sale price of $166.61 per share, at prices ranging from $166.30 to $167.08 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 21

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 787,841

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F22 · price: Reflects a weighted average sale price of $165.40 per share, at prices ranging from $165.25 to $166.10 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 20

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 788,620

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F21 · price: Reflects a weighted average sale price of $164.37 per share, at prices ranging from $164.10 to $165.05 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 19

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 790,108

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F20 · price: Reflects a weighted average sale price of $163.43 per share, at prices ranging from $163.06 to $164.06 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 18

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 791,185

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F19 · price: Reflects a weighted average sale price of $162.58 per share, at prices ranging from $162.04 to $163.04 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 17

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 793,534

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F18 · price: Reflects a weighted average sale price of $161.43 per share, at prices ranging from $161.02 to $162.00 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 16

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 794,859

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F17 · price: Reflects a weighted average sale price of $160.52 per share, at prices ranging from $160.00 to $160.96 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 15

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 797,745

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F16 · price: Reflects a weighted average sale price of $159.37 per share, at prices ranging from $158.92 to $159.65 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 14

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 799,436

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F15 · price: Reflects a weighted average sale price of $158.26 per share, at prices ranging from $157.89 to $158.83 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 13

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 808,248

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F14 · price: Reflects a weighted average sale price of $157.27 per share, at prices ranging from $156.88 to $157.88 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 12

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 811,532

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F13 · price: Reflects a weighted average sale price of $156.24 per share, at prices ranging from $155.79 to $156.73 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 11

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 821,998

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F12 · price: Reflects a weighted average sale price of $155.34 per share, at prices ranging from $154.78 to $155.78 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 10

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 835,377

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F11 · price: Reflects a weighted average sale price of $168.21 per share, at prices ranging from $168.16 to $168.71 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 9

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 836,390

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F10 · price: Reflects a weighted average sale price of $166.71 per share, at prices ranging from $166.57 to $166.93 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 8

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 836,823

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F9 · price: Reflects a weighted average sale price of $165.50 per share, at prices ranging from $165.21 to $166.00 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 7

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 839,940

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F8 · price: Reflects a weighted average sale price of $164.60 per share, at prices ranging from $164.19 to $165.18 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 6

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 845,054

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F7 · price: Reflects a weighted average sale price of $163.58 per share, at prices ranging from $163.14 to $164.04 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 5

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 847,774

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F6 · price: Reflects a weighted average sale price of $162.54 per share, at prices ranging from $162.12 to $163.10 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 4

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 854,945

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F5 · price: Reflects a weighted average sale price of $161.60 per share, at prices ranging from $161.08 to $162.08 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 3

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 869,812

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F4 · price: Reflects a weighted average sale price of $160.64 per share, at prices ranging from $160.07 to $161.04 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 2

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 882,446

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · price: Reflects a weighted average sale price of $159.59 per share, at prices ranging from $159.06 to $160.05 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-009022 · doc1.xml · nonDerivative · entry 1

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 889,331

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · price: Reflects a weighted average sale price of $158.65 per share, at prices ranging from $158.04 to $159.04 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-011577 · doc1.xml · derivative · entry 3

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,333,609

Underlying: Ordinary Shares · 111,111 shares

Expires 2025-10-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On May 4, 2021, the Reporting Person filed a Form 4 which inadvertently did not report that she exercised 111,111 Stock Options in connection with the sales of Ordinary Shares reported in such filing. However, as reported in this amendment, the Reporting Person exercised 111,111 Stock Options for Ordinary Shares, granted to her in connection with a stock option plan that fully vested on October 22, 2020. Accordingly, Table I, Column 5 is amended to reflect such acquisition of Ordinary Shares, pursuant to such exercise of Stock Options, giving effect to the various sale transactions previously reported on the initial filing of this Form 4.

F2 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1931.

F3 · derivative.exercise_date: The Stock Options fully vested as of October 22, 2020.

SEC source: 0001567619-21-011577 · doc1.xml · nonDerivative · entry 1

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,119,764

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On May 4, 2021, the Reporting Person filed a Form 4 which inadvertently did not report that she exercised 111,111 Stock Options in connection with the sales of Ordinary Shares reported in such filing. However, as reported in this amendment, the Reporting Person exercised 111,111 Stock Options for Ordinary Shares, granted to her in connection with a stock option plan that fully vested on October 22, 2020. Accordingly, Table I, Column 5 is amended to reflect such acquisition of Ordinary Shares, pursuant to such exercise of Stock Options, giving effect to the various sale transactions previously reported on the initial filing of this Form 4.

F2 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 3, 2021, expires December 31, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1931.

F1 · balance_after: On May 4, 2021, the Reporting Person filed a Form 4 which inadvertently did not report that she exercised 111,111 Stock Options in connection with the sales of Ordinary Shares reported in such filing. However, as reported in this amendment, the Reporting Person exercised 111,111 Stock Options for Ordinary Shares, granted to her in connection with a stock option plan that fully vested on October 22, 2020. Accordingly, Table I, Column 5 is amended to reflect such acquisition of Ordinary Shares, pursuant to such exercise of Stock Options, giving effect to the various sale transactions previously reported on the initial filing of this Form 4.

SEC source: 0001567619-21-008429 · doc1.xml · derivative · entry 6

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 84,000

Underlying: Ordinary Shares · 8,000 shares

Expires 2028-03-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · derivative.exercise_date: The options vest in equal annual installments over five years beginning on 03/28/2019, the first anniversary of the date of grant.

SEC source: 0001567619-21-008429 · doc1.xml · nonDerivative · entry 4

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-008429 · doc1.xml · nonDerivative · entry 3

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-008429 · doc1.xml · derivative · entry 5

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 92,000

Underlying: Ordinary Shares · 8,000 shares

Expires 2028-03-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · derivative.exercise_date: The options vest in equal annual installments over five years beginning on 03/28/2019, the first anniversary of the date of grant.

SEC source: 0001567619-21-008429 · doc1.xml · nonDerivative · entry 2

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-008429 · doc1.xml · nonDerivative · entry 1

Reinhart Harald · CIK 0001835824 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires August 30, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0001567619-21-008430 · doc1.xml · derivative · entry 6

Fu Tao · CIK 0001644888 · Director · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 470,000

Underlying: Ordinary Shares · 10,000 shares

Expires 2028-09-24

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires September 15, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F6 · derivative.exercise_date: The Stock Options vest in equal annual installments over five years beginning on 09/24/2019, the first anniversary of the date of grant.

SEC source: 0001567619-21-008430 · doc1.xml · nonDerivative · entry 4

Fu Tao · CIK 0001644888 · Director · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 207,000

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires September 15, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F4 · price: Reflects a weighted average sale price of $164.15 per share, at prices ranging from $164.14 to $164.15 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-008430 · doc1.xml · nonDerivative · entry 3

Fu Tao · CIK 0001644888 · Director · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 207,200

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires September 15, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · price: Reflects a weighted average sale price of $163.38 per share, at prices ranging from $163.05 to $163.78 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-008430 · doc1.xml · nonDerivative · entry 2

Fu Tao · CIK 0001644888 · Director · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 211,200

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires September 15, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · price: Reflects a weighted average sale price of $162.55 per share, at prices ranging from $162.02 to $163.00 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001567619-21-008430 · doc1.xml · nonDerivative · entry 1

Fu Tao · CIK 0001644888 · Director · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 217,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a sales plan adopted by the Reporting Person, dated March 17, 2021, expires September 15, 2021 and is intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000899243-21-015354 · doc4.xml · nonDerivative · entry 22

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 897,541

F1 · kind: This transaction was automatically triggered pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F23 · price: Reflects a weighted average sale price of $135.94 per share, at prices ranging from $135.84 to $136.02 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0000899243-21-015354 · doc4.xml · nonDerivative · entry 21

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 898,481

F1 · kind: This transaction was automatically triggered pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F22 · price: Reflects a weighted average sale price of $135.17 per share, at prices ranging from $134.83 to $135.78 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0000899243-21-015354 · doc4.xml · nonDerivative · entry 20

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 906,498

F1 · kind: This transaction was automatically triggered pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F21 · price: Reflects a weighted average sale price of $134.40 per share, at prices ranging from $133.81 to $134.81 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0000899243-21-015354 · doc4.xml · nonDerivative · entry 19

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 916,867

F1 · kind: This transaction was automatically triggered pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F20 · price: Reflects a weighted average sale price of $133.12 per share, at prices ranging from $132.78 to $133.74 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0000899243-21-015354 · doc4.xml · nonDerivative · entry 18

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 917,180

F1 · kind: This transaction was automatically triggered pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F19 · price: Reflects a weighted average sale price of $131.83 per share, at prices ranging from $131.31 to $132.22 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0000899243-21-015354 · doc4.xml · nonDerivative · entry 17

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 918,900

F1 · kind: This transaction was automatically triggered pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F18 · price: Reflects a weighted average sale price of $130.34 per share, at prices ranging from $130.15 to $131.09 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0000899243-21-015354 · doc4.xml · nonDerivative · entry 16

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 919,477

F1 · kind: This transaction was automatically triggered pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F17 · price: Reflects a weighted average sale price of $129.21 per share, at prices ranging from $129.02 to $129.44 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0000899243-21-015354 · doc4.xml · nonDerivative · entry 15

Du Ying · CIK 0001731790 · Director · Chairwoman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 920,961

F1 · kind: This transaction was automatically triggered pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F16 · price: Reflects a weighted average sale price of $128.38 per share, at prices ranging from $127.95 to $128.91 per share. The Reporting Person will provide, upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.