XENE

SEC source: 0000950170-23-044403 · ownership.xml · nonDerivative · entry 1

Svoronos Dawn · CIK 0001574579 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

F1 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $38.70 to $38.79, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0000950170-23-041534 · ownership.xml · derivative · entry 1

Gover Justin D. · CIK 0001754129 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,000

Underlying: Common Shares · 28,000 shares

Expires 2033-08-09

F1 · derivative.exercise_date: One-third of the total shares subject to the Option shall vest on the first anniversary of August 8, 2023 (the "Start Date"), one-third on the second anniversary of the Start Date and the balance on the third anniversary of the Start Date.

SEC source: 0000950170-23-041528 · ownership.xml · derivative · entry 1

Cannon Gillian · CIK 0001833910 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,000

Underlying: Common Shares · 28,000 shares

Expires 2033-08-09

F1 · derivative.exercise_date: One-third of the total shares subject to the Option shall vest on the first anniversary of August 8, 2023 (the "Start Date"), one-third on the second anniversary of the Start Date and the balance on the third anniversary of the Start Date.

SEC source: 0000950170-23-026184 · ownership.xml · derivative · entry 1

GANNON STEVEN · CIK 0001643085 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,475

Underlying: Common Shares · 18,475 shares

Expires 2033-06-01

F1 · derivative.exercise_date: Vesting 100% on the earlier of (i) June 1, 2024 or (ii) the day immediately preceding the day of the following year's annual meeting.

SEC source: 0000950170-23-026169 · ownership.xml · derivative · entry 1

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,475

Underlying: Common Shares · 18,475 shares

Expires 2033-06-01

F1 · derivative.exercise_date: Vesting 100% on the earlier of (i) June 1, 2024 or (ii) the day immediately preceding the day of the following year's annual meeting.

SEC source: 0000950170-23-026190 · ownership.xml · derivative · entry 1

PATOU GARY · CIK 0001283535 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,475

Underlying: Common Shares · 18,475 shares

Expires 2033-06-01

F1 · derivative.exercise_date: Vesting 100% on the earlier of (i) June 1, 2024 or (ii) the day immediately preceding the day of the following year's annual meeting.

SEC source: 0000950170-23-026195 · ownership.xml · derivative · entry 1

AZAB MOHAMMAD · CIK 0001309653 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,475

Underlying: Common Shares · 18,475 shares

Expires 2033-06-01

F1 · derivative.exercise_date: Vesting 100% on the earlier of (i) June 1, 2024 or (ii) the day immediately preceding the day of the following year's annual meeting.

SEC source: 0000950170-23-026167 · ownership.xml · derivative · entry 1

Machado Patrick · CIK 0001311210 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,475

Underlying: Common Shares · 18,475 shares

Expires 2033-06-01

F1 · derivative.exercise_date: Vesting 100% on the earlier of (i) June 1, 2024 or (ii) the day immediately preceding the day of the following year's annual meeting.

SEC source: 0000950170-23-026178 · ownership.xml · derivative · entry 1

Svoronos Dawn · CIK 0001574579 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,475

Underlying: Common Shares · 18,475 shares

Expires 2033-06-01

F1 · derivative.exercise_date: Vesting 100% on the earlier of (i) June 1, 2024 or (ii) the day immediately preceding the day of the following year's annual meeting.

SEC source: 0000950170-23-026171 · ownership.xml · derivative · entry 1

GAROFALO ELIZABETH A. · CIK 0001826361 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,475

Underlying: Common Shares · 18,475 shares

Expires 2033-06-01

F1 · derivative.exercise_date: Vesting 100% on the earlier of (i) June 1, 2024 or (ii) the day immediately preceding the day of the following year's annual meeting.

SEC source: 0000950170-23-025802 · ownership.xml · derivative · entry 19

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 45,000 shares

Expires 2025-03-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F10 · derivative.exercise_date: The shares subject to the options are fully vested and exercisable.

SEC source: 0000950170-23-025802 · ownership.xml · derivative · entry 18

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,682

Underlying: Common Shares · 9,318 shares

Expires 2025-12-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F10 · derivative.exercise_date: The shares subject to the options are fully vested and exercisable.

SEC source: 0000950170-23-025802 · ownership.xml · nonDerivative · entry 15

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,000

F9 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $38.78 to $38.81, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0000950170-23-025802 · ownership.xml · nonDerivative · entry 14

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,255

F8 · price: Represents the closing price of the Company's common shares on May 31, 2023 for purposes of net settlement calculations.

SEC source: 0000950170-23-025802 · ownership.xml · nonDerivative · entry 13

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-23-025802 · ownership.xml · nonDerivative · entry 12

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,000

SEC source: 0000950170-23-025802 · ownership.xml · nonDerivative · entry 11

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,458

F8 · price: Represents the closing price of the Company's common shares on May 31, 2023 for purposes of net settlement calculations.

SEC source: 0000950170-23-025802 · ownership.xml · nonDerivative · entry 10

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,318

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-23-025802 · ownership.xml · derivative · entry 17

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Shares · 50,000 shares

Expires 2025-03-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F10 · derivative.exercise_date: The shares subject to the options are fully vested and exercisable.

SEC source: 0000950170-23-025802 · ownership.xml · derivative · entry 16

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 29,835 shares

Expires 2024-01-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: The exercise price was converted to U.S. dollars from $10.78 CAD using the closing rate of exchange on the Bank of Canada on the date of grant. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

F10 · derivative.exercise_date: The shares subject to the options are fully vested and exercisable.

SEC source: 0000950170-23-025802 · ownership.xml · nonDerivative · entry 9

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,000

F7 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $38.50 to $38.90, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0000950170-23-025802 · ownership.xml · nonDerivative · entry 8

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,856

F5 · price: Represents the closing price of the Company's common shares on May 30, 2023 for purposes of net settlement calculations.

SEC source: 0000950170-23-025802 · ownership.xml · nonDerivative · entry 7

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-23-025802 · ownership.xml · nonDerivative · entry 6

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,000

F6 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $38.66 to $39.01, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0000950170-23-025802 · ownership.xml · nonDerivative · entry 5

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,670

F5 · price: Represents the closing price of the Company's common shares on May 30, 2023 for purposes of net settlement calculations.

SEC source: 0000950170-23-025802 · ownership.xml · nonDerivative · entry 4

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,835

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · price: The exercise price was converted to U.S. dollars from $10.78 CAD using the closing rate of exchange on the Bank of Canada on the date of grant. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

SEC source: 0000950170-23-025802 · ownership.xml · nonDerivative · entry 3

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,000

F3 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $38.20 to $38.70, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0000950170-23-025802 · ownership.xml · nonDerivative · entry 2

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,000

F2 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $39.50 to $40.00, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0000950170-23-025802 · ownership.xml · nonDerivative · entry 1

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,000

F1 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $38.50 to $39.25, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0000950170-23-024600 · ownership.xml · derivative · entry 13

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 6,172 shares

Expires 2024-01-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: The exercise price was converted from $10.78 CAD using the closing rate of exchange of the Bank of Canada on the date of grant, after giving effect to the Reverse Stock Split. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

F7 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

SEC source: 0000950170-23-024600 · ownership.xml · derivative · entry 12

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 20,576 shares

Expires 2024-01-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: The exercise price was converted from $10.78 CAD using the closing rate of exchange of the Bank of Canada on the date of grant, after giving effect to the Reverse Stock Split. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

F7 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

SEC source: 0000950170-23-024600 · ownership.xml · derivative · entry 11

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 42,592 shares

Expires 2023-07-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: The exercise price was converted from $9.76 CAD using the closing rate of exchange of the Bank of Canada on the date of grant, after giving effect to the 1-for-4.86 reverse stock split of the Issuer's outstanding shares effected October 1, 2014 (the "Reverse Stock Split"). The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

F7 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

SEC source: 0000950170-23-024600 · ownership.xml · nonDerivative · entry 9

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,302

F6 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $41.48 to $41.52, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0000950170-23-024600 · ownership.xml · nonDerivative · entry 8

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,709

F2 · price: Represents the closing price of the Company's common shares on May 23, 2023 for purposes of net settlement calculations.

SEC source: 0000950170-23-024600 · ownership.xml · nonDerivative · entry 7

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,880

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · price: The exercise price was converted from $10.78 CAD using the closing rate of exchange of the Bank of Canada on the date of grant, after giving effect to the Reverse Stock Split. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

SEC source: 0000950170-23-024600 · ownership.xml · nonDerivative · entry 6

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,708

F5 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $41.26 to $41.47, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0000950170-23-024600 · ownership.xml · nonDerivative · entry 5

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,887

F2 · price: Represents the closing price of the Company's common shares on May 23, 2023 for purposes of net settlement calculations.

SEC source: 0000950170-23-024600 · ownership.xml · nonDerivative · entry 4

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 44,789

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · price: The exercise price was converted from $10.78 CAD using the closing rate of exchange of the Bank of Canada on the date of grant, after giving effect to the Reverse Stock Split. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

SEC source: 0000950170-23-024600 · ownership.xml · nonDerivative · entry 3

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,213

F3 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $41.29 to $41.60, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0000950170-23-024600 · ownership.xml · nonDerivative · entry 2

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,282

F2 · price: Represents the closing price of the Company's common shares on May 23, 2023 for purposes of net settlement calculations.

SEC source: 0000950170-23-024600 · ownership.xml · nonDerivative · entry 1

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,592

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The exercise price was converted from $9.76 CAD using the closing rate of exchange of the Bank of Canada on the date of grant, after giving effect to the 1-for-4.86 reverse stock split of the Issuer's outstanding shares effected October 1, 2014 (the "Reverse Stock Split"). The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

SEC source: 0001209191-23-021136 · doc4.xml · nonDerivative · entry 1

KENNEY CHRISTOPHER JOHN · CIK 0001880129 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

SEC source: 0001209191-23-018476 · doc4.xml · derivative · entry 1

KENNEY CHRISTOPHER JOHN · CIK 0001880129 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Shares · 120,000 shares

Expires 2033-03-09

F1 · derivative.exercise_date: Vesting 25% on January 1, 2024 and 75% vesting thereafter over the course of the next 3 years, in equal amounts, on the last day of each month.

SEC source: 0001209191-23-018467 · doc4.xml · derivative · entry 1

AULIN SHERRY · CIK 0001862144 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Shares · 120,000 shares

Expires 2033-03-09

F1 · derivative.exercise_date: Vesting 25% on January 1, 2024 and 75% vesting thereafter over the course of the next 3 years, in equal amounts, on the last day of each month.

SEC source: 0001209191-23-018501 · doc4.xml · derivative · entry 1

DiFabio Andrea · CIK 0001692506 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Shares · 45,000 shares

Expires 2033-03-09

F1 · derivative.exercise_date: Vesting 25% on January 1, 2024 and 75% vesting thereafter over the course of the next 3 years, in equal amounts, on the last day of each month.

SEC source: 0001209191-23-018508 · doc4.xml · derivative · entry 1

Von Seggern Christopher · CIK 0001821192 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 90,000

Underlying: Common Shares · 90,000 shares

Expires 2033-03-09

F1 · derivative.exercise_date: Vesting 25% on January 1, 2024 and 75% vesting thereafter over the course of the next 3 years, in equal amounts, on the last day of each month.

SEC source: 0001209191-23-018505 · doc4.xml · derivative · entry 1

ROBIN SHERRINGTON · CIK 0001619962 · EVP, Strategy & Innovation

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Shares · 75,000 shares

Expires 2033-03-09

F1 · derivative.exercise_date: Vesting 25% on January 1, 2024 and 75% vesting thereafter over the course of the next 3 years, in equal amounts, on the last day of each month.

SEC source: 0001209191-23-018482 · doc4.xml · derivative · entry 1

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 380,000

Underlying: Common Shares · 380,000 shares

Expires 2033-03-09

F1 · derivative.exercise_date: Vesting 25% on January 1, 2024 and 75% vesting thereafter over the course of the next 3 years, in equal amounts, on the last day of each month.

SEC source: 0001209191-23-018470 · doc4.xml · derivative · entry 1

EMPFIELD JAMES R. · CIK 0001665430 · EVP, Drug Discovery

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Shares · 75,000 shares

Expires 2033-03-09

F1 · derivative.exercise_date: Vesting 25% on January 1, 2024 and 75% vesting thereafter over the course of the next 3 years, in equal amounts, on the last day of each month.

SEC source: 0001209191-23-017636 · doc4.xml · derivative · entry 8

PIMSTONE SIMON N. · CIK 0001620084 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 30,864 shares

Expires 2023-03-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: The exercise price was converted to U.S. dollars from $2.67 CAD using the closing rate of exchange on the Bank of Canada on the date of grant. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

F5 · derivative.exercise_date: The shares subject to the options are fully vested and exercisable.