XENE

SEC source: 0000950170-24-130378 · ownership.xml · nonDerivative · entry 1

PATOU GARY · CIK 0001283535 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,073

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-24-069466 · ownership.xml · derivative · entry 1

Gover Justin D. · CIK 0001754129 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,542

Underlying: Common Shares · 15,542 shares

Expires 2034-06-04

F1 · derivative.exercise_date: Vesting 100% on the earlier of (i) June 4, 2025 or (ii) the day before the date of the issuer's 2025 annual meeting of shareholders.

SEC source: 0000950170-24-069464 · ownership.xml · derivative · entry 1

GANNON STEVEN · CIK 0001643085 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,542

Underlying: Common Shares · 15,542 shares

Expires 2034-06-04

F1 · derivative.exercise_date: Vesting 100% on the earlier of (i) June 4, 2025 or (ii) the day before the date of the issuer's 2025 annual meeting of shareholders.

SEC source: 0000950170-24-069468 · ownership.xml · derivative · entry 1

PATOU GARY · CIK 0001283535 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,542

Underlying: Common Shares · 15,542 shares

Expires 2034-06-04

F1 · derivative.exercise_date: Vesting 100% on the earlier of (i) June 4, 2025 or (ii) the day before the date of the issuer's 2025 annual meeting of shareholders.

SEC source: 0000950170-24-069467 · ownership.xml · derivative · entry 1

Machado Patrick · CIK 0001311210 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,542

Underlying: Common Shares · 15,542 shares

Expires 2034-06-04

F1 · derivative.exercise_date: Vesting 100% on the earlier of (i) June 4, 2025 or (ii) the day before the date of the issuer's 2025 annual meeting of shareholders.

SEC source: 0000950170-24-069462 · ownership.xml · derivative · entry 1

Svoronos Dawn · CIK 0001574579 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,542

Underlying: Common Shares · 15,542 shares

Expires 2034-06-04

F1 · derivative.exercise_date: Vesting 100% on the earlier of (i) June 4, 2025 or (ii) the day before the date of the issuer's 2025 annual meeting of shareholders.

SEC source: 0000950170-24-069465 · ownership.xml · derivative · entry 1

GAROFALO ELIZABETH A. · CIK 0001826361 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,542

Underlying: Common Shares · 15,542 shares

Expires 2034-06-04

F1 · derivative.exercise_date: Vesting 100% on the earlier of (i) June 4, 2025 or (ii) the day before the date of the issuer's 2025 annual meeting of shareholders.

SEC source: 0000950170-24-069463 · ownership.xml · derivative · entry 1

Cannon Gillian · CIK 0001833910 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,542

Underlying: Common Shares · 15,542 shares

Expires 2034-06-04

F1 · derivative.exercise_date: Vesting 100% on the earlier of (i) June 4, 2025 or (ii) the day before the date of the issuer's 2025 annual meeting of shareholders.

SEC source: 0000950170-24-030239 · ownership.xml · derivative · entry 1

KENNEY CHRISTOPHER JOHN · CIK 0001880129 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Shares · 100,000 shares

Expires 2034-03-10

F1 · derivative.exercise_date: Vesting 25% on January 1, 2025, and 75% vesting thereafter over the course of the next 3 years, in equal amounts, on the last day of each month.

SEC source: 0000950170-24-030245 · ownership.xml · derivative · entry 1

AULIN SHERRY · CIK 0001862144 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Shares · 100,000 shares

Expires 2034-03-10

F1 · derivative.exercise_date: Vesting 25% on January 1, 2025, and 75% vesting thereafter over the course of the next 3 years, in equal amounts, on the last day of each month.

SEC source: 0000950170-24-030228 · ownership.xml · derivative · entry 1

DiFabio Andrea · CIK 0001692506 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Shares · 100,000 shares

Expires 2034-03-10

F1 · derivative.exercise_date: Vesting 25% on January 1, 2025, and 75% vesting thereafter over the course of the next 3 years, in equal amounts, on the last day of each month.

SEC source: 0000950170-24-030250 · ownership.xml · derivative · entry 1

Von Seggern Christopher · CIK 0001821192 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Shares · 100,000 shares

Expires 2034-03-10

F1 · derivative.exercise_date: Vesting 25% on January 1, 2025, and 75% vesting thereafter over the course of the next 3 years, in equal amounts, on the last day of each month.

SEC source: 0000950170-24-030236 · ownership.xml · derivative · entry 1

EMPFIELD JAMES R. · CIK 0001665430 · EVP, Drug Discovery

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,000

Underlying: Common Shares · 65,000 shares

Expires 2034-03-10

F1 · derivative.exercise_date: Vesting 25% on January 1, 2025, and 75% vesting thereafter over the course of the next 3 years, in equal amounts, on the last day of each month.

SEC source: 0000950170-24-030233 · ownership.xml · derivative · entry 1

ROBIN SHERRINGTON · CIK 0001619962 · EVP, Strategy & Innovation

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,000

Underlying: Common Shares · 65,000 shares

Expires 2034-03-10

F1 · derivative.exercise_date: Vesting 25% on January 1, 2025, and 75% vesting thereafter over the course of the next 3 years, in equal amounts, on the last day of each month.

SEC source: 0000950170-24-030226 · ownership.xml · derivative · entry 1

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 250,000

Underlying: Common Shares · 250,000 shares

Expires 2034-03-10

F1 · derivative.exercise_date: Vesting 25% on January 1, 2025, and 75% vesting thereafter over the course of the next 3 years, in equal amounts, on the last day of each month.

SEC source: 0000950170-24-029542 · ownership.xml · derivative · entry 4

GAROFALO ELIZABETH A. · CIK 0001826361 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Shares · 20,000 shares

Expires 2031-06-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: One-third of the total shares subject to the Option vested on the one year anniversary of the grant date, one-third of the total shares subject to the Option vested on the two year anniversary of the grant date, and one-third of the total shares subject to the Option shall vest on the three year anniversary of the grant date.

SEC source: 0000950170-24-029542 · ownership.xml · nonDerivative · entry 3

GAROFALO ELIZABETH A. · CIK 0001826361 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

SEC source: 0000950170-24-029542 · ownership.xml · nonDerivative · entry 2

GAROFALO ELIZABETH A. · CIK 0001826361 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,092

F1 · price: Represents the closing price of the Company's common shares on March 7, 2024 for purposes of net settlement calculations.

SEC source: 0000950170-24-029542 · ownership.xml · nonDerivative · entry 1

GAROFALO ELIZABETH A. · CIK 0001826361 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-24-028788 · ownership.xml · nonDerivative · entry 4

GANNON STEVEN · CIK 0001643085 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,000

F2 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These share were sold in multiple transactions at prices ranging from $46.20 to $46.21, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0000950170-24-028788 · ownership.xml · nonDerivative · entry 3

GANNON STEVEN · CIK 0001643085 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,000

F1 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These share were sold in multiple transactions at prices ranging from $46.3025 to $46.3675, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0000950170-24-028788 · ownership.xml · nonDerivative · entry 2

GANNON STEVEN · CIK 0001643085 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,000

SEC source: 0000950170-24-028788 · ownership.xml · nonDerivative · entry 1

GANNON STEVEN · CIK 0001643085 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,000

SEC source: 0000950170-24-028795 · ownership.xml · derivative · entry 8

ROBIN SHERRINGTON · CIK 0001619962 · EVP, Strategy & Innovation

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 7,407 shares

Expires 2024-03-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: The exercise price was converted from $10.78 CAD using the closing rate of exchange of the Bank of Canada on the date of grant, after giving effect to the 1-for-4.86 reverse stock split of the Issuer's outstanding shares effected October 1, 2014 (the "Reverse Stock Split"). The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

F5 · derivative.exercise_date: The shares subject to this option are fully vested and exercisable.

SEC source: 0000950170-24-028795 · ownership.xml · derivative · entry 7

ROBIN SHERRINGTON · CIK 0001619962 · EVP, Strategy & Innovation

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 1,234 shares

Expires 2024-03-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: The exercise price was converted from $10.78 CAD using the closing rate of exchange of the Bank of Canada on the date of grant, after giving effect to the 1-for-4.86 reverse stock split of the Issuer's outstanding shares effected October 1, 2014 (the "Reverse Stock Split"). The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

F5 · derivative.exercise_date: The shares subject to this option are fully vested and exercisable.

SEC source: 0000950170-24-028795 · ownership.xml · nonDerivative · entry 6

ROBIN SHERRINGTON · CIK 0001619962 · EVP, Strategy & Innovation

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,398

F4 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These share were sold in multiple transactions at prices ranging from $46.25 to $46.36, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0000950170-24-028795 · ownership.xml · nonDerivative · entry 5

ROBIN SHERRINGTON · CIK 0001619962 · EVP, Strategy & Innovation

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,516

F3 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These share were sold in multiple transactions at prices ranging from $46.15 to $46.17, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0000950170-24-028795 · ownership.xml · nonDerivative · entry 4

ROBIN SHERRINGTON · CIK 0001619962 · EVP, Strategy & Innovation

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,535

F2 · price: Represents the closing price of the Company's common shares on March 6, 2024 for purposes of net settlement calculations.

SEC source: 0000950170-24-028795 · ownership.xml · nonDerivative · entry 3

ROBIN SHERRINGTON · CIK 0001619962 · EVP, Strategy & Innovation

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,824

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The exercise price was converted from $10.78 CAD using the closing rate of exchange of the Bank of Canada on the date of grant, after giving effect to the 1-for-4.86 reverse stock split of the Issuer's outstanding shares effected October 1, 2014 (the "Reverse Stock Split"). The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

SEC source: 0000950170-24-028795 · ownership.xml · nonDerivative · entry 2

ROBIN SHERRINGTON · CIK 0001619962 · EVP, Strategy & Innovation

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,417

F2 · price: Represents the closing price of the Company's common shares on March 6, 2024 for purposes of net settlement calculations.

SEC source: 0000950170-24-028795 · ownership.xml · nonDerivative · entry 1

ROBIN SHERRINGTON · CIK 0001619962 · EVP, Strategy & Innovation

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,632

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The exercise price was converted from $10.78 CAD using the closing rate of exchange of the Bank of Canada on the date of grant, after giving effect to the 1-for-4.86 reverse stock split of the Issuer's outstanding shares effected October 1, 2014 (the "Reverse Stock Split"). The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

SEC source: 0000950170-24-000304 · ownership.xml · nonDerivative · entry 1

ROBIN SHERRINGTON · CIK 0001619962 · EVP, Strategy & Innovation

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,398

F1 · kind: Shares were transferred to the Reporting Person's former spouse pursuant to the terms of a settlement agreement dated December 29, 2023 entered into in connection with the dissolution of the Reporting Person's marriage. The Reporting Person no longer reports as beneficially owned any securities owned by his former spouse.

SEC source: 0000950170-23-071929 · ownership.xml · derivative · entry 4

AZAB MOHAMMAD · CIK 0001309653 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 3,497 shares

Expires 2024-01-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: The exercise price was converted to U.S. dollars from $10.78 CAD using the closing rate of exchange on the Bank of Canada on the date of grant. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

SEC source: 0000950170-23-071929 · ownership.xml · derivative · entry 3

AZAB MOHAMMAD · CIK 0001309653 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 823 shares

Expires 2024-01-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: The exercise price was converted to U.S. dollars from $10.78 CAD using the closing rate of exchange on the Bank of Canada on the date of grant. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

SEC source: 0000950170-23-071929 · ownership.xml · nonDerivative · entry 2

AZAB MOHAMMAD · CIK 0001309653 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 74,225

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: The common shares issued as a result of the exercise are subject to the terms of a Lock-Up Agreement executed by the Reporting Person in favor of the underwriters of the Company's follow-on public offering in November 2023.

F2 · price: The exercise price was converted to U.S. dollars from $10.78 CAD using the closing rate of exchange on the Bank of Canada on the date of grant. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

SEC source: 0000950170-23-071929 · ownership.xml · nonDerivative · entry 1

AZAB MOHAMMAD · CIK 0001309653 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,728

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: The common shares issued as a result of the exercise are subject to the terms of a Lock-Up Agreement executed by the Reporting Person in favor of the underwriters of the Company's follow-on public offering in November 2023.

F2 · price: The exercise price was converted to U.S. dollars from $10.78 CAD using the closing rate of exchange on the Bank of Canada on the date of grant. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

SEC source: 0000950170-23-070912 · ownership.xml · nonDerivative · entry 1

PATOU GARY · CIK 0001283535 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note

Disclosed balance after: 4,902

F1 · shares: Pursuant to the terms of a Lock-Up Agreement executed by the Reporting Person in favor of the underwriters of the Company's follow-on public offering in November 2023, the Reporting Person is permitted to transfer up to 22,000 common shares beneficially owned prior to November 29, 2023 or received upon the exercise of an option to purchase common shares during the lock-up period.

F2 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $41.00 to $41.06, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

F3 · ownership.nature: By Gary & Karen Barbara Patou TTEE Patou Family Trust FBO Gary Patou Karen Barbara Patou.

SEC source: 0000950170-23-070841 · ownership.xml · derivative · entry 13

PATOU GARY · CIK 0001283535 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 5,144 shares

Expires 2024-11-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-23-070841 · ownership.xml · derivative · entry 12

PATOU GARY · CIK 0001283535 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 2,800 shares

Expires 2024-01-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: The exercise price was converted to U.S. dollars from $10.78 CAD using the closing rate of exchange on the Bank of Canada on the date of grant. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

SEC source: 0000950170-23-070841 · ownership.xml · derivative · entry 11

PATOU GARY · CIK 0001283535 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 6,378 shares

Expires 2024-01-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: The exercise price was converted to U.S. dollars from $10.78 CAD using the closing rate of exchange on the Bank of Canada on the date of grant. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

SEC source: 0000950170-23-070841 · ownership.xml · nonDerivative · entry 10

PATOU GARY · CIK 0001283535 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note

Disclosed balance after: 4,902

F1 · shares: Pursuant to the terms of a Lock-Up Agreement executed by the Reporting Person in favor of the underwriters of the Company's follow-on public offering in November 2023, the Reporting Person is permitted to transfer up to 22,000 common shares beneficially owned prior to November 29, 2023 or received upon the exercise of an option to purchase common shares during the lock-up period.

F6 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $41.00 to $41.06, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

F7 · ownership.nature: By Gary & Karen Barbara Patou TTEE Patou Family Trust FBO Gary Patou Karen Barbara Patou.

SEC source: 0000950170-23-070841 · ownership.xml · nonDerivative · entry 9

PATOU GARY · CIK 0001283535 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,573

F1 · shares: Pursuant to the terms of a Lock-Up Agreement executed by the Reporting Person in favor of the underwriters of the Company's follow-on public offering in November 2023, the Reporting Person is permitted to transfer up to 22,000 common shares beneficially owned prior to November 29, 2023 or received upon the exercise of an option to purchase common shares during the lock-up period.

SEC source: 0000950170-23-070841 · ownership.xml · nonDerivative · entry 8

PATOU GARY · CIK 0001283535 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,550

F1 · shares: Pursuant to the terms of a Lock-Up Agreement executed by the Reporting Person in favor of the underwriters of the Company's follow-on public offering in November 2023, the Reporting Person is permitted to transfer up to 22,000 common shares beneficially owned prior to November 29, 2023 or received upon the exercise of an option to purchase common shares during the lock-up period.

F3 · price: Represents the closing price of the Company's common shares in U.S. dollars on December 12, 2023, which was converted to a Canadian dollar amount for purposes of net settlement calculations.

SEC source: 0000950170-23-070841 · ownership.xml · nonDerivative · entry 7

PATOU GARY · CIK 0001283535 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,717

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Pursuant to the terms of a Lock-Up Agreement executed by the Reporting Person in favor of the underwriters of the Company's follow-on public offering in November 2023, the Reporting Person is permitted to transfer up to 22,000 common shares beneficially owned prior to November 29, 2023 or received upon the exercise of an option to purchase common shares during the lock-up period.

SEC source: 0000950170-23-070841 · ownership.xml · nonDerivative · entry 6

PATOU GARY · CIK 0001283535 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,573

F1 · shares: Pursuant to the terms of a Lock-Up Agreement executed by the Reporting Person in favor of the underwriters of the Company's follow-on public offering in November 2023, the Reporting Person is permitted to transfer up to 22,000 common shares beneficially owned prior to November 29, 2023 or received upon the exercise of an option to purchase common shares during the lock-up period.

F5 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $39.04 to $39.16, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0000950170-23-070841 · ownership.xml · nonDerivative · entry 5

PATOU GARY · CIK 0001283535 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,876

F1 · shares: Pursuant to the terms of a Lock-Up Agreement executed by the Reporting Person in favor of the underwriters of the Company's follow-on public offering in November 2023, the Reporting Person is permitted to transfer up to 22,000 common shares beneficially owned prior to November 29, 2023 or received upon the exercise of an option to purchase common shares during the lock-up period.

F3 · price: Represents the closing price of the Company's common shares in U.S. dollars on December 12, 2023, which was converted to a Canadian dollar amount for purposes of net settlement calculations.

SEC source: 0000950170-23-070841 · ownership.xml · nonDerivative · entry 4

PATOU GARY · CIK 0001283535 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,453

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Pursuant to the terms of a Lock-Up Agreement executed by the Reporting Person in favor of the underwriters of the Company's follow-on public offering in November 2023, the Reporting Person is permitted to transfer up to 22,000 common shares beneficially owned prior to November 29, 2023 or received upon the exercise of an option to purchase common shares during the lock-up period.

F2 · price: The exercise price was converted to U.S. dollars from $10.78 CAD using the closing rate of exchange on the Bank of Canada on the date of grant. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

SEC source: 0000950170-23-070841 · ownership.xml · nonDerivative · entry 3

PATOU GARY · CIK 0001283535 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,573

F1 · shares: Pursuant to the terms of a Lock-Up Agreement executed by the Reporting Person in favor of the underwriters of the Company's follow-on public offering in November 2023, the Reporting Person is permitted to transfer up to 22,000 common shares beneficially owned prior to November 29, 2023 or received upon the exercise of an option to purchase common shares during the lock-up period.

F4 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $38.81 to $39.13, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0000950170-23-070841 · ownership.xml · nonDerivative · entry 2

PATOU GARY · CIK 0001283535 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,673

F1 · shares: Pursuant to the terms of a Lock-Up Agreement executed by the Reporting Person in favor of the underwriters of the Company's follow-on public offering in November 2023, the Reporting Person is permitted to transfer up to 22,000 common shares beneficially owned prior to November 29, 2023 or received upon the exercise of an option to purchase common shares during the lock-up period.

F3 · price: Represents the closing price of the Company's common shares in U.S. dollars on December 12, 2023, which was converted to a Canadian dollar amount for purposes of net settlement calculations.

SEC source: 0000950170-23-070841 · ownership.xml · nonDerivative · entry 1

PATOU GARY · CIK 0001283535 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,951

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Pursuant to the terms of a Lock-Up Agreement executed by the Reporting Person in favor of the underwriters of the Company's follow-on public offering in November 2023, the Reporting Person is permitted to transfer up to 22,000 common shares beneficially owned prior to November 29, 2023 or received upon the exercise of an option to purchase common shares during the lock-up period.

F2 · price: The exercise price was converted to U.S. dollars from $10.78 CAD using the closing rate of exchange on the Bank of Canada on the date of grant. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.