XENE

SEC source: 0001193125-26-102669 · ownership.xml · nonDerivative · entry 2

KENNEY CHRISTOPHER JOHN · CIK 0001880129 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,729

F2 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading arrangement, in the form of a durable sell-to-cover instruction, adopted by the reporting person on December 3, 2025, solely to satisfy tax withholding obligations related to the vesting of PSUs granted on March 11, 2024.

SEC source: 0001193125-26-102667 · ownership.xml · nonDerivative · entry 2

DiFabio Andrea · CIK 0001692506 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,893

F2 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading arrangement, in the form of a durable sell-to-cover instruction, adopted by the reporting person on December 3, 2025, solely to satisfy tax withholding obligations related to the vesting of PSUs granted on March 11, 2024.

SEC source: 0001193125-26-102666 · ownership.xml · nonDerivative · entry 15

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 14,731

F12 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading arrangement, in the form of a durable sell-to-cover instruction, adopted by the reporting person on December 3, 2025, solely to satisfy tax withholding obligations related to the vesting of PSUs granted on March 11, 2024.

SEC source: 0001193125-26-102669 · ownership.xml · derivative · entry 4

KENNEY CHRISTOPHER JOHN · CIK 0001880129 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 7,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

F1 · derivative.exercise_date: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

F1 · derivative.expiration_date: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

SEC source: 0001193125-26-102669 · ownership.xml · derivative · entry 3

KENNEY CHRISTOPHER JOHN · CIK 0001880129 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Common Shares · 7,500 shares

Expires not disclosed

F1 · derivative.exercise_price: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

F1 · shares: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

F1 · derivative.exercise_date: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

F1 · derivative.expiration_date: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

SEC source: 0001193125-26-102669 · ownership.xml · nonDerivative · entry 1

KENNEY CHRISTOPHER JOHN · CIK 0001880129 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

F1 · price: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

SEC source: 0001193125-26-102667 · ownership.xml · derivative · entry 4

DiFabio Andrea · CIK 0001692506 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 7,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

F1 · derivative.exercise_date: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

F1 · derivative.expiration_date: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

SEC source: 0001193125-26-102667 · ownership.xml · derivative · entry 3

DiFabio Andrea · CIK 0001692506 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Common Shares · 7,500 shares

Expires not disclosed

F1 · derivative.exercise_price: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

F1 · shares: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

F1 · derivative.exercise_date: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

F1 · derivative.expiration_date: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

SEC source: 0001193125-26-102667 · ownership.xml · nonDerivative · entry 1

DiFabio Andrea · CIK 0001692506 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

F1 · price: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

SEC source: 0001193125-26-102666 · ownership.xml · derivative · entry 22

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 20,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F11 · derivative.exercise_price: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

F11 · derivative.exercise_date: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

F11 · derivative.expiration_date: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

SEC source: 0001193125-26-102666 · ownership.xml · derivative · entry 21

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Shares · 20,000 shares

Expires not disclosed

F11 · derivative.exercise_price: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

F11 · shares: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

F11 · derivative.exercise_date: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

F11 · derivative.expiration_date: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

SEC source: 0001193125-26-102666 · ownership.xml · derivative · entry 20

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 65,000 shares

Expires 2029-09-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F13 · derivative.exercise_date: The shares subject to this option are fully vested and exercisable.

SEC source: 0001193125-26-102666 · ownership.xml · derivative · entry 19

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 105,000 shares

Expires 2028-03-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F13 · derivative.exercise_date: The shares subject to this option are fully vested and exercisable.

SEC source: 0001193125-26-102666 · ownership.xml · derivative · entry 18

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 25,000 shares

Expires 2027-10-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F13 · derivative.exercise_date: The shares subject to this option are fully vested and exercisable.

SEC source: 0001193125-26-102666 · ownership.xml · derivative · entry 17

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 75,000 shares

Expires 2027-03-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F13 · derivative.exercise_date: The shares subject to this option are fully vested and exercisable.

SEC source: 0001193125-26-102666 · ownership.xml · nonDerivative · entry 14

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F11 · shares: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

F11 · price: Represents shares earned and vested under a performance share unit ("PSU") award granted to the reporting person on March 11, 2024. The number of shares earned is based on a determination by the issuer's Board of Directors of the achievement of one or more prescribed milestones under the terms of the PSU award agreement. The PSUs vested immediately upon such determination.

SEC source: 0001193125-26-102666 · ownership.xml · nonDerivative · entry 13

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,000

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 27, 2024.

F10 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, or shares sold. These shares were sold in multiple transactions at prices ranging from $62.00 to $62.30, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001193125-26-102666 · ownership.xml · nonDerivative · entry 12

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 71,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-102666 · ownership.xml · nonDerivative · entry 11

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,000

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 27, 2024.

F9 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, or shares sold. These shares were sold in multiple transactions at prices ranging from $59.75 to $60.60, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001193125-26-102666 · ownership.xml · nonDerivative · entry 10

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 72,652

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 27, 2024.

F8 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, or shares sold. These shares were sold in multiple transactions at prices ranging from $58.745 to $59.735, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001193125-26-102666 · ownership.xml · nonDerivative · entry 9

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 111,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-102666 · ownership.xml · nonDerivative · entry 8

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,000

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 27, 2024.

F7 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, or shares sold. These shares were sold in multiple transactions at prices ranging from $61.055 to $61.555, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001193125-26-102666 · ownership.xml · nonDerivative · entry 7

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,449

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 27, 2024.

F6 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, or shares sold. These shares were sold in multiple transactions at prices ranging from $60.05 to $61.035, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001193125-26-102666 · ownership.xml · nonDerivative · entry 6

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 18,521

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 27, 2024.

F5 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, or shares sold. These shares were sold in multiple transactions at prices ranging from $59.03 to $60.02, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001193125-26-102666 · ownership.xml · nonDerivative · entry 5

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 31,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-102666 · ownership.xml · nonDerivative · entry 4

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,000

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 27, 2024.

F4 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, or shares sold. These shares were sold in multiple transactions at prices ranging from $60.16 to $61.00, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001193125-26-102666 · ownership.xml · nonDerivative · entry 3

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 27,515

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 27, 2024.

F3 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, or shares sold. These shares were sold in multiple transactions at prices ranging from $59.16 to $60.15, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001193125-26-102666 · ownership.xml · nonDerivative · entry 2

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 59,209

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 27, 2024.

F2 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, or shares sold. These shares were sold in multiple transactions at prices ranging from $58.16 to $59.1425, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001193125-26-102666 · ownership.xml · nonDerivative · entry 1

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 81,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-009238 · ownership.xml · derivative · entry 2

KENNEY CHRISTOPHER JOHN · CIK 0001880129 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Shares · 20,000 shares

Expires not disclosed

F2 · derivative.exercise_date: Each restricted share unit represents a contingent right to receive one Common Share vesting 25% on each of the first four anniversaries of the date of grant, beginning on January 9, 2027.

F2 · derivative.expiration_date: Each restricted share unit represents a contingent right to receive one Common Share vesting 25% on each of the first four anniversaries of the date of grant, beginning on January 9, 2027.

SEC source: 0001193125-26-009238 · ownership.xml · derivative · entry 1

KENNEY CHRISTOPHER JOHN · CIK 0001880129 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Shares · 100,000 shares

Expires 2036-01-08

F1 · derivative.exercise_date: Vesting 25% on January 9, 2027, and 75% vesting thereafter over the course of the next 3 years, in equal amounts, on the last day of each month.

SEC source: 0001193125-26-009232 · ownership.xml · derivative · entry 2

DiFabio Andrea · CIK 0001692506 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Shares · 15,000 shares

Expires not disclosed

F2 · derivative.exercise_date: Each restricted share unit represents a contingent right to receive one Common Share vesting 25% on each of the first four anniversaries of the date of grant, beginning on January 9, 2027.

F2 · derivative.expiration_date: Each restricted share unit represents a contingent right to receive one Common Share vesting 25% on each of the first four anniversaries of the date of grant, beginning on January 9, 2027.

SEC source: 0001193125-26-009232 · ownership.xml · derivative · entry 1

DiFabio Andrea · CIK 0001692506 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Shares · 80,000 shares

Expires 2036-01-08

F1 · derivative.exercise_date: Vesting 25% on January 9, 2027, and 75% vesting thereafter over the course of the next 3 years, in equal amounts, on the last day of each month.

SEC source: 0001193125-26-009235 · ownership.xml · derivative · entry 2

Cline Darren S · CIK 0001633639 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Shares · 20,000 shares

Expires not disclosed

F2 · derivative.exercise_date: Each restricted share unit represents a contingent right to receive one Common Share vesting 25% on each of the first four anniversaries of the date of grant, beginning on January 9, 2027.

F2 · derivative.expiration_date: Each restricted share unit represents a contingent right to receive one Common Share vesting 25% on each of the first four anniversaries of the date of grant, beginning on January 9, 2027.

SEC source: 0001193125-26-009235 · ownership.xml · derivative · entry 1

Cline Darren S · CIK 0001633639 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Shares · 40,000 shares

Expires 2036-01-08

F1 · derivative.exercise_date: Vesting 25% on January 9, 2027, and 75% vesting thereafter over the course of the next 3 years, in equal amounts, on the last day of each month.

SEC source: 0001193125-26-009230 · ownership.xml · derivative · entry 2

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,000

Underlying: Common Shares · 65,000 shares

Expires not disclosed

F2 · derivative.exercise_date: Each restricted share unit represents a contingent right to receive one Common Share vesting 25% on each of the first four anniversaries of the date of grant, beginning on January 9, 2027.

F2 · derivative.expiration_date: Each restricted share unit represents a contingent right to receive one Common Share vesting 25% on each of the first four anniversaries of the date of grant, beginning on January 9, 2027.

SEC source: 0001193125-26-009230 · ownership.xml · derivative · entry 1

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 350,000

Underlying: Common Shares · 350,000 shares

Expires 2036-01-08

F1 · derivative.exercise_date: Vesting 25% on January 9, 2027, and 75% vesting thereafter over the course of the next 3 years, in equal amounts, on the last day of each month.

SEC source: 0001193125-26-001172 · ownership.xml · derivative · entry 5

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 40,000 shares

Expires 2026-03-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

SEC source: 0001193125-26-001172 · ownership.xml · nonDerivative · entry 3

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,000

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 27, 2024.

F3 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, of shares sold. These share were sold in multiple transactions at prices ranging from $44.91 to $45.125, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001193125-26-001172 · ownership.xml · nonDerivative · entry 2

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,062

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 27, 2024.

F2 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, of shares sold. These share were sold in multiple transactions at prices ranging from $43.91 to $44.90, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001193125-26-001172 · ownership.xml · nonDerivative · entry 1

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 46,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-25-313147 · ownership.xml · nonDerivative · entry 3

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,000

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 27, 2024.

F4 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, of shares sold. These share were sold in multiple transactions at prices ranging from $46.02 to $46.49, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001193125-25-313147 · ownership.xml · nonDerivative · entry 2

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,010

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 27, 2024.

F3 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, of shares sold. These share were sold in multiple transactions at prices ranging from $45.02 to $46.013, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001193125-25-313147 · ownership.xml · nonDerivative · entry 1

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,830

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 27, 2024.

F2 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, of shares sold. These share were sold in multiple transactions at prices ranging from $45.00 to $45.135, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001193125-25-307211 · ownership.xml · nonDerivative · entry 1

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 31,205

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 27, 2024.

SEC source: 0001193125-25-242700 · ownership.xml · derivative · entry 2

Kelly Thomas Patrick · CIK 0001410514 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Shares · 30,000 shares

Expires not disclosed

F2 · derivative.exercise_date: Each restricted share unit represents a contingent right to receive one Common Share vesting 25% on each of the first four anniversaries of the date of grant, beginning on October 15, 2026.

F2 · derivative.expiration_date: Each restricted share unit represents a contingent right to receive one Common Share vesting 25% on each of the first four anniversaries of the date of grant, beginning on October 15, 2026.

SEC source: 0001193125-25-242700 · ownership.xml · derivative · entry 1

Kelly Thomas Patrick · CIK 0001410514 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 225,000

Underlying: Common Shares · 225,000 shares

Expires 2035-10-14

F1 · derivative.exercise_date: Vesting 25% on October 15, 2026, and 75% vesting thereafter over the course of the next 3 years, in equal amounts, on the last day of each month.

SEC source: 0001193125-25-227202 · ownership.xml · derivative · entry 4

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT, CEO & INTERIM CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 25,000 shares

Expires 2025-12-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

SEC source: 0001193125-25-227202 · ownership.xml · nonDerivative · entry 2

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT, CEO & INTERIM CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 31,302

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 27, 2024.

F2 · price: The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price (rounded to two decimal places), respectively, of shares sold. These share were sold in multiple transactions at prices ranging from $40.00 to $40.495, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001193125-25-227202 · ownership.xml · nonDerivative · entry 1

MORTIMER IAN · CIK 0001619961 · Director · PRESIDENT, CEO & INTERIM CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 56,302

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.