WVE

SEC source: 0000950170-24-110141 · ownership.xml · nonDerivative · entry 1

Moran Kyle · CIK 0001657765 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,777

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 21, 2023.

F2 · balance_after: Includes 3,002 ordinary shares acquired on July 14, 2024, under the issuer's 2019 Employee Share Purchase Plan.

SEC source: 0000950170-24-100274 · ownership.xml · nonDerivative · entry 1

BOLNO PAUL · CIK 0001657710 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 359,059

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 22, 2024.

F2 · price: The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $5.68 to $5.94 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price.

SEC source: 0000950170-24-097287 · ownership.xml · derivative · entry 2

HENRY CHRISTIAN O · CIK 0001263805 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,230

Underlying: Ordinary Shares · 32,230 shares

Expires 2029-08-12

F2 · derivative.exercise_date: The reporting person was granted this option pursuant to the 2024 Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2025 annual general meeting or August 12, 2025.

SEC source: 0000950170-24-097287 · ownership.xml · nonDerivative · entry 1

HENRY CHRISTIAN O · CIK 0001263805 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,115

F1 · shares: The reporting person was granted this restricted share unit award (RSU) pursuant to the 2024 Non-Employee Director Compensation Policy. The RSU vests as to 100% of the shares on the earlier of the Company's 2025 annual general meeting or August 12, 2025.

SEC source: 0000950170-24-097286 · ownership.xml · derivative · entry 2

CORRIGAN MARK · CIK 0001250661 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 64,460

Underlying: Ordinary Shares · 64,460 shares

Expires 2029-08-12

F2 · derivative.exercise_date: The reporting person was granted this option pursuant to the 2024 Non-Employee Director Compensation Policy. The option vests as to 12.5% on a quarterly basis beginning August 12, 2024, through the two-year period following the grant date.

SEC source: 0000950170-24-097286 · ownership.xml · nonDerivative · entry 1

CORRIGAN MARK · CIK 0001250661 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,230

F1 · shares: The reporting person was granted this restricted share unit award (RSU) pursuant to the 2024 Non-Employee Director Compensation Policy. The RSU vests as to 50% on each of (i) the earlier of the Company's 2025 annual general meeting or August 12, 2025; and (ii) the earlier of the Company's 2026 annual general meeting or August 12, 2026.

SEC source: 0001415889-24-021318 · form4-08142024_100845.xml · derivative · entry 3

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 32,230

Underlying: Ordinary Shares · 32,230 shares

Expires 2029-08-12

F5 · derivative.exercise_date: Dr. Kolchinsky was granted this option pursuant to the 2024 Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Issuer's 2025 annual general meeting or August 12, 2025.

F2 · ownership.nature: Dr. Kolchinsky is a Managing Partner of the Adviser who serves on the Issuer's board of directors. Under Dr. Kolchinsky's arrangement with the Adviser, Dr. Kolchinsky holds the RSUs and options for the benefit of the Fund. Dr. Kolchinsky is obligated to turn over to the Adviser any net cash or shares received upon settlement of the RSUs, or exercise of the options, as applicable, which will offset advisory fees owed by the Fund to the Adviser.

F3 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. Each of the Adviser, the Adviser GP, the Fund, Dr. Kolchinsky and Mr. Shah disclaims beneficial ownership of any of the reported securities, except to the extent of its or his respective pecuniary interest therein.

SEC source: 0001415889-24-021318 · form4-08142024_100845.xml · nonDerivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 16,115

F1 · shares: Dr. Kolchinsky was granted this restricted share unit award (RSU) pursuant to the 2024 Non-Employee Director Compensation Policy. The RSU vests as to 100% of the shares on the earlier of the Issuer's 2025 annual general meeting or August 12, 2025.

F2 · ownership.nature: Dr. Kolchinsky is a Managing Partner of the Adviser who serves on the Issuer's board of directors. Under Dr. Kolchinsky's arrangement with the Adviser, Dr. Kolchinsky holds the RSUs and options for the benefit of the Fund. Dr. Kolchinsky is obligated to turn over to the Adviser any net cash or shares received upon settlement of the RSUs, or exercise of the options, as applicable, which will offset advisory fees owed by the Fund to the Adviser.

F3 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. Each of the Adviser, the Adviser GP, the Fund, Dr. Kolchinsky and Mr. Shah disclaims beneficial ownership of any of the reported securities, except to the extent of its or his respective pecuniary interest therein.

SEC source: 0000950170-24-097290 · ownership.xml · derivative · entry 2

Rawcliffe Adrian · CIK 0001555851 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,230

Underlying: Ordinary Shares · 32,230 shares

Expires 2029-08-12

F2 · derivative.exercise_date: The reporting person was granted this option pursuant to the 2024 Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2025 annual general meeting or August 12, 2025.

SEC source: 0000950170-24-097290 · ownership.xml · nonDerivative · entry 1

Rawcliffe Adrian · CIK 0001555851 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,115

F1 · shares: The reporting person was granted this restricted share unit award (RSU) pursuant to the 2024 Non-Employee Director Compensation Policy. The RSU vests as to 100% of the shares on the earlier of the Company's 2025 annual general meeting or August 12, 2025.

SEC source: 0000950170-24-097285 · ownership.xml · derivative · entry 2

Verdine Gregory L. · CIK 0001572315 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,230

Underlying: Ordinary Shares · 32,230 shares

Expires 2029-08-12

F2 · derivative.exercise_date: The reporting person was granted this option pursuant to the 2024 Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2025 annual general meeting or August 12, 2025.

SEC source: 0000950170-24-097285 · ownership.xml · nonDerivative · entry 1

Verdine Gregory L. · CIK 0001572315 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,115

F1 · shares: The reporting person was granted this restricted share unit award (RSU) pursuant to the 2024 Non-Employee Director Compensation Policy. The RSU vests as to 100% of the shares on the earlier of the Company's 2025 annual general meeting or August 12, 2025.

SEC source: 0000950170-24-097289 · ownership.xml · derivative · entry 2

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,230

Underlying: Ordinary Shares · 32,230 shares

Expires 2029-08-12

F2 · derivative.exercise_date: The reporting person was granted this option pursuant to the 2024 Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2025 annual general meeting or August 12, 2025.

SEC source: 0000950170-24-097289 · ownership.xml · nonDerivative · entry 1

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,115

F1 · shares: The reporting person was granted this restricted share unit award (RSU) pursuant to the 2024 Non-Employee Director Compensation Policy. The RSU vests as to 100% of the shares on the earlier of the Company's 2025 annual general meeting or August 12, 2025.

SEC source: 0000950170-24-097284 · ownership.xml · derivative · entry 2

Wagner Heidi L · CIK 0001655029 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 64,460

Underlying: Ordinary Shares · 64,460 shares

Expires 2029-08-12

F2 · derivative.exercise_date: The reporting person was granted this option pursuant to the 2024 Non-Employee Director Compensation Policy. The option vests as to 12.5% on a quarterly basis beginning August 12, 2024, through the two-year period following the grant date.

SEC source: 0000950170-24-097284 · ownership.xml · nonDerivative · entry 1

Wagner Heidi L · CIK 0001655029 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,230

F1 · shares: The reporting person was granted this restricted share unit award (RSU) pursuant to the 2024 Non-Employee Director Compensation Policy. The RSU vests as to 50% on each of (i) the earlier of the Company's 2025 annual general meeting or August 12, 2025; and (ii) the earlier of the Company's 2026 annual general meeting or August 12, 2026.

SEC source: 0000950170-24-097283 · ownership.xml · derivative · entry 2

TAKANASHI KEN · CIK 0001657768 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,230

Underlying: Ordinary Shares · 32,230 shares

Expires 2029-08-12

F2 · derivative.exercise_date: The reporting person was granted this option pursuant to the 2024 Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2025 annual general meeting or August 12, 2025.

SEC source: 0000950170-24-097283 · ownership.xml · nonDerivative · entry 1

TAKANASHI KEN · CIK 0001657768 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,721,175

F1 · shares: The reporting person was granted this restricted share unit award (RSU) pursuant to the 2024 Non-Employee Director Compensation Policy. The RSU vests as to 100% of the shares on the earlier of the Company's 2025 annual general meeting or August 12, 2025.

SEC source: 0000950170-24-086173 · ownership.xml · derivative · entry 2

Vargeese Chandra · CIK 0001657675 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,332

Underlying: Ordinary Shares · 68,210 shares

Expires 2025-03-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The share options that were exercised via cash purchase in this reportable transaction were fully vested.

SEC source: 0000950170-24-086173 · ownership.xml · nonDerivative · entry 1

Vargeese Chandra · CIK 0001657675 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 185,061

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 2,559 ordinary shares acquired on July 14, 2023, 4,135 ordinary shares acquired on January 14, 2024, and 3,533 ordinary shares acquired on July 14, 2024, under the issuer's 2019 Employee Share Purchase Plan.

SEC source: 0000950170-24-042381 · ownership.xml · nonDerivative · entry 1

Moran Kyle · CIK 0001657765 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 33,921

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 21, 2023.

F2 · price: The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $6.115 to $6.23 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 3,431 ordinary shares acquired on January 14, 2024, under the issuer's 2019 Employee Share Purchase Plan.

SEC source: 0000950170-24-012392 · ownership.xml · derivative · entry 1

Vargeese Chandra · CIK 0001657675 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 361,700

Underlying: Ordinary Shares · 361,700 shares

Expires 2034-02-05

F1 · derivative.exercise_date: The option vests as to 25% of the shares on February 5, 2025, and vests as to an additional 6.25% of the shares quarterly thereafter until February 5, 2028.

SEC source: 0000950170-24-012401 · ownership.xml · derivative · entry 1

Francis Chris · CIK 0001657709 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 286,400

Underlying: Ordinary Shares · 286,400 shares

Expires 2034-02-05

F1 · derivative.exercise_date: The option vests as to 25% of the shares on February 5, 2025, and vests as to an additional 6.25% of the shares quarterly thereafter until February 5, 2028.

SEC source: 0000950170-24-012395 · ownership.xml · derivative · entry 1

BOLNO PAUL · CIK 0001657710 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,008,600

Underlying: Ordinary Shares · 1,008,600 shares

Expires 2034-02-05

F1 · derivative.exercise_date: The option vests as to 25% of the shares on February 5, 2025, and vests as to an additional 6.25% of the shares quarterly thereafter until February 5, 2028.

SEC source: 0000950170-24-012394 · ownership.xml · derivative · entry 1

Moran Kyle · CIK 0001657765 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 371,500

Underlying: Ordinary Shares · 371,500 shares

Expires 2034-02-05

F1 · derivative.exercise_date: The option vests as to 25% of the shares on February 5, 2025, and vests as to an additional 6.25% of the shares quarterly thereafter until February 5, 2028.

SEC source: 0001104659-23-125724 · tm2332743-1_4seq1.xml · nonDerivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 19,202,009

F1 · price: Acquired from the Issuer pursuant to the public offering described in the Issuer's Prospectus filed with the Securities and Exchange Commission on December 8, 2023.

F2 · balance_after: Held directly by RA Capital Healthcare Fund, L.P. (the "Fund").

F1 · ownership.nature: Acquired from the Issuer pursuant to the public offering described in the Issuer's Prospectus filed with the Securities and Exchange Commission on December 8, 2023.

F2 · ownership.nature: Held directly by RA Capital Healthcare Fund, L.P. (the "Fund").

F3 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for the Fund. The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

SEC source: 0001104659-24-004581 · tm243566-1_4aseq1.xml · nonDerivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 18,202,009

F1 · price: Acquired from the Issuer pursuant to the public offering described in the Issuer's Prospectus filed with the Securities and Exchange Commission on December 8, 2023.

F2 · balance_after: Held directly by RA Capital Healthcare Fund, L.P. (the "Fund").

F4 · balance_after: This amendment is being filed solely to rectify a clerical error in column 5 which reflected a total shares held as 19,202,009 where it should have read 18,202,009.

F1 · ownership.nature: Acquired from the Issuer pursuant to the public offering described in the Issuer's Prospectus filed with the Securities and Exchange Commission on December 8, 2023.

F2 · ownership.nature: Held directly by RA Capital Healthcare Fund, L.P. (the "Fund").

F3 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for the Fund. The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

SEC source: 0001999371-24-001192 · gsk-form4_120723.xml · nonDerivative · entry 1

GSK plc · CIK 0001131399 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Corporation

Disclosed balance after: 13,983,761

F1 · ownership.nature: The shares reported herein are held of record by Glaxo Group Limited, a wholly-owned subsidiary of GSK plc (the "Reporting Person").

SEC source: 0000899243-23-018361 · doc4.xml · nonDerivative · entry 1

Moran Kyle · CIK 0001657765 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 46,120

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on April 10, 2023.

F2 · price: The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $4.75 to $4.76 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 3,431 ordinary shares acquired on July 14, 2023, under the issuer's 2019 Employee Share Purchase Plan.

SEC source: 0000899243-23-017911 · doc4.xml · derivative · entry 1

HENRY CHRISTIAN O · CIK 0001263805 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Ordinary Shares · 45,000 shares

Expires 2028-08-07

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2024 annual general meeting or August 7, 2024.

SEC source: 0000899243-23-017913 · doc4.xml · derivative · entry 1

CORRIGAN MARK · CIK 0001250661 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Ordinary Shares · 45,000 shares

Expires 2028-08-07

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2024 annual general meeting or August 7, 2024.

SEC source: 0001104659-23-089416 · tm2323213-1_4seq1.xml · derivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 45,000

Underlying: Ordinary Shares · 45,000 shares

Expires 2028-08-07

F1 · derivative.exercise_date: Dr. Kolchinsky was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2024 annual general meeting or August 7, 2024.

F1 · ownership.nature: Dr. Kolchinsky was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2024 annual general meeting or August 7, 2024.

F2 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

F3 · ownership.nature: Under Dr. Kolchinsky's arrangement with the Adviser, Dr. Kolchinsky holds the option for the benefit of the Fund. Dr. Kolchinsky is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option, which will offset advisory fees owed by the Fund. The Reporting Persons therefore disclaim beneficial ownership of the option and underlying common stock.

SEC source: 0000899243-23-017912 · doc4.xml · derivative · entry 1

Rawcliffe Adrian · CIK 0001555851 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Ordinary Shares · 45,000 shares

Expires 2028-08-07

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2024 annual general meeting or August 7, 2024.

SEC source: 0000899243-23-017910 · doc4.xml · derivative · entry 1

Verdine Gregory L. · CIK 0001572315 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Ordinary Shares · 45,000 shares

Expires 2028-08-07

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2024 annual general meeting or August 7, 2024.

SEC source: 0000899243-23-017916 · doc4.xml · derivative · entry 1

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Ordinary Shares · 45,000 shares

Expires 2028-08-07

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2024 annual general meeting or August 7, 2024.

SEC source: 0000899243-23-017915 · doc4.xml · derivative · entry 1

TAKANASHI KEN · CIK 0001657768 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Ordinary Shares · 45,000 shares

Expires 2028-08-07

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2024 annual general meeting or August 7, 2024.

SEC source: 0000899243-23-017914 · doc4.xml · derivative · entry 1

Wagner Heidi L · CIK 0001655029 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Ordinary Shares · 45,000 shares

Expires 2028-08-07

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2024 annual general meeting or August 7, 2024.

SEC source: 0000899243-23-005565 · doc4.xml · derivative · entry 2

Vargeese Chandra · CIK 0001657675 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 295,400

Underlying: Ordinary Shares · 295,400 shares

Expires 2033-02-17

F4 · derivative.exercise_date: The option vests as to 25% of the shares on February 17, 2024 and vests as to an additional 6.25% of the shares quarterly thereafter until February 17, 2027.

SEC source: 0000899243-23-005563 · doc4.xml · derivative · entry 2

Francis Chris · CIK 0001657709 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 244,700

Underlying: Ordinary Shares · 244,700 shares

Expires 2033-02-17

F3 · derivative.exercise_date: The option vests as to 25% of the shares on February 17, 2024 and vests as to an additional 6.25% of the shares quarterly thereafter until February 17, 2027.

SEC source: 0000899243-23-005564 · doc4.xml · derivative · entry 2

BOLNO PAUL · CIK 0001657710 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 771,000

Underlying: Ordinary Shares · 771,000 shares

Expires 2033-02-17

F3 · derivative.exercise_date: The option vests as to 25% of the shares on February 17, 2024 and vests as to an additional 6.25% of the shares quarterly thereafter until February 17, 2027.

SEC source: 0000899243-23-005562 · doc4.xml · derivative · entry 2

Moran Kyle · CIK 0001657765 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 272,700

Underlying: Ordinary Shares · 272,700 shares

Expires 2033-02-17

F4 · derivative.exercise_date: The option vests as to 25% of the shares on February 17, 2024 and vests as to an additional 6.25% of the shares quarterly thereafter until February 17, 2027.

SEC source: 0000899243-23-005565 · doc4.xml · nonDerivative · entry 1

Vargeese Chandra · CIK 0001657675 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,624

F1 · kind: On February 16, 2023, the reporting person sold 10,249 ordinary shares solely to cover taxes associated with the vesting of restricted share units ("RSUs") on February 15, 2023. These sales were made pursuant to a provision in the reporting person's RSU agreement that requires automatic sales of shares to cover tax withholding obligations.

F2 · price: The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $4.03 to $4.17 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 1,500 ordinary shares acquired on July 14, 2022, and 4,278 ordinary shares acquired on January 14, 2023, under the issuer's 2019 Employee Share Purchase Plan.

SEC source: 0000899243-23-005563 · doc4.xml · nonDerivative · entry 1

Francis Chris · CIK 0001657709 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 79,714

F1 · kind: On February 16, 2023, the reporting person sold 10,258 ordinary shares solely to cover taxes associated with the vesting of restricted share units ("RSUs") on February 15, 2023. These sales were made pursuant to a provision in the reporting person's RSU agreement that requires automatic sales of shares to cover tax withholding obligations.

F2 · price: The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $4.03 to $4.18 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price.

SEC source: 0000899243-23-005564 · doc4.xml · nonDerivative · entry 1

BOLNO PAUL · CIK 0001657710 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 407,425

F1 · kind: On February 16, 2023, the reporting person sold 29,400 ordinary shares solely to cover taxes associated with the vesting of restricted share units ("RSUs") on February 15, 2023. These sales were made pursuant to a provision in the reporting person's RSU agreement that requires automatic sales of shares to cover tax withholding obligations.

F2 · price: The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $4.03 to $4.17 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price.

SEC source: 0000899243-23-005562 · doc4.xml · nonDerivative · entry 1

Moran Kyle · CIK 0001657765 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 79,751

F1 · kind: On February 16, 2023, the reporting person sold 9,729 ordinary shares solely to cover taxes associated with the vesting of restricted share units ("RSUs") on February 15, 2023. These sales were made pursuant to a provision in the reporting person's RSU agreement that requires automatic sales of shares to cover tax withholding obligations.

F2 · price: The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $4.03 to $4.18 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price.

F3 · balance_after: Includes 1,500 ordinary shares acquired on July 14, 2022, and 3,413 ordinary shares acquired on January 14, 2023, under the issuer's 2019 Employee Share Purchase Plan.

SEC source: 0000899243-22-034493 · doc4.xml · derivative · entry 1

Verdine Gregory L. · CIK 0001572315 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 163,467

Underlying: Ordinary Shares · 163,467 shares

Expires 2027-10-27

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to his existing consulting agreement with Wave. The option vests in equal monthly installments beginning on October 31, 2022, through December 31, 2024, subject to the reporting person's continued services through the applicable vesting date.

SEC source: 0000899243-22-029099 · doc4.xml · derivative · entry 1

HENRY CHRISTIAN O · CIK 0001263805 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,000

Underlying: Ordinary Shares · 21,000 shares

Expires 2027-08-15

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2023 annual general meeting or August 15, 2023.

SEC source: 0000899243-22-029095 · doc4.xml · derivative · entry 1

CORRIGAN MARK · CIK 0001250661 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,000

Underlying: Ordinary Shares · 21,000 shares

Expires 2027-08-15

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2023 annual general meeting or August 15, 2023.

SEC source: 0001104659-22-092280 · tm2223727-1_4seq1.xml · derivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · 10% owner

Kolchinsky Peter · CIK 0001384859 · 10% owner

Shah Rajeev M. · CIK 0001619841 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 21,000

Underlying: Ordinary Shares · 21,000 shares

Expires 2027-08-15

F2 · derivative.exercise_date: All shares subject to the option vest 100% on the first to occur of (i) August 15, 2023 or (ii) the Issuer's 2023 annual general meeting.

F1 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for the RA Capital Healthcare Fund, L.P. (the "Fund"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

F2 · ownership.nature: All shares subject to the option vest 100% on the first to occur of (i) August 15, 2023 or (ii) the Issuer's 2023 annual general meeting.

F3 · ownership.nature: Under Dr. Kolchinsky's arrangement with the Adviser, Dr. Kolchisnky holds the options for the benefit of the Fund. Dr. Kolchinsky is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option, which will offset advisory fees owed by the Fund to the Adviser. The Reporting Persons therefore disclaim beneficial ownership of the option and underlying common stock except to the extent of their pecuniary interest.

SEC source: 0000899243-22-029100 · doc4.xml · derivative · entry 1

Rawcliffe Adrian · CIK 0001555851 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,000

Underlying: Ordinary Shares · 21,000 shares

Expires 2027-08-15

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2023 annual general meeting or August 15, 2023.