WVE

SEC source: 0001193125-25-314741 · ownership.xml · nonDerivative · entry 2

Wagner Heidi L · CIK 0001655029 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 44,930

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2025.

SEC source: 0001193125-25-314741 · ownership.xml · nonDerivative · entry 1

Wagner Heidi L · CIK 0001655029 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 51,930

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2025.

SEC source: 0001193125-25-314739 · ownership.xml · derivative · entry 16

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 21,000 shares

Expires 2026-08-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 6, 2025.

F2 · derivative.exercise_date: These share options are fully vested.

SEC source: 0001193125-25-314739 · ownership.xml · derivative · entry 15

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 21,000 shares

Expires 2027-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 6, 2025.

F2 · derivative.exercise_date: These share options are fully vested.

SEC source: 0001193125-25-314739 · ownership.xml · derivative · entry 14

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 45,000 shares

Expires 2028-08-07

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 6, 2025.

F2 · derivative.exercise_date: These share options are fully vested.

SEC source: 0001193125-25-314739 · ownership.xml · derivative · entry 13

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 32,230 shares

Expires 2029-08-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 6, 2025.

F2 · derivative.exercise_date: These share options are fully vested.

SEC source: 0001193125-25-314739 · ownership.xml · nonDerivative · entry 12

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,400

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 6, 2025.

SEC source: 0001193125-25-314739 · ownership.xml · nonDerivative · entry 11

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 46,400

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 6, 2025.

SEC source: 0001193125-25-314739 · ownership.xml · nonDerivative · entry 10

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,400

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 6, 2025.

SEC source: 0001193125-25-314739 · ownership.xml · nonDerivative · entry 9

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 46,400

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 6, 2025.

SEC source: 0001193125-25-314739 · ownership.xml · nonDerivative · entry 8

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,400

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 6, 2025.

SEC source: 0001193125-25-314739 · ownership.xml · nonDerivative · entry 7

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 50,400

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 6, 2025.

SEC source: 0001193125-25-314739 · ownership.xml · nonDerivative · entry 6

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 70,400

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 6, 2025.

SEC source: 0001193125-25-314739 · ownership.xml · nonDerivative · entry 5

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,400

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 6, 2025.

SEC source: 0001193125-25-314739 · ownership.xml · nonDerivative · entry 4

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 42,630

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 6, 2025.

SEC source: 0001193125-25-314739 · ownership.xml · nonDerivative · entry 3

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 57,630

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 6, 2025.

SEC source: 0001193125-25-314739 · ownership.xml · nonDerivative · entry 2

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,400

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 6, 2025.

SEC source: 0001193125-25-314739 · ownership.xml · nonDerivative · entry 1

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 32,894

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 6, 2025.

SEC source: 0001193125-25-314736 · ownership.xml · derivative · entry 14

Moran Kyle · CIK 0001657765 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 222,700

Underlying: Ordinary Shares · 50,000 shares

Expires 2033-02-17

F5 · derivative.exercise_date: The share option represented a right to purchase a total of 272,200 ordinary shares that vest as to 25% of the shares on February 17, 2024 and vests as to an additional 6.25% of the shares quarterly thereafter until February 17, 2027.

SEC source: 0001193125-25-314736 · ownership.xml · derivative · entry 13

Moran Kyle · CIK 0001657765 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Ordinary Shares · 100,000 shares

Expires 2032-01-01

F3 · derivative.exercise_date: The share option represented a right to purchase a total of 175,000 ordinary shares that vest as to 25% of the shares on January 1, 2023 and vests as to an additional 6.25% of the shares quarterly thereafter until January 1, 2026.

SEC source: 0001193125-25-314736 · ownership.xml · derivative · entry 12

Moran Kyle · CIK 0001657765 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 60,000 shares

Expires 2032-07-25

F2 · derivative.exercise_date: These share options are fully vested.

SEC source: 0001193125-25-314736 · ownership.xml · nonDerivative · entry 7

Moran Kyle · CIK 0001657765 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 89,218

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2025.

SEC source: 0001193125-25-314736 · ownership.xml · nonDerivative · entry 6

Moran Kyle · CIK 0001657765 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 139,218

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2025.

SEC source: 0001193125-25-314736 · ownership.xml · nonDerivative · entry 5

Moran Kyle · CIK 0001657765 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 89,218

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2025.

SEC source: 0001193125-25-314736 · ownership.xml · nonDerivative · entry 4

Moran Kyle · CIK 0001657765 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 139,218

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2025.

F4 · price: The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $15.00 to $15.045 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price.

SEC source: 0001193125-25-314736 · ownership.xml · nonDerivative · entry 3

Moran Kyle · CIK 0001657765 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 189,218

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2025.

SEC source: 0001193125-25-314736 · ownership.xml · nonDerivative · entry 2

Moran Kyle · CIK 0001657765 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 89,218

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2025.

SEC source: 0001193125-25-314736 · ownership.xml · nonDerivative · entry 1

Moran Kyle · CIK 0001657765 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 149,218

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2025.

SEC source: 0001231919-25-000499 · form4-11142025_111155.xml · nonDerivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 18,203,009

F1 · shares: This purchase was made for the purpose of extending the period during which acquisitions can be made pursuant to RA Capital Healthcare Fund, L.P.'s filing under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 (as amended).

F2 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $6.685 to $6.695 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

F3 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. Each of the Adviser, the Adviser GP, the Fund, Dr. Kolchinsky and Mr. Shah disclaims beneficial ownership of any of the reported securities, except to the extent of its or his respective pecuniary interest therein.

F4 · ownership.nature: Held directly by the Fund.

SEC source: 0001193125-25-283619 · ownership.xml · nonDerivative · entry 1

Rawcliffe Adrian · CIK 0001555851 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,700

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 5, 2025.

F2 · price: The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $6.64 to $7.00 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price.

SEC source: 0000950170-25-111567 · ownership.xml · nonDerivative · entry 1

BOLNO PAUL · CIK 0001657710 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 121,000

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 19, 2025.

F2 · price: The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $10.00 to $10.27 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price.

SEC source: 0000950170-25-111568 · ownership.xml · nonDerivative · entry 1

Verdine Gregory L. · CIK 0001572315 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 285,217

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2025.

SEC source: 0000950170-25-110287 · ownership.xml · derivative · entry 3

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 21,000 shares

Expires 2025-08-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2025.

F2 · derivative.exercise_date: These share options are fully vested.

SEC source: 0000950170-25-110287 · ownership.xml · nonDerivative · entry 2

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 40,388

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2025.

SEC source: 0000950170-25-110287 · ownership.xml · nonDerivative · entry 1

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 61,388

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2025.

SEC source: 0000950170-25-108287 · ownership.xml · nonDerivative · entry 2

HENRY CHRISTIAN O · CIK 0001263805 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 29,645

F2 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 24, 2024.

F3 · price: The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $8.45 to $9.03 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price.

SEC source: 0000950170-25-108287 · ownership.xml · derivative · entry 3

HENRY CHRISTIAN O · CIK 0001263805 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 76,200

Underlying: Ordinary Shares · 76,200 shares

Expires 2030-08-11

F4 · derivative.exercise_date: The reporting person was granted this option pursuant to the 2025 Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2026 annual general meeting or August 11, 2026

SEC source: 0000950170-25-108287 · ownership.xml · nonDerivative · entry 1

HENRY CHRISTIAN O · CIK 0001263805 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 39,315

F1 · shares: The reporting person was granted this restricted share unit award (RSU) pursuant to the 2025 Non-Employee Director Compensation Policy. The RSU vests as to 100% of the shares on the earlier of the Company's 2026 annual general meeting or August 11, 2026.

SEC source: 0000950170-25-108291 · ownership.xml · derivative · entry 2

CORRIGAN MARK · CIK 0001250661 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 76,200

Underlying: Ordinary Shares · 76,200 shares

Expires 2030-08-11

F2 · derivative.exercise_date: The reporting person was granted this option pursuant to the 2025 Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2026 annual general meeting or August 11, 2026.

SEC source: 0000950170-25-108291 · ownership.xml · nonDerivative · entry 1

CORRIGAN MARK · CIK 0001250661 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 44,930

F1 · shares: The reporting person was granted this restricted share unit award (RSU) pursuant to the 2025 Non-Employee Director Compensation Policy. The RSU vests as to 100% of the shares on the earlier of the Company's 2026 annual general meeting or August 11, 2026.

SEC source: 0001415889-25-021689 · form4-08142025_120830.xml · derivative · entry 3

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 76,200

Underlying: Ordinary Shares · 76,200 shares

Expires 2030-08-11

F5 · derivative.exercise_date: Dr. Kolchinsky was granted this option pursuant to the 2025 Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Issuer's 2026 annual general meeting or August 11, 2026.

F2 · ownership.nature: Dr. Kolchinsky is a Managing Partner of the Adviser who serves on the Issuer's board of directors. Under Dr. Kolchinsky's arrangement with the Adviser, Dr. Kolchinsky holds the RSUs and options for the benefit of the Fund. Dr. Kolchinsky is obligated to turn over to the Adviser any net cash or shares received upon settlement of the RSUs, or exercise of the options, as applicable, which will offset advisory fees owed by the Fund to the Adviser.

F3 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. Each of the Adviser, the Adviser GP, the Fund, Dr. Kolchinsky and Mr. Shah disclaims beneficial ownership of any of the reported securities, except to the extent of its or his respective pecuniary interest therein.

SEC source: 0001415889-25-021689 · form4-08142025_120830.xml · nonDerivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 28,815

F1 · shares: Dr. Kolchinsky was granted this restricted share unit award (RSU) pursuant to the 2025 Non-Employee Director Compensation Policy. The RSU vests as to 100% of the shares on the earlier of the Issuer's 2026 annual general meeting or August 11, 2026.

F2 · ownership.nature: Dr. Kolchinsky is a Managing Partner of the Adviser who serves on the Issuer's board of directors. Under Dr. Kolchinsky's arrangement with the Adviser, Dr. Kolchinsky holds the RSUs and options for the benefit of the Fund. Dr. Kolchinsky is obligated to turn over to the Adviser any net cash or shares received upon settlement of the RSUs, or exercise of the options, as applicable, which will offset advisory fees owed by the Fund to the Adviser.

F3 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. Each of the Adviser, the Adviser GP, the Fund, Dr. Kolchinsky and Mr. Shah disclaims beneficial ownership of any of the reported securities, except to the extent of its or his respective pecuniary interest therein.

SEC source: 0000950170-25-108286 · ownership.xml · derivative · entry 2

Rawcliffe Adrian · CIK 0001555851 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 76,200

Underlying: Ordinary Shares · 76,200 shares

Expires 2030-08-11

F2 · derivative.exercise_date: The reporting person was granted this option pursuant to the 2025 Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2026 annual general meeting or August 11, 2026.

SEC source: 0000950170-25-108286 · ownership.xml · nonDerivative · entry 1

Rawcliffe Adrian · CIK 0001555851 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,815

F1 · shares: The reporting person was granted this restricted share unit award (RSU) pursuant to the 2025 Non-Employee Director Compensation Policy. The RSU vests as to 100% of the shares on the earlier of the Company's 2026 annual general meeting or August 11, 2026.

SEC source: 0000950170-25-108285 · ownership.xml · derivative · entry 2

Verdine Gregory L. · CIK 0001572315 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 76,200

Underlying: Ordinary Shares · 76,200 shares

Expires 2030-08-11

F2 · derivative.exercise_date: The reporting person was granted this option pursuant to the 2025 Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2026 annual general meeting or August 11, 2026.

SEC source: 0000950170-25-108285 · ownership.xml · nonDerivative · entry 1

Verdine Gregory L. · CIK 0001572315 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 295,217

F1 · shares: The reporting person was granted this restricted share unit award (RSU) pursuant to the 2025 Non-Employee Director Compensation Policy. The RSU vests as to 100% of the shares on the earlier of the Company's 2026 annual general meeting or August 11, 2026.

SEC source: 0000950170-25-108290 · ownership.xml · derivative · entry 2

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 152,400

Underlying: Ordinary Shares · 152,400 shares

Expires 2030-08-11

F2 · derivative.exercise_date: The reporting person was granted this option pursuant to the 2025 Non-Employee Director Compensation Policy. The option vests as to 12.5% on a quarterly basis beginning August 11, 2025, through the two-year period following the grant date.

SEC source: 0000950170-25-108290 · ownership.xml · nonDerivative · entry 1

Tan Aik Na · CIK 0001821285 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,388

F1 · shares: The reporting person was granted this restricted share unit award (RSU) pursuant to the 2025 Non-Employee Director Compensation Policy. The RSU vests as to 50% on each of (i) the earlier of the Company's 2026 annual general meeting or August 11, 2026; and (ii) the earlier of the Company's 2027 annual general meeting or August 11, 2027.

SEC source: 0000950170-25-108289 · ownership.xml · derivative · entry 2

TAKANASHI KEN · CIK 0001657768 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 76,200

Underlying: Ordinary Shares · 76,200 shares

Expires 2030-08-11

F2 · derivative.exercise_date: The reporting person was granted this option pursuant to the 2025 Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2026 annual general meeting or August 11, 2026.

SEC source: 0000950170-25-108289 · ownership.xml · nonDerivative · entry 1

TAKANASHI KEN · CIK 0001657768 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,729,003

F1 · shares: The reporting person was granted this restricted share unit award (RSU) pursuant to the 2025 Non-Employee Director Compensation Policy. The RSU vests as to 100% of the shares on the earlier of the Company's 2026 annual general meeting or August 11, 2026.