WVE

SEC source: 0000899243-18-002039 · doc4.xml · derivative · entry 2

Panzara Michael A. · CIK 0001679039 · Franchise Lead, Neurology

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,000

Underlying: Ordinary Shares · 35,000 shares

Expires 2028-01-23

F2 · derivative.exercise_date: The option vests as to 25% of the shares on February 15, 2019 and vests as to an additional 6.25% of the shares quarterly thereafter until February 15, 2022.

SEC source: 0000899243-18-002039 · doc4.xml · nonDerivative · entry 1

Panzara Michael A. · CIK 0001679039 · Franchise Lead, Neurology

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,736

F1 · shares: Consists of restricted share units (RSUs). The RSUs vest in four equal annual installments of 25% on February 15, 2019, through February 15, 2022.

SEC source: 0000899243-17-027374 · doc4.xml · derivative · entry 3

Vargeese Chandra · CIK 0001657675 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 156,542

Underlying: Ordinary Shares · 1,500 shares

Expires 2025-03-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sale reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2017.

F2 · derivative.exercise_date: The incentive share option represented a right to purchase a total of 158,042 ordinary shares, 25% of which became exercisable on August 1, 2015, and the remaining shares vest in 36 equal monthly installments thereafter.

SEC source: 0000899243-17-027374 · doc4.xml · nonDerivative · entry 2

Vargeese Chandra · CIK 0001657675 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sale reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2017.

SEC source: 0000899243-17-027374 · doc4.xml · nonDerivative · entry 1

Vargeese Chandra · CIK 0001657675 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sale reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 11, 2017.

SEC source: 0001144204-17-059447 · tv479710_form4.xml · nonDerivative · entry 2

RA CAPITAL MANAGEMENT, LLC · CIK 0001346824 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 7,512,049

F1 · shares: These securities are held in a separately managed account (the "Account").

F4 · price: The prices reported in Column 4 are weighted average prices. The shares were purchased in multiple transactions at prices ranging from $23.78 to $23.70, inclusive. The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range.

F5 · balance_after: Following the reported transactions, the Fund held 6,582,428 shares and the Account held 929,621 shares.

F2 · ownership.nature: RA Capital Management, LLC (the "Adviser") is the general partner of RA Capital Healthcare Fund, L.P. (the "Fund") and the investment adviser of the Account. Peter Kolchinsky is a director of the issuer and is the sole manager of the Adviser. In their respective capacities, each of Mr. Kolchinsky and the Adviser may be deemed to beneficially own the reported securities for purposes of Section 13(d) of the Securities Exchange Act of 1934.

F3 · ownership.nature: The Adviser and Mr. Kolchinsky disclaim beneficial ownership of the reported securities for purposes of Rule 16a-1(a)(1) under the Exchange Act in reliance on Rule 16a-1(a)(1)(v) and (vii), respectively. The filing of this Form 4 shall not be construed as an admission that either the Adviser or Mr. Kolchinsky is or was, for purposes of Rule 16a-1(a)(1) under the Exchange Act, the beneficial owner of any of the securities reported herein. Mr. Kolchinsky and the Adviser disclaim beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a)(2) under the Exchange Act except to the extent of their pecuniary interest therein.

SEC source: 0001144204-17-059447 · tv479710_form4.xml · nonDerivative · entry 1

RA CAPITAL MANAGEMENT, LLC · CIK 0001346824 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 7,488,651

F1 · shares: These securities are held in a separately managed account (the "Account").

F2 · ownership.nature: RA Capital Management, LLC (the "Adviser") is the general partner of RA Capital Healthcare Fund, L.P. (the "Fund") and the investment adviser of the Account. Peter Kolchinsky is a director of the issuer and is the sole manager of the Adviser. In their respective capacities, each of Mr. Kolchinsky and the Adviser may be deemed to beneficially own the reported securities for purposes of Section 13(d) of the Securities Exchange Act of 1934.

F3 · ownership.nature: The Adviser and Mr. Kolchinsky disclaim beneficial ownership of the reported securities for purposes of Rule 16a-1(a)(1) under the Exchange Act in reliance on Rule 16a-1(a)(1)(v) and (vii), respectively. The filing of this Form 4 shall not be construed as an admission that either the Adviser or Mr. Kolchinsky is or was, for purposes of Rule 16a-1(a)(1) under the Exchange Act, the beneficial owner of any of the securities reported herein. Mr. Kolchinsky and the Adviser disclaim beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a)(2) under the Exchange Act except to the extent of their pecuniary interest therein.

SEC source: 0000899243-17-022303 · doc4.xml · nonDerivative · entry 2

Tanaka Masaharu · CIK 0001657771 · Director · 10% owner

Kagoshima Shinsangyo Sousei Investment Limited Partnership · CIK 0001657769 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 2,774,118

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $23.62 to $24.35, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F2 · ownership.nature: Shares held by Kagoshima Shinsangyo Sousei Investment Limited Partnership ("KSS"). Masaharu Tanaka previously was a director of the Issuer and the representative director of Kagoshima Development Co., Ltd., the general partner of KSS. Mr. Tanaka resigned as a director of the Issuer and resigned as an employee of Kagoshima Development Co., Ltd. and, as a result of the resignations, may no longer be deemed to beneficially own the securities previously reported in prior Form 3 and Form 4 filings filed jointly with KSS. The filing of this Form 4 shall not be construed as an admission that Mr. Tanaka is or was for the purposes of Section 16(a) of the Act, or otherwise, the beneficial owner of any of the reported securities.

F3 · ownership.nature: (Continued from footnote 2) As a result of Mr. Tanaka's resignation as director and the reduction in the number of Ordinary Shares beneficially owned upon the sale of Ordinary Shares reported in Table I, Mr. Tanaka and KSS are no longer subject to Section 16 of the Securities Exchange Act of 1934, as amended.

SEC source: 0000899243-17-022303 · doc4.xml · nonDerivative · entry 1

Tanaka Masaharu · CIK 0001657771 · Director · 10% owner

Kagoshima Shinsangyo Sousei Investment Limited Partnership · CIK 0001657769 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 2,780,480

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $23.60 to $24.50, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F2 · ownership.nature: Shares held by Kagoshima Shinsangyo Sousei Investment Limited Partnership ("KSS"). Masaharu Tanaka previously was a director of the Issuer and the representative director of Kagoshima Development Co., Ltd., the general partner of KSS. Mr. Tanaka resigned as a director of the Issuer and resigned as an employee of Kagoshima Development Co., Ltd. and, as a result of the resignations, may no longer be deemed to beneficially own the securities previously reported in prior Form 3 and Form 4 filings filed jointly with KSS. The filing of this Form 4 shall not be construed as an admission that Mr. Tanaka is or was for the purposes of Section 16(a) of the Act, or otherwise, the beneficial owner of any of the reported securities.

F3 · ownership.nature: (Continued from footnote 2) As a result of Mr. Tanaka's resignation as director and the reduction in the number of Ordinary Shares beneficially owned upon the sale of Ordinary Shares reported in Table I, Mr. Tanaka and KSS are no longer subject to Section 16 of the Securities Exchange Act of 1934, as amended.

SEC source: 0000899243-17-020600 · doc4.xml · derivative · entry 1

HENRY CHRISTIAN O · CIK 0001263805 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,000

Underlying: Ordinary Shares · 9,000 shares

Expires 2022-08-10

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on August 10, 2018.

SEC source: 0000899243-17-020603 · doc4.xml · derivative · entry 1

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,000

Underlying: Ordinary Shares · 9,000 shares

Expires 2022-08-10

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on August 10, 2018.

SEC source: 0000899243-17-020604 · doc4.xml · derivative · entry 1

Rawcliffe Adrian · CIK 0001555851 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,000

Underlying: Ordinary Shares · 9,000 shares

Expires 2022-08-10

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on August 10, 2018.

SEC source: 0000899243-17-020601 · doc4.xml · derivative · entry 1

Verdine Gregory L. · CIK 0001572315 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,000

Underlying: Ordinary Shares · 9,000 shares

Expires 2022-08-10

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on August 10, 2018.

SEC source: 0000899243-17-020602 · doc4.xml · derivative · entry 1

TAKANASHI KEN · CIK 0001657768 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,000

Underlying: Ordinary Shares · 9,000 shares

Expires 2022-08-10

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on August 10, 2018.

SEC source: 0000899243-17-020598 · doc4.xml · derivative · entry 1

Miura Koji · CIK 0001657766 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,000

Underlying: Ordinary Shares · 9,000 shares

Expires 2022-08-10

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on August 10, 2018.

SEC source: 0000899243-18-003953 · doc5.xml · nonDerivative · entry 1

Verdine Gregory L. · CIK 0001572315 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,039

SEC source: 0000899243-17-018236 · doc4.xml · nonDerivative · entry 1

Panzara Michael A. · CIK 0001679039 · Franchise Lead, Neurology

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,336

F1 · kind: On July 12, 2017, the reporting person sold 7,414 ordinary shares solely to cover taxes associated with the vesting of restricted share units on July 11, 2017. These sales were made pursuant to a 10b5-1 Trading Plan entered into solely for the purpose described in the prior sentence.

F2 · price: The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $16.55 to $16.95 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price.

SEC source: 0000899243-17-008992 · doc4.xml · nonDerivative · entry 1

Tanaka Masaharu · CIK 0001657771 · Director · 10% owner

Kagoshima Shinsangyo Sousei Investment Limited Partnership · CIK 0001657769 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 2,794,865

F1 · price: The aggregate purchase price for the 433,825 Ordinary Shares was 1,199,998,712 Japanese yen. The purchase price per share in Column 4 of Table I was calculated based on the aggregate purchase price divided by the number of Ordinary Shares sold. The purchase price per share is shown in U.S. dollars and was converted based on the currency exchange rate as of the transaction date, March 29, 2017, rounded to the nearest whole cent.

F2 · ownership.nature: Shares held by Kagoshima Shinsangyo Sousei Investment Limited Partnership ("KSS"). Masaharu Tanaka, a director of the Issuer, is the representative director of Kagoshima Development Co., Ltd., the general partner of KSS and may be deemed to beneficially own the reported securities. Pursuant to Rule 16a-1 under the Securities Exchange Act of 1934, as amended (the "Act"), Mr. Tanaka disclaims beneficial ownership of the reported securities except to the extent of his pecuniary interest therein. The filing of this Form 4 shall not be construed as an admission that Mr. Tanaka is or was for the purposes of Section 16(a) of the Act, or otherwise, the beneficial owner of any of the reported securities.

SEC source: 0000899243-17-002388 · doc4.xml · derivative · entry 1

Rawcliffe Adrian · CIK 0001555851 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,000

Underlying: Ordinary Shares · 18,000 shares

Expires 2022-02-01

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy.The option vests as to 25% of the shares on February 1, 2018 and vests as to an additional 2.0833% of the shares monthly thereafter until February 1, 2021.

SEC source: 0000899243-17-002143 · doc4.xml · derivative · entry 2

Francis Chris · CIK 0001657709 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,500

Underlying: Ordinary Shares · 19,500 shares

Expires 2027-01-25

F2 · derivative.exercise_date: The option vests as to 25% of the shares on February 15, 2018 and vests as to an additional 2.0833% of the shares monthly thereafter until February 15, 2021.

SEC source: 0000899243-17-002143 · doc4.xml · nonDerivative · entry 1

Francis Chris · CIK 0001657709 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,800

F1 · shares: Consists of restricted share units (RSUs). The RSUs vest in four equal annual installments of 25% on February 15, 2018, through February 15, 2021.

SEC source: 0000899243-17-002148 · doc4.xml · derivative · entry 2

Vargeese Chandra · CIK 0001657675 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,500

Underlying: Ordinary Shares · 19,500 shares

Expires 2027-01-25

F2 · derivative.exercise_date: The option vests as to 25% of the shares on February 15, 2018 and vests as to an additional 2.0833% of the shares monthly thereafter until February 15, 2021.

SEC source: 0000899243-17-002148 · doc4.xml · nonDerivative · entry 1

Vargeese Chandra · CIK 0001657675 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,800

F1 · shares: Consists of restricted share units (RSUs). The RSUs vest in four equal annual installments of 25% on February 15, 2018, through February 15, 2021.

SEC source: 0000899243-17-002145 · doc4.xml · derivative · entry 2

BOLNO PAUL · CIK 0001657710 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 72,500

Underlying: Ordinary Shares · 72,500 shares

Expires 2027-01-25

F2 · derivative.exercise_date: The option vests as to 25% of the shares on February 15, 2018 and vests as to an additional 2.0833% of the shares monthly thereafter until February 15, 2021.

SEC source: 0000899243-17-002145 · doc4.xml · nonDerivative · entry 1

BOLNO PAUL · CIK 0001657710 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 227,156

F1 · shares: Consists of restricted share units (RSUs). The RSUs vest in four equal annual installments of 25% on February 15, 2018, through February 15, 2021.

SEC source: 0000899243-17-002146 · doc4.xml · derivative · entry 2

Regnante Keith · CIK 0001682068 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,600

Underlying: Ordinary Shares · 8,600 shares

Expires 2027-01-25

F2 · derivative.exercise_date: The option vests as to 25% of the shares on February 15, 2018 and vests as to an additional 2.0833% of the shares monthly thereafter until February 15, 2021.

SEC source: 0000899243-17-002146 · doc4.xml · nonDerivative · entry 1

Regnante Keith · CIK 0001682068 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,300

F1 · shares: Consists of restricted share units (RSUs). The RSUs vest in four equal annual installments of 25% on February 15, 2018, through February 15, 2021.

SEC source: 0000899243-17-002144 · doc4.xml · derivative · entry 2

Panzara Michael A. · CIK 0001679039 · Head of Neurology Franchise

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,800

Underlying: Ordinary Shares · 13,800 shares

Expires 2027-01-25

F2 · derivative.exercise_date: The option vests as to 25% of the shares on February 15, 2018 and vests as to an additional 2.0833% of the shares monthly thereafter until February 15, 2021.

SEC source: 0000899243-17-002144 · doc4.xml · nonDerivative · entry 1

Panzara Michael A. · CIK 0001679039 · Head of Neurology Franchise

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,650

F1 · shares: Consists of restricted share units (RSUs). The RSUs vest in four equal annual installments of 25% on February 15, 2018, through February 15, 2021.

SEC source: 0000899243-16-035267 · doc4.xml · derivative · entry 4

GUERCIOLINI ROBERTO · CIK 0001286837 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,629

Underlying: Ordinary Shares · 4,000 shares

Expires 2025-03-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The non-qualified option represented a right to purchase a total of 12,629 ordinary shares, 25% of which became exercisable on March 10, 2016, which was the first anniversary on which the option was granted, and the remaining shares vest in 36 equal monthly installments thereafter.

SEC source: 0000899243-16-035267 · doc4.xml · derivative · entry 3

GUERCIOLINI ROBERTO · CIK 0001286837 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 78,617

Underlying: Ordinary Shares · 20,000 shares

Expires 2025-03-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The incentive share option represented a right to purchase a total of 108,617 ordinary shares, 25% of which became exercisable on March 10, 2016, which was the first anniversary on which the option was granted, and the remaining shares vest in 36 equal monthly installments thereafter.

SEC source: 0000899243-16-035267 · doc4.xml · nonDerivative · entry 2

GUERCIOLINI ROBERTO · CIK 0001286837 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-16-035267 · doc4.xml · nonDerivative · entry 1

GUERCIOLINI ROBERTO · CIK 0001286837 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-16-033365 · doc4.xml · derivative · entry 1

HENRY CHRISTIAN O · CIK 0001263805 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,000

Underlying: Ordinary Shares · 18,000 shares

Expires 2021-11-10

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 25% of the shares on November 10, 2017 and vests as to an additional 2.0833% of the shares monthly thereafter until November 10, 2020.

SEC source: 0001144204-16-134458 · v453037_form4.xml · derivative · entry 1

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,000

Underlying: Ordinary Shares · 9,000 shares

Expires 2021-11-10

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on November 10, 2017.

SEC source: 0000899243-16-033354 · doc4.xml · derivative · entry 1

Verdine Gregory L. · CIK 0001572315 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,000

Underlying: Ordinary Shares · 9,000 shares

Expires 2021-11-10

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on November 10, 2017.

SEC source: 0000899243-16-033374 · doc4.xml · derivative · entry 1

TAKANASHI KEN · CIK 0001657768 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,000

Underlying: Ordinary Shares · 9,000 shares

Expires 2021-11-10

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on November 10, 2017.

SEC source: 0000899243-16-033357 · doc4.xml · derivative · entry 1

Tanaka Masaharu · CIK 0001657771 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,000

Underlying: Ordinary Shares · 9,000 shares

Expires 2021-11-10

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on November 10, 2017.

SEC source: 0000899243-16-033352 · doc4.xml · derivative · entry 1

Miura Koji · CIK 0001657766 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,000

Underlying: Ordinary Shares · 9,000 shares

Expires 2021-11-10

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on November 10, 2017.

SEC source: 0000899243-16-033351 · doc4.xml · derivative · entry 1

Wada Takeshi · CIK 0001657767 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,000

Underlying: Ordinary Shares · 9,000 shares

Expires 2021-11-10

F1 · derivative.exercise_date: The reporting person was granted this option pursuant to the Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on November 10, 2017.