VSTM

SEC source: 0001104659-25-092973 · tm2526868-1_4seq1.xml · nonDerivative · entry 2

Calkins Daniel · CIK 0001951861 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 109,838

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-092973 · tm2526868-1_4seq1.xml · nonDerivative · entry 1

Calkins Daniel · CIK 0001951861 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 109,863

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-091362 · tm2526484-3_4seq1.xml · nonDerivative · entry 1

Stuglik Brian M · CIK 0001716328 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 101,739

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-091361 · tm2526484-2_4seq1.xml · nonDerivative · entry 1

Gagnon Robert E. · CIK 0001504983 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 41,961

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-091360 · tm2526484-1_4seq1.xml · nonDerivative · entry 1

Paterson Dan · CIK 0001563202 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 442,117

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-074843 · tm2522778-1_4seq1.xml · nonDerivative · entry 1

Paterson Dan · CIK 0001563202 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 442,507

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-062130 · tm2518795-1_4seq1.xml · nonDerivative · entry 2

Calkins Daniel · CIK 0001951861 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 109,920

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-062130 · tm2518795-1_4seq1.xml · nonDerivative · entry 1

Calkins Daniel · CIK 0001951861 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 109,945

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-062131 · tm2518795-2_4seq1.xml · nonDerivative · entry 1

Paterson Dan · CIK 0001563202 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 443,839

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-061039 · tm2518337-1_4seq1.xml · nonDerivative · entry 1

Stuglik Brian M · CIK 0001716328 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 102,326

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-061040 · tm2518337-2_4seq1.xml · nonDerivative · entry 1

Gagnon Robert E. · CIK 0001504983 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,242

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-061041 · tm2518337-3_4seq1.xml · nonDerivative · entry 1

Paterson Dan · CIK 0001563202 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 461,647

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-053095 · tm2516118-3_4seq1.xml · derivative · entry 2

Tollefson Karin Anna · CIK 0001976551 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2035-05-22

F2 · derivative.exercise_date: The stock option vests in twelve equal installments (rounded down to the nearest whole share on each vesting date except with respect to the final vesting date on which the remaining unvested portion shall vest). The first eleven installments shall vest beginning on the last day of each month over a period from June, 2025 to April, 2026 and the last installment shall vest on the earlier of (i) the day before the 2026 Annual Meeting of Stockholders is held or (ii) May 31, 2026, provided that the Reporting Person continues to serve as a director of the Issuer on each such vesting date.

SEC source: 0001104659-25-053095 · tm2516118-3_4seq1.xml · nonDerivative · entry 1

Tollefson Karin Anna · CIK 0001976551 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,666

F1 · shares: RSUs granted to the Reporting Person under the Issuer's Amended and Restated 2021 Equity Incentive Plan. Each RSU represents the contingent right to receive one share of Common Stock. The RSUs vest in twelve equal installments (rounded down to the nearest whole share on each vesting date except with respect to the final vesting date on which the remaining unvested portion shall vest). The first eleven installments shall vest beginning on the last day of each month over a period from June, 2025 to April, 2026 and the last installment shall vest on the earlier of (i) the day before the 2026 Annual Meeting of Stockholders is held or (ii) May 31, 2026, provided that the Reporting Person continues to serve as a director of the Issuer on each such vesting date.

SEC source: 0001104659-25-053103 · tm2516118-9_4seq1.xml · derivative · entry 2

ROBERTSON MICHELLE · CIK 0001755098 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2035-05-22

F2 · derivative.exercise_date: The stock option vests in twelve equal installments (rounded down to the nearest whole share on each vesting date except with respect to the final vesting date on which the remaining unvested portion shall vest). The first eleven installments shall vest beginning on the last day of each month over a period from June, 2025 to April, 2026 and the last installment shall vest on the earlier of (i) the day before the 2026 Annual Meeting of Stockholders is held or (ii) May 31, 2026, provided that the Reporting Person continues to serve as a director of the Issuer on each such vesting date.

SEC source: 0001104659-25-053103 · tm2516118-9_4seq1.xml · nonDerivative · entry 1

ROBERTSON MICHELLE · CIK 0001755098 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,666

F1 · shares: RSUs granted to the Reporting Person under the Issuer's Amended and Restated 2021 Equity Incentive Plan. Each RSU represents the contingent right to receive one share of Common Stock. The RSUs vest in twelve equal installments (rounded down to the nearest whole share on each vesting date except with respect to the final vesting date on which the remaining unvested portion shall vest). The first eleven installments shall vest beginning on the last day of each month over a period from June, 2025 to April, 2026 and the last installment shall vest on the earlier of (i) the day before the 2026 Annual Meeting of Stockholders is held or (ii) May 31, 2026, provided that the Reporting Person continues to serve as a director of the Issuer on each such vesting date.

SEC source: 0001104659-25-053099 · tm2516118-6_4seq1.xml · derivative · entry 2

Stuglik Brian M · CIK 0001716328 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2035-05-22

F2 · derivative.exercise_date: The stock option vests in twelve equal installments (rounded down to the nearest whole share on each vesting date except with respect to the final vesting date on which the remaining unvested portion shall vest). The first eleven installments shall vest beginning on the last day of each month over a period from June, 2025 to April, 2026 and the last installment shall vest on the earlier of (i) the day before the 2026 Annual Meeting of Stockholders is held or (ii) May 31, 2026, provided that the Reporting Person continues to serve as a director of the Issuer on each such vesting date.

SEC source: 0001104659-25-053099 · tm2516118-6_4seq1.xml · nonDerivative · entry 1

Stuglik Brian M · CIK 0001716328 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 102,920

F1 · shares: RSUs granted to the Reporting Person under the Issuer's Amended and Restated 2021 Equity Incentive Plan. Each RSU represents the contingent right to receive one share of Common Stock. The RSUs vest in twelve equal installments (rounded down to the nearest whole share on each vesting date except with respect to the final vesting date on which the remaining unvested portion shall vest). The first eleven installments shall vest beginning on the last day of each month over a period from June, 2025 to April, 2026 and the last installment shall vest on the earlier of (i) the day before the 2026 Annual Meeting of Stockholders is held or (ii) May 31, 2026, provided that the Reporting Person continues to serve as a director of the Issuer on each such vesting date.

SEC source: 0001104659-25-053093 · tm2516118-2_4seq1.xml · derivative · entry 2

JOHNSON JOHN · CIK 0001410781 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2035-05-22

F2 · derivative.exercise_date: The stock option vests in twelve equal installments (rounded down to the nearest whole share on each vesting date except with respect to the final vesting date on which the remaining unvested portion shall vest). The first eleven installments shall vest beginning on the last day of each month over a period from June, 2025 to April, 2026 and the last installment shall vest on the earlier of (i) the day before the 2026 Annual Meeting of Stockholders is held or (ii) May 31, 2026, provided that the Reporting Person continues to serve as a director of the Issuer on each such vesting date.

SEC source: 0001104659-25-053093 · tm2516118-2_4seq1.xml · nonDerivative · entry 1

JOHNSON JOHN · CIK 0001410781 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,666

F1 · shares: RSUs granted to the Reporting Person under the Issuer's Amended and Restated 2021 Equity Incentive Plan. Each RSU represents the contingent right to receive one share of Common Stock. The RSUs vest in twelve equal installments (rounded down to the nearest whole share on each vesting date except with respect to the final vesting date on which the remaining unvested portion shall vest). The first eleven installments shall vest beginning on the last day of each month over a period from June, 2025 to April, 2026 and the last installment shall vest on the earlier of (i) the day before the 2026 Annual Meeting of Stockholders is held or (ii) May 31, 2026, provided that the Reporting Person continues to serve as a director of the Issuer on each such vesting date.

SEC source: 0001104659-25-053092 · tm2516118-1_4seq1.xml · derivative · entry 2

Rowinsky Eric K · CIK 0001318886 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2035-05-22

F2 · derivative.exercise_date: The stock option vests in twelve equal installments (rounded down to the nearest whole share on each vesting date except with respect to the final vesting date on which the remaining unvested portion shall vest). The first eleven installments shall vest beginning on the last day of each month over a period from June, 2025 to April, 2026 and the last installment shall vest on the earlier of (i) the day before the 2026 Annual Meeting of Stockholders is held or (ii) May 31, 2026, provided that the Reporting Person continues to serve as a director of the Issuer on each such vesting date.

SEC source: 0001104659-25-053092 · tm2516118-1_4seq1.xml · nonDerivative · entry 1

Rowinsky Eric K · CIK 0001318886 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,666

F1 · shares: RSUs granted to the Reporting Person under the Issuer's Amended and Restated 2021 Equity Incentive Plan. Each RSU represents the contingent right to receive one share of Common Stock. The RSUs vest in twelve equal installments (rounded down to the nearest whole share on each vesting date except with respect to the final vesting date on which the remaining unvested portion shall vest). The first eleven installments shall vest beginning on the last day of each month over a period from June, 2025 to April, 2026 and the last installment shall vest on the earlier of (i) the day before the 2026 Annual Meeting of Stockholders is held or (ii) May 31, 2026, provided that the Reporting Person continues to serve as a director of the Issuer on each such vesting date.

SEC source: 0001104659-25-053096 · tm2516118-4_4seq1.xml · derivative · entry 2

Kauffman Michael · CIK 0001364719 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2035-05-22

F2 · derivative.exercise_date: The stock option vests in twelve equal installments (rounded down to the nearest whole share on each vesting date except with respect to the final vesting date on which the remaining unvested portion shall vest). The first eleven installments shall vest beginning on the last day of each month over a period from June, 2025 to April, 2026 and the last installment shall vest on the earlier of (i) the day before the 2026 Annual Meeting of Stockholders is held or (ii) May 31, 2026, provided that the Reporting Person continues to serve as a director of the Issuer on each such vesting date.

SEC source: 0001104659-25-053096 · tm2516118-4_4seq1.xml · nonDerivative · entry 1

Kauffman Michael · CIK 0001364719 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,216

F1 · shares: RSUs granted to the Reporting Person under the Issuer's Amended and Restated 2021 Equity Incentive Plan. Each RSU represents the contingent right to receive one share of Common Stock. The RSUs vest in twelve equal installments (rounded down to the nearest whole share on each vesting date except with respect to the final vesting date on which the remaining unvested portion shall vest). The first eleven installments shall vest beginning on the last day of each month over a period from June, 2025 to April, 2026 and the last installment shall vest on the earlier of (i) the day before the 2026 Annual Meeting of Stockholders is held or (ii) May 31, 2026, provided that the Reporting Person continues to serve as a director of the Issuer on each such vesting date.

SEC source: 0001104659-25-053097 · tm2516118-5_4seq1.xml · derivative · entry 2

Gagnon Robert E. · CIK 0001504983 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2035-05-22

F2 · derivative.exercise_date: The stock option vests in twelve equal installments (rounded down to the nearest whole share on each vesting date except with respect to the final vesting date on which the remaining unvested portion shall vest). The first eleven installments shall vest beginning on the last day of each month over a period from June, 2025 to April, 2026 and the last installment shall vest on the earlier of (i) the day before the 2026 Annual Meeting of Stockholders is held or (ii) May 31, 2026, provided that the Reporting Person continues to serve as a director of the Issuer on each such vesting date.

SEC source: 0001104659-25-053097 · tm2516118-5_4seq1.xml · nonDerivative · entry 1

Gagnon Robert E. · CIK 0001504983 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,526

F1 · shares: RSUs granted to the Reporting Person under the Issuer's Amended and Restated 2021 Equity Incentive Plan. Each RSU represents the contingent right to receive one share of Common Stock. The RSUs vest in twelve equal installments (rounded down to the nearest whole share on each vesting date except with respect to the final vesting date on which the remaining unvested portion shall vest). The first eleven installments shall vest beginning on the last day of each month over a period from June, 2025 to April, 2026 and the last installment shall vest on the earlier of (i) the day before the 2026 Annual Meeting of Stockholders is held or (ii) May 31, 2026, provided that the Reporting Person continues to serve as a director of the Issuer on each such vesting date.

SEC source: 0001104659-25-053101 · tm2516118-8_4seq1.xml · derivative · entry 2

Bunn Paul A. · CIK 0001868760 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2035-05-22

F2 · derivative.exercise_date: The stock option vests in twelve equal installments (rounded down to the nearest whole share on each vesting date except with respect to the final vesting date on which the remaining unvested portion shall vest). The first eleven installments shall vest beginning on the last day of each month over a period from June, 2025 to April, 2026 and the last installment shall vest on the earlier of (i) the day before the 2026 Annual Meeting of Stockholders is held or (ii) May 31, 2026, provided that the Reporting Person continues to serve as a director of the Issuer on each such vesting date.

SEC source: 0001104659-25-053101 · tm2516118-8_4seq1.xml · nonDerivative · entry 1

Bunn Paul A. · CIK 0001868760 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,666

F1 · shares: RSUs granted to the Reporting Person under the Issuer's Amended and Restated 2021 Equity Incentive Plan. Each RSU represents the contingent right to receive one share of Common Stock. The RSUs vest in twelve equal installments (rounded down to the nearest whole share on each vesting date except with respect to the final vesting date on which the remaining unvested portion shall vest). The first eleven installments shall vest beginning on the last day of each month over a period from June, 2025 to April, 2026 and the last installment shall vest on the earlier of (i) the day before the 2026 Annual Meeting of Stockholders is held or (ii) May 31, 2026, provided that the Reporting Person continues to serve as a director of the Issuer on each such vesting date.

SEC source: 0001104659-25-053100 · tm2516118-7_4seq1.xml · derivative · entry 2

Kapur Anil · CIK 0001730703 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2035-05-22

F2 · derivative.exercise_date: The stock option vests in twelve equal installments (rounded down to the nearest whole share on each vesting date except with respect to the final vesting date on which the remaining unvested portion shall vest). The first eleven installments shall vest beginning on the last day of each month over a period from June, 2025 to April, 2026 and the last installment shall vest on the earlier of (i) the day before the 2026 Annual Meeting of Stockholders is held or (ii) May 31, 2026, provided that the Reporting Person continues to serve as a director of the Issuer on each such vesting date.

SEC source: 0001104659-25-053100 · tm2516118-7_4seq1.xml · nonDerivative · entry 1

Kapur Anil · CIK 0001730703 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,666

F1 · shares: RSUs granted to the Reporting Person under the Issuer's Amended and Restated 2021 Equity Incentive Plan. Each RSU represents the contingent right to receive one share of Common Stock. The RSUs vest in twelve equal installments (rounded down to the nearest whole share on each vesting date except with respect to the final vesting date on which the remaining unvested portion shall vest). The first eleven installments shall vest beginning on the last day of each month over a period from June, 2025 to April, 2026 and the last installment shall vest on the earlier of (i) the day before the 2026 Annual Meeting of Stockholders is held or (ii) May 31, 2026, provided that the Reporting Person continues to serve as a director of the Issuer on each such vesting date.

SEC source: 0001104659-25-051163 · tm2515719-2_4seq1.xml · nonDerivative · entry 2

Calkins Daniel · CIK 0001951861 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 114,055

F2 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-051161 · tm2515719-1_4seq1.xml · nonDerivative · entry 3

Paterson Dan · CIK 0001563202 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 461,982

F3 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-051163 · tm2515719-2_4seq1.xml · nonDerivative · entry 1

Calkins Daniel · CIK 0001951861 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 125,198

F1 · shares: The reported securities were subject to a performance RSU award that was granted on June 18, 2024. 150,000 RSUs vested on May 16, 2025, upon the Issuer's Compensation Committee of the board of directors determining the performance criteria of approval by the FDA of an NDA for the Company's combination therapy of avutometinib and defactinib for the treatment of low-grade serous ovarian cancer had occurred.

SEC source: 0001104659-25-051161 · tm2515719-1_4seq1.xml · nonDerivative · entry 2

Paterson Dan · CIK 0001563202 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 520,659

F2 · shares: The reported securities were subject to a performance RSU award that was granted on June 18, 2024. 150,000 RSUs vested on May 16, 2025, upon the Issuer's Compensation Committee of the board of directors determining the performance criteria of approval by the FDA of an NDA for the Company's combination therapy of avutometinib and defactinib for the treatment of low-grade serous ovarian cancer had occurred.

SEC source: 0001104659-25-051161 · tm2515719-1_4seq1.xml · nonDerivative · entry 1

Paterson Dan · CIK 0001563202 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 370,659

F1 · shares: The reported securities were subject to a performance restricted stock units ("RSU") award that was granted on August 2, 2023. 25,000 RSUs vested on May 16, 2025, upon the Issuer's Compensation Committee of the board of directors determining the performance criteria of approval by the U.S. Food and Drug Administration (the "FDA") of a new drug application ("NDA") for a product which contains avutometinib in combination with defactinib had occurred.

SEC source: 0001104659-25-045570 · tm2514367-1_4seq1.xml · nonDerivative · entry 1

Paterson Dan · CIK 0001563202 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 345,659

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-031706 · tm2511477-1_4seq1.xml · nonDerivative · entry 1

Ros Matthew · CIK 0001673802 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

F1 · shares: Restricted stock units ("RSUs") granted to the Reporting Person under the Issuer's inducement award program. Each RSU represents the contingent right to receive one share of Common Stock. The RSUs vest as to 25% of the shares subject to the award on the first anniversary of the date of grant and as to an additional 6.25% of the shares at the end of each successive three month period following the first anniversary of the date of grant until the 4th anniversary of the date of grant (with the number of shares vesting on each vesting date rounded down to the nearest whole share, except with respect to the final vesting date on which all remaining unvested shares shall vest), provided that the Reporting Person continues to serve as an employee of or other service provider to the Issuer on each such vesting date.

SEC source: 0001104659-25-027252 · tm2510143-1_4seq1.xml · nonDerivative · entry 2

Calkins Daniel · CIK 0001951861 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 86,348

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-027252 · tm2510143-1_4seq1.xml · nonDerivative · entry 1

Calkins Daniel · CIK 0001951861 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 86,374

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-025608 · tm259809-1_4seq1.xml · nonDerivative · entry 1

Stuglik Brian M · CIK 0001716328 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 94,587

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-025610 · tm259809-2_4seq1.xml · nonDerivative · entry 1

Gagnon Robert E. · CIK 0001504983 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,193

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-025612 · tm259809-3_4seq1.xml · nonDerivative · entry 1

Paterson Dan · CIK 0001563202 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 346,479

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-009693 · tm255621-1_4seq1.xml · nonDerivative · entry 1

Paterson Dan · CIK 0001563202 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 346,723

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-25-003458 · tm253202-3_4seq1.xml · nonDerivative · entry 3

Paterson Dan · CIK 0001563202 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 347,581

F3 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of the performance-based restricted stock units.

SEC source: 0001104659-25-003458 · tm253202-3_4seq1.xml · nonDerivative · entry 2

Paterson Dan · CIK 0001563202 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 356,149

F2 · shares: The reported securities were subject to a performance RSU award that was granted on August 2, 2023. 25,000 RSUs vested on January 10, 2025 upon the Issuer's board of directors determining the performance criteria of acceptance of a new drug application for a product which contains avutometinib in combination with defactinib by the U.S. Food and Drug Administration had occurred.

SEC source: 0001104659-25-003458 · tm253202-3_4seq1.xml · nonDerivative · entry 1

Paterson Dan · CIK 0001563202 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 331,149

F1 · shares: Restricted stock units ("RSUs") granted to the Reporting Person under the Issuer's Amended and Restated 2021 Equity Incentive Plan. Each RSU represents the contingent right to receive one share of Common Stock. The RSUs vest as to 33.3% of the RSUs on the first three anniversaries of January 10, 2025 (the "RSU Grant Date") such that the award is fully vested on January 10, 2028 (with the number of RSUs vesting on each vesting date rounded down to the nearest whole RSU, except with respect to the final vesting date on which all remaining unvested RSUs shall vest), provided that the Reporting Person continues to serve as an employee of or other service provider to the Issuer on each such vesting date.

SEC source: 0001104659-25-003455 · tm253202-2_4seq1.xml · nonDerivative · entry 1

Calkins Daniel · CIK 0001951861 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 86,439

F1 · shares: Restricted stock units ("RSUs") granted to the Reporting Person under the Issuer's Amended and Restated 2021 Equity Incentive Plan. Each RSU represents the contingent right to receive one share of Common Stock. The RSUs vest as to 33.3% of the RSUs on the first three anniversaries of January 10, 2025 (the "RSU Grant Date") such that the award is fully vested on January 10, 2028 (with the number of RSUs vesting on each vesting date rounded down to the nearest whole RSU, except with respect to the final vesting date on which all remaining unvested RSUs shall vest), provided that the Reporting Person continues to serve as an employee of or other service provider to the Issuer on each such vesting date.

SEC source: 0001104659-25-002049 · tm252685-1_4seq1.xml · nonDerivative · entry 1

Calkins Daniel · CIK 0001951861 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,639

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

F2 · balance_after: Includes 277 shares of common stock purchased pursuant to the Issuer's 2018 Employee Stock Purchase Plan.

SEC source: 0001104659-24-131727 · tm2432013-1_4seq1.xml · nonDerivative · entry 2

Calkins Daniel · CIK 0001951861 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,368

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.

SEC source: 0001104659-24-131727 · tm2432013-1_4seq1.xml · nonDerivative · entry 1

Calkins Daniel · CIK 0001951861 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,396

F1 · shares: The sale reported on this Form 4 represents shares sold by the Reporting Person to satisfy statutory withholding requirements in connection with the vesting of restricted stock units.