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Nasdaq · USD

VRTX

VERTEX PHARMACEUTICALS INC / MA

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Tapewire entity
2875
SEC CIK
0000875320
Parsed reports
2,554

Last 12 months

Inside the activity.

0 purchase rows · 93 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202506
Dec 2025016
Jan 202602
Feb 2026049
Mar 202605
Apr 202601
May 202606
Jun 202605
Jul 202603
Aug 202600
Sep 202600
Oct 202600

Latest available

Insider transactions

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
January 14, 2019 Filed Jan 15, 2019 21:03 UTC
Parini MichaelEVP, CL&AO
Exercise / conversionCommon Stock 2,125 $90.29 $191,866.25
Disclosure

SEC source: 0001209191-19-003714 · doc4.xml · nonDerivative · entry 1

Parini Michael · CIK 0001661567 · EVP, CL&AO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,734

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 04, 2019 Filed Jan 7, 2019 21:02 UTC
Parini MichaelEVP, CL&AO
Exercise / conversionStock Option (Right to Buy) · Derivative 4,250 $0.00 Strike: $122.45 $0.00
Disclosure

SEC source: 0001209191-19-002485 · doc4.xml · derivative · entry 3

Parini Michael · CIK 0001661567 · EVP, CL&AO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,000

Underlying: Common Stock · 4,250 shares

Expires 2026-01-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option vests in 16 quarterly installments from 01/04/2016.

Read SEC document
January 04, 2019 Filed Jan 7, 2019 21:02 UTC
Parini MichaelEVP, CL&AO
SaleCommon Stock 4,250 $165.90 $705,075.00
Disclosure

SEC source: 0001209191-19-002485 · doc4.xml · nonDerivative · entry 2

Parini Michael · CIK 0001661567 · EVP, CL&AO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,609

F1 · kind: Transaction made pursuant to Mr. Parini's company-approved trading plan under Rule 10b5-1.

Read SEC document
January 04, 2019 Filed Jan 7, 2019 21:02 UTC
Parini MichaelEVP, CL&AO
Exercise / conversionCommon Stock 4,250 $122.45 $520,412.50
Disclosure

SEC source: 0001209191-19-002485 · doc4.xml · nonDerivative · entry 1

Parini Michael · CIK 0001661567 · EVP, CL&AO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 43,859

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 28, 2018 Filed Jan 2, 2019 21:58 UTC GiftCommon Stock 10,000 $0.00 $0.00
Disclosure

SEC source: 0001209191-19-000315 · doc4.xml · nonDerivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,011

F1 · kind: Represents a gift to a charitable foundation.

Read SEC document
December 06, 2018 Filed Dec 7, 2018 21:06 UTC Exercise / conversionStock Option (Right to Buy) · Derivative 10,000 $0.00 Strike: $34.24 $0.00
Disclosure

SEC source: 0001209191-18-061479 · doc4.xml · derivative · entry 2

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,000 shares

Expires 2020-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Fully vested.

Read SEC document
December 06, 2018 Filed Dec 7, 2018 21:06 UTC Exercise / conversionCommon Stock 10,000 $34.24 $342,400.00
Disclosure

SEC source: 0001209191-18-061479 · doc4.xml · nonDerivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,011

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 03, 2018 Filed Dec 4, 2018 21:04 UTC
Silva Paul MSVP & Corp Controller
Exercise / conversionStock Option (Right to Buy) · Derivative 809 $0.00 Strike: $86.52 $0.00
Disclosure

SEC source: 0001209191-18-060817 · doc4.xml · derivative · entry 4

Silva Paul M · CIK 0001446372 · SVP & Corp Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,281

Underlying: Common Stock · 809 shares

Expires 2027-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option vests in 16 quarterly installments from 02/03/2017.

Read SEC document
December 03, 2018 Filed Dec 4, 2018 21:04 UTC
Silva Paul MSVP & Corp Controller
SaleCommon Stock 809 $186.52 $150,894.68
Disclosure

SEC source: 0001209191-18-060817 · doc4.xml · nonDerivative · entry 2

Silva Paul M · CIK 0001446372 · SVP & Corp Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,087

F1 · kind: Transaction made pursuant to Mr. Silva's company approved trading plan under Rule 10b5-1.

Read SEC document
December 03, 2018 Filed Dec 4, 2018 21:04 UTC
Silva Paul MSVP & Corp Controller
Exercise / conversionCommon Stock 809 $86.52 $69,994.68
Disclosure

SEC source: 0001209191-18-060817 · doc4.xml · nonDerivative · entry 1

Silva Paul M · CIK 0001446372 · SVP & Corp Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,896

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 15, 2018 Filed Nov 19, 2018 22:23 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
SaleCommon Stock 100 $163.75 $16,375.00
Disclosure

SEC source: 0001209191-18-059246 · doc4.xml · nonDerivative · entry 1

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,113

F1 · kind: Transaction made pursuant to Dr. Altshuler's company approved trading plan under Rule 10b5-1.

Read SEC document
November 15, 2018 Filed Nov 19, 2018 22:28 UTC
Arbuckle Stuart AEVP\Chief Commercial Officer
SaleCommon Stock 29 $163.75 $4,748.75
Disclosure

SEC source: 0001209191-18-059261 · doc4.xml · nonDerivative · entry 1

Arbuckle Stuart A · CIK 0001557290 · EVP\Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,752

F1 · kind: Transaction made pursuant to Mr. Arbuckle's company-approved trading plan under Rule 10b5-1.

Read SEC document
November 15, 2018 Filed Nov 19, 2018 22:47 UTC
Parini MichaelEVP, CL&AO
SaleCommon Stock 90 $163.75 $14,737.50
Disclosure

SEC source: 0001209191-18-059274 · doc4.xml · nonDerivative · entry 1

Parini Michael · CIK 0001661567 · EVP, CL&AO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,609

F1 · kind: Transaction made pursuant to Mr. Parini's company-approved trading plan under Rule 10b5-1.

Read SEC document
November 15, 2018 Filed Nov 19, 2018 22:34 UTC
Sachdev AmitEVP, CRO
SaleCommon Stock 61 $163.75 $9,988.75
Disclosure

SEC source: 0001209191-18-059268 · doc4.xml · nonDerivative · entry 1

Sachdev Amit · CIK 0001406338 · EVP, CRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,662

F1 · kind: Transaction made pursuant to Mr. Sachdev's company-approved trading plan under Rule 10b5-1.

Read SEC document
November 15, 2018 Filed Nov 19, 2018 22:52 UTC
Silva Paul MSVP & Corp Controller
SaleCommon Stock 12 $163.75 $1,965.00
Disclosure

SEC source: 0001209191-18-059275 · doc4.xml · nonDerivative · entry 1

Silva Paul M · CIK 0001446372 · SVP & Corp Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,087

F1 · kind: Transaction made pursuant to Mr. Silva's company-approved trading plan under Rule 10b5-1.

Read SEC document
November 07, 2018 Filed Nov 8, 2018 21:18 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
Exercise / conversionStock Option (Right to Buy) · Derivative 2,125 $0.00 Strike: $131.89 $0.00
Disclosure

SEC source: 0001209191-18-057744 · doc4.xml · derivative · entry 3

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,375

Underlying: Common Stock · 2,125 shares

Expires 2025-07-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option vests in 16 quarterly installments from 7/21/2015.

Read SEC document
November 07, 2018 Filed Nov 8, 2018 21:18 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
SaleCommon Stock 2,125 $181.89 $386,516.25
Disclosure

SEC source: 0001209191-18-057744 · doc4.xml · nonDerivative · entry 2

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,113

F1 · kind: Transaction made pursuant to Dr. Altshuler's company approved trading plan under Rule 10b5-1.

Read SEC document
November 07, 2018 Filed Nov 8, 2018 21:18 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
Exercise / conversionCommon Stock 2,125 $131.89 $280,266.25
Disclosure

SEC source: 0001209191-18-057744 · doc4.xml · nonDerivative · entry 1

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,238

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 07, 2018 Filed Nov 8, 2018 21:26 UTC
Arbuckle Stuart AEVP\Chief Commercial Officer
Exercise / conversionStock Option (Right to Buy) · Derivative 2,125 $0.00 Strike: $131.89 $0.00
Disclosure

SEC source: 0001209191-18-057746 · doc4.xml · derivative · entry 4

Arbuckle Stuart A · CIK 0001557290 · EVP\Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,375

Underlying: Common Stock · 2,125 shares

Expires 2025-07-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option vests in 16 quarterly installments from 07/21/2015.

Read SEC document
November 07, 2018 Filed Nov 8, 2018 21:26 UTC
Arbuckle Stuart AEVP\Chief Commercial Officer
SaleCommon Stock 2,125 $179.00 $380,375.00
Disclosure

SEC source: 0001209191-18-057746 · doc4.xml · nonDerivative · entry 2

Arbuckle Stuart A · CIK 0001557290 · EVP\Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,752

F1 · kind: Transaction made pursuant to Mr. Arbuckle's company approved trading plan under Rule 10b5-1.

Read SEC document
November 07, 2018 Filed Nov 8, 2018 21:26 UTC
Arbuckle Stuart AEVP\Chief Commercial Officer
Exercise / conversionCommon Stock 2,125 $131.89 $280,266.25
Disclosure

SEC source: 0001209191-18-057746 · doc4.xml · nonDerivative · entry 1

Arbuckle Stuart A · CIK 0001557290 · EVP\Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,877

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 05, 2018 Filed Nov 6, 2018 21:11 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
Exercise / conversionStock Option (Right to Buy) · Derivative 2,330 $0.00 Strike: $86.52 $0.00
Disclosure

SEC source: 0001209191-18-057370 · doc4.xml · derivative · entry 6

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,969

Underlying: Common Stock · 2,330 shares

Expires 2027-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option vests in 16 quarterly installments from 02/03/2017.

Read SEC document
November 05, 2018 Filed Nov 6, 2018 21:11 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
SaleCommon Stock 2,330 $172.08 $400,946.40
Disclosure

SEC source: 0001209191-18-057370 · doc4.xml · nonDerivative · entry 4

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,113

F1 · kind: Transaction made pursuant to Dr. Altshuler's company approved trading plan under Rule 10b5-1.

Read SEC document
November 05, 2018 Filed Nov 6, 2018 21:11 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
Exercise / conversionCommon Stock 2,330 $86.52 $201,591.60
Disclosure

SEC source: 0001209191-18-057370 · doc4.xml · nonDerivative · entry 3

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,443

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 05, 2018 Filed Nov 6, 2018 21:24 UTC
Arbuckle Stuart AEVP\Chief Commercial Officer
Exercise / conversionStock Option (Right to Buy) · Derivative 1,553 $0.00 Strike: $86.52 $0.00
Disclosure

SEC source: 0001209191-18-057391 · doc4.xml · derivative · entry 7

Arbuckle Stuart A · CIK 0001557290 · EVP\Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,980

Underlying: Common Stock · 1,553 shares

Expires 2027-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option vests in 16 quarterly installments from 02/03/2017.

Read SEC document
November 05, 2018 Filed Nov 6, 2018 21:24 UTC
Arbuckle Stuart AEVP\Chief Commercial Officer
Exercise / conversionStock Option (Right to Buy) · Derivative 4,250 $0.00 Strike: $109.14 $0.00
Disclosure

SEC source: 0001209191-18-057391 · doc4.xml · derivative · entry 6

Arbuckle Stuart A · CIK 0001557290 · EVP\Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,250

Underlying: Common Stock · 4,250 shares

Expires 2025-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option vests in 16 quarterly installments from 02/03/2015.

Read SEC document
November 05, 2018 Filed Nov 6, 2018 21:24 UTC
Arbuckle Stuart AEVP\Chief Commercial Officer
SaleCommon Stock 1,553 $172.08 $267,240.24
Disclosure

SEC source: 0001209191-18-057391 · doc4.xml · nonDerivative · entry 4

Arbuckle Stuart A · CIK 0001557290 · EVP\Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,752

F1 · kind: Transaction made pursuant to Mr. Arbuckle's company approved trading plan under Rule 10b5-1.

Read SEC document
November 05, 2018 Filed Nov 6, 2018 21:24 UTC
Arbuckle Stuart AEVP\Chief Commercial Officer
Exercise / conversionCommon Stock 1,553 $86.52 $134,365.56
Disclosure

SEC source: 0001209191-18-057391 · doc4.xml · nonDerivative · entry 3

Arbuckle Stuart A · CIK 0001557290 · EVP\Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,305

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 05, 2018 Filed Nov 6, 2018 21:24 UTC
Arbuckle Stuart AEVP\Chief Commercial Officer
SaleCommon Stock 4,250 $172.08 $731,340.00
Disclosure

SEC source: 0001209191-18-057391 · doc4.xml · nonDerivative · entry 2

Arbuckle Stuart A · CIK 0001557290 · EVP\Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,752

F1 · kind: Transaction made pursuant to Mr. Arbuckle's company approved trading plan under Rule 10b5-1.

Read SEC document
November 05, 2018 Filed Nov 6, 2018 21:24 UTC
Arbuckle Stuart AEVP\Chief Commercial Officer
Exercise / conversionCommon Stock 4,250 $109.14 $463,845.00
Disclosure

SEC source: 0001209191-18-057391 · doc4.xml · nonDerivative · entry 1

Arbuckle Stuart A · CIK 0001557290 · EVP\Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 51,002

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 05, 2018 Filed Nov 6, 2018 21:32 UTC
Parini MichaelEVP, CL&AO
Exercise / conversionStock Option (Right to Buy) · Derivative 2,330 $0.00 Strike: $86.52 $0.00
Disclosure

SEC source: 0001209191-18-057409 · doc4.xml · derivative · entry 3

Parini Michael · CIK 0001661567 · EVP, CL&AO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,969

Underlying: Common Stock · 2,330 shares

Expires 2027-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option vests in 16 quarterly installments from 02/03/2017.

Read SEC document
November 05, 2018 Filed Nov 6, 2018 21:32 UTC
Parini MichaelEVP, CL&AO
SaleCommon Stock 2,330 $172.08 $400,946.40
Disclosure

SEC source: 0001209191-18-057409 · doc4.xml · nonDerivative · entry 2

Parini Michael · CIK 0001661567 · EVP, CL&AO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,609

F1 · kind: Transaction made pursuant to Mr. Parini's company-approved trading plan under Rule 10b5-1.

Read SEC document
November 05, 2018 Filed Nov 6, 2018 21:32 UTC
Parini MichaelEVP, CL&AO
Exercise / conversionCommon Stock 2,330 $86.52 $201,591.60
Disclosure

SEC source: 0001209191-18-057409 · doc4.xml · nonDerivative · entry 1

Parini Michael · CIK 0001661567 · EVP, CL&AO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,939

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 05, 2018 Filed Nov 6, 2018 21:45 UTC
Sachdev AmitEVP, CRO
Exercise / conversionStock Option (Right to Buy) · Derivative 1,941 $0.00 Strike: $86.52 $0.00
Disclosure

SEC source: 0001209191-18-057421 · doc4.xml · derivative · entry 14

Sachdev Amit · CIK 0001406338 · EVP, CRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,475

Underlying: Common Stock · 1,941 shares

Expires 2027-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F9 · derivative.exercise_date: The option vests in 16 quarterly installments from 02/03/2017.

Read SEC document
November 05, 2018 Filed Nov 6, 2018 21:45 UTC
Sachdev AmitEVP, CRO
SaleCommon Stock 428 $174.41 $74,647.48
Disclosure

SEC source: 0001209191-18-057421 · doc4.xml · nonDerivative · entry 10

Sachdev Amit · CIK 0001406338 · EVP, CRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,662

F1 · kind: Transaction made pursuant to Mr. Sachdev's company approved trading plan under Rule 10b5-1.

F3 · price: Mr. Sachdev undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F7 · price: Open market sales reported on this line occurred at a weighted average price of $174.41(range $174.31 to $174.50).

Read SEC document
November 05, 2018 Filed Nov 6, 2018 21:45 UTC
Sachdev AmitEVP, CRO
SaleCommon Stock 1,213 $173.74 $210,746.62
Disclosure

SEC source: 0001209191-18-057421 · doc4.xml · nonDerivative · entry 9

Sachdev Amit · CIK 0001406338 · EVP, CRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,090

F1 · kind: Transaction made pursuant to Mr. Sachdev's company approved trading plan under Rule 10b5-1.

F3 · price: Mr. Sachdev undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F6 · price: Open market sales reported on this line occurred at a weighted average price of $173.74 (range $173.28 to $174.15).

Read SEC document
November 05, 2018 Filed Nov 6, 2018 21:45 UTC
Sachdev AmitEVP, CRO
SaleCommon Stock 300 $172.70 $51,810.00
Disclosure

SEC source: 0001209191-18-057421 · doc4.xml · nonDerivative · entry 8

Sachdev Amit · CIK 0001406338 · EVP, CRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,303

F1 · kind: Transaction made pursuant to Mr. Sachdev's company approved trading plan under Rule 10b5-1.

F3 · price: Mr. Sachdev undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F5 · price: Open market sales reported on this line occurred at a weighted average price of $172.70 (range $172.16 to $173.12).

Read SEC document
November 05, 2018 Filed Nov 6, 2018 21:45 UTC
Sachdev AmitEVP, CRO
Exercise / conversionCommon Stock 1,941 $86.52 $167,935.32
Disclosure

SEC source: 0001209191-18-057421 · doc4.xml · nonDerivative · entry 7

Sachdev Amit · CIK 0001406338 · EVP, CRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,603

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 02, 2018 Filed Nov 5, 2018 21:52 UTC
Arbuckle Stuart AEVP\Chief Commercial Officer
Exercise / conversionStock Option (Right to Buy) · Derivative 2,155 $0.00 Strike: $91.05 $0.00
Disclosure

SEC source: 0001209191-18-057214 · doc4.xml · derivative · entry 4

Arbuckle Stuart A · CIK 0001557290 · EVP\Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,776

Underlying: Common Stock · 2,155 shares

Expires 2026-02-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option vests in 16 quarterly installments from 02/02/2016.

Read SEC document
November 02, 2018 Filed Nov 5, 2018 21:52 UTC
Arbuckle Stuart AEVP\Chief Commercial Officer
SaleCommon Stock 2,155 $175.36 $377,900.80
Disclosure

SEC source: 0001209191-18-057214 · doc4.xml · nonDerivative · entry 2

Arbuckle Stuart A · CIK 0001557290 · EVP\Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,752

F1 · kind: Transaction made pursuant to Mr. Arbuckle's company approved trading plan under Rule 10b5-1.

Read SEC document
November 02, 2018 Filed Nov 5, 2018 21:52 UTC
Arbuckle Stuart AEVP\Chief Commercial Officer
Exercise / conversionCommon Stock 2,155 $91.05 $196,212.75
Disclosure

SEC source: 0001209191-18-057214 · doc4.xml · nonDerivative · entry 1

Arbuckle Stuart A · CIK 0001557290 · EVP\Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,907

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 02, 2018 Filed Nov 6, 2018 21:11 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
Exercise / conversionStock Option (Right to Buy) · Derivative 1,796 $0.00 Strike: $91.05 $0.00
Disclosure

SEC source: 0001209191-18-057370 · doc4.xml · derivative · entry 5

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,980

Underlying: Common Stock · 1,796 shares

Expires 2026-02-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option vests in 16 quarterly installments from 02/02/2016.

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November 02, 2018 Filed Nov 6, 2018 21:11 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
SaleCommon Stock 1,796 $175.36 $314,946.56
Disclosure

SEC source: 0001209191-18-057370 · doc4.xml · nonDerivative · entry 2

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,113

F1 · kind: Transaction made pursuant to Dr. Altshuler's company approved trading plan under Rule 10b5-1.

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November 02, 2018 Filed Nov 6, 2018 21:11 UTC
ALTSHULER DAVIDEVP, Global Research and CSO
Exercise / conversionCommon Stock 1,796 $91.05 $163,525.80
Disclosure

SEC source: 0001209191-18-057370 · doc4.xml · nonDerivative · entry 1

ALTSHULER DAVID · CIK 0001550395 · EVP, Global Research and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,909

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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November 02, 2018 Filed Nov 6, 2018 21:45 UTC
Sachdev AmitEVP, CRO
Exercise / conversionStock Option (Right to Buy) · Derivative 2,155 $0.00 Strike: $91.05 $0.00
Disclosure

SEC source: 0001209191-18-057421 · doc4.xml · derivative · entry 13

Sachdev Amit · CIK 0001406338 · EVP, CRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,777

Underlying: Common Stock · 2,155 shares

Expires 2026-02-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · derivative.exercise_date: The option vests in 16 quarterly installments from 2/2/2016.

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November 02, 2018 Filed Nov 6, 2018 21:45 UTC
Sachdev AmitEVP, CRO
SaleCommon Stock 100 $176.04 $17,604.00
Disclosure

SEC source: 0001209191-18-057421 · doc4.xml · nonDerivative · entry 6

Sachdev Amit · CIK 0001406338 · EVP, CRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,662

F1 · kind: Transaction made pursuant to Mr. Sachdev's company approved trading plan under Rule 10b5-1.

Read SEC document
November 02, 2018 Filed Nov 6, 2018 21:45 UTC
Sachdev AmitEVP, CRO
SaleCommon Stock 100 $175.31 $17,531.00
Disclosure

SEC source: 0001209191-18-057421 · doc4.xml · nonDerivative · entry 5

Sachdev Amit · CIK 0001406338 · EVP, CRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,762

F1 · kind: Transaction made pursuant to Mr. Sachdev's company approved trading plan under Rule 10b5-1.

Read SEC document
November 02, 2018 Filed Nov 6, 2018 21:45 UTC
Sachdev AmitEVP, CRO
SaleCommon Stock 100 $173.35 $17,335.00
Disclosure

SEC source: 0001209191-18-057421 · doc4.xml · nonDerivative · entry 4

Sachdev Amit · CIK 0001406338 · EVP, CRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,862

F1 · kind: Transaction made pursuant to Mr. Sachdev's company approved trading plan under Rule 10b5-1.

Read SEC document
November 02, 2018 Filed Nov 6, 2018 21:45 UTC
Sachdev AmitEVP, CRO
SaleCommon Stock 1,255 $172.81 $216,876.55
Disclosure

SEC source: 0001209191-18-057421 · doc4.xml · nonDerivative · entry 3

Sachdev Amit · CIK 0001406338 · EVP, CRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,962

F1 · kind: Transaction made pursuant to Mr. Sachdev's company approved trading plan under Rule 10b5-1.

F3 · price: Mr. Sachdev undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F4 · price: Open market sales reported on this line occurred at a weighted average price of $172.81 (range $172.32 to $173.27).

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November 02, 2018 Filed Nov 6, 2018 21:45 UTC
Sachdev AmitEVP, CRO
SaleCommon Stock 600 $171.93 $103,158.00
Disclosure

SEC source: 0001209191-18-057421 · doc4.xml · nonDerivative · entry 2

Sachdev Amit · CIK 0001406338 · EVP, CRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,217

F1 · kind: Transaction made pursuant to Mr. Sachdev's company approved trading plan under Rule 10b5-1.

F2 · price: Open market sales reported on this line occurred at a weighted average price of $171.93 (range $171.25 to $172.24).

F3 · price: Mr. Sachdev undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.