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VRTX

VERTEX PHARMACEUTICALS INC / MA

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2875
SEC CIK
0000875320
Parsed reports
2,554

Last 12 months

Inside the activity.

0 purchase rows · 93 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202506
Dec 2025016
Jan 202602
Feb 2026049
Mar 202605
Apr 202601
May 202606
Jun 202605
Jul 202603
Aug 202600
Sep 202600
Oct 202600

Latest available

Insider transactions

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
February 02, 2006 Filed Feb 6, 2006 21:25 UTC
SMITH IAN FEVP & CFO
GrantStock Option · Derivative 73,500 $0.00 Strike: $35.64 $0.00
Disclosure

SEC source: 0000875320-06-000008 · edgar.xml · derivative · entry 3

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 335,209

Underlying: Common Stock · 73,500 shares

Expires 2016-02-01

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 16 equal quarterly installments from 02/02/2006.

Read SEC document
February 02, 2006 Filed Feb 6, 2006 21:25 UTC
SMITH IAN FEVP & CFO
GrantCommon Stock 12,200 $0.01 $122.00
Disclosure

SEC source: 0000875320-06-000008 · edgar.xml · nonDerivative · entry 1

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 82,450

F1 · shares: Stock grant made under 1996 Stock and Option Plan, vesting on 02/02/2010, subject to acceleration upon achievement of certain performance-based milestones.

Read SEC document
February 02, 2006 Filed Feb 6, 2006 21:31 UTC
BOGER JOSHUA SDirector · President, Chairman & CEO
GrantStock Option · Derivative 600,000 $0.00 Strike: $35.64 $0.00
Disclosure

SEC source: 0000875320-06-000009 · edgar.xml · derivative · entry 4

BOGER JOSHUA S · CIK 0001197023 · Director · President, Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,032,411

Underlying: Common Stock · 600,000 shares

Expires 2016-02-01

F3 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 16 equal quarterly installments from 02/02/2006.

Read SEC document
February 02, 2006 Filed Feb 6, 2006 21:31 UTC
BOGER JOSHUA SDirector · President, Chairman & CEO
GrantCommon Stock 47,201 $0.01 $472.01
Disclosure

SEC source: 0000875320-06-000009 · edgar.xml · nonDerivative · entry 1

BOGER JOSHUA S · CIK 0001197023 · Director · President, Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,035,403

F1 · shares: Stock grant made under 1996 Stock and Option Plan, vesting on 02/02/2010, subject to acceleration upon achievement of certain performance-based milestones.

Read SEC document
February 02, 2006 Filed Feb 6, 2006 21:32 UTC
MUELLER PETEREVP Drug Disc., Innov & Realiz
GrantStock Option · Derivative 73,500 $0.00 Strike: $35.64 $0.00
Disclosure

SEC source: 0000875320-06-000010 · edgar.xml · derivative · entry 3

MUELLER PETER · CIK 0001256126 · EVP Drug Disc., Innov & Realiz

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 374,300

Underlying: Common Stock · 73,500 shares

Expires 2016-02-01

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 16 equal quarterly installments from 02/02/2006.

Read SEC document
February 02, 2006 Filed Feb 6, 2006 21:32 UTC
MUELLER PETEREVP Drug Disc., Innov & Realiz
GrantCommon Stock 12,200 $0.01 $122.00
Disclosure

SEC source: 0000875320-06-000010 · edgar.xml · nonDerivative · entry 1

MUELLER PETER · CIK 0001256126 · EVP Drug Disc., Innov & Realiz

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 85,531

F1 · shares: Stock grant made under 1996 Stock and Option Plan, vesting on 02/02/2010, subject to acceleration upon achievement of certain performance-based milestones.

Read SEC document
February 02, 2006 Filed Feb 6, 2006 21:35 UTC
BOGER KENNETH SSVP & General Counsel
GrantStock Option · Derivative 73,500 $0.00 Strike: $35.64 $0.00
Disclosure

SEC source: 0000875320-06-000011 · edgar.xml · derivative · entry 4

BOGER KENNETH S · CIK 0001046336 · SVP & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 338,945

Underlying: Common Stock · 73,500 shares

Expires 2016-02-01

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 16 equal quarterly installments from 02/02/2006.

Read SEC document
February 02, 2006 Filed Feb 6, 2006 21:35 UTC
BOGER KENNETH SSVP & General Counsel
GrantCommon Stock 12,200 $0.01 $122.00
Disclosure

SEC source: 0000875320-06-000011 · edgar.xml · nonDerivative · entry 1

BOGER KENNETH S · CIK 0001046336 · SVP & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,529

F1 · shares: Stock grant made under 1996 Stock and Option Plan, vesting on 2/2/2010, subject to acceleration upon achievement of certain performance-based milestones.

Read SEC document
February 02, 2006 Filed Feb 6, 2006 21:38 UTC
ALAM JOHN JEVP, Med. Product Dev. & CMO
GrantStock Option · Derivative 73,500 $0.00 Strike: $35.64 $0.00
Disclosure

SEC source: 0000875320-06-000012 · edgar.xml · derivative · entry 3

ALAM JOHN J · CIK 0001197014 · EVP, Med. Product Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 495,245

Underlying: Common Stock · 73,500 shares

Expires 2016-02-01

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 16 equal quarterly installments from 02/02/2006.

Read SEC document
February 02, 2006 Filed Feb 6, 2006 21:38 UTC
ALAM JOHN JEVP, Med. Product Dev. & CMO
GrantCommon Stock 12,200 $0.01 $122.00
Disclosure

SEC source: 0000875320-06-000012 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · EVP, Med. Product Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,856

F1 · shares: Stock grant made under 1996 Stock and Option Plan, vesting on 2/2/2010, subject to acceleration upon achievement of certain performance-based milestones.

Read SEC document
February 02, 2006 Filed Feb 6, 2006 21:45 UTC
BRUM LYNNE HVP, Strategic Communications
GrantStock Option · Derivative 14,066 $0.00 Strike: $35.64 $0.00
Disclosure

SEC source: 0000875320-06-000014 · edgar.xml · derivative · entry 4

BRUM LYNNE H · CIK 0001197017 · VP, Strategic Communications

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 294,433

Underlying: Common stock · 14,066 shares

Expires 2016-02-01

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 16 equal quarterly installments from 02/02/2006.

Read SEC document
February 02, 2006 Filed Feb 6, 2006 21:45 UTC
BRUM LYNNE HVP, Strategic Communications
GrantCommon Stock 3,240 $0.01 $32.40
Disclosure

SEC source: 0000875320-06-000014 · edgar.xml · nonDerivative · entry 1

BRUM LYNNE H · CIK 0001197017 · VP, Strategic Communications

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,587

F1 · shares: Stock grant made under 1996 Stock and Option Plan, vesting on 2/2/2010, subject to acceleration upon achievement of certain performance-based milestones.

Read SEC document
February 02, 2006 Filed Feb 6, 2006 21:43 UTC
POWER JOHANNA MESSINAVP & Controller
GrantStock Option · Derivative 15,422 $0.00 Strike: $35.64 $0.00
Disclosure

SEC source: 0000875320-06-000013 · edgar.xml · derivative · entry 3

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,960

Underlying: Common Stock · 15,422 shares

Expires 2016-02-01

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 16 equal quarterly installments from 02/02/2006.

Read SEC document
February 02, 2006 Filed Feb 6, 2006 21:43 UTC
POWER JOHANNA MESSINAVP & Controller
GrantCommon Stock 3,000 $0.01 $30.00
Disclosure

SEC source: 0000875320-06-000013 · edgar.xml · nonDerivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,864

F1 · shares: Stock grant made under 1996 Stock and Option Plan, vesting on 02/02/2010, subject to acceleration upon achievement of certain performance-based milestones.

Read SEC document
February 02, 2006 Filed Feb 6, 2006 21:47 UTC
Hartmann Victor AEVP, Strategic & Corp. Devlp.
GrantStock Option · Derivative 108,750 $0.00 Strike: $35.64 $0.00
Disclosure

SEC source: 0000875320-06-000015 · edgar.xml · derivative · entry 3

Hartmann Victor A · CIK 0001317101 · EVP, Strategic & Corp. Devlp.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 258,750

Underlying: Common Stock · 108,750 shares

Expires 2016-02-01

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 16 equal quarterly installments from 02/02/2006.

Read SEC document
February 02, 2006 Filed Feb 6, 2006 21:47 UTC
Hartmann Victor AEVP, Strategic & Corp. Devlp.
GrantCommon Stock 14,501 $0.01 $145.01
Disclosure

SEC source: 0000875320-06-000015 · edgar.xml · nonDerivative · entry 1

Hartmann Victor A · CIK 0001317101 · EVP, Strategic & Corp. Devlp.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 84,501

F1 · shares: Stock grant made under 1996 Stock and Option Plan, vesting on 2/2/2010, subject to acceleration upon achievement of certain performance-based milestoned.

Read SEC document
February 02, 2006 Filed Feb 6, 2006 21:49 UTC
GARRISON RICHARD CSVP, Organizational Developmen
GrantStock Option · Derivative 30,000 $0.00 Strike: $35.64 $0.00
Disclosure

SEC source: 0000875320-06-000016 · edgar.xml · derivative · entry 2

GARRISON RICHARD C · CIK 0001256466 · SVP, Organizational Developmen

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 59,000

Underlying: Common Stock · 30,000 shares

Expires 2016-02-01

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 16 equal quarterly installments from 02/02/2006.

Read SEC document
February 02, 2006 Filed Feb 6, 2006 21:49 UTC
GARRISON RICHARD CSVP, Organizational Developmen
GrantCommon Stock 5,000 $0.01 $50.00
Disclosure

SEC source: 0000875320-06-000016 · edgar.xml · nonDerivative · entry 1

GARRISON RICHARD C · CIK 0001256466 · SVP, Organizational Developmen

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,900

F1 · shares: Stock grant made under 1996 Stock and Option Plan, vesting on 2/2/2010, subject to acceleration upon achievement of certain performance-based milestones.

Read SEC document
January 31, 2006 Filed Feb 1, 2006 17:54 UTC
BRUM LYNNE HVP, Strategic Communications
GrantStock Option · Derivative 1,000 $0.00 Strike: $15.56 $0.00
Disclosure

SEC source: 0000875320-06-000006 · edgar.xml · derivative · entry 5

BRUM LYNNE H · CIK 0001197017 · VP, Strategic Communications

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 280,367

Underlying: Common Stock · 1,000 shares

Expires 2006-12-11

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 years from 12/12/96.

Read SEC document
January 31, 2006 Filed Feb 1, 2006 17:54 UTC
BRUM LYNNE HVP, Strategic Communications
SaleCommon Stock 1,000 $35.29 $35,290.00
Disclosure

SEC source: 0000875320-06-000006 · edgar.xml · nonDerivative · entry 2

BRUM LYNNE H · CIK 0001197017 · VP, Strategic Communications

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,196

F1 · kind: Transaction made pursuant to Ms. Brum's company approved trading plan established under Rule 10b5-1.

Read SEC document
January 31, 2006 Filed Feb 1, 2006 17:54 UTC
BRUM LYNNE HVP, Strategic Communications
Exercise / conversionCommon Stock 1,000 $15.56 $15,560.00
Disclosure

SEC source: 0000875320-06-000006 · edgar.xml · nonDerivative · entry 1

BRUM LYNNE H · CIK 0001197017 · VP, Strategic Communications

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,196

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 23, 2006 Filed Jan 24, 2006 20:31 UTC
BRUM LYNNE HVP, Strategic Communications
GrantStock Option · Derivative 1,000 $0.00 Strike: $15.56 $0.00
Disclosure

SEC source: 0000875320-06-000003 · edgar.xml · derivative · entry 5

BRUM LYNNE H · CIK 0001197017 · VP, Strategic Communications

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 281,367

Underlying: Common Stock · 1,000 shares

Expires 2006-12-11

F2 · derivative.exercise_date: Right to buy under 1995 Stock and Option Plan, vesting quarterly over 5 years from 12/14/95.

Read SEC document
January 23, 2006 Filed Jan 24, 2006 20:31 UTC
BRUM LYNNE HVP, Strategic Communications
SaleCommon Stock 1,000 $33.63 $33,630.00
Disclosure

SEC source: 0000875320-06-000003 · edgar.xml · nonDerivative · entry 2

BRUM LYNNE H · CIK 0001197017 · VP, Strategic Communications

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,196

F1 · kind: Transaction made pursuant to Ms. Brum's company approved trading plan established under Rule 10b5-1.

Read SEC document
January 23, 2006 Filed Jan 24, 2006 20:31 UTC
BRUM LYNNE HVP, Strategic Communications
Exercise / conversionCommon Stock 1,000 $15.56 $15,560.00
Disclosure

SEC source: 0000875320-06-000003 · edgar.xml · nonDerivative · entry 1

BRUM LYNNE H · CIK 0001197017 · VP, Strategic Communications

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,196

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 23, 2006 Filed Jan 24, 2006 21:32 UTC
SMITH IAN FSVP & CFO
GrantStock Option · Derivative 14,381 $0.00 Strike: $15.60 $0.00
Disclosure

SEC source: 0000875320-06-000004 · edgar.xml · derivative · entry 7

SMITH IAN F · CIK 0001197032 · SVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 261,709

Underlying: Common Stock · 14,381 shares

Expires 2013-04-17

F3 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 years from 1/18/2003.

Read SEC document
January 23, 2006 Filed Jan 24, 2006 21:32 UTC
SMITH IAN FSVP & CFO
GrantStock Option · Derivative 12,051 $0.00 Strike: $15.87 $0.00
Disclosure

SEC source: 0000875320-06-000004 · edgar.xml · derivative · entry 6

SMITH IAN F · CIK 0001197032 · SVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 276,090

Underlying: Common Stock · 12,051 shares

Expires 2012-07-21

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 years from 7/22/2002.

Read SEC document
January 23, 2006 Filed Jan 24, 2006 21:32 UTC
SMITH IAN FSVP & CFO
SaleCommon Stock 14,381 $33.64 $483,776.84
Disclosure

SEC source: 0000875320-06-000004 · edgar.xml · nonDerivative · entry 4

SMITH IAN F · CIK 0001197032 · SVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,250

F1 · kind: Transaction made pursuant to Mr. Smith's company approved trading plan established under Rule 10b5-1.

Read SEC document
January 23, 2006 Filed Jan 24, 2006 21:32 UTC
SMITH IAN FSVP & CFO
Exercise / conversionCommon Stock 14,381 $15.60 $224,343.60
Disclosure

SEC source: 0000875320-06-000004 · edgar.xml · nonDerivative · entry 3

SMITH IAN F · CIK 0001197032 · SVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 84,631

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 23, 2006 Filed Jan 24, 2006 21:32 UTC
SMITH IAN FSVP & CFO
SaleCommon Stock 12,051 $33.64 $405,395.64
Disclosure

SEC source: 0000875320-06-000004 · edgar.xml · nonDerivative · entry 2

SMITH IAN F · CIK 0001197032 · SVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,250

F1 · kind: Transaction made pursuant to Mr. Smith's company approved trading plan established under Rule 10b5-1.

Read SEC document
January 23, 2006 Filed Jan 24, 2006 21:32 UTC
SMITH IAN FSVP & CFO
Exercise / conversionCommon Stock 12,051 $15.87 $191,249.37
Disclosure

SEC source: 0000875320-06-000004 · edgar.xml · nonDerivative · entry 1

SMITH IAN F · CIK 0001197032 · SVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 82,301

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 17, 2006 Filed Jan 18, 2006 17:13 UTC
BRUM LYNNE HVP, Corp. Comm.&Financial Plan
GrantStock Option · Derivative 1,000 $0.00 Strike: $15.56 $0.00
Disclosure

SEC source: 0000875320-06-000002 · edgar.xml · derivative · entry 5

BRUM LYNNE H · CIK 0001197017 · VP, Corp. Comm.&Financial Plan

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 282,367

Underlying: Common Stock · 1,000 shares

Expires 2006-12-11

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 years from 12/12/96.

Read SEC document
January 17, 2006 Filed Jan 18, 2006 17:13 UTC
BRUM LYNNE HVP, Corp. Comm.&Financial Plan
SaleCommon Stock 1,000 $33.62 $33,620.00
Disclosure

SEC source: 0000875320-06-000002 · edgar.xml · nonDerivative · entry 2

BRUM LYNNE H · CIK 0001197017 · VP, Corp. Comm.&Financial Plan

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,196

F1 · kind: Transaction made pursuant to Ms. Brum's company approved trading plan established under Rule 10b5-1.

Read SEC document
January 17, 2006 Filed Jan 18, 2006 17:13 UTC
BRUM LYNNE HVP, Corp. Comm.&Financial Plan
Exercise / conversionCommon Stock 1,000 $15.56 $15,560.00
Disclosure

SEC source: 0000875320-06-000002 · edgar.xml · nonDerivative · entry 1

BRUM LYNNE H · CIK 0001197017 · VP, Corp. Comm.&Financial Plan

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,196

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 06, 2006 Filed Jan 9, 2006 18:25 UTC
MUELLER PETERCSO & SVP Drug Discovery
SaleCommon Stock 1,213 $30.78 $37,336.14
Disclosure

SEC source: 0000875320-06-000001 · edgar.xml · nonDerivative · entry 1

MUELLER PETER · CIK 0001256126 · CSO & SVP Drug Discovery

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 73,331

F1 · kind: Transaction made pursuant to Dr. Mueller's company approved trading plan established under Rule 10b5-1.

Read SEC document
December 21, 2005 Filed Dec 21, 2005 21:25 UTC Amendment
SMITH IAN FSVP & CFO
SaleCommon Stock 11,811 $27.88 $329,290.68
Disclosure

SEC source: 0000875320-05-000077 · edgar.xml · nonDerivative · entry 1

SMITH IAN F · CIK 0001197032 · SVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,250

F1 · date: This Form 4 amends the Form 4 filed on behalf of Mr. Smith on December 20, 2005 to reflect a different transaction date and price.

Read SEC document
December 21, 2005 Filed Dec 21, 2005 21:21 UTC
MUELLER PETERCSO & SVP Drug Discovery
SaleCommon Stock 1,496 $27.84 $41,648.64
Disclosure

SEC source: 0000875320-05-000076 · edgar.xml · nonDerivative · entry 1

MUELLER PETER · CIK 0001256126 · CSO & SVP Drug Discovery

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 74,554

F1 · kind: Transaction made pursuant to Dr. Mueller's company approved trading plan established under Rule 10b5-1.

Read SEC document
December 16, 2005 Filed Dec 20, 2005 17:06 UTC
SMITH IAN FSVP & CFO
SaleCommon Stock 2,337 $27.66 $64,641.42
Disclosure

SEC source: 0000875320-05-000075 · edgar.xml · nonDerivative · entry 2

SMITH IAN F · CIK 0001197032 · SVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,250

Read SEC document
December 16, 2005 Filed Dec 20, 2005 17:06 UTC
SMITH IAN FSVP & CFO
SaleCommon Stock 9,474 $27.64 $261,861.36
Disclosure

SEC source: 0000875320-05-000075 · edgar.xml · nonDerivative · entry 1

SMITH IAN F · CIK 0001197032 · SVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 72,587

Read SEC document
December 14, 2005 Filed Dec 15, 2005 19:55 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
SaleCommon Stock 1,750 $27.59 $48,282.50
Disclosure

SEC source: 0000875320-05-000073 · edgar.xml · nonDerivative · entry 3

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 88,714

Read SEC document
December 14, 2005 Filed Dec 15, 2005 19:55 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
SaleCommon Stock 250 $27.58 $6,895.00
Disclosure

SEC source: 0000875320-05-000073 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 90,464

Read SEC document
December 14, 2005 Filed Dec 15, 2005 19:55 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
SaleCommon Stock 3,220 $27.40 $88,228.00
Disclosure

SEC source: 0000875320-05-000073 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 90,714

Read SEC document
December 14, 2005 Filed Dec 15, 2005 19:57 UTC GiftCommon Stock 38,487 $0.00 $0.00
Disclosure

SEC source: 0000875320-05-000074 · edgar.xml · nonDerivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 64,000

F1 · shares: Common stock gifted to the Water Cove Charitable Foundation.

Read SEC document
December 06, 2005 Filed Dec 7, 2005 20:16 UTC
BOGER JOSHUA SDirector · Chairman, President & CEO
GrantStock Option · Derivative 8,300 $0.00 Strike: $9.50 $0.00
Disclosure

SEC source: 0000875320-05-000070 · edgar.xml · derivative · entry 5

BOGER JOSHUA S · CIK 0001197023 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,432,411

Underlying: Common Stock · 8,300 shares

Expires 2005-12-13

F3 · derivative.exercise_date: Right to buy under 1994 Stock and Option Plan, vesting quarterly over 5 years from 12/14/95.

Read SEC document
December 06, 2005 Filed Dec 7, 2005 20:16 UTC
BOGER JOSHUA SDirector · Chairman, President & CEO
SaleCommon Stock 8,300 $24.80 $205,840.00
Disclosure

SEC source: 0000875320-05-000070 · edgar.xml · nonDerivative · entry 2

BOGER JOSHUA S · CIK 0001197023 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 988,202

F1 · kind: Transaction made pursuant to Dr. Boger's company approved trading plan established under Rule 10b5-1.

Read SEC document
December 06, 2005 Filed Dec 7, 2005 20:16 UTC
BOGER JOSHUA SDirector · Chairman, President & CEO
Exercise / conversionCommon Stock 8,300 $9.50 $78,850.00
Disclosure

SEC source: 0000875320-05-000070 · edgar.xml · nonDerivative · entry 1

BOGER JOSHUA S · CIK 0001197023 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 996,502

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 06, 2005 Filed Dec 7, 2005 20:19 UTC
BRUM LYNNE HVP, Corp. Comm.&Financial Plan
GrantStock Option · Derivative 2,000 $0.00 Strike: $9.50 $0.00
Disclosure

SEC source: 0000875320-05-000071 · edgar.xml · derivative · entry 5

BRUM LYNNE H · CIK 0001197017 · VP, Corp. Comm.&Financial Plan

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 283,367

Underlying: Common Stock · 2,000 shares

Expires 2005-12-13

F2 · derivative.exercise_date: Right to buy under 1995 Stock and Option Plan, vesting quarterly over 5 years from 12/14/95.

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December 06, 2005 Filed Dec 7, 2005 20:19 UTC
BRUM LYNNE HVP, Corp. Comm.&Financial Plan
SaleCommon Stock 2,000 $24.80 $49,600.00
Disclosure

SEC source: 0000875320-05-000071 · edgar.xml · nonDerivative · entry 2

BRUM LYNNE H · CIK 0001197017 · VP, Corp. Comm.&Financial Plan

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,196

F1 · kind: Transaction made pursuant to Ms. Brum's company approved trading plan established under Rule 10b5-1.

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December 06, 2005 Filed Dec 7, 2005 20:19 UTC
BRUM LYNNE HVP, Corp. Comm.&Financial Plan
Exercise / conversionCommon Stock 2,000 $9.50 $19,000.00
Disclosure

SEC source: 0000875320-05-000071 · edgar.xml · nonDerivative · entry 1

BRUM LYNNE H · CIK 0001197017 · VP, Corp. Comm.&Financial Plan

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,196

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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December 02, 2005 Filed Dec 5, 2005 19:18 UTC Amendment SaleCommon Stock 600 $25.03 $15,018.00
Disclosure

SEC source: 0000875320-05-000069 · edgar.xml · nonDerivative · entry 1

ULLIAN ELAINE · CIK 0001190290 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · date: This Form 4 amends the Form 4 filed on behalf of Ms. Ullian on November 28, 2005 to reflect a different transaction date and price.

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November 29, 2005 Filed Nov 30, 2005 16:14 UTC
BOGER JOSHUA SDirector · Chairman, President & CEO
GrantStock Option · Derivative 7,100 $0.00 Strike: $9.50 $0.00
Disclosure

SEC source: 0000875320-05-000068 · edgar.xml · derivative · entry 5

BOGER JOSHUA S · CIK 0001197023 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,440,711

Underlying: Common Stock · 7,100 shares

Expires 2005-12-13

F3 · derivative.exercise_date: Right to buy under 1994 Stock and Option Plan, vesting quarterly over 5 years from 12/14/95.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.