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Nasdaq · USD

VRTX

VERTEX PHARMACEUTICALS INC / MA

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Tapewire entity
2875
SEC CIK
0000875320
Parsed reports
2,554

Last 12 months

Inside the activity.

0 purchase rows · 93 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202506
Dec 2025016
Jan 202602
Feb 2026049
Mar 202605
Apr 202601
May 202606
Jun 202605
Jul 202603
Aug 202600
Sep 202600
Oct 202600

Latest available

Insider transactions

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
December 27, 2006 Filed Dec 28, 2006 17:34 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
Exercise / conversionStock Options · Derivative 500 $0.00 Strike: $9.07 $0.00
Disclosure

SEC source: 0000875320-06-000127 · edgar.xml · derivative · entry 7

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 498,495

Underlying: Common Stock · 500 shares

Expires 2013-12-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years from 12/11/2003.

Read SEC document
December 27, 2006 Filed Dec 28, 2006 17:34 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
Exercise / conversionStock Options · Derivative 1,000 $0.00 Strike: $18.47 $0.00
Disclosure

SEC source: 0000875320-06-000127 · edgar.xml · derivative · entry 6

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 498,995

Underlying: Common Stock · 1,000 shares

Expires 2007-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 years from 9/26/1997.

Read SEC document
December 27, 2006 Filed Dec 28, 2006 17:34 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
SaleCommon Stock 500 $37.56 $18,780.00
Disclosure

SEC source: 0000875320-06-000127 · edgar.xml · nonDerivative · entry 4

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,376

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1.

Read SEC document
December 27, 2006 Filed Dec 28, 2006 17:34 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
SaleCommon Stock 1,000 $37.56 $37,560.00
Disclosure

SEC source: 0000875320-06-000127 · edgar.xml · nonDerivative · entry 3

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,876

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1.

Read SEC document
December 27, 2006 Filed Dec 28, 2006 17:34 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
Exercise / conversionCommon Stock 500 $9.07 $4,535.00
Disclosure

SEC source: 0000875320-06-000127 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,876

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 27, 2006 Filed Dec 28, 2006 17:34 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
Exercise / conversionCommon Stock 1,000 $18.47 $18,470.00
Disclosure

SEC source: 0000875320-06-000127 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,376

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 26, 2006 Filed Dec 27, 2006 18:57 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock · Derivative 125 $0.00 Strike: $9.69 $0.00
Disclosure

SEC source: 0000875320-06-000126 · edgar.xml · derivative · entry 4

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,460

Underlying: Common Stock · 125 shares

Expires 2014-03-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 20 equal quarterly installments from 3/17/2004.

Read SEC document
December 26, 2006 Filed Dec 27, 2006 18:57 UTC
POWER JOHANNA MESSINAVP & Controller
SaleCommon Stock 125 $37.25 $4,656.25
Disclosure

SEC source: 0000875320-06-000126 · edgar.xml · nonDerivative · entry 2

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,287

F1 · kind: Transaction made pursuant to Ms. Messina-Power's company approved trading plan established under Rule 10b5-1.

Read SEC document
December 26, 2006 Filed Dec 27, 2006 18:57 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock 125 $9.69 $1,211.25
Disclosure

SEC source: 0000875320-06-000126 · edgar.xml · nonDerivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,412

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 22, 2006 Filed Dec 27, 2006 18:53 UTC
GARRISON RICHARD CSVP, Catalyst
SaleCommon Stock 1,975 $37.56 $74,181.00
Disclosure

SEC source: 0000875320-06-000125 · edgar.xml · nonDerivative · entry 1

GARRISON RICHARD C · CIK 0001256466 · SVP, Catalyst

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,208

F1 · kind: Transaction made pursuant to Mr. Garrison's company approved trading plan established under Rule 10b5-1.

Read SEC document
December 20, 2006 Filed Dec 21, 2006 19:28 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
Exercise / conversionStock Options · Derivative 500 $0.00 Strike: $9.07 $0.00
Disclosure

SEC source: 0000875320-06-000124 · edgar.xml · derivative · entry 7

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 499,995

Underlying: Common Stock · 500 shares

Expires 2013-12-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years from 12/11/2003.

Read SEC document
December 20, 2006 Filed Dec 21, 2006 19:28 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
Exercise / conversionStock Options · Derivative 1,000 $0.00 Strike: $18.47 $0.00
Disclosure

SEC source: 0000875320-06-000124 · edgar.xml · derivative · entry 6

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 500,495

Underlying: Common Stock · 1,000 shares

Expires 2007-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 years from 9/26/1997.

Read SEC document
December 20, 2006 Filed Dec 21, 2006 19:28 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
SaleCommon Stock 500 $37.78 $18,890.00
Disclosure

SEC source: 0000875320-06-000124 · edgar.xml · nonDerivative · entry 4

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,376

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1.

Read SEC document
December 20, 2006 Filed Dec 21, 2006 19:28 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
SaleCommon Stock 1,000 $37.78 $37,780.00
Disclosure

SEC source: 0000875320-06-000124 · edgar.xml · nonDerivative · entry 3

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,876

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1.

Read SEC document
December 20, 2006 Filed Dec 21, 2006 19:28 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
Exercise / conversionCommon Stock 500 $9.07 $4,535.00
Disclosure

SEC source: 0000875320-06-000124 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,876

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 20, 2006 Filed Dec 21, 2006 19:28 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
Exercise / conversionCommon Stock 1,000 $18.47 $18,470.00
Disclosure

SEC source: 0000875320-06-000124 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,376

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 19, 2006 Filed Dec 20, 2006 17:55 UTC
MUELLER PETERCSO&EVP Drug Innov&Realization
SaleCommon Stock 165 $38.00 $6,270.00
Disclosure

SEC source: 0000875320-06-000123 · edgar.xml · nonDerivative · entry 1

MUELLER PETER · CIK 0001256126 · CSO&EVP Drug Innov&Realization

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,747

F1 · kind: Transaction made pursuant to Dr. Mueller's company approved trading plan established under Rule 10b5-1.

Read SEC document
December 18, 2006 Filed Dec 19, 2006 16:44 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock · Derivative 125 $0.00 Strike: $9.69 $0.00
Disclosure

SEC source: 0000875320-06-000122 · edgar.xml · derivative · entry 4

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,585

Underlying: Common Stock · 125 shares

Expires 2014-03-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 20 equal quarterly installments from 3/17/2004.

Read SEC document
December 18, 2006 Filed Dec 19, 2006 16:44 UTC
POWER JOHANNA MESSINAVP & Controller
SaleCommon Stock 125 $38.94 $4,867.50
Disclosure

SEC source: 0000875320-06-000122 · edgar.xml · nonDerivative · entry 2

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,287

F1 · kind: Transaction made pursuant to Ms. Messina-Power's company approved trading plan established under Rule 10b5-1.

Read SEC document
December 18, 2006 Filed Dec 19, 2006 16:44 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock 125 $9.69 $1,211.25
Disclosure

SEC source: 0000875320-06-000122 · edgar.xml · nonDerivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,412

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 15, 2006 Filed Dec 18, 2006 21:49 UTC GrantStock Option · Derivative 20,000 $0.00 Strike: $38.95 $0.00
Disclosure

SEC source: 0000875320-06-000121 · edgar.xml · derivative · entry 1

SANDERS CHARLES A · CIK 0001022936 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Stock · 20,000 shares

Expires 2016-12-14

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan. Fully vested.

Read SEC document
December 14, 2006 Filed Dec 15, 2006 16:29 UTC Exercise / conversionStock Option · Derivative 420 $0.00 Strike: $9.68 $0.00
Disclosure

SEC source: 0000875320-06-000119 · edgar.xml · derivative · entry 5

COLLINSON STUART J · CIK 0001197037 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 165,104

Underlying: Common Stock · 420 shares

Expires 2009-04-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Right to buy under the 1996 Stock and Option Plan, fully vested as of 4/29/1999.

Read SEC document
December 14, 2006 Filed Dec 15, 2006 16:29 UTC Exercise / conversionStock Option · Derivative 49,599 $0.00 Strike: $18.25 $0.00
Disclosure

SEC source: 0000875320-06-000119 · edgar.xml · derivative · entry 4

COLLINSON STUART J · CIK 0001197037 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 165,524

Underlying: Common Stock · 49,599 shares

Expires 2009-12-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under the 1996 Stock and Option Plan, fully vested as of 12/7/1999.

Read SEC document
December 14, 2006 Filed Dec 15, 2006 16:29 UTC SaleCommon Stock 50,019 $37.81 $1,891,218.39
Disclosure

SEC source: 0000875320-06-000119 · edgar.xml · nonDerivative · entry 3

COLLINSON STUART J · CIK 0001197037 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,279

F1 · kind: Transaction made pursuant to Dr. Collinson's company approved trading plan established under Rule 10b5-1.

Read SEC document
December 14, 2006 Filed Dec 15, 2006 16:29 UTC Exercise / conversionCommon Stock 420 $9.68 $4,065.60
Disclosure

SEC source: 0000875320-06-000119 · edgar.xml · nonDerivative · entry 2

COLLINSON STUART J · CIK 0001197037 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,298

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 14, 2006 Filed Dec 15, 2006 16:29 UTC Exercise / conversionCommon Stock 49,599 $18.25 $905,181.75
Disclosure

SEC source: 0000875320-06-000119 · edgar.xml · nonDerivative · entry 1

COLLINSON STUART J · CIK 0001197037 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,878

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 13, 2006 Filed Dec 14, 2006 15:31 UTC
POWER JOHANNA MESSINAVP & Controller
SaleCommon Stock 10 $38.76 $387.60
Disclosure

SEC source: 0000875320-06-000116 · edgar.xml · nonDerivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,287

F1 · kind: Transaction made pursuant to Ms. Messina-Power's company approved trading plan established under Rule 10b5-1.

Read SEC document
December 13, 2006 Filed Dec 14, 2006 15:34 UTC
SMITH IAN FEVP & CFO
SaleCommon Stock 480 $38.55 $18,504.00
Disclosure

SEC source: 0000875320-06-000117 · edgar.xml · nonDerivative · entry 1

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,530

F1 · kind: Transaction made pursuant to Mr. Smith's company approved trading plan established under Rule 10b5-1.

Read SEC document
December 13, 2006 Filed Dec 14, 2006 15:36 UTC
ALAM JOHN JEVP, Medicines Dev. & CMO
SaleCommon Stock 480 $38.85 $18,648.00
Disclosure

SEC source: 0000875320-06-000118 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 101,876

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1.

Read SEC document
December 13, 2006 Filed Dec 14, 2006 15:36 UTC
ALAM JOHN JEVP, Medicines Dev. & CMO
SaleCommon Stock 1,500 $38.54 $57,810.00
Disclosure

SEC source: 0000875320-06-000118 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 102,356

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1.

Read SEC document
December 13, 2006 Filed Dec 15, 2006 16:31 UTC Amendment
ALAM JOHN JEVP, Medicines Dev. & CMO
Exercise / conversionStock Option · Derivative 500 $0.00 Strike: $9.07 $0.00
Disclosure

SEC source: 0000875320-06-000120 · edgar.xml · derivative · entry 7

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 501,495

Underlying: Common Stock · 500 shares

Expires 2013-12-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years from 12/11/2003.

Read SEC document
December 13, 2006 Filed Dec 15, 2006 16:31 UTC Amendment
ALAM JOHN JEVP, Medicines Dev. & CMO
Exercise / conversionStock Option · Derivative 1,000 $0.00 Strike: $18.47 $0.00
Disclosure

SEC source: 0000875320-06-000120 · edgar.xml · derivative · entry 6

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 501,995

Underlying: Common Stock · 1,000 shares

Expires 2007-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 ;years from 9/26/1997.

Read SEC document
December 13, 2006 Filed Dec 15, 2006 16:31 UTC Amendment
ALAM JOHN JEVP, Medicines Dev. & CMO
SaleCommon Stock 480 $38.85 $18,648.00
Disclosure

SEC source: 0000875320-06-000120 · edgar.xml · nonDerivative · entry 4

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,376

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1.

Read SEC document
December 13, 2006 Filed Dec 15, 2006 16:31 UTC Amendment
ALAM JOHN JEVP, Medicines Dev. & CMO
SaleCommon Stock 1,500 $38.54 $57,810.00
Disclosure

SEC source: 0000875320-06-000120 · edgar.xml · nonDerivative · entry 3

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,856

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1.

Read SEC document
December 13, 2006 Filed Dec 15, 2006 16:31 UTC Amendment
ALAM JOHN JEVP, Medicines Dev. & CMO
Exercise / conversionCommon Stock 500 $9.07 $4,535.00
Disclosure

SEC source: 0000875320-06-000120 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,356

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 13, 2006 Filed Dec 15, 2006 16:31 UTC Amendment
ALAM JOHN JEVP, Medicines Dev. & CMO
Exercise / conversionCommon Stock 1,000 $18.47 $18,470.00
Disclosure

SEC source: 0000875320-06-000120 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,856

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 11, 2006 Filed Dec 12, 2006 15:46 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock · Derivative 250 $0.00 Strike: $9.69 $0.00
Disclosure

SEC source: 0000875320-06-000115 · edgar.xml · derivative · entry 4

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,710

Underlying: Common Stock · 250 shares

Expires 2014-06-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 20 equal quarterly installments from 3/17/2004.

Read SEC document
December 11, 2006 Filed Dec 12, 2006 15:46 UTC
POWER JOHANNA MESSINAVP & Controller
SaleCommon Stock 250 $40.98 $10,245.00
Disclosure

SEC source: 0000875320-06-000115 · edgar.xml · nonDerivative · entry 2

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,297

F1 · kind: Transaction made pursuant to Ms. Messina-Power's company approved trading plan established under Rule 10b5-1.

Read SEC document
December 11, 2006 Filed Dec 12, 2006 15:46 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock 250 $9.69 $2,422.50
Disclosure

SEC source: 0000875320-06-000115 · edgar.xml · nonDerivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,547

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 08, 2006 Filed Dec 11, 2006 16:46 UTC Exercise / conversionStock Option · Derivative 2,000 $0.00 Strike: $13.23 $0.00
Disclosure

SEC source: 0000875320-06-000114 · edgar.xml · derivative · entry 6

SANDERS CHARLES A · CIK 0001022936 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 2,000 shares

Expires 2006-12-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1994 Stock and Option Plan. Fully vested.

Read SEC document
December 08, 2006 Filed Dec 11, 2006 16:46 UTC SaleCommon Stock 2,000 $42.95 $85,900.00
Disclosure

SEC source: 0000875320-06-000114 · edgar.xml · nonDerivative · entry 4

SANDERS CHARLES A · CIK 0001022936 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,000

F1 · kind: Transaction made pursuant to Dr. Sanders' company approved trading plan established under Rule 10b5-1.

Read SEC document
December 08, 2006 Filed Dec 11, 2006 16:46 UTC Exercise / conversionCommon Stock 2,000 $13.23 $26,460.00
Disclosure

SEC source: 0000875320-06-000114 · edgar.xml · nonDerivative · entry 3

SANDERS CHARLES A · CIK 0001022936 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 07, 2006 Filed Dec 11, 2006 16:46 UTC Exercise / conversionStock Option · Derivative 3,000 $0.00 Strike: $13.23 $0.00
Disclosure

SEC source: 0000875320-06-000114 · edgar.xml · derivative · entry 5

SANDERS CHARLES A · CIK 0001022936 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 102,000

Underlying: Common Stock · 3,000 shares

Expires 2006-12-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1994 Stock and Option Plan. Fully vested.

Read SEC document
December 07, 2006 Filed Dec 11, 2006 16:46 UTC SaleCommon Stock 3,000 $43.97 $131,910.00
Disclosure

SEC source: 0000875320-06-000114 · edgar.xml · nonDerivative · entry 2

SANDERS CHARLES A · CIK 0001022936 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,000

F1 · kind: Transaction made pursuant to Dr. Sanders' company approved trading plan established under Rule 10b5-1.

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December 07, 2006 Filed Dec 11, 2006 16:46 UTC Exercise / conversionComon Stock 3,000 $13.23 $39,690.00
Disclosure

SEC source: 0000875320-06-000114 · edgar.xml · nonDerivative · entry 1

SANDERS CHARLES A · CIK 0001022936 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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December 06, 2006 Filed Dec 7, 2006 17:56 UTC
ALAM JOHN JEVP, Medicines Dev. & CMO
Exercise / conversionStock Option · Derivative 500 $0.00 Strike: $9.07 $0.00
Disclosure

SEC source: 0000875320-06-000112 · edgar.xml · derivative · entry 6

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 502,995

Underlying: Common Stock · 500 shares

Expires 2013-12-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years from 12/11/2003.

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December 06, 2006 Filed Dec 7, 2006 17:56 UTC
ALAM JOHN JEVP, Medicines Dev. & CMO
Exercise / conversionStock Option · Derivative 1,000 $0.00 Strike: $18.47 $0.00
Disclosure

SEC source: 0000875320-06-000112 · edgar.xml · derivative · entry 5

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 503,495

Underlying: Common Stock · 1,000 shares

Expires 2007-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 years from 9/26/1997.

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December 06, 2006 Filed Dec 7, 2006 17:56 UTC
ALAM JOHN JEVP, Medicines Dev. & CMO
SaleCommon Stock 1,500 $44.69 $67,035.00
Disclosure

SEC source: 0000875320-06-000112 · edgar.xml · nonDerivative · entry 3

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,856

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1.

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December 06, 2006 Filed Dec 7, 2006 17:56 UTC
ALAM JOHN JEVP, Medicines Dev. & CMO
Exercise / conversionCommon Stock 500 $9.07 $4,535.00
Disclosure

SEC source: 0000875320-06-000112 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,356

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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December 06, 2006 Filed Dec 7, 2006 17:56 UTC
ALAM JOHN JEVP, Medicines Dev. & CMO
Exercise / conversionCommon Stock 1,000 $18.47 $18,470.00
Disclosure

SEC source: 0000875320-06-000112 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,856

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.