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Nasdaq · USD

VRTX

VERTEX PHARMACEUTICALS INC / MA

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Tapewire entity
2875
SEC CIK
0000875320
Parsed reports
2,554

Last 12 months

Inside the activity.

0 purchase rows · 93 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202506
Dec 2025016
Jan 202602
Feb 2026049
Mar 202605
Apr 202601
May 202606
Jun 202605
Jul 202603
Aug 202600
Sep 202600
Oct 202600

Latest available

Insider transactions

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
January 24, 2007 Filed Jan 26, 2007 20:32 UTC
BOGER JOSHUA SDirector · Chairman, President & CEO
GrantStock Option · Derivative 177,000 $0.00 Strike: $36.30 $0.00
Disclosure

SEC source: 0000875320-07-000012 · edgar.xml · derivative · entry 4

BOGER JOSHUA S · CIK 0001197023 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 177,000

Underlying: Common Stock · 177,000 shares

Expires 2017-01-23

F3 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan, vesting in 16 quarterly installments from 01/24/2007.

Read SEC document
January 24, 2007 Filed Jan 26, 2007 20:32 UTC
BOGER JOSHUA SDirector · Chairman, President & CEO
GrantCommon Stock 39,334 $0.01 $393.34
Disclosure

SEC source: 0000875320-07-000012 · edgar.xml · nonDerivative · entry 1

BOGER JOSHUA S · CIK 0001197023 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,074,737

F1 · shares: Stock grant made under 2006 Stock and Option Plan, vesting on 1/24/2011, subject to acceleration upon achievement of certain performance-based milestones.

Read SEC document
January 24, 2007 Filed Jan 26, 2007 20:34 UTC
POWER JOHANNA MESSINAVP & Controller
GrantStock Option · Derivative 11,250 $0.00 Strike: $36.30 $0.00
Disclosure

SEC source: 0000875320-07-000013 · edgar.xml · derivative · entry 3

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,250

Underlying: Common Stock · 11,250 shares

Expires 2017-01-23

F2 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from 01/24/2007.

Read SEC document
January 24, 2007 Filed Jan 26, 2007 20:34 UTC
POWER JOHANNA MESSINAVP & Controller
GrantCommon Stock 2,500 $0.01 $25.00
Disclosure

SEC source: 0000875320-07-000013 · edgar.xml · nonDerivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,487

F1 · shares: Stock grant made under 2006 Stock and Option Plan, vesting on 1/24/2011, subject to acceleration upon achievement of certain performance-based milestones.

Read SEC document
January 24, 2007 Filed Jan 26, 2007 20:40 UTC
SMITH IAN FEVP & CFO
GrantStock Options · Derivative 54,375 $0.00 Strike: $36.30 $0.00
Disclosure

SEC source: 0000875320-07-000014 · edgar.xml · derivative · entry 4

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 54,375

Underlying: Common Stock · 54,375 shares

Expires 2017-01-23

F3 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from 01/24/2007.

Read SEC document
January 24, 2007 Filed Jan 26, 2007 20:40 UTC
SMITH IAN FEVP & CFO
GrantCommon Stock 20,000 $0.01 $200.00
Disclosure

SEC source: 0000875320-07-000014 · edgar.xml · nonDerivative · entry 2

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 112,614

F2 · shares: Stock grant made under 2006 Stock and Option Plan, vesting as to 5,000 shares on May 6, 2008, and as to 15,000 shares on May 6, 2010.

Read SEC document
January 24, 2007 Filed Jan 26, 2007 20:40 UTC
SMITH IAN FEVP & CFO
GrantCommon Stock 12,084 $0.01 $120.84
Disclosure

SEC source: 0000875320-07-000014 · edgar.xml · nonDerivative · entry 1

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 92,614

F1 · shares: Stock grant made under 2006 Stock and Option Plan, vesting on 1/24/2011, subject to acceleration upon achievement of certain performance-based milestones.

Read SEC document
January 24, 2007 Filed Jan 26, 2007 20:42 UTC
MUELLER PETEREVP Drug Innov.& Realiz, CSO
GrantStock Option · Derivative 54,375 $0.00 Strike: $36.30 $0.00
Disclosure

SEC source: 0000875320-07-000015 · edgar.xml · derivative · entry 4

MUELLER PETER · CIK 0001256126 · EVP Drug Innov.& Realiz, CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 54,375

Underlying: Common Stock · 54,375 shares

Expires 2017-01-23

F3 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from 01/24/2007.

Read SEC document
January 24, 2007 Filed Jan 26, 2007 20:42 UTC
MUELLER PETEREVP Drug Innov.& Realiz, CSO
GrantCommon Stock 20,000 $0.01 $200.00
Disclosure

SEC source: 0000875320-07-000015 · edgar.xml · nonDerivative · entry 2

MUELLER PETER · CIK 0001256126 · EVP Drug Innov.& Realiz, CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 84,831

F2 · shares: Stock grant made under 2006 Stock and Option Plan, vesting as to 5,000 shares on May 6, 2008, and as to 15,000 shares on May 6, 2010.

Read SEC document
January 24, 2007 Filed Jan 26, 2007 20:42 UTC
MUELLER PETEREVP Drug Innov.& Realiz, CSO
GrantCommon Stock 12,084 $0.01 $120.84
Disclosure

SEC source: 0000875320-07-000015 · edgar.xml · nonDerivative · entry 1

MUELLER PETER · CIK 0001256126 · EVP Drug Innov.& Realiz, CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 64,831

F1 · shares: Stock grant made under 2006 Stock and Option Plan, vesting on 1/24/2011, subject to acceleration upon achievement of certain performance-based milestones.

Read SEC document
January 24, 2007 Filed Jan 26, 2007 20:44 UTC
Hartmann Victor AEVP, Strategic & Corp. Devlp.
GrantStock Option · Derivative 54,375 $0.00 Strike: $36.30 $0.00
Disclosure

SEC source: 0000875320-07-000016 · edgar.xml · derivative · entry 4

Hartmann Victor A · CIK 0001317101 · EVP, Strategic & Corp. Devlp.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 54,375

Underlying: Common Stock · 54,375 shares

Expires 2017-01-23

F3 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from 01/24/2007.

Read SEC document
January 24, 2007 Filed Jan 26, 2007 20:44 UTC
Hartmann Victor AEVP, Strategic & Corp. Devlp.
GrantCommon Stock 20,000 $0.01 $200.00
Disclosure

SEC source: 0000875320-07-000016 · edgar.xml · nonDerivative · entry 2

Hartmann Victor A · CIK 0001317101 · EVP, Strategic & Corp. Devlp.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 97,273

F2 · shares: Stock grant made under 2006 Stock and Option Plan, vesting as to 5,000 shares on May 6, 2008, and as to 15,000 shares on May 6, 2010.

Read SEC document
January 24, 2007 Filed Jan 26, 2007 20:44 UTC
Hartmann Victor AEVP, Strategic & Corp. Devlp.
GrantCommon Stock 12,084 $0.01 $120.84
Disclosure

SEC source: 0000875320-07-000016 · edgar.xml · nonDerivative · entry 1

Hartmann Victor A · CIK 0001317101 · EVP, Strategic & Corp. Devlp.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 77,273

F1 · shares: Stock grant made under 2006 Stock and Option Plan, vesting on 1/24/2011, subject to acceleration upon achievement of certain performance-based milestones.

Read SEC document
January 24, 2007 Filed Jan 26, 2007 20:47 UTC
GARRISON RICHARD CSVP and Catalyst
GrantStock Option · Derivative 45,750 $0.00 Strike: $36.30 $0.00
Disclosure

SEC source: 0000875320-07-000017 · edgar.xml · derivative · entry 3

GARRISON RICHARD C · CIK 0001256466 · SVP and Catalyst

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,750

Underlying: Common Stock · 45,750 shares

Expires 2017-01-23

F2 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from 01/24/2007.

Read SEC document
January 24, 2007 Filed Jan 26, 2007 20:47 UTC
GARRISON RICHARD CSVP and Catalyst
GrantCommon Stock 10,166 $0.01 $101.66
Disclosure

SEC source: 0000875320-07-000017 · edgar.xml · nonDerivative · entry 1

GARRISON RICHARD C · CIK 0001256466 · SVP and Catalyst

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,374

F1 · shares: Stock grant made under 2006 Stock and Option Plan, vesting on 1/24/2011, subject to acceleration upon achievement of certain performance-based milestones.

Read SEC document
January 22, 2007 Filed Jan 24, 2007 21:47 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionStock Option · Derivative 125 $0.00 Strike: $10.41 $0.00
Disclosure

SEC source: 0000875320-07-000008 · edgar.xml · derivative · entry 4

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,698

Underlying: Common Stock · 125 shares

Expires 2015-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 16 equal quarterly installments from 2/3/2005.

Read SEC document
January 22, 2007 Filed Jan 24, 2007 21:47 UTC
POWER JOHANNA MESSINAVP & Controller
SaleCommon Stock 125 $36.21 $4,526.25
Disclosure

SEC source: 0000875320-07-000008 · edgar.xml · nonDerivative · entry 2

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,987

F1 · kind: Transaction made pursuant to Ms. Messina-Power's company approved trading plan established under Rule 10b5-1.

Read SEC document
January 22, 2007 Filed Jan 24, 2007 21:47 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock 125 $10.41 $1,301.25
Disclosure

SEC source: 0000875320-07-000008 · edgar.xml · nonDerivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,112

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 17, 2007 Filed Jan 18, 2007 20:16 UTC
ALAM JOHN JEVP, Medicines Dev., & CMO
Exercise / conversionStock Options · Derivative 500 $0.00 Strike: $9.07 $0.00
Disclosure

SEC source: 0000875320-07-000007 · edgar.xml · derivative · entry 7

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev., & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 493,995

Underlying: Common Stock · 500 shares

Expires 2013-12-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years from 12/11/2003.

Read SEC document
January 17, 2007 Filed Jan 18, 2007 20:16 UTC
ALAM JOHN JEVP, Medicines Dev., & CMO
Exercise / conversionStock Options · Derivative 1,000 $0.00 Strike: $18.47 $0.00
Disclosure

SEC source: 0000875320-07-000007 · edgar.xml · derivative · entry 6

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev., & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 494,495

Underlying: Common Stock · 1,000 shares

Expires 2007-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 years from 9/26/1997.

Read SEC document
January 17, 2007 Filed Jan 18, 2007 20:16 UTC
ALAM JOHN JEVP, Medicines Dev., & CMO
SaleCommon Stock 500 $38.29 $19,145.00
Disclosure

SEC source: 0000875320-07-000007 · edgar.xml · nonDerivative · entry 4

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev., & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,376

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1.

Read SEC document
January 17, 2007 Filed Jan 18, 2007 20:16 UTC
ALAM JOHN JEVP, Medicines Dev., & CMO
SaleCommon Stock 1,000 $38.29 $38,290.00
Disclosure

SEC source: 0000875320-07-000007 · edgar.xml · nonDerivative · entry 3

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev., & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,876

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1.

Read SEC document
January 17, 2007 Filed Jan 18, 2007 20:16 UTC
ALAM JOHN JEVP, Medicines Dev., & CMO
Exercise / conversionCommon Stock 500 $9.07 $4,535.00
Disclosure

SEC source: 0000875320-07-000007 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev., & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,876

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 17, 2007 Filed Jan 18, 2007 20:16 UTC
ALAM JOHN JEVP, Medicines Dev., & CMO
Exercise / conversionCommon Stock 1,000 $18.47 $18,470.00
Disclosure

SEC source: 0000875320-07-000007 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev., & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,376

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 16, 2007 Filed Jan 17, 2007 22:04 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionStock Option · Derivative 125 $0.00 Strike: $10.41 $0.00
Disclosure

SEC source: 0000875320-07-000006 · edgar.xml · derivative · entry 4

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,085

Underlying: Common Stock · 125 shares

Expires 2015-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 16 equal quarterly installments from 2/3/2005.

Read SEC document
January 16, 2007 Filed Jan 17, 2007 22:04 UTC
POWER JOHANNA MESSINAVP & Controller
SaleCommon Stock 125 $38.31 $4,788.75
Disclosure

SEC source: 0000875320-07-000006 · edgar.xml · nonDerivative · entry 2

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,987

F1 · kind: Transaction made pursuant to Ms. Messina-Power's company approved trading plan established under Rule 10b5-1.

Read SEC document
January 16, 2007 Filed Jan 17, 2007 22:04 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock 125 $10.41 $1,301.25
Disclosure

SEC source: 0000875320-07-000006 · edgar.xml · nonDerivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,112

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 10, 2007 Filed Jan 11, 2007 20:46 UTC
ALAM JOHN JEVP, Medicines Dev., & CMO
Exercise / conversionStock Options · Derivative 500 $0.00 Strike: $9.07 $0.00
Disclosure

SEC source: 0000875320-07-000005 · edgar.xml · derivative · entry 7

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev., & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 495,495

Underlying: Common Stock · 500 shares

Expires 2013-12-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years from 12/11/2003.

Read SEC document
January 10, 2007 Filed Jan 11, 2007 20:46 UTC
ALAM JOHN JEVP, Medicines Dev., & CMO
Exercise / conversionStock Options · Derivative 1,000 $0.00 Strike: $18.47 $0.00
Disclosure

SEC source: 0000875320-07-000005 · edgar.xml · derivative · entry 6

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev., & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 495,995

Underlying: Common Stock · 1,000 shares

Expires 2007-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 years from 9/26/1997.

Read SEC document
January 10, 2007 Filed Jan 11, 2007 20:46 UTC
ALAM JOHN JEVP, Medicines Dev., & CMO
SaleCommon Stock 500 $35.00 $17,500.00
Disclosure

SEC source: 0000875320-07-000005 · edgar.xml · nonDerivative · entry 4

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev., & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,376

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1.

Read SEC document
January 10, 2007 Filed Jan 11, 2007 20:46 UTC
ALAM JOHN JEVP, Medicines Dev., & CMO
SaleCommon Stock 1,000 $35.00 $35,000.00
Disclosure

SEC source: 0000875320-07-000005 · edgar.xml · nonDerivative · entry 3

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev., & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,876

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1.

Read SEC document
January 10, 2007 Filed Jan 11, 2007 20:46 UTC
ALAM JOHN JEVP, Medicines Dev., & CMO
Exercise / conversionCommon Stock 500 $9.07 $4,535.00
Disclosure

SEC source: 0000875320-07-000005 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev., & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,876

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 10, 2007 Filed Jan 11, 2007 20:46 UTC
ALAM JOHN JEVP, Medicines Dev., & CMO
Exercise / conversionCommon Stock 1,000 $18.47 $18,470.00
Disclosure

SEC source: 0000875320-07-000005 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev., & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,376

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 08, 2007 Filed Jan 9, 2007 19:05 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionStock Option · Derivative 7 $0.00 Strike: $10.41 $0.00
Disclosure

SEC source: 0000875320-07-000004 · edgar.xml · derivative · entry 6

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,210

Underlying: Common Stock · 7 shares

Expires 2015-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 16 equal quarterly installments from 2/3/2005.

Read SEC document
January 08, 2007 Filed Jan 9, 2007 19:05 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionStock Option · Derivative 118 $0.00 Strike: $9.69 $0.00
Disclosure

SEC source: 0000875320-07-000004 · edgar.xml · derivative · entry 5

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,217

Underlying: Common Stock · 118 shares

Expires 2014-03-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 16 equal quarterly installments from 3/17/2004.

Read SEC document
January 08, 2007 Filed Jan 9, 2007 19:05 UTC
POWER JOHANNA MESSINAVP & Controller
SaleCommon Stock 125 $35.28 $4,410.00
Disclosure

SEC source: 0000875320-07-000004 · edgar.xml · nonDerivative · entry 3

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,987

F1 · kind: Transaction made pursuant to Ms. Messina-Power's company approved trading plan established under Rule 10b5-1.

Read SEC document
January 08, 2007 Filed Jan 9, 2007 19:05 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock 7 $10.41 $72.87
Disclosure

SEC source: 0000875320-07-000004 · edgar.xml · nonDerivative · entry 2

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,112

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 08, 2007 Filed Jan 9, 2007 19:05 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock 118 $9.69 $1,143.42
Disclosure

SEC source: 0000875320-07-000004 · edgar.xml · nonDerivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,105

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 03, 2007 Filed Jan 4, 2007 21:21 UTC
Hartmann Victor AEVP, Strategic & Corp. Devlp.
Exercise / conversionStock Option · Derivative 3,000 $0.00 Strike: $11.40 $0.00
Disclosure

SEC source: 0000875320-07-000001 · edgar.xml · derivative · entry 4

Hartmann Victor A · CIK 0001317101 · EVP, Strategic & Corp. Devlp.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 257,000

Underlying: Common Stock · 3,000 shares

Expires 2015-02-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 16 equal quarterly installments from 2/15/2005.

Read SEC document
January 03, 2007 Filed Jan 4, 2007 21:21 UTC
Hartmann Victor AEVP, Strategic & Corp. Devlp.
SaleCommon Stock 3,000 $37.61 $112,830.00
Disclosure

SEC source: 0000875320-07-000001 · edgar.xml · nonDerivative · entry 2

Hartmann Victor A · CIK 0001317101 · EVP, Strategic & Corp. Devlp.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,189

F1 · kind: Transaction made pursuant to Dr. Hartmann's company approved trading plan established under Rule 10b5-1.

Read SEC document
January 03, 2007 Filed Jan 4, 2007 21:21 UTC
Hartmann Victor AEVP, Strategic & Corp. Devlp.
Exercise / conversionCommon Stock 3,000 $11.40 $34,200.00
Disclosure

SEC source: 0000875320-07-000001 · edgar.xml · nonDerivative · entry 1

Hartmann Victor A · CIK 0001317101 · EVP, Strategic & Corp. Devlp.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 68,189

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 03, 2007 Filed Jan 4, 2007 21:24 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock · Derivative 125 $0.00 Strike: $9.69 $0.00
Disclosure

SEC source: 0000875320-07-000002 · edgar.xml · derivative · entry 4

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,335

Underlying: Common Stock · 125 shares

Expires 2014-03-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 20 equal quarterly installments from 3/17/2004.

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January 03, 2007 Filed Jan 4, 2007 21:24 UTC
POWER JOHANNA MESSINAVP & Controller
SaleCommon Stock 425 $37.60 $15,980.00
Disclosure

SEC source: 0000875320-07-000002 · edgar.xml · nonDerivative · entry 2

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,987

F1 · kind: Transaction made pursuant to Ms. Messina-Power's company approved trading plan established under Rule 10b5-1.

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January 03, 2007 Filed Jan 4, 2007 21:24 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock 125 $9.69 $1,211.25
Disclosure

SEC source: 0000875320-07-000002 · edgar.xml · nonDerivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,412

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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January 03, 2007 Filed Jan 4, 2007 21:26 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
Exercise / conversionStock Options · Derivative 500 $0.00 Strike: $9.07 $0.00
Disclosure

SEC source: 0000875320-07-000003 · edgar.xml · derivative · entry 7

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 496,995

Underlying: Common Stock · 500 shares

Expires 2013-12-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years from 12/11/2003.

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January 03, 2007 Filed Jan 4, 2007 21:26 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
Exercise / conversionStock Options · Derivative 1,000 $0.00 Strike: $18.47 $0.00
Disclosure

SEC source: 0000875320-07-000003 · edgar.xml · derivative · entry 6

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 497,495

Underlying: Common Stock · 1,000 shares

Expires 2007-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 5 years from 9/26/1997.

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January 03, 2007 Filed Jan 4, 2007 21:26 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
SaleCommon Stock 500 $37.61 $18,805.00
Disclosure

SEC source: 0000875320-07-000003 · edgar.xml · nonDerivative · entry 4

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,376

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1.

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January 03, 2007 Filed Jan 4, 2007 21:26 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
SaleCommon Stock 1,000 $37.12 $37,120.00
Disclosure

SEC source: 0000875320-07-000003 · edgar.xml · nonDerivative · entry 3

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,876

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1.

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January 03, 2007 Filed Jan 4, 2007 21:26 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
Exercise / conversionCommon Stock 500 $9.07 $4,535.00
Disclosure

SEC source: 0000875320-07-000003 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,876

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 03, 2007 Filed Jan 4, 2007 21:26 UTC
ALAM JOHN JSVP, Drug Eval. & Appr.
Exercise / conversionCommon Stock 1,000 $18.47 $18,470.00
Disclosure

SEC source: 0000875320-07-000003 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · SVP, Drug Eval. & Appr.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,376

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.