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Nasdaq · USD

VRTX

VERTEX PHARMACEUTICALS INC / MA

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Tapewire entity
2875
SEC CIK
0000875320
Parsed reports
2,554

Last 12 months

Inside the activity.

0 purchase rows · 93 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202506
Dec 2025016
Jan 202602
Feb 2026049
Mar 202605
Apr 202601
May 202606
Jun 202605
Jul 202603
Aug 202600
Sep 202600
Oct 202600

Latest available

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
February 26, 2007 Filed Feb 27, 2007 19:23 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionStock Option · Derivative 125 $0.00 Strike: $11.18 $0.00
Disclosure

SEC source: 0000875320-07-000026 · edgar.xml · derivative · entry 4

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 951

Underlying: Common Stock · 125 shares

Expires 2009-06-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

Read SEC document
February 26, 2007 Filed Feb 27, 2007 19:23 UTC
POWER JOHANNA MESSINAVP & Controller
SaleCommon Stock 125 $31.63 $3,953.75
Disclosure

SEC source: 0000875320-07-000026 · edgar.xml · nonDerivative · entry 2

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,187

F1 · kind: Transaction made pursuant to Ms. Messina-Power's company approved trading plan established under Rule 10b5-1.

Read SEC document
February 26, 2007 Filed Feb 27, 2007 19:23 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock 125 $11.18 $1,397.50
Disclosure

SEC source: 0000875320-07-000026 · edgar.xml · nonDerivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,312

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 20, 2007 Filed Feb 22, 2007 16:35 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionStock Option · Derivative 24 $0.00 Strike: $11.18 $0.00
Disclosure

SEC source: 0000875320-07-000025 · edgar.xml · derivative · entry 6

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,076

Underlying: Common Stock · 24 shares

Expires 2009-06-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Fully vested.

Read SEC document
February 20, 2007 Filed Feb 22, 2007 16:35 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionStock Option · Derivative 101 $0.00 Strike: $10.41 $0.00
Disclosure

SEC source: 0000875320-07-000025 · edgar.xml · derivative · entry 5

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,222

Underlying: Common Stock · 101 shares

Expires 2015-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 16 equal quarterly installments from 2/3/2005.

Read SEC document
February 20, 2007 Filed Feb 22, 2007 16:35 UTC
POWER JOHANNA MESSINAVP & Controller
SaleCommon Stock 125 $31.02 $3,877.50
Disclosure

SEC source: 0000875320-07-000025 · edgar.xml · nonDerivative · entry 3

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,187

F1 · kind: Transaction made pursuant to Ms. Messina-Power's company approved trading plan established under Rule 10b5-1.

Read SEC document
February 20, 2007 Filed Feb 22, 2007 16:35 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock 24 $11.18 $268.32
Disclosure

SEC source: 0000875320-07-000025 · edgar.xml · nonDerivative · entry 2

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,312

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 20, 2007 Filed Feb 22, 2007 16:35 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock 101 $10.41 $1,051.41
Disclosure

SEC source: 0000875320-07-000025 · edgar.xml · nonDerivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,288

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 12, 2007 Filed Feb 13, 2007 17:55 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionStock Option · Derivative 125 $0.00 Strike: $10.41 $0.00
Disclosure

SEC source: 0000875320-07-000024 · edgar.xml · derivative · entry 4

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,323

Underlying: Common Stock · 125 shares

Expires 2015-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 16 equal quarterly installments from 2/3/2005.

Read SEC document
February 12, 2007 Filed Feb 13, 2007 17:55 UTC
POWER JOHANNA MESSINAVP & Controller
SaleCommon Stock 125 $31.93 $3,991.25
Disclosure

SEC source: 0000875320-07-000024 · edgar.xml · nonDerivative · entry 2

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,187

F1 · kind: Transaction made pursuant to Ms. Messina-Power's company approved trading plan established under Rule 10b5-1.

Read SEC document
February 12, 2007 Filed Feb 13, 2007 17:55 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock 125 $10.41 $1,301.25
Disclosure

SEC source: 0000875320-07-000024 · edgar.xml · nonDerivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,312

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 07, 2007 Filed Feb 8, 2007 18:46 UTC Exercise / conversionStock Option · Derivative 2,500 $0.00 Strike: $11.62 $0.00
Disclosure

SEC source: 0000875320-07-000023 · edgar.xml · derivative · entry 11

ULLIAN ELAINE · CIK 0001190290 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,500 shares

Expires 2007-12-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Fully vested.

Read SEC document
February 07, 2007 Filed Feb 8, 2007 18:46 UTC Exercise / conversionStock Option · Derivative 10,000 $0.00 Strike: $13.32 $0.00
Disclosure

SEC source: 0000875320-07-000023 · edgar.xml · derivative · entry 10

ULLIAN ELAINE · CIK 0001190290 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,000 shares

Expires 2015-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Fully vested.

Read SEC document
February 07, 2007 Filed Feb 8, 2007 18:46 UTC Exercise / conversionStock Option · Derivative 7,500 $0.00 Strike: $14.46 $0.00
Disclosure

SEC source: 0000875320-07-000023 · edgar.xml · derivative · entry 9

ULLIAN ELAINE · CIK 0001190290 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 7,500 shares

Expires 2013-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Fully vested.

Read SEC document
February 07, 2007 Filed Feb 8, 2007 18:46 UTC Exercise / conversionStock Option · Derivative 7,500 $0.00 Strike: $19.84 $0.00
Disclosure

SEC source: 0000875320-07-000023 · edgar.xml · derivative · entry 8

ULLIAN ELAINE · CIK 0001190290 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 7,500 shares

Expires 2012-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Fully vested.

Read SEC document
February 07, 2007 Filed Feb 8, 2007 18:46 UTC Exercise / conversionStock Option · Derivative 10,000 $0.00 Strike: $14.20 $0.00
Disclosure

SEC source: 0000875320-07-000023 · edgar.xml · derivative · entry 7

ULLIAN ELAINE · CIK 0001190290 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,000 shares

Expires 2008-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Fully vested.

Read SEC document
February 07, 2007 Filed Feb 8, 2007 18:46 UTC SaleCommon Stock 37,500 $32.89 $1,233,375.00
Disclosure

SEC source: 0000875320-07-000023 · edgar.xml · nonDerivative · entry 6

ULLIAN ELAINE · CIK 0001190290 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Read SEC document
February 07, 2007 Filed Feb 8, 2007 18:46 UTC Exercise / conversionCommon Stock 2,500 $11.62 $29,050.00
Disclosure

SEC source: 0000875320-07-000023 · edgar.xml · nonDerivative · entry 5

ULLIAN ELAINE · CIK 0001190290 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 07, 2007 Filed Feb 8, 2007 18:46 UTC Exercise / conversionCommon Stock 10,000 $13.32 $133,200.00
Disclosure

SEC source: 0000875320-07-000023 · edgar.xml · nonDerivative · entry 4

ULLIAN ELAINE · CIK 0001190290 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 07, 2007 Filed Feb 8, 2007 18:46 UTC Exercise / conversionCommon Stock 7,500 $14.46 $108,450.00
Disclosure

SEC source: 0000875320-07-000023 · edgar.xml · nonDerivative · entry 3

ULLIAN ELAINE · CIK 0001190290 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 07, 2007 Filed Feb 8, 2007 18:46 UTC Exercise / conversionCommon Stock 7,500 $19.84 $148,800.00
Disclosure

SEC source: 0000875320-07-000023 · edgar.xml · nonDerivative · entry 2

ULLIAN ELAINE · CIK 0001190290 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 07, 2007 Filed Feb 8, 2007 18:46 UTC Exercise / conversionCommon Stock 10,000 $14.20 $142,000.00
Disclosure

SEC source: 0000875320-07-000023 · edgar.xml · nonDerivative · entry 1

ULLIAN ELAINE · CIK 0001190290 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 05, 2007 Filed Feb 6, 2007 20:33 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionStock Option · Derivative 125 $0.00 Strike: $10.41 $0.00
Disclosure

SEC source: 0000875320-07-000022 · edgar.xml · derivative · entry 4

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,448

Underlying: Common Stock · 125 shares

Expires 2015-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 16 equal quarterly installments from 2/3/2005.

Read SEC document
February 05, 2007 Filed Feb 6, 2007 20:33 UTC
POWER JOHANNA MESSINAVP & Controller
SaleCommon Stock 125 $32.64 $4,080.00
Disclosure

SEC source: 0000875320-07-000022 · edgar.xml · nonDerivative · entry 2

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,187

F1 · kind: Transaction made pursuant to Ms. Messina-Power's company approved trading plan established under Rule 10b5-1.

Read SEC document
February 05, 2007 Filed Feb 6, 2007 20:33 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock 125 $10.41 $1,301.25
Disclosure

SEC source: 0000875320-07-000022 · edgar.xml · nonDerivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,312

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 05, 2007 Filed Feb 6, 2007 20:30 UTC
Hartmann Victor AEVP, Strategic & Corp. Devlp.
Exercise / conversionStock Option · Derivative 3,000 $0.00 Strike: $11.40 $0.00
Disclosure

SEC source: 0000875320-07-000021 · edgar.xml · derivative · entry 4

Hartmann Victor A · CIK 0001317101 · EVP, Strategic & Corp. Devlp.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 109,000

Underlying: Common Stock · 3,000 shares

Expires 2015-02-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 16 equal quarterly installments from 2/15/2005.

Read SEC document
February 05, 2007 Filed Feb 6, 2007 20:30 UTC
Hartmann Victor AEVP, Strategic & Corp. Devlp.
SaleCommon Stock 3,000 $32.76 $98,280.00
Disclosure

SEC source: 0000875320-07-000021 · edgar.xml · nonDerivative · entry 2

Hartmann Victor A · CIK 0001317101 · EVP, Strategic & Corp. Devlp.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 97,273

F1 · kind: Transaction made pursuant to Dr. Hartmann's company approved trading plan established under Rule 10b5-1.

Read SEC document
February 05, 2007 Filed Feb 6, 2007 20:30 UTC
Hartmann Victor AEVP, Strategic & Corp. Devlp.
Exercise / conversionCommon Stock 3,000 $11.40 $34,200.00
Disclosure

SEC source: 0000875320-07-000021 · edgar.xml · nonDerivative · entry 1

Hartmann Victor A · CIK 0001317101 · EVP, Strategic & Corp. Devlp.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,273

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 01, 2007 Filed Feb 2, 2007 17:50 UTC
POWER JOHANNA MESSINAVP & Controller
SaleCommon Stock 300 $34.85 $10,455.00
Disclosure

SEC source: 0000875320-07-000020 · edgar.xml · nonDerivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,187

Read SEC document
January 31, 2007 Filed Feb 1, 2007 17:42 UTC
ALAM JOHN JEVP, Medicines Dev., & CMO
Exercise / conversionStock Options · Derivative 500 $0.00 Strike: $9.07 $0.00
Disclosure

SEC source: 0000875320-07-000019 · edgar.xml · derivative · entry 7

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev., & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,400

Underlying: Common Stock · 500 shares

Expires 2013-12-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years from 12/11/2003.

Read SEC document
January 31, 2007 Filed Feb 1, 2007 17:42 UTC
ALAM JOHN JEVP, Medicines Dev., & CMO
Exercise / conversionStock Options · Derivative 1,000 $0.00 Strike: $18.47 $0.00
Disclosure

SEC source: 0000875320-07-000019 · edgar.xml · derivative · entry 6

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev., & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,966

Underlying: Common Stock · 1,000 shares

Expires 2007-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully exercisable.

Read SEC document
January 31, 2007 Filed Feb 1, 2007 17:42 UTC
ALAM JOHN JEVP, Medicines Dev., & CMO
SaleCommon Stock 500 $35.46 $17,730.00
Disclosure

SEC source: 0000875320-07-000019 · edgar.xml · nonDerivative · entry 4

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev., & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 135,460

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1.

Read SEC document
January 31, 2007 Filed Feb 1, 2007 17:42 UTC
ALAM JOHN JEVP, Medicines Dev., & CMO
SaleCommon Stock 1,000 $35.46 $35,460.00
Disclosure

SEC source: 0000875320-07-000019 · edgar.xml · nonDerivative · entry 3

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev., & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 135,960

F1 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1.

Read SEC document
January 31, 2007 Filed Feb 1, 2007 17:42 UTC
ALAM JOHN JEVP, Medicines Dev., & CMO
Exercise / conversionCommon Stock 500 $9.07 $4,535.00
Disclosure

SEC source: 0000875320-07-000019 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev., & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 136,960

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 31, 2007 Filed Feb 1, 2007 17:42 UTC
ALAM JOHN JEVP, Medicines Dev., & CMO
Exercise / conversionCommon Stock 1,000 $18.47 $18,470.00
Disclosure

SEC source: 0000875320-07-000019 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · EVP, Medicines Dev., & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 136,460

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 29, 2007 Filed Jan 30, 2007 17:47 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionStock Option · Derivative 125 $0.00 Strike: $10.41 $0.00
Disclosure

SEC source: 0000875320-07-000018 · edgar.xml · derivative · entry 4

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,573

Underlying: Common Stock · 125 shares

Expires 2015-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting in 16 equal quarterly installments from 2/3/2005.

Read SEC document
January 29, 2007 Filed Jan 30, 2007 17:47 UTC
POWER JOHANNA MESSINAVP & Controller
SaleCommon Stock 125 $35.20 $4,400.00
Disclosure

SEC source: 0000875320-07-000018 · edgar.xml · nonDerivative · entry 2

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,487

F1 · kind: Transaction made pursuant to Ms. Messina-Power's company approved trading plan established under Rule 10b5-1.

Read SEC document
January 29, 2007 Filed Jan 30, 2007 17:47 UTC
POWER JOHANNA MESSINAVP & Controller
Exercise / conversionCommon Stock 125 $10.41 $1,301.25
Disclosure

SEC source: 0000875320-07-000018 · edgar.xml · nonDerivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,612

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 24, 2007 Filed Jan 26, 2007 15:55 UTC GrantCommon Stock 383 $0.01 $3.83
Disclosure

SEC source: 0000875320-07-000009 · edgar.xml · nonDerivative · entry 1

SANDERS CHARLES A · CIK 0001022936 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,383

Read SEC document
January 24, 2007 Filed Jan 26, 2007 20:26 UTC
ALAM JOHN JEVP, Med. Product Dev. & CMO
Exercise / conversionStock Option · Derivative 500 $0.00 Strike: $9.07 $0.00
Disclosure

SEC source: 0000875320-07-000010 · edgar.xml · derivative · entry 10

ALAM JOHN J · CIK 0001197014 · EVP, Med. Product Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,900

Underlying: Common Stock · 500 shares

Expires 2013-12-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years from 12/11/2003.

Read SEC document
January 24, 2007 Filed Jan 26, 2007 20:26 UTC
ALAM JOHN JEVP, Med. Product Dev. & CMO
Exercise / conversionStock Option · Derivative 1,000 $0.00 Strike: $18.47 $0.00
Disclosure

SEC source: 0000875320-07-000010 · edgar.xml · derivative · entry 9

ALAM JOHN J · CIK 0001197014 · EVP, Med. Product Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,966

Underlying: Common Stock · 1,000 shares

Expires 2007-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: Fully exercisable.

Read SEC document
January 24, 2007 Filed Jan 26, 2007 20:26 UTC
ALAM JOHN JEVP, Med. Product Dev. & CMO
GrantStock Option · Derivative 54,375 $0.00 Strike: $36.30 $0.00
Disclosure

SEC source: 0000875320-07-000010 · edgar.xml · derivative · entry 8

ALAM JOHN J · CIK 0001197014 · EVP, Med. Product Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 54,375

Underlying: Common Stock · 54,375 shares

Expires 2017-01-23

F4 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from 01/24/2007.

Read SEC document
January 24, 2007 Filed Jan 26, 2007 20:26 UTC
ALAM JOHN JEVP, Med. Product Dev. & CMO
SaleCommon Stock 500 $36.20 $18,100.00
Disclosure

SEC source: 0000875320-07-000010 · edgar.xml · nonDerivative · entry 6

ALAM JOHN J · CIK 0001197014 · EVP, Med. Product Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 135,460

F3 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1.

Read SEC document
January 24, 2007 Filed Jan 26, 2007 20:26 UTC
ALAM JOHN JEVP, Med. Product Dev. & CMO
SaleCommon Stock 1,000 $36.20 $36,200.00
Disclosure

SEC source: 0000875320-07-000010 · edgar.xml · nonDerivative · entry 5

ALAM JOHN J · CIK 0001197014 · EVP, Med. Product Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 135,960

F3 · kind: Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1.

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January 24, 2007 Filed Jan 26, 2007 20:26 UTC
ALAM JOHN JEVP, Med. Product Dev. & CMO
Exercise / conversionCommon Stock 500 $9.07 $4,535.00
Disclosure

SEC source: 0000875320-07-000010 · edgar.xml · nonDerivative · entry 4

ALAM JOHN J · CIK 0001197014 · EVP, Med. Product Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 136,960

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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January 24, 2007 Filed Jan 26, 2007 20:26 UTC
ALAM JOHN JEVP, Med. Product Dev. & CMO
Exercise / conversionCommon Stock 1,000 $18.47 $18,470.00
Disclosure

SEC source: 0000875320-07-000010 · edgar.xml · nonDerivative · entry 3

ALAM JOHN J · CIK 0001197014 · EVP, Med. Product Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 136,460

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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January 24, 2007 Filed Jan 26, 2007 20:26 UTC
ALAM JOHN JEVP, Med. Product Dev. & CMO
GrantCommon Stock 20,000 $0.01 $200.00
Disclosure

SEC source: 0000875320-07-000010 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · EVP, Med. Product Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 135,460

F2 · shares: Stock grant made under 2006 Stock and Option Plan, vesting as to 5,000 shares on May 6, 2008, and as to 15,000 shares on May 6, 2010.

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January 24, 2007 Filed Jan 26, 2007 20:26 UTC
ALAM JOHN JEVP, Med. Product Dev. & CMO
GrantCommon Stock 12,084 $0.01 $120.84
Disclosure

SEC source: 0000875320-07-000010 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · EVP, Med. Product Dev. & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 115,460

F1 · shares: Stock grant made under 2006 Stock and Option Plan, vesting on 1/24/2011, subject to acceleration upon achievement of certain performance-based milestones.

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January 24, 2007 Filed Jan 26, 2007 20:29 UTC
BOGER KENNETH SSVP & General Counsel
GrantStock Option · Derivative 45,750 $0.00 Strike: $36.30 $0.00
Disclosure

SEC source: 0000875320-07-000011 · edgar.xml · derivative · entry 4

BOGER KENNETH S · CIK 0001046336 · SVP & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,750

Underlying: Common Stock · 45,750 shares

Expires 2017-01-23

F2 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from 01/24/2007.

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January 24, 2007 Filed Jan 26, 2007 20:29 UTC
BOGER KENNETH SSVP & General Counsel
GrantCommon Stock 10,166 $0.01 $101.66
Disclosure

SEC source: 0000875320-07-000011 · edgar.xml · nonDerivative · entry 1

BOGER KENNETH S · CIK 0001046336 · SVP & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 116,361

F1 · shares: Stock grant made under 2006 Stock and Option Plan, vesting on 1/24/2011, subject to acceleration upon achievement of certain performance-based milestones.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.