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Nasdaq · USD

VRTX

VERTEX PHARMACEUTICALS INC / MA

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Tapewire entity
2875
SEC CIK
0000875320
Parsed reports
2,554

Last 12 months

Inside the activity.

0 purchase rows · 93 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202506
Dec 2025016
Jan 202602
Feb 2026049
Mar 202605
Apr 202601
May 202606
Jun 202605
Jul 202603
Aug 202600
Sep 202600
Oct 202600

Latest available

Insider transactions

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
July 30, 2008 Filed Jul 31, 2008 19:16 UTC
BOGER JOSHUA SDirector · President & CEO
SaleCommon Stock 2,584 $32.38 $83,669.92
Disclosure

SEC source: 0000875320-08-000062 · edgar.xml · nonDerivative · entry 2

BOGER JOSHUA S · CIK 0001197023 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 84,594

F1 · kind: Transaction for sales of common stock made pursuant to Dr. Boger's company approved trading plan established under Rule 10b5-1.

F2 · price: Open market sales reported on this line occurred at a weighted average price of $32.38 (range $31.58 to $32.57).

F4 · price: Dr. Boger undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

Read SEC document
July 30, 2008 Filed Jul 31, 2008 19:16 UTC
BOGER JOSHUA SDirector · President & CEO
Exercise / conversionCommon Stock 12,400 $10.19 $126,356.00
Disclosure

SEC source: 0000875320-08-000062 · edgar.xml · nonDerivative · entry 1

BOGER JOSHUA S · CIK 0001197023 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 87,178

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
July 30, 2008 Filed Aug 7, 2008 16:47 UTC Amendment
BOGER JOSHUA SDirector · President & CEO
SaleCommon Stock 9,816 $32.91 $323,044.56
Disclosure

SEC source: 0000875320-08-000064 · edgar.xml · nonDerivative · entry 3

BOGER JOSHUA S · CIK 0001197023 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,095,044

F1 · kind: Transaction for sales of common stock made pursuant to Dr. Boger's company approved trading plan established under Rule 10b5-1.

F3 · price: Open market sales reported on this line occurred at a weighted average price of $32.91 (range $32.59 to $33.25).

F4 · price: Dr. Boger undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F5 · balance_after: Amount of securities beneficially owned following reported transaction was incorrect in original filing.

Read SEC document
July 30, 2008 Filed Aug 7, 2008 16:47 UTC Amendment
BOGER JOSHUA SDirector · President & CEO
SaleCommon Stock 2,584 $32.38 $83,669.92
Disclosure

SEC source: 0000875320-08-000064 · edgar.xml · nonDerivative · entry 2

BOGER JOSHUA S · CIK 0001197023 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,104,860

F1 · kind: Transaction for sales of common stock made pursuant to Dr. Boger's company approved trading plan established under Rule 10b5-1.

F2 · price: Open market sales reported on this line occurred at a weighted average price of $32.38 (range $31.58 to $32.57).

F4 · price: Dr. Boger undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

F5 · balance_after: Amount of securities beneficially owned following reported transaction was incorrect in original filing.

Read SEC document
July 30, 2008 Filed Aug 7, 2008 16:47 UTC Amendment
BOGER JOSHUA SDirector · President & CEO
Exercise / conversionCommon Stock 12,400 $10.19 $126,356.00
Disclosure

SEC source: 0000875320-08-000064 · edgar.xml · nonDerivative · entry 1

BOGER JOSHUA S · CIK 0001197023 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,107,444

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · balance_after: Amount of securities beneficially owned following reported transaction was incorrect in original filing.

Read SEC document
July 24, 2008 Filed Jul 25, 2008 14:56 UTC
ALAM JOHN JEVP, Med. Dev. Group & CMO
GrantStock Options · Derivative 36,250 $0.00 Strike: $32.16 $0.00
Disclosure

SEC source: 0000875320-08-000052 · edgar.xml · derivative · entry 1

ALAM JOHN J · CIK 0001197014 · EVP, Med. Dev. Group & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,250

Underlying: Common Stock · 36,250 shares

Expires 2018-07-23

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from 07/24/2008.

Read SEC document
July 24, 2008 Filed Jul 25, 2008 14:57 UTC
BOGER KENNETH SSVP & General Counsel
GrantStock Options · Derivative 30,500 $0.00 Strike: $32.16 $0.00
Disclosure

SEC source: 0000875320-08-000053 · edgar.xml · derivative · entry 1

BOGER KENNETH S · CIK 0001046336 · SVP & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,500

Underlying: Common Stock · 30,500 shares

Expires 2018-07-23

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from 07/24/2008.

Read SEC document
July 24, 2008 Filed Jul 25, 2008 15:01 UTC
BOGER JOSHUA SDirector · President & CEO
GrantStock Options · Derivative 118,000 $0.00 Strike: $32.16 $0.00
Disclosure

SEC source: 0000875320-08-000054 · edgar.xml · derivative · entry 1

BOGER JOSHUA S · CIK 0001197023 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 118,000

Underlying: Common Stock · 118,000 shares

Expires 2018-07-23

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from 07/24/2008.

Read SEC document
July 24, 2008 Filed Jul 25, 2008 15:04 UTC
POWER JOHANNA MESSINAVP & Controller
GrantStock Options · Derivative 7,500 $0.00 Strike: $32.16 $0.00
Disclosure

SEC source: 0000875320-08-000055 · edgar.xml · derivative · entry 1

POWER JOHANNA MESSINA · CIK 0001197030 · VP & Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Common Stock · 7,500 shares

Expires 2018-07-23

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from 07/24/2008.

Read SEC document
July 24, 2008 Filed Jul 25, 2008 15:06 UTC
SMITH IAN FEVP & CFO
GrantStock Options · Derivative 36,250 $0.00 Strike: $32.16 $0.00
Disclosure

SEC source: 0000875320-08-000056 · edgar.xml · derivative · entry 1

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,250

Underlying: Common Stock · 36,250 shares

Expires 2018-07-23

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from 07/24/2008.

Read SEC document
July 24, 2008 Filed Jul 25, 2008 15:07 UTC
MUELLER PETEREVP Drug Innov.& Realiz, CSO
GrantStock Options · Derivative 36,250 $0.00 Strike: $32.16 $0.00
Disclosure

SEC source: 0000875320-08-000057 · edgar.xml · derivative · entry 1

MUELLER PETER · CIK 0001256126 · EVP Drug Innov.& Realiz, CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,250

Underlying: Common Stock · 36,250 shares

Expires 2018-07-23

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from 07/24/2008.

Read SEC document
July 24, 2008 Filed Jul 25, 2008 15:11 UTC
GARRISON RICHARD CSVP and Catalyst
GrantStock Options · Derivative 30,500 $0.00 Strike: $32.16 $0.00
Disclosure

SEC source: 0000875320-08-000058 · edgar.xml · derivative · entry 1

GARRISON RICHARD C · CIK 0001256466 · SVP and Catalyst

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,500

Underlying: Common Stock · 30,500 shares

Expires 2018-07-23

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from 07/24/2008.

Read SEC document
July 24, 2008 Filed Jul 25, 2008 15:12 UTC
Kelly LisaSVP, Human Resources
GrantStock Options · Derivative 30,500 $0.00 Strike: $32.16 $0.00
Disclosure

SEC source: 0000875320-08-000059 · edgar.xml · derivative · entry 1

Kelly Lisa · CIK 0001349077 · SVP, Human Resources

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,500

Underlying: Common Stock · 30,500 shares

Expires 2018-07-23

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from 07/24/2008.

Read SEC document
July 24, 2008 Filed Jul 25, 2008 15:14 UTC
Graves KurtEVP, Chief Commercial Officer
GrantStock Options · Derivative 36,250 $0.00 Strike: $32.16 $0.00
Disclosure

SEC source: 0000875320-08-000060 · edgar.xml · derivative · entry 1

Graves Kurt · CIK 0001406337 · EVP, Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,250

Underlying: Common Stock · 36,250 shares

Expires 2018-07-23

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from 07/24/2008.

Read SEC document
July 24, 2008 Filed Jul 25, 2008 15:15 UTC
Sachdev AmitSVP, Public Policy,Gov Affairs
GrantStock Options · Derivative 30,500 $0.00 Strike: $32.16 $0.00
Disclosure

SEC source: 0000875320-08-000061 · edgar.xml · derivative · entry 1

Sachdev Amit · CIK 0001406338 · SVP, Public Policy,Gov Affairs

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,500

Underlying: Common Stock · 30,500 shares

Expires 2018-07-23

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from 07/24/2008.

Read SEC document
July 21, 2008 Filed Jul 23, 2008 16:10 UTC
Graves KurtEVP, Chief Commercial Officer
SaleCommon Stock 2,325 $32.71 $76,050.75
Disclosure

SEC source: 0000875320-08-000051 · edgar.xml · nonDerivative · entry 2

Graves Kurt · CIK 0001406337 · EVP, Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,649

F1 · kind: Transaction made pursuant to Mr. Graves' company approved trading plan under Rule 10b5-1.

F2 · price: Open market sales reported on this line occurred at a weighted average price of $32.71 (range $32.54 to $32.94).

F3 · price: Mr. Graves undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

Read SEC document
July 21, 2008 Filed Jul 23, 2008 16:10 UTC
Graves KurtEVP, Chief Commercial Officer
SaleCommon Stock 600 $31.89 $19,134.00
Disclosure

SEC source: 0000875320-08-000051 · edgar.xml · nonDerivative · entry 1

Graves Kurt · CIK 0001406337 · EVP, Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 58,974

F1 · kind: Transaction made pursuant to Mr. Graves' company approved trading plan under Rule 10b5-1.

Read SEC document
July 15, 2008 Filed Jul 17, 2008 16:37 UTC
MUELLER PETEREVP Drug Innov.& Realiz, CSO
Exercise / conversionStock Option · Derivative 2,400 $0.00 Strike: $9.07 $0.00
Disclosure

SEC source: 0000875320-08-000050 · edgar.xml · derivative · entry 5

MUELLER PETER · CIK 0001256126 · EVP Drug Innov.& Realiz, CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,000

Underlying: Common Stock · 2,400 shares

Expires 2013-12-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: Fully vested.

Read SEC document
July 15, 2008 Filed Jul 17, 2008 16:37 UTC
MUELLER PETEREVP Drug Innov.& Realiz, CSO
SaleCommon Stock 1,200 $32.21 $38,652.00
Disclosure

SEC source: 0000875320-08-000050 · edgar.xml · nonDerivative · entry 3

MUELLER PETER · CIK 0001256126 · EVP Drug Innov.& Realiz, CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,390

F1 · kind: Transaction made pursuant to Dr. Mueller's company approved trading plan under Rule 10b5-1.

F3 · price: Open market sales reported on this line occurred at a weighted average price of $32.21 (range $32.08 to $32.33).

F4 · price: Dr. Mueller undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

Read SEC document
July 15, 2008 Filed Jul 17, 2008 16:37 UTC
MUELLER PETEREVP Drug Innov.& Realiz, CSO
SaleCommon Stock 1,200 $32.59 $39,108.00
Disclosure

SEC source: 0000875320-08-000050 · edgar.xml · nonDerivative · entry 2

MUELLER PETER · CIK 0001256126 · EVP Drug Innov.& Realiz, CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 87,590

F1 · kind: Transaction made pursuant to Dr. Mueller's company approved trading plan under Rule 10b5-1.

F2 · price: Open market sales reported on this line occurred at a weighted average price of $32.59 (range $32.38 to $33.10).

F4 · price: Dr. Mueller undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.

Read SEC document
July 15, 2008 Filed Jul 17, 2008 16:37 UTC
MUELLER PETEREVP Drug Innov.& Realiz, CSO
Exercise / conversionCommon Stock 2,400 $9.07 $21,768.00
Disclosure

SEC source: 0000875320-08-000050 · edgar.xml · nonDerivative · entry 1

MUELLER PETER · CIK 0001256126 · EVP Drug Innov.& Realiz, CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 88,790

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
July 09, 2008 Filed Jul 11, 2008 13:56 UTC
SMITH IAN FEVP & CFO
Exercise / conversionStock Option · Derivative 10,125 $0.00 Strike: $17.16 $0.00
Disclosure

SEC source: 0000875320-08-000049 · edgar.xml · derivative · entry 18

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,875

Underlying: Common Stock · 10,125 shares

Expires 2015-07-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years.

Read SEC document
July 09, 2008 Filed Jul 11, 2008 13:56 UTC
SMITH IAN FEVP & CFO
Exercise / conversionStock Option · Derivative 2,700 $0.00 Strike: $10.41 $0.00
Disclosure

SEC source: 0000875320-08-000049 · edgar.xml · derivative · entry 17

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,050

Underlying: Common Stock · 2,700 shares

Expires 2015-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years.

Read SEC document
July 09, 2008 Filed Jul 11, 2008 13:56 UTC
SMITH IAN FEVP & CFO
Exercise / conversionStock Option · Derivative 21,600 $0.00 Strike: $9.69 $0.00
Disclosure

SEC source: 0000875320-08-000049 · edgar.xml · derivative · entry 16

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 21,600 shares

Expires 2014-03-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

Read SEC document
July 09, 2008 Filed Jul 11, 2008 13:56 UTC
SMITH IAN FEVP & CFO
Exercise / conversionStock Option · Derivative 14,400 $0.00 Strike: $9.07 $0.00
Disclosure

SEC source: 0000875320-08-000049 · edgar.xml · derivative · entry 15

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 14,400 shares

Expires 2013-12-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

Read SEC document
July 09, 2008 Filed Jul 11, 2008 13:56 UTC
SMITH IAN FEVP & CFO
Exercise / conversionStock Option · Derivative 3,715 $0.00 Strike: $15.60 $0.00
Disclosure

SEC source: 0000875320-08-000049 · edgar.xml · derivative · entry 14

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,715 shares

Expires 2013-01-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

Read SEC document
July 09, 2008 Filed Jul 11, 2008 13:56 UTC
SMITH IAN FEVP & CFO
Exercise / conversionStock Option · Derivative 4,821 $0.00 Strike: $15.87 $0.00
Disclosure

SEC source: 0000875320-08-000049 · edgar.xml · derivative · entry 13

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 4,821 shares

Expires 2012-07-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

Read SEC document
July 09, 2008 Filed Jul 11, 2008 13:56 UTC
SMITH IAN FEVP & CFO
Exercise / conversionStock Option · Derivative 5,000 $0.00 Strike: $24.66 $0.00
Disclosure

SEC source: 0000875320-08-000049 · edgar.xml · derivative · entry 12

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 5,000 shares

Expires 2011-12-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

Read SEC document
July 09, 2008 Filed Jul 11, 2008 13:56 UTC
SMITH IAN FEVP & CFO
Exercise / conversionStock Option · Derivative 19,075 $0.00 Strike: $26.20 $0.00
Disclosure

SEC source: 0000875320-08-000049 · edgar.xml · derivative · entry 11

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 19,075 shares

Expires 2011-10-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Fully vested.

Read SEC document
July 09, 2008 Filed Jul 11, 2008 13:56 UTC
SMITH IAN FEVP & CFO
SaleCommon Stock 81,436 $35.00 $2,850,260.00
Disclosure

SEC source: 0000875320-08-000049 · edgar.xml · nonDerivative · entry 9

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 84,301

F1 · kind: Transaction made pursuant to Mr. Smith's company approved trading plan established under Rule 10b5-1.

Read SEC document
July 09, 2008 Filed Jul 11, 2008 13:56 UTC
SMITH IAN FEVP & CFO
Exercise / conversionCommon Stock 10,125 $17.16 $173,745.00
Disclosure

SEC source: 0000875320-08-000049 · edgar.xml · nonDerivative · entry 8

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 165,737

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
July 09, 2008 Filed Jul 11, 2008 13:56 UTC
SMITH IAN FEVP & CFO
Exercise / conversionCommon Stock 2,700 $10.41 $28,107.00
Disclosure

SEC source: 0000875320-08-000049 · edgar.xml · nonDerivative · entry 7

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 155,612

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
July 09, 2008 Filed Jul 11, 2008 13:56 UTC
SMITH IAN FEVP & CFO
Exercise / conversionCommon Stock 21,600 $9.69 $209,304.00
Disclosure

SEC source: 0000875320-08-000049 · edgar.xml · nonDerivative · entry 6

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 152,912

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
July 09, 2008 Filed Jul 11, 2008 13:56 UTC
SMITH IAN FEVP & CFO
Exercise / conversionCommon Stock 14,400 $9.07 $130,608.00
Disclosure

SEC source: 0000875320-08-000049 · edgar.xml · nonDerivative · entry 5

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 131,312

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
July 09, 2008 Filed Jul 11, 2008 13:56 UTC
SMITH IAN FEVP & CFO
Exercise / conversionCommon Stock 3,715 $15.60 $57,954.00
Disclosure

SEC source: 0000875320-08-000049 · edgar.xml · nonDerivative · entry 4

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 116,912

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
July 09, 2008 Filed Jul 11, 2008 13:56 UTC
SMITH IAN FEVP & CFO
Exercise / conversionCommon Stock 4,821 $15.87 $76,509.27
Disclosure

SEC source: 0000875320-08-000049 · edgar.xml · nonDerivative · entry 3

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 113,197

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
July 09, 2008 Filed Jul 11, 2008 13:56 UTC
SMITH IAN FEVP & CFO
Exercise / conversionCommon Stock 5,000 $24.66 $123,300.00
Disclosure

SEC source: 0000875320-08-000049 · edgar.xml · nonDerivative · entry 2

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 108,376

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
July 09, 2008 Filed Jul 11, 2008 13:56 UTC
SMITH IAN FEVP & CFO
Exercise / conversionCommon Stock 19,075 $26.20 $499,765.00
Disclosure

SEC source: 0000875320-08-000049 · edgar.xml · nonDerivative · entry 1

SMITH IAN F · CIK 0001197032 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,376

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
July 01, 2008 Filed Jul 2, 2008 15:00 UTC GiftCommon Stock 64,000 $0.00 $0.00
Disclosure

SEC source: 0000875320-08-000048 · edgar.xml · nonDerivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 168,710

F1 · shares: Common stock gifted to a charitable entity.

Read SEC document
June 27, 2008 Filed Jun 30, 2008 18:56 UTC
BOGER JOSHUA SDirector · Chairman, President & CEO
GiftCommon Stock 45,000 $0.00 $0.00
Disclosure

SEC source: 0000875320-08-000047 · edgar.xml · nonDerivative · entry 1

BOGER JOSHUA S · CIK 0001197023 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,095,044

F1 · shares: Common stock gifted to a variety of non-profit entities.

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June 19, 2008 Filed Jun 23, 2008 15:21 UTC
ALAM JOHN JEVP, Med. Dev. Group & CMO
Exercise / conversionStock Option · Derivative 3,459 $0.00 Strike: $15.60 $0.00
Disclosure

SEC source: 0000875320-08-000046 · edgar.xml · derivative · entry 5

ALAM JOHN J · CIK 0001197014 · EVP, Med. Dev. Group & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,459 shares

Expires 2013-01-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years.

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June 19, 2008 Filed Jun 23, 2008 15:21 UTC
ALAM JOHN JEVP, Med. Dev. Group & CMO
Exercise / conversionStock Option · Derivative 4,822 $0.00 Strike: $15.87 $0.00
Disclosure

SEC source: 0000875320-08-000046 · edgar.xml · derivative · entry 4

ALAM JOHN J · CIK 0001197014 · EVP, Med. Dev. Group & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 4,822 shares

Expires 2012-07-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years.

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June 19, 2008 Filed Jun 23, 2008 15:21 UTC
ALAM JOHN JEVP, Med. Dev. Group & CMO
Exercise / conversionCommon Stock 3,459 $15.60 $53,960.40
Disclosure

SEC source: 0000875320-08-000046 · edgar.xml · nonDerivative · entry 2

ALAM JOHN J · CIK 0001197014 · EVP, Med. Dev. Group & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 136,792

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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June 19, 2008 Filed Jun 23, 2008 15:21 UTC
ALAM JOHN JEVP, Med. Dev. Group & CMO
Exercise / conversionCommon Stock 4,822 $15.87 $76,525.14
Disclosure

SEC source: 0000875320-08-000046 · edgar.xml · nonDerivative · entry 1

ALAM JOHN J · CIK 0001197014 · EVP, Med. Dev. Group & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 133,333

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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June 18, 2008 Filed Jun 19, 2008 20:45 UTC
Lewis-Hall Freda CEVP, Medicines Development
GrantStock Option · Derivative 100,000 $0.00 Strike: $33.47 $0.00
Disclosure

SEC source: 0000875320-08-000045 · edgar.xml · derivative · entry 3

Lewis-Hall Freda C · CIK 0001437909 · EVP, Medicines Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2018-06-17

F3 · shares: Right to buy under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments over four years.

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June 18, 2008 Filed Jun 19, 2008 20:45 UTC
Lewis-Hall Freda CEVP, Medicines Development
GrantCommon Stock 10,000 $0.01 $100.00
Disclosure

SEC source: 0000875320-08-000045 · edgar.xml · nonDerivative · entry 2

Lewis-Hall Freda C · CIK 0001437909 · EVP, Medicines Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,000

F2 · shares: Stock grant made under 2006 Stock and Option Plan vesting in eight quarterly installments over two years.

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June 18, 2008 Filed Jun 19, 2008 20:45 UTC
Lewis-Hall Freda CEVP, Medicines Development
GrantCommon Stock 35,000 $0.01 $350.00
Disclosure

SEC source: 0000875320-08-000045 · edgar.xml · nonDerivative · entry 1

Lewis-Hall Freda C · CIK 0001437909 · EVP, Medicines Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,000

F1 · shares: Stock grant made under 2006 Stock and Option Plan vesting in four equal annual installments over four years.

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June 05, 2008 Filed Jun 9, 2008 16:30 UTC
Graves KurtEVP, Chief Commercial Officer
SaleCommon Stock 3,549 $31.05 $110,196.45
Disclosure

SEC source: 0000875320-08-000043 · edgar.xml · nonDerivative · entry 1

Graves Kurt · CIK 0001406337 · EVP, Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 59,574

F1 · kind: Transaction made pursuant to Mr. Grave's company approved trading plan established under Rule 10b5-1.

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June 01, 2008 Filed Jun 2, 2008 20:38 UTC GrantStock Option · Derivative 20,000 $0.00 Strike: $28.40 $0.00
Disclosure

SEC source: 0000875320-08-000035 · edgar.xml · derivative · entry 1

CORDES EUGENE · CIK 0001192609 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2018-05-31

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan. Fully vested.

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June 01, 2008 Filed Jun 2, 2008 20:40 UTC GrantStock Option · Derivative 20,000 $0.00 Strike: $28.40 $0.00
Disclosure

SEC source: 0000875320-08-000036 · edgar.xml · derivative · entry 1

SANDERS CHARLES A · CIK 0001022936 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2018-05-31

F1 · derivative.exercise_date: Right to buy under 2006 Stock and Option Plan. Fully vested.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.