VRTX

SEC source: 0000875320-26-000272 · wk-form4_1789072310.xml · nonDerivative · entry 1

van Grunsven Jasper · CIK 0002154061 · EVP, CP and NPPO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,682

F1 · shares: Restricted stock unit award that vests in installments beginning on 09/08/2027.

SEC source: 0000875320-26-000267 · wk-form4_1788295172.xml · nonDerivative · entry 1

Ambrose Kristen · CIK 0001856587 · SVP & Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,624

F1 · shares: Restricted stock unit award that vests on 03/01/2029.

SEC source: 0000875320-26-000261 · wk-form4_1788207608.xml · nonDerivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,000

SEC source: 0000875320-26-000251 · wk-form4_1784837586.xml · nonDerivative · entry 1

Sachdev Amit · CIK 0001406338 · EVP Chief Patient & Ext Af Off

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 66,512

F1 · shares: Restricted stock unit award that vests on 03/31/2030.

SEC source: 0000875320-26-000253 · wk-form4_1784837739.xml · nonDerivative · entry 1

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,572

F1 · shares: Restricted stock unit award that vests on 03/31/2030.

SEC source: 0000875320-26-000247 · wk-form4_1784318742.xml · derivative · entry 1

Garber Alan M · CIK 0001312907 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65.458

Underlying: Common Stock · 31.56 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Dr. Garber's service on our board of directors, (ii) a change of control of our company and (iii) Dr. Garber's disability or death.

F1 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Dr. Garber's service on our board of directors, (ii) a change of control of our company and (iii) Dr. Garber's disability or death.

F1 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Dr. Garber's service on our board of directors, (ii) a change of control of our company and (iii) Dr. Garber's disability or death.

SEC source: 0000875320-26-000249 · wk-form4_1784318797.xml · derivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,771.807

Underlying: Common Stock · 99.941 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

F1 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

F1 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

SEC source: 0000875320-26-000243 · wk-form4_1783454880.xml · nonDerivative · entry 1

McKechnie Duncan · CIK 0002062139 · EVP, Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,001

F1 · kind: Transaction made pursuant to Mr. McKechnie's company approved trading plan under Rule 10b5-1, which was entered into on 11/25/2025.

SEC source: 0000875320-26-000245 · wk-form4_1783455338.xml · nonDerivative · entry 1

Tatsis Ourania · CIK 0001789815 · EVP, Chief Reg. & Quality Off.

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 45,321

F1 · kind: Transaction made pursuant to Dr. Tatsis' company approved trading plan under Rule 10b5-1, which was entered into on 08/21/2025.

SEC source: 0000875320-26-000241 · wk-form4_1783368787.xml · nonDerivative · entry 1

Liu Joy · CIK 0001847529 · EVP and Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,131

F1 · kind: Transaction made pursuant to Ms. Liu's company approved trading plan under Rule 10b5-1, which was entered into on 11/25/2025.

SEC source: 0000875320-26-000239 · wk-form4_1782850180.xml · nonDerivative · entry 1

Bozic Carmen · CIK 0001790029 · EVP and CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,337

F1 · kind: Transaction made pursuant to Dr. Bozic's company approved trading plan under Rule 10b5-1, which was entered into on 11/20/2025.

SEC source: 0000875320-26-000237 · wk-form4_1782245334.xml · nonDerivative · entry 1

Bozic Carmen · CIK 0001790029 · EVP and CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,933

F1 · kind: Transaction made pursuant to Dr. Bozic's company approved trading plan under Rule 10b5-1, which was entered into on 11/20/2025.

SEC source: 0000875320-26-000235 · wk-form4_1781727153.xml · nonDerivative · entry 1

Bozic Carmen · CIK 0001790029 · EVP and CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,953

F1 · kind: Transaction made pursuant to Dr. Bozic's company approved trading plan under Rule 10b5-1, which was entered into on 11/20/2025.

SEC source: 0000875320-26-000233 · wk-form4_1781036661.xml · nonDerivative · entry 1

Bozic Carmen · CIK 0001790029 · EVP and CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,015

F1 · kind: Transaction made pursuant to Dr. Bozic's company approved trading plan under Rule 10b5-1, which was entered into on 11/20/2025.

SEC source: 0000875320-26-000230 · wk-form4_1780517191.xml · nonDerivative · entry 1

Liu Joy · CIK 0001847529 · EVP and Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,959

F1 · kind: Transaction made pursuant to Ms. Liu's company approved trading plan under Rule 10b5-1, which was entered into on 11/25/2025.

SEC source: 0000875320-26-000228 · wk-form4_1780430661.xml · nonDerivative · entry 1

Bozic Carmen · CIK 0001790029 · EVP and CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,760

F1 · kind: Transaction made pursuant to Dr. Bozic's company approved trading plan under Rule 10b5-1, which was entered into on 11/20/2025.

SEC source: 0000875320-26-000225 · wk-form4_1779221059.xml · nonDerivative · entry 1

Bozic Carmen · CIK 0001790029 · EVP and CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,734

F1 · kind: Transaction made pursuant to Dr. Bozic's company approved trading plan under Rule 10b5-1, which was entered into on 11/20/2025.

SEC source: 0000875320-26-000226 · wk-form4_1779221100.xml · nonDerivative · entry 1

Bunnage Mark E. · CIK 0002100735 · EVP, Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,284

F1 · kind: Transaction made pursuant to Dr. Bunnage's company approved trading plan under Rule 10b5-1, which was entered into on 11/26/2025.

SEC source: 0000875320-26-000222 · wk-form4_1778789402.xml · nonDerivative · entry 1

Bozic Carmen · CIK 0001790029 · EVP and CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,088

F1 · kind: Transaction made pursuant to Dr. Bozic's company approved trading plan under Rule 10b5-1, which was entered into on 11/20/2025.

SEC source: 0000875320-26-000175 · wk-form4_1778014276.xml · nonDerivative · entry 2

Bhatia Sangeeta N. · CIK 0001643921 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,924

F2 · kind: Transaction made pursuant to Dr. Bhatia's company approved trading plan under Rule 10b5-1, which was entered into on 05/27/2025.

SEC source: 0000875320-26-000175 · wk-form4_1778014276.xml · nonDerivative · entry 1

Bhatia Sangeeta N. · CIK 0001643921 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,242

F1 · shares: Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date.

SEC source: 0000875320-26-000177 · wk-form4_1778014467.xml · derivative · entry 1

CARNEY LLOYD · CIK 0001204424 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,866

Underlying: Common Stock · 2,866 shares

Expires 2036-04-30

F1 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-26-000179 · wk-form4_1778014724.xml · derivative · entry 2

Garber Alan M · CIK 0001312907 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,433

Underlying: Common Stock · 1,433 shares

Expires 2036-04-30

F2 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-26-000179 · wk-form4_1778014724.xml · nonDerivative · entry 1

Garber Alan M · CIK 0001312907 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,344

F1 · shares: Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date.

SEC source: 0000875320-26-000181 · wk-form4_1778015211.xml · derivative · entry 1

Lagarde Michel · CIK 0001518973 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,866

Underlying: Common Stock · 2,866 shares

Expires 2036-04-30

F1 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-26-000183 · wk-form4_1778015480.xml · nonDerivative · entry 1

Liu Joy · CIK 0001847529 · EVP and Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,729

F1 · kind: Transaction made pursuant to Ms. Liu's company approved trading plan under Rule 10b5-1, which was entered into on 11/25/2025.

SEC source: 0000875320-26-000185 · wk-form4_1778015893.xml · derivative · entry 4

MCKENZIE DIANA · CIK 0001754648 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,787.483

Underlying: Common Stock · 796 shares

Expires not disclosed

F3 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Ms. McKenzie's service on our board of directors, (ii) a change of control of our company and (iii) Ms. McKenzie's disability or death.

F2 · price: Upon the vesting of restricted stock units granted to Ms. McKenzie on May 1, 2025, Ms. McKenzie deferred the receipt of 796 shares of common stock and received instead 796 deferred stock units pursuant to our deferred compensation plan. As a result, Ms. McKenzie is reporting the disposition of 796 shares of common stock in exchange for an equal number of deferred stock units.

F3 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Ms. McKenzie's service on our board of directors, (ii) a change of control of our company and (iii) Ms. McKenzie's disability or death.

F3 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Ms. McKenzie's service on our board of directors, (ii) a change of control of our company and (iii) Ms. McKenzie's disability or death.

SEC source: 0000875320-26-000185 · wk-form4_1778015893.xml · nonDerivative · entry 2

MCKENZIE DIANA · CIK 0001754648 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,378

F2 · price: Upon the vesting of restricted stock units granted to Ms. McKenzie on May 1, 2025, Ms. McKenzie deferred the receipt of 796 shares of common stock and received instead 796 deferred stock units pursuant to our deferred compensation plan. As a result, Ms. McKenzie is reporting the disposition of 796 shares of common stock in exchange for an equal number of deferred stock units.

SEC source: 0000875320-26-000185 · wk-form4_1778015893.xml · nonDerivative · entry 1

MCKENZIE DIANA · CIK 0001754648 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,174

F1 · shares: Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date.

SEC source: 0000875320-26-000187 · wk-form4_1778016282.xml · derivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,866

Underlying: Common Stock · 2,866 shares

Expires 2036-04-30

F1 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-26-000189 · wk-form4_1778016579.xml · derivative · entry 4

Schneider Jennifer · CIK 0001783060 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 796

Underlying: Common Stock · 796 shares

Expires not disclosed

F4 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Dr. Schneider's service on our board of directors, (ii) a change of control of our company and (iii) Dr. Schneider's disability or death.

F2 · price: Upon the vesting of restricted stock units granted to Dr. Schneider on May 1, 2025, Dr. Schneider deferred the receipt of 796 shares of common stock and received instead 796 deferred stock units pursuant to our deferred compensation plan. As a result, Dr. Schneider is reporting the disposition of 796 shares of common stock in exchange for an equal number of deferred stock units.

F4 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Dr. Schneider's service on our board of directors, (ii) a change of control of our company and (iii) Dr. Schneider's disability or death.

F4 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Dr. Schneider's service on our board of directors, (ii) a change of control of our company and (iii) Dr. Schneider's disability or death.

SEC source: 0000875320-26-000189 · wk-form4_1778016579.xml · derivative · entry 3

Schneider Jennifer · CIK 0001783060 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,433

Underlying: Common Stock · 1,433 shares

Expires 2036-04-30

F3 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-26-000189 · wk-form4_1778016579.xml · nonDerivative · entry 2

Schneider Jennifer · CIK 0001783060 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,394

F2 · price: Upon the vesting of restricted stock units granted to Dr. Schneider on May 1, 2025, Dr. Schneider deferred the receipt of 796 shares of common stock and received instead 796 deferred stock units pursuant to our deferred compensation plan. As a result, Dr. Schneider is reporting the disposition of 796 shares of common stock in exchange for an equal number of deferred stock units.

SEC source: 0000875320-26-000189 · wk-form4_1778016579.xml · nonDerivative · entry 1

Schneider Jennifer · CIK 0001783060 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,190

F1 · shares: Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date.

SEC source: 0000875320-26-000191 · wk-form4_1778017046.xml · derivative · entry 4

Thornberry Nancy · CIK 0001797826 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 398

Underlying: Common Stock · 398 shares

Expires not disclosed

F4 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Ms. Thornberry's service on our board of directors, (ii) a change of control of our company and (iii) Ms. Thornberry's disability or death.

F2 · price: Upon the vesting of restricted stock units granted to Ms. Thornberry on May 1, 2025, Ms. Thornberry deferred the receipt of 398 shares of common stock and received instead 398 deferred stock units pursuant to our deferred compensation plan. As a result, Ms. Thornberry is reporting the disposition of 398 shares of common stock in exchange for an equal number of deferred stock units.

F4 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Ms. Thornberry's service on our board of directors, (ii) a change of control of our company and (iii) Ms. Thornberry's disability or death.

F4 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Ms. Thornberry's service on our board of directors, (ii) a change of control of our company and (iii) Ms. Thornberry's disability or death.

SEC source: 0000875320-26-000191 · wk-form4_1778017046.xml · derivative · entry 3

Thornberry Nancy · CIK 0001797826 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,433

Underlying: Common Stock · 1,433 shares

Expires 2036-04-30

F3 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-26-000191 · wk-form4_1778017046.xml · nonDerivative · entry 2

Thornberry Nancy · CIK 0001797826 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,109

F2 · price: Upon the vesting of restricted stock units granted to Ms. Thornberry on May 1, 2025, Ms. Thornberry deferred the receipt of 398 shares of common stock and received instead 398 deferred stock units pursuant to our deferred compensation plan. As a result, Ms. Thornberry is reporting the disposition of 398 shares of common stock in exchange for an equal number of deferred stock units.

SEC source: 0000875320-26-000191 · wk-form4_1778017046.xml · nonDerivative · entry 1

Thornberry Nancy · CIK 0001797826 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,507

F1 · shares: Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date.

SEC source: 0000875320-26-000193 · wk-form4_1778017445.xml · derivative · entry 3

Upadhyay Suketu · CIK 0001533149 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,595.156

Underlying: Common Stock · 796 shares

Expires not disclosed

F3 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

F1 · price: Upon the vesting of restricted stock units granted to Mr. Upadhyay on May 1, 2025, Mr. Upadhyay deferred the receipt of 796 shares of common stock and received instead 796 deferred stock units pursuant to our deferred compensation plan. As a result, Mr. Upadhyay is reporting the disposition of 796 shares of common stock in exchange for an equal number of deferred stock units.

F3 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

F3 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

SEC source: 0000875320-26-000193 · wk-form4_1778017445.xml · derivative · entry 2

Upadhyay Suketu · CIK 0001533149 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,866

Underlying: Common Stock · 2,866 shares

Expires 2036-04-30

F2 · derivative.exercise_date: Fully vested.

SEC source: 0000875320-26-000193 · wk-form4_1778017445.xml · nonDerivative · entry 1

Upadhyay Suketu · CIK 0001533149 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,558

F1 · price: Upon the vesting of restricted stock units granted to Mr. Upadhyay on May 1, 2025, Mr. Upadhyay deferred the receipt of 796 shares of common stock and received instead 796 deferred stock units pursuant to our deferred compensation plan. As a result, Mr. Upadhyay is reporting the disposition of 796 shares of common stock in exchange for an equal number of deferred stock units.

SEC source: 0000875320-26-000159 · wk-form4_1776456893.xml · derivative · entry 1

Garber Alan M · CIK 0001312907 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33.898

Underlying: Common Stock · 33.898 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Dr. Garber's service on our board of directors, (ii) a change of control of our company and (iii) Dr. Garber's disability or death.

F1 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Dr. Garber's service on our board of directors, (ii) a change of control of our company and (iii) Dr. Garber's disability or death.

F1 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Dr. Garber's service on our board of directors, (ii) a change of control of our company and (iii) Dr. Garber's disability or death.

SEC source: 0000875320-26-000161 · wk-form4_1776457052.xml · derivative · entry 1

SACHS BRUCE I · CIK 0001197036 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,671.866

Underlying: Common Stock · 107.345 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

F1 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

F1 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Sachs' service on our board of directors, (ii) a change of control of our company and (iii) Mr. Sachs' disability or death.

SEC source: 0000875320-26-000163 · wk-form4_1776457233.xml · derivative · entry 1

Upadhyay Suketu · CIK 0001533149 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,799.156

Underlying: Common Stock · 80.508 shares

Expires not disclosed

F1 · derivative.exercise_price: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

F1 · derivative.exercise_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

F1 · derivative.expiration_date: Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Upadhyay's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Upadhyay's disability or death.

SEC source: 0000875320-26-000157 · wk-form4_1775249628.xml · nonDerivative · entry 1

Liu Joy · CIK 0001847529 · EVP and Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,833

F1 · kind: Transaction made pursuant to Ms. Liu's company approved trading plan under Rule 10b5-1, which was entered into on 11/25/2025.

SEC source: 0000875320-26-000149 · wk-form4_1774987818.xml · nonDerivative · entry 1

Bozic Carmen · CIK 0001790029 · EVP and CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 33,076

F1 · kind: Transaction made pursuant to Dr. Bozic's company approved trading plan under Rule 10b5-1, which was entered into on 11/20/2025.

SEC source: 0000875320-26-000140 · wk-form4_1773777858.xml · nonDerivative · entry 1

Bozic Carmen · CIK 0001790029 · EVP and CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 35,405

F1 · kind: Transaction made pursuant to Dr. Bozic's company approved trading plan under Rule 10b5-1, which was entered into on 11/20/2025.

SEC source: 0000875320-26-000138 · wk-form4_1773432707.xml · nonDerivative · entry 1

McKechnie Duncan · CIK 0002062139 · EVP, Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,489

F1 · kind: Transaction made pursuant to Mr. McKechnie's company approved trading plan under Rule 10b5-1, which was entered into on 11/25/2025.

SEC source: 0000875320-26-000136 · wk-form4_1772831152.xml · nonDerivative · entry 1

McKechnie Duncan · CIK 0002062139 · EVP, Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,122

F1 · kind: Transaction made pursuant to Mr. McKechnie's company approved trading plan under Rule 10b5-1, which was entered into on 11/25/2025.

SEC source: 0000875320-26-000134 · wk-form4_1772659274.xml · nonDerivative · entry 1

Liu Joy · CIK 0001847529 · EVP and Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,811

F1 · kind: Transaction made pursuant to Ms. Liu's company approved trading plan under Rule 10b5-1, which was entered into on 11/25/2025.