VERA

SEC source: 0001415889-24-013504 · form4-05172024_080555.xml · nonDerivative · entry 6

Young Joseph R · CIK 0001861684 · SVP, FINANCE, CHIEF ACCT OFFCR

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,706

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001415889-24-013504 · form4-05172024_080555.xml · nonDerivative · entry 5

Young Joseph R · CIK 0001861684 · SVP, FINANCE, CHIEF ACCT OFFCR

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,206

F1 · price: The price reported is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $42.00 to $42.86, inclusive. The Reporting Person will provide upon request to the staff of the Securities and Exchange Commission, the Issuer or any security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-24-013504 · form4-05172024_080555.xml · nonDerivative · entry 4

Young Joseph R · CIK 0001861684 · SVP, FINANCE, CHIEF ACCT OFFCR

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 69,357

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001415889-24-013473 · form4-05172024_080545.xml · derivative · entry 1

Hall Kimball · CIK 0001897965 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,000

Underlying: Class A Common Stock · 14,000 shares

Expires 2034-05-14

F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of the first anniversary of the grant date or the date of the Company's 2025 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date. Notwithstanding the foregoing, the shares will vest in full upon a change in control, subject to the Reporting Person's continuous service through the date of such change in control.

SEC source: 0001415889-24-013504 · form4-05172024_080555.xml · derivative · entry 8

Young Joseph R · CIK 0001861684 · SVP, FINANCE, CHIEF ACCT OFFCR

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 58,589

Underlying: Class A Common Stock · 8,221 shares

Expires 2031-04-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: 1/4 of the shares subject to the option vested on March 9, 2022, and 1/48 of the shares vest monthly thereafter.

SEC source: 0001415889-24-013504 · form4-05172024_080555.xml · nonDerivative · entry 3

Young Joseph R · CIK 0001861684 · SVP, FINANCE, CHIEF ACCT OFFCR

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,206

SEC source: 0001415889-24-013504 · form4-05172024_080555.xml · nonDerivative · entry 2

Young Joseph R · CIK 0001861684 · SVP, FINANCE, CHIEF ACCT OFFCR

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,171

SEC source: 0001415889-24-013504 · form4-05172024_080555.xml · nonDerivative · entry 1

Young Joseph R · CIK 0001861684 · SVP, FINANCE, CHIEF ACCT OFFCR

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 61,392

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001415889-24-013498 · form4-05172024_080552.xml · derivative · entry 1

SEIDENBERG BETH C · CIK 0001184592 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,000

Underlying: Class A Common Stock · 14,000 shares

Expires 2034-05-14

F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of the first anniversary of the grant date or the date of the Company's 2025 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date. Notwithstanding the foregoing, the shares will vest in full upon a change in control, subject to the Reporting Person's continuous service through the date of such change in control.

SEC source: 0001415889-24-013478 · form4-05172024_080522.xml · derivative · entry 1

MORRISSEY MICHAEL · CIK 0001202096 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,000

Underlying: Class A Common Stock · 14,000 shares

Expires 2034-05-14

F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of the first anniversary of the grant date or the date of the Company's 2025 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date. Notwithstanding the foregoing, the shares will vest in full upon a change in control, subject to the Reporting Person's continuous service through the date of such change in control.

SEC source: 0001415889-24-013472 · form4-05172024_080506.xml · derivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,000

Underlying: Class A Common Stock · 14,000 shares

Expires 2034-05-14

F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of the first anniversary of the grant date or the date of the Company's 2025 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date. Notwithstanding the foregoing, the shares will vest in full upon a change in control, subject to the Reporting Person's continuous service through the date of such change in control.

SEC source: 0001415889-24-013490 · form4-05172024_080541.xml · derivative · entry 1

Morrison Scott W · CIK 0001662426 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,000

Underlying: Class A Common Stock · 14,000 shares

Expires 2034-05-14

F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of the first anniversary of the grant date or the date of the Company's 2025 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date. Notwithstanding the foregoing, the shares will vest in full upon a change in control, subject to the Reporting Person's continuous service through the date of such change in control.

SEC source: 0001415889-24-013476 · form4-05172024_080515.xml · derivative · entry 1

Katabi Maha · CIK 0001720685 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,000

Underlying: Class A Common Stock · 14,000 shares

Expires 2034-05-14

F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of the first anniversary of the grant date or the date of the Company's 2025 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date. Notwithstanding the foregoing, the shares will vest in full upon a change in control, subject to the Reporting Person's continuous service through the date of such change in control.

SEC source: 0001415889-24-013470 · form4-05172024_080535.xml · derivative · entry 1

Cheng Andrew · CIK 0001778307 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,000

Underlying: Class A Common Stock · 14,000 shares

Expires 2034-05-14

F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of the first anniversary of the grant date or the date of the Company's 2025 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date. Notwithstanding the foregoing, the shares will vest in full upon a change in control, subject to the Reporting Person's continuous service through the date of such change in control.

SEC source: 0001415889-24-010753 · form4-04122024_080416.xml · nonDerivative · entry 1

Young Joseph R · CIK 0001861684 · SVP, FINANCE, CHIEF ACCT OFFCR

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,171

F1 · balance_after: Includes 1,831 shares of Class A Common Stock acquired under the Issuer's 2021 Employee Stock Purchase Plan on March 13, 2024.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · derivative · entry 21

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,172

Underlying: Class A Common Stock · 99,828 shares

Expires 2031-07-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F11 · derivative.exercise_date: 1/4 of 180,000 shares subject to the option vested on July 12, 2022, and 1/48 of the shares vest monthly thereafter.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · nonDerivative · entry 20

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 5,000

F8 · price: The price reported is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $39.82 to $40.355, inclusive. The Reporting Person will provide upon request to the staff of the Securities and Exchange Commission, the Issuer or any security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · nonDerivative · entry 19

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 11,965

F7 · price: The price reported is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $38.75 to $39.67, inclusive. The Reporting Person will provide upon request to the staff of the Securities and Exchange Commission, the Issuer or any security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · nonDerivative · entry 18

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 14,909

F6 · price: The price reported is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $37.70 to $38.64, inclusive. The Reporting Person will provide upon request to the staff of the Securities and Exchange Commission, the Issuer or any security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · nonDerivative · entry 17

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse's IRA

Disclosed balance after: 0

F8 · price: The price reported is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $39.82 to $40.355, inclusive. The Reporting Person will provide upon request to the staff of the Securities and Exchange Commission, the Issuer or any security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · nonDerivative · entry 16

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse's IRA

Disclosed balance after: 453

F7 · price: The price reported is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $38.75 to $39.67, inclusive. The Reporting Person will provide upon request to the staff of the Securities and Exchange Commission, the Issuer or any security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · nonDerivative · entry 15

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse's IRA

Disclosed balance after: 656

F6 · price: The price reported is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $37.70 to $38.64, inclusive. The Reporting Person will provide upon request to the staff of the Securities and Exchange Commission, the Issuer or any security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · nonDerivative · entry 14

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Indirect · By IRA

Disclosed balance after: 0

F8 · price: The price reported is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $39.82 to $40.355, inclusive. The Reporting Person will provide upon request to the staff of the Securities and Exchange Commission, the Issuer or any security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · nonDerivative · entry 13

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Indirect · By IRA

Disclosed balance after: 1,505

F7 · price: The price reported is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $38.75 to $39.67, inclusive. The Reporting Person will provide upon request to the staff of the Securities and Exchange Commission, the Issuer or any security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · nonDerivative · entry 12

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Indirect · By IRA

Disclosed balance after: 2,144

F6 · price: The price reported is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $37.70 to $38.64, inclusive. The Reporting Person will provide upon request to the staff of the Securities and Exchange Commission, the Issuer or any security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · nonDerivative · entry 11

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Indirect · As Custodian for UTMA account

Disclosed balance after: 0

F8 · price: The price reported is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $39.82 to $40.355, inclusive. The Reporting Person will provide upon request to the staff of the Securities and Exchange Commission, the Issuer or any security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F9 · ownership.nature: The shares were acquired through a custodial account established for an immediate family member of the Reporting Person pursuant to the Uniform Transfers to Minors Act, for which the Reporting Person serves as a custodian.

F10 · ownership.nature: The Reporting Person disclaims beneficial ownership of these shares, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these shares for purposes of Section 16 or for any other purpose.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · nonDerivative · entry 10

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Indirect · As Custodian for UTMA account

Disclosed balance after: 867

F7 · price: The price reported is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $38.75 to $39.67, inclusive. The Reporting Person will provide upon request to the staff of the Securities and Exchange Commission, the Issuer or any security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F9 · ownership.nature: The shares were acquired through a custodial account established for an immediate family member of the Reporting Person pursuant to the Uniform Transfers to Minors Act, for which the Reporting Person serves as a custodian.

F10 · ownership.nature: The Reporting Person disclaims beneficial ownership of these shares, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these shares for purposes of Section 16 or for any other purpose.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · nonDerivative · entry 9

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Indirect · As custodian for UTMA account

Disclosed balance after: 1,233

F6 · price: The price reported is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $37.70 to $38.64, inclusive. The Reporting Person will provide upon request to the staff of the Securities and Exchange Commission, the Issuer or any security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F9 · ownership.nature: The shares were acquired through a custodial account established for an immediate family member of the Reporting Person pursuant to the Uniform Transfers to Minors Act, for which the Reporting Person serves as a custodian.

F10 · ownership.nature: The Reporting Person disclaims beneficial ownership of these shares, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these shares for purposes of Section 16 or for any other purpose.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · nonDerivative · entry 8

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Indirect · By Roth IRA

Disclosed balance after: 0

F8 · price: The price reported is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $39.82 to $40.355, inclusive. The Reporting Person will provide upon request to the staff of the Securities and Exchange Commission, the Issuer or any security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · nonDerivative · entry 7

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Indirect · By Roth IRA

Disclosed balance after: 177

F7 · price: The price reported is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $38.75 to $39.67, inclusive. The Reporting Person will provide upon request to the staff of the Securities and Exchange Commission, the Issuer or any security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · nonDerivative · entry 6

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Indirect · By Roth IRA

Disclosed balance after: 257

F6 · price: The price reported is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $37.70 to $38.64, inclusive. The Reporting Person will provide upon request to the staff of the Securities and Exchange Commission, the Issuer or any security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · nonDerivative · entry 5

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 66,337

F5 · price: The price reported is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $39.075 to $39.35, inclusive. The Reporting Person will provide upon request to the staff of the Securities and Exchange Commission, the Issuer or any security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · nonDerivative · entry 4

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 73,698

F4 · price: The price reported is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $38.00 to $38.52, inclusive. The Reporting Person will provide upon request to the staff of the Securities and Exchange Commission, the Issuer or any security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · nonDerivative · entry 3

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 85,346

F3 · price: The price reported is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $38.25 to $39.225, inclusive. The Reporting Person will provide upon request to the staff of the Securities and Exchange Commission, the Issuer or any security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · nonDerivative · entry 2

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 96,334

F2 · price: The price reported is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $39.50 to $40.36, inclusive. The Reporting Person will provide upon request to the staff of the Securities and Exchange Commission, the Issuer or any security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-24-010473 · form4-04062024_010405.xml · nonDerivative · entry 1

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 166,165

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 1,939 shares of Class A Common Stock acquired under the Issuer's 2021 Employee Stock Purchase Plan on March 13, 2024.

SEC source: 0001104659-24-038589 · tm249771-1_4seq1.xml · nonDerivative · entry 6

Katabi Maha · CIK 0001720685 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Sofinnova Venture Partners X, L.P.

Disclosed balance after: 2,793,987

F1 · kind: A portion of the sales reported herein are matchable, for purposes of Section 16(b) of the Exchange Act, with a purchase (the "Purchase") of shares of Class A Common Stock on January 30, 2024 by Sofinnova Venture Partners X, L.P. ("SVP X"), an entity in which Dr. Katabi has a pecuniary interest. As a result, Dr. Katabi is liable for short-swing profits to the extent of her pecuniary interest in the Purchase and such portion of the sales reported herein. Dr. Katabi has agreed with the Issuer to disgorge her short-swing profits attributable to the matching of the Purchase with the sales reported herein.

F7 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $40.50 to $41.40, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (7) to this Form 4.

F3 · ownership.nature: The shares are held directly by SVP X. Sofinnova Management X, L.P. ("SM X LP") is the general partner of SVP X and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by SVP X. Sofinnova Management X-A, L.L.C. ("SM X LLC") is the general partner of SVP X LP and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by SVP X. James I. Healy and Maha Katabi are the managing members of SM X LLC and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by SVP X. Such entities and individuals each disclaim beneficial ownership of such securities, except to the extent of his, her or its proportionate pecuniary interest therein.

SEC source: 0001104659-24-038589 · tm249771-1_4seq1.xml · nonDerivative · entry 5

Katabi Maha · CIK 0001720685 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Sofinnova Venture Partners X, L.P.

Disclosed balance after: 3,133,987

F1 · kind: A portion of the sales reported herein are matchable, for purposes of Section 16(b) of the Exchange Act, with a purchase (the "Purchase") of shares of Class A Common Stock on January 30, 2024 by Sofinnova Venture Partners X, L.P. ("SVP X"), an entity in which Dr. Katabi has a pecuniary interest. As a result, Dr. Katabi is liable for short-swing profits to the extent of her pecuniary interest in the Purchase and such portion of the sales reported herein. Dr. Katabi has agreed with the Issuer to disgorge her short-swing profits attributable to the matching of the Purchase with the sales reported herein.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $40.50 to $41.18, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (6) to this Form 4.

F3 · ownership.nature: The shares are held directly by SVP X. Sofinnova Management X, L.P. ("SM X LP") is the general partner of SVP X and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by SVP X. Sofinnova Management X-A, L.L.C. ("SM X LLC") is the general partner of SVP X LP and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by SVP X. James I. Healy and Maha Katabi are the managing members of SM X LLC and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by SVP X. Such entities and individuals each disclaim beneficial ownership of such securities, except to the extent of his, her or its proportionate pecuniary interest therein.

SEC source: 0001104659-24-038589 · tm249771-1_4seq1.xml · nonDerivative · entry 4

Katabi Maha · CIK 0001720685 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Sofinnova Venture Partners X, L.P.

Disclosed balance after: 3,547,437

F1 · kind: A portion of the sales reported herein are matchable, for purposes of Section 16(b) of the Exchange Act, with a purchase (the "Purchase") of shares of Class A Common Stock on January 30, 2024 by Sofinnova Venture Partners X, L.P. ("SVP X"), an entity in which Dr. Katabi has a pecuniary interest. As a result, Dr. Katabi is liable for short-swing profits to the extent of her pecuniary interest in the Purchase and such portion of the sales reported herein. Dr. Katabi has agreed with the Issuer to disgorge her short-swing profits attributable to the matching of the Purchase with the sales reported herein.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $46.00 to $46.94, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (5) to this Form 4.

F3 · ownership.nature: The shares are held directly by SVP X. Sofinnova Management X, L.P. ("SM X LP") is the general partner of SVP X and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by SVP X. Sofinnova Management X-A, L.L.C. ("SM X LLC") is the general partner of SVP X LP and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by SVP X. James I. Healy and Maha Katabi are the managing members of SM X LLC and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by SVP X. Such entities and individuals each disclaim beneficial ownership of such securities, except to the extent of his, her or its proportionate pecuniary interest therein.

SEC source: 0001104659-24-038589 · tm249771-1_4seq1.xml · nonDerivative · entry 3

Katabi Maha · CIK 0001720685 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Sofinnova Venture Partners X, L.P.

Disclosed balance after: 3,561,155

F1 · kind: A portion of the sales reported herein are matchable, for purposes of Section 16(b) of the Exchange Act, with a purchase (the "Purchase") of shares of Class A Common Stock on January 30, 2024 by Sofinnova Venture Partners X, L.P. ("SVP X"), an entity in which Dr. Katabi has a pecuniary interest. As a result, Dr. Katabi is liable for short-swing profits to the extent of her pecuniary interest in the Purchase and such portion of the sales reported herein. Dr. Katabi has agreed with the Issuer to disgorge her short-swing profits attributable to the matching of the Purchase with the sales reported herein.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $45.06 to $45.96, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (4) to this Form 4.

F3 · ownership.nature: The shares are held directly by SVP X. Sofinnova Management X, L.P. ("SM X LP") is the general partner of SVP X and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by SVP X. Sofinnova Management X-A, L.L.C. ("SM X LLC") is the general partner of SVP X LP and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by SVP X. James I. Healy and Maha Katabi are the managing members of SM X LLC and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by SVP X. Such entities and individuals each disclaim beneficial ownership of such securities, except to the extent of his, her or its proportionate pecuniary interest therein.

SEC source: 0001104659-24-038589 · tm249771-1_4seq1.xml · nonDerivative · entry 2

Katabi Maha · CIK 0001720685 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Sofinnova Venture Partners X, L.P.

Disclosed balance after: 3,573,772

F1 · kind: A portion of the sales reported herein are matchable, for purposes of Section 16(b) of the Exchange Act, with a purchase (the "Purchase") of shares of Class A Common Stock on January 30, 2024 by Sofinnova Venture Partners X, L.P. ("SVP X"), an entity in which Dr. Katabi has a pecuniary interest. As a result, Dr. Katabi is liable for short-swing profits to the extent of her pecuniary interest in the Purchase and such portion of the sales reported herein. Dr. Katabi has agreed with the Issuer to disgorge her short-swing profits attributable to the matching of the Purchase with the sales reported herein.

F3 · ownership.nature: The shares are held directly by SVP X. Sofinnova Management X, L.P. ("SM X LP") is the general partner of SVP X and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by SVP X. Sofinnova Management X-A, L.L.C. ("SM X LLC") is the general partner of SVP X LP and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by SVP X. James I. Healy and Maha Katabi are the managing members of SM X LLC and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by SVP X. Such entities and individuals each disclaim beneficial ownership of such securities, except to the extent of his, her or its proportionate pecuniary interest therein.

SEC source: 0001104659-24-038589 · tm249771-1_4seq1.xml · nonDerivative · entry 1

Katabi Maha · CIK 0001720685 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Sofinnova Venture Partners X, L.P.

Disclosed balance after: 3,595,690

F1 · kind: A portion of the sales reported herein are matchable, for purposes of Section 16(b) of the Exchange Act, with a purchase (the "Purchase") of shares of Class A Common Stock on January 30, 2024 by Sofinnova Venture Partners X, L.P. ("SVP X"), an entity in which Dr. Katabi has a pecuniary interest. As a result, Dr. Katabi is liable for short-swing profits to the extent of her pecuniary interest in the Purchase and such portion of the sales reported herein. Dr. Katabi has agreed with the Issuer to disgorge her short-swing profits attributable to the matching of the Purchase with the sales reported herein.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $43.00 to $43.06, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (2) to this Form 4.

F3 · ownership.nature: The shares are held directly by SVP X. Sofinnova Management X, L.P. ("SM X LP") is the general partner of SVP X and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by SVP X. Sofinnova Management X-A, L.L.C. ("SM X LLC") is the general partner of SVP X LP and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by SVP X. James I. Healy and Maha Katabi are the managing members of SM X LLC and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by SVP X. Such entities and individuals each disclaim beneficial ownership of such securities, except to the extent of his, her or its proportionate pecuniary interest therein.

SEC source: 0001104659-24-009537 · tm244970-1_4seq1.xml · nonDerivative · entry 1

Katabi Maha · CIK 0001720685 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Sofinnova Venture Partners X, L.P.

Disclosed balance after: 3,628,446

F1 · ownership.nature: The shares are held directly by Sofinnova Venture Partners X, L.P. ("SVP X"). Sofinnova Management X, L.P. ("SM X LP") is the general partner of SVP X and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by SVP X. Sofinnova Management X-A, L.L.C. ("SM X LLC") is the general partner of SVP X LP and may be deemed to have sole voting, investment and dispositive power with respect to the shares held by SVP X. James I. Healy and Maha Katabi are the managing members of SM X LLC and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by SVP X. Such entities and individuals each disclaim beneficial ownership of such securities, except to the extent of his, her or its proportionate pecuniary interest therein.

SEC source: 0001415889-24-001518 · form4-01182024_090112.xml · derivative · entry 2

Young Joseph R · CIK 0001861684 · SVP, FINANCE, CHIEF ACCT OFFCR

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 81,250

Underlying: Class A Common Stock · 81,250 shares

Expires 2034-01-15

F3 · derivative.exercise_date: 1/48 of the shares subject to the stock option will vest and become exercisable on February 16, 2024, and 1/48th of the shares subject to the stock option will vest and become exercisable monthly on the same day of each month thereafter, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001415889-24-001518 · form4-01182024_090112.xml · nonDerivative · entry 1

Young Joseph R · CIK 0001861684 · SVP, FINANCE, CHIEF ACCT OFFCR

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 57,054

F1 · shares: Represents the number of shares of Class A Common Stock underlying the restricted stock units ("RSUs") under the Issuer's 2021 Equity Incentive Plan. One-fourth of the RSUs, rounded to the nearest whole share, vest on each of February 20, 2025, 2026, 2027 and 2028, subject to the Reporting Person's continuous service through each vesting date.

F2 · balance_after: Includes 2,500 shares of Class A Common Stock acquired under the Issuer's 2021 Employee Stock Purchase Plan on September 13, 2023.

SEC source: 0001415889-24-001526 · form4-01182024_090156.xml · derivative · entry 2

Fordyce Marshall · CIK 0001859453 · Director · PRESIDENT AND CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 292,500

Underlying: Class A Common Stock · 292,500 shares

Expires 2034-01-15

F2 · derivative.exercise_date: 1/48 of the shares subject to the stock option will vest and become exercisable on February 16, 2024, and 1/48th of the shares subject to the stock option will vest and become exercisable monthly on the same day of each month thereafter, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001415889-24-001526 · form4-01182024_090156.xml · nonDerivative · entry 1

Fordyce Marshall · CIK 0001859453 · Director · PRESIDENT AND CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 335,627

F1 · shares: Represents the number of shares of Class A Common Stock underlying the restricted stock units ("RSUs") under the Issuer's 2021 Equity Incentive Plan. One-fourth of the RSUs, rounded to the nearest whole share, vest on each of February 20, 2025, 2026, 2027 and 2028, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001415889-24-001514 · form4-01182024_090121.xml · derivative · entry 6

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 97,500

Underlying: Class A Common Stock · 97,500 shares

Expires 2034-01-15

F3 · derivative.exercise_date: 1/48 of the shares subject to the stock option will vest and become exercisable on February 16, 2024, and 1/48th of the shares subject to the stock option will vest and become exercisable monthly on the same day of each month thereafter, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001415889-24-001514 · form4-01182024_090121.xml · nonDerivative · entry 1

Grant Sean · CIK 0001872792 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 78,683

F1 · shares: Represents the number of shares of Class A Common Stock underlying the restricted stock units ("RSUs") under the Issuer's 2021 Equity Incentive Plan. One-fourth of the RSUs vest, rounded to the nearest whole share, on each of February 20, 2025, 2026, 2027 and 2028, subject to the Reporting Person's continuous service through each vesting date.

F2 · balance_after: Includes 2,500 shares of Class A Common Stock acquired under the Issuer's 2021 Employee Stock Purchase Plan on September 13, 2023.

SEC source: 0001493152-24-002290 · ownership.xml · nonDerivative · entry 1

COMMODORE CAPITAL LP · CIK 0001831942 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Commodore Capital Master LP

Disclosed balance after: 4,400,000

F1 · ownership.nature: The shares are held directly by Commodore Capital Master LP ("Commodore Master"). Commodore Capital LP ("Commodore Capital") is the investment manager to Commodore Master. Michael Kramarz and Robert Egen Atkinson are the managing partners of Commodore Capital and exercise investment and dispositive power over the securities held by Commodore Master. Each of Commodore Capital, Dr. Kramarz and Dr. Atkinson disclaim beneficial ownership of such securities, except to the extent of their pecuniary interest therein. This report shall not be deemed an admission that Commodore Capital, Commodore Master, Dr. Kramarz and Dr. Atkinson or any other person is the beneficial owner of the securities reported herein for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.