VCEL

SEC source: 0001140361-25-005257 · form4.xml · nonDerivative · entry 4

SIEGAL JONATHAN · CIK 0001916145 · Principal Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,916

F3 · shares: These shares were withheld by the Issuer to satisfy the tax withholding requirements in connection with the vesting of RSUs.

F2 · balance_after: These shares include shares acquired pursuant to the Issuer's 2015 Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001140361-25-005257 · form4.xml · nonDerivative · entry 3

SIEGAL JONATHAN · CIK 0001916145 · Principal Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,082

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · price: The shares of common stock were acquired by the Reporting Person as a result of the vesting of RSUs granted to the Reporting Person on February 18, 2022. The remaining RSUs will vest on February 18, 2026.

F2 · balance_after: These shares include shares acquired pursuant to the Issuer's 2015 Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001140361-25-005257 · form4.xml · nonDerivative · entry 2

SIEGAL JONATHAN · CIK 0001916145 · Principal Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,662

F3 · shares: These shares were withheld by the Issuer to satisfy the tax withholding requirements in connection with the vesting of RSUs.

F2 · balance_after: These shares include shares acquired pursuant to the Issuer's 2015 Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001140361-25-005257 · form4.xml · nonDerivative · entry 1

SIEGAL JONATHAN · CIK 0001916145 · Principal Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,706

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The shares of common stock were acquired by the Reporting Person as a result of the vesting of Restricted Stock Units (RSUs) granted to the Reporting Person on February 17, 2023. The remaining RSUs will vest in annual installments on February 17, 2026, and February 17, 2027, respectively.

F2 · balance_after: These shares include shares acquired pursuant to the Issuer's 2015 Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001140361-25-004765 · form4.xml · derivative · entry 6

MCLAUGHLIN KEVIN F · CIK 0001214938 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 14,000

Underlying: Common Stock · 1,000 shares

Expires 2026-05-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: These options, representing the right to purchase a total of 15,000 shares, were originally granted on May 4, 2016, and became exercisable in equal monthly installments over the course of one year, contingent upon continued service to the Company.

SEC source: 0001140361-25-004765 · form4.xml · derivative · entry 5

MCLAUGHLIN KEVIN F · CIK 0001214938 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 6,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: These options, representing the right to purchase 15,000 shares, were originally granted on March 20, 2015, with 624 shares becoming exercisable on the grant date, 312 shares becoming exercisable on March 31, 2015, and the remainder becoming exercisable in equal monthly installments, contingent upon continued service to the Company, from April 30, 2015 through December 31, 2017.

F3 · derivative.expiration_date: These options, which were awarded on March 20, 2015, would otherwise expire and become forfeitable on March 20, 2025

SEC source: 0001140361-25-004765 · form4.xml · nonDerivative · entry 4

MCLAUGHLIN KEVIN F · CIK 0001214938 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,900

F1 · acquired: The sales reported in this Form 4 were effected by an automatic sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 11, 2024.

SEC source: 0001140361-25-004765 · form4.xml · nonDerivative · entry 3

MCLAUGHLIN KEVIN F · CIK 0001214938 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,900

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-25-004765 · form4.xml · nonDerivative · entry 2

MCLAUGHLIN KEVIN F · CIK 0001214938 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,900

F1 · acquired: The sales reported in this Form 4 were effected by an automatic sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 11, 2024.

SEC source: 0001140361-25-004765 · form4.xml · nonDerivative · entry 1

MCLAUGHLIN KEVIN F · CIK 0001214938 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 17,900

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-25-003834 · form4.xml · derivative · entry 4

Rubino Alan L · CIK 0001340228 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 15,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: These options, representing the right to purchase 15,000 shares, were originally granted on March 20, 2015, with 624 shares becoming exercisable on the grant date, 312 shares becoming exercisable on March 31, 2015, and the remainder becoming exercisable in equal monthly installments, contingent upon continued service to the Company, from April 30, 2015 through December 31, 2017.

F3 · derivative.expiration_date: These options, which were awarded on March 20, 2015, would otherwise expire and become forfeitable on March 20, 2025.

SEC source: 0001140361-25-003834 · form4.xml · derivative · entry 3

Rubino Alan L · CIK 0001340228 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 4,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: These options, representing the right to purchase a total of 4,000 shares, became exercisable in three installments, contingent upon continued service to the Company, with the first vesting date on March 20, 2015, which was the date on which the option was granted, and the final vesting date on May 1, 2015.

F3 · derivative.expiration_date: These options, which were awarded on March 20, 2015, would otherwise expire and become forfeitable on March 20, 2025.

SEC source: 0001140361-25-003834 · form4.xml · nonDerivative · entry 2

Rubino Alan L · CIK 0001340228 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,794

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: The Reporting Person has elected to exercise and hold these shares at this time.

SEC source: 0001140361-25-003834 · form4.xml · nonDerivative · entry 1

Rubino Alan L · CIK 0001340228 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,794

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: The Reporting Person has elected to exercise and hold these shares at this time.

SEC source: 0001140361-25-003571 · form4.xml · derivative · entry 3

ZERBE ROBERT L MD · CIK 0001220363 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Common Stock · 2,500 shares

Expires 2028-05-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: These options, representing the right to purchase 17,500 shares, were originally granted on May 2, 2018, becoming exercisable in equal monthly installments, contingent upon continued service to the Company, from June 2, 2018 through May 2, 2019.

SEC source: 0001140361-25-003571 · form4.xml · nonDerivative · entry 2

ZERBE ROBERT L MD · CIK 0001220363 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,595

F1 · acquired: The sales reported in this Form 4 were effected by an automatic sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 12, 2024.

SEC source: 0001140361-25-003571 · form4.xml · nonDerivative · entry 1

ZERBE ROBERT L MD · CIK 0001220363 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 29,095

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-25-003567 · form4.xml · derivative · entry 3

SIEGAL JONATHAN · CIK 0001916145 · Principal Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 51,875

Underlying: Common Stock · 1,092 shares

Expires 2031-09-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: These options, representing the right to purchase 56,875 shares, became exercisable on September 30, 2022, the first anniversary of the date of grant, with 25% vesting and the remaining 75% vesting in equal quarterly installments over three years thereafter, contingent upon continued service to the Company.

SEC source: 0001140361-25-003567 · form4.xml · nonDerivative · entry 2

SIEGAL JONATHAN · CIK 0001916145 · Principal Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,206

F2 · acquired: The sales reported in this Form 4 were effected by an automatic sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2024.

F1 · balance_after: These shares include shares acquired pursuant to the Issuer's 2015 Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001140361-25-003567 · form4.xml · nonDerivative · entry 1

SIEGAL JONATHAN · CIK 0001916145 · Principal Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,298

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: These shares include shares acquired pursuant to the Issuer's 2015 Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001140361-25-002441 · form4.xml · derivative · entry 3

SIEGAL JONATHAN · CIK 0001916145 · Principal Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 52,967

Underlying: Common Stock · 3,908 shares

Expires 2031-09-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: These options, representing the right to purchase 56,875 shares, became exercisable on September 30, 2022, the first anniversary of the date of grant, with 25% vesting and the remaining 75% vesting in equal quarterly installments over three years thereafter, contingent upon continued service to the Company.

SEC source: 0001140361-25-002441 · form4.xml · nonDerivative · entry 2

SIEGAL JONATHAN · CIK 0001916145 · Principal Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,206

F2 · acquired: The sales reported in this Form 4 were effected by an automatic sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2024.

F1 · balance_after: These shares include shares acquired pursuant to the Issuer's 2015 Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001140361-25-002441 · form4.xml · nonDerivative · entry 1

SIEGAL JONATHAN · CIK 0001916145 · Principal Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,114

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: These shares include shares acquired pursuant to the Issuer's 2015 Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001140361-25-004301 · form5.xml · nonDerivative · entry 3

Halpin Michael · CIK 0001778858 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,608

F1 · shares: Shares acquired pursuant to the Issuer's 2015 Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001140361-25-004299 · form5.xml · nonDerivative · entry 2

Mara Joseph Anthony Jr · CIK 0001841148 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,580

F1 · shares: Shares acquired pursuant to the Issuer's 2015 Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001140361-25-004298 · form5.xml · nonDerivative · entry 1

Hopper Jonathan Mark · CIK 0001626325 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 58,500

F1 · shares: Shares acquired pursuant to the Issuer's 2015 Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001140361-24-048466 · form4.xml · nonDerivative · entry 1

Wotton Paul K · CIK 0001300997 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,402

SEC source: 0001140361-24-048294 · form4.xml · derivative · entry 3

Hopper Jonathan Mark · CIK 0001626325 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Common Stock · 10,000 shares

Expires 2029-02-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: These options, representing the right to purchase 26,000 shares, became exercisable in equal quarterly installments, contingent upon continued service to the Company, with the first vesting date on May 6, 2019, which was one quarter after the date on which the option was granted.

SEC source: 0001140361-24-048294 · form4.xml · nonDerivative · entry 2

Hopper Jonathan Mark · CIK 0001626325 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 58,371

F2 · acquired: The sales reported in this Form 4 were effected by an automatic sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 28, 2024.

F1 · balance_after: These shares include shares acquired pursuant to the Issuer's 2015 Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001140361-24-048294 · form4.xml · nonDerivative · entry 1

Hopper Jonathan Mark · CIK 0001626325 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 68,371

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: These shares include shares acquired pursuant to the Issuer's 2015 Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001140361-24-047758 · form4.xml · derivative · entry 3

ZERBE ROBERT L MD · CIK 0001220363 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 2,500 shares

Expires 2028-05-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: These options, representing the right to purchase 17,500 shares, were originally granted on May 2, 2018, becoming exercisable in equal monthly installments, contingent upon continued service to the Company, from June 2, 2018 through May 2, 2019.

SEC source: 0001140361-24-047758 · form4.xml · nonDerivative · entry 2

ZERBE ROBERT L MD · CIK 0001220363 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,595

F1 · acquired: The sales reported in this Form 4 were effected by an automatic sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 12, 2024.

SEC source: 0001140361-24-047758 · form4.xml · nonDerivative · entry 1

ZERBE ROBERT L MD · CIK 0001220363 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 29,095

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-24-047069 · form4.xml · derivative · entry 6

Colangelo Dominick · CIK 0001313403 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 17,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: These options, representing the right to purchase 440,000 shares, became exercisable in equal quarterly installments, contingent upon continued service to the Company, with the first vesting date on April 5, 2015, which was one quarter after the date on which the option was granted.

F4 · derivative.expiration_date: These options, which were awarded on January 5, 2015, would otherwise expire and become forfeitable on January 5, 2025.

SEC source: 0001140361-24-047069 · form4.xml · nonDerivative · entry 4

Colangelo Dominick · CIK 0001313403 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 220,937

F2 · acquired: The sales reported in this Form 4 were effected by an automatic sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 1, 2023.

F1 · balance_after: These shares include shares acquired pursuant to the Issuer's 2015 Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001140361-24-047069 · form4.xml · nonDerivative · entry 3

Colangelo Dominick · CIK 0001313403 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 238,437

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: These shares include shares acquired pursuant to the Issuer's 2015 Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001140361-24-047070 · form4.xml · derivative · entry 3

MCLAUGHLIN KEVIN F · CIK 0001214938 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Common Stock · 7,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: These options, representing the right to purchase 15,000 shares, were originally granted on March 20, 2015, with 624 shares becoming exercisable on the grant date, 312 shares becoming exercisable on March 31, 2015, and the remainder becoming exercisable in equal monthly installments, contingent upon continued service to the Company, from April 30, 2015 through December 31, 2017.

F3 · derivative.expiration_date: These options, which were awarded on March 20, 2015, would otherwise expire and become forfeitable on March 20, 2025.

SEC source: 0001140361-24-047070 · form4.xml · nonDerivative · entry 2

MCLAUGHLIN KEVIN F · CIK 0001214938 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,900

F1 · acquired: The sales reported in this Form 4 were effected by an automatic sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 11, 2024.

SEC source: 0001140361-24-047070 · form4.xml · nonDerivative · entry 1

MCLAUGHLIN KEVIN F · CIK 0001214938 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 18,900

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-24-047069 · form4.xml · derivative · entry 5

Colangelo Dominick · CIK 0001313403 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: These options, representing the right to purchase 440,000 shares, became exercisable in equal quarterly installments, contingent upon continued service to the Company, with the first vesting date on April 5, 2015, which was one quarter after the date on which the option was granted.

F4 · derivative.expiration_date: These options, which were awarded on January 5, 2015, would otherwise expire and become forfeitable on January 5, 2025.

SEC source: 0001140361-24-047069 · form4.xml · nonDerivative · entry 2

Colangelo Dominick · CIK 0001313403 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 220,937

F2 · acquired: The sales reported in this Form 4 were effected by an automatic sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 1, 2023.

F1 · balance_after: These shares include shares acquired pursuant to the Issuer's 2015 Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001140361-24-047069 · form4.xml · nonDerivative · entry 1

Colangelo Dominick · CIK 0001313403 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 238,437

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: These shares include shares acquired pursuant to the Issuer's 2015 Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001140361-24-046456 · form4.xml · derivative · entry 6

ZERBE ROBERT L MD · CIK 0001220363 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 2,500 shares

Expires 2028-05-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: These options, representing the right to purchase 17,500 shares, were originally granted on May 2, 2018, becoming exercisable in equal monthly installments, contingent upon continued service to the Company, from June 2, 2018 through May 2, 2019.

SEC source: 0001140361-24-046456 · form4.xml · nonDerivative · entry 4

ZERBE ROBERT L MD · CIK 0001220363 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,595

F1 · acquired: The sales reported in this Form 4 were effected by an automatic sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 12, 2024.

SEC source: 0001140361-24-046456 · form4.xml · nonDerivative · entry 3

ZERBE ROBERT L MD · CIK 0001220363 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 29,095

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-24-046456 · form4.xml · derivative · entry 5

ZERBE ROBERT L MD · CIK 0001220363 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 2,500 shares

Expires 2028-05-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: These options, representing the right to purchase 17,500 shares, were originally granted on May 2, 2018, becoming exercisable in equal monthly installments, contingent upon continued service to the Company, from June 2, 2018 through May 2, 2019.

SEC source: 0001140361-24-046456 · form4.xml · nonDerivative · entry 2

ZERBE ROBERT L MD · CIK 0001220363 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,595

F1 · acquired: The sales reported in this Form 4 were effected by an automatic sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 12, 2024.

SEC source: 0001140361-24-046456 · form4.xml · nonDerivative · entry 1

ZERBE ROBERT L MD · CIK 0001220363 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 29,095

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-24-043696 · form4.xml · derivative · entry 6

Colangelo Dominick · CIK 0001313403 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 35,000

Underlying: Common Stock · 17,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: These options, representing the right to purchase 440,000 shares, became exercisable in equal quarterly installments, contingent upon continued service to the Company, with the first vesting date on April 5, 2015, which was one quarter after the date on which the option was granted.

F4 · derivative.expiration_date: These options, which were awarded on January 5, 2015, would otherwise expire and become forfeitable on January 5, 2025.

SEC source: 0001140361-24-043696 · form4.xml · nonDerivative · entry 4

Colangelo Dominick · CIK 0001313403 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 220,937

F2 · acquired: The sales reported in this Form 4 were effected by an automatic sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 1, 2023.

F1 · balance_after: These shares include shares acquired pursuant to the Issuer's 2015 Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).