UTHR

SEC source: 0001415889-24-021584 · form4-08192024_040822.xml · nonDerivative · entry 13

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F12 · price: This transaction was executed in multiple trades at prices ranging from $322.81 to $323.73. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021584 · form4-08192024_040822.xml · nonDerivative · entry 12

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 287

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F11 · price: This transaction was executed in multiple trades at prices ranging from $321.58 to $322.41. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021584 · form4-08192024_040822.xml · nonDerivative · entry 11

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 947

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F10 · price: This transaction was executed in multiple trades at prices ranging from $320.57 to $321.50. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021584 · form4-08192024_040822.xml · nonDerivative · entry 10

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,681

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F9 · price: This transaction was executed in multiple trades at prices ranging from $319.44 to $320.34. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021584 · form4-08192024_040822.xml · nonDerivative · entry 9

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,294

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F8 · price: This transaction was executed in multiple trades at prices ranging from $318.38 to $318.60. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021584 · form4-08192024_040822.xml · nonDerivative · entry 8

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,296

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F7 · price: This transaction was executed in multiple trades at prices ranging from $317.38 to $318.30. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021584 · form4-08192024_040822.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,730

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-021584 · form4-08192024_040822.xml · derivative · entry 19

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,869

Underlying: Common Stock · 3,600 shares

Expires 2024-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-021584 · form4-08192024_040822.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F6 · price: This transaction was executed in multiple trades at prices ranging from $325.69 to $326.38. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021584 · form4-08192024_040822.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 502

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F5 · price: This transaction was executed in multiple trades at prices ranging from $324.53 to $325.28. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021584 · form4-08192024_040822.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 796

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F4 · price: This transaction was executed in multiple trades at prices ranging from $323.43 to $324.41. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021584 · form4-08192024_040822.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,821

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F3 · price: This transaction was executed in multiple trades at prices ranging from $322.36 to $323.31. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021584 · form4-08192024_040822.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,905

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F2 · price: This transaction was executed in multiple trades at prices ranging from $321.32 to $322.27. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021584 · form4-08192024_040822.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,730

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · derivative · entry 27

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,469

Underlying: Common Stock · 3,600 shares

Expires 2024-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · nonDerivative · entry 20

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F16 · price: This transaction was executed in multiple trades at prices ranging from $327.74 to $327.95. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · nonDerivative · entry 19

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 176

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F15 · price: This transaction was executed in multiple trades at prices ranging from $326.69 to $327.65. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · nonDerivative · entry 18

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 600

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F14 · price: This transaction was executed in multiple trades at prices ranging from $325.39 to $326.24. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · nonDerivative · entry 17

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,114

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F13 · price: This transaction was executed in multiple trades at prices ranging from $324.38 to $325.36. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · nonDerivative · entry 16

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,436

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F12 · price: This transaction was executed in multiple trades at prices ranging from $323.34 to $324.33. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · nonDerivative · entry 15

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,137

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F11 · price: This transaction was executed in multiple trades at prices ranging from $322.32 to $323.31. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · nonDerivative · entry 14

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,730

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · derivative · entry 26

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 29,069

Underlying: Common Stock · 3,600 shares

Expires 2024-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · nonDerivative · entry 13

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · nonDerivative · entry 12

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 215

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F10 · price: This transaction was executed in multiple trades at prices ranging from $337.35 to $338.295. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · nonDerivative · entry 11

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 741

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F9 · price: This transaction was executed in multiple trades at prices ranging from $335.725 to $336.66. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · nonDerivative · entry 10

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,023

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F8 · price: This transaction was executed in multiple trades at prices ranging from $334.65 to $335.30. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · nonDerivative · entry 9

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,145

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F7 · price: This transaction was executed in multiple trades at prices ranging from $333.45 to $334.33. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · nonDerivative · entry 8

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,312

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,465

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F6 · price: This transaction was executed in multiple trades at prices ranging from $328.02 to $328.30. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,623

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F5 · price: This transaction was executed in multiple trades at prices ranging from $326.40 to $326.68. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,989

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,055

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F4 · price: This transaction was executed in multiple trades at prices ranging from $322.255 to $323.14. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,862

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F3 · price: This transaction was executed in multiple trades at prices ranging from $321.05 to $322.01. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,587

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F2 · price: This transaction was executed in multiple trades at prices ranging from $319.02 to $319.83. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021361 · form4-08152024_040802.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,730

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-021168 · form4-08132024_040820.xml · derivative · entry 19

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 32,669

Underlying: Common Stock · 3,600 shares

Expires 2024-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-021168 · form4-08132024_040820.xml · nonDerivative · entry 12

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-021168 · form4-08132024_040820.xml · nonDerivative · entry 11

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 213

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F9 · price: This transaction was executed in multiple trades at prices ranging from $335.54 to $336.46. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021168 · form4-08132024_040820.xml · nonDerivative · entry 10

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,071

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F8 · price: This transaction was executed in multiple trades at prices ranging from $334.495 to $335.11. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021168 · form4-08132024_040820.xml · nonDerivative · entry 9

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,905

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F7 · price: This transaction was executed in multiple trades at prices ranging from $333.42 to $334.35. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021168 · form4-08132024_040820.xml · nonDerivative · entry 8

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,275

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F6 · price: This transaction was executed in multiple trades at prices ranging from $332.415 to $333.20. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021168 · form4-08132024_040820.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,419

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F5 · price: This transaction was executed in multiple trades at prices ranging from $329.82 to $330.46. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021168 · form4-08132024_040820.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,504

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F4 · price: This transaction was executed in multiple trades at prices ranging from $328.63 to $329.21. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021168 · form4-08132024_040820.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,730

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-021168 · form4-08132024_040820.xml · derivative · entry 18

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 36,269

Underlying: Common Stock · 3,600 shares

Expires 2024-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-021168 · form4-08132024_040820.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-021168 · form4-08132024_040820.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 460

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F3 · price: This transaction was executed in multiple trades at prices ranging from $330.35 to $331.13. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021168 · form4-08132024_040820.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,678

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F2 · price: This transaction was executed in multiple trades at prices ranging from $329.31 to $330.15. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-021168 · form4-08132024_040820.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,730

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.