UTHR

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 26

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 96

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F26 · price: This transaction was executed in multiple trades at prices ranging from $428.34 to $429.17. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F16 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person's family members are beneficiaries, and as to which the Reporting Person has sole investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 25

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 360

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F25 · price: This transaction was executed in multiple trades at prices ranging from $425.73 to $426.37. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F16 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person's family members are beneficiaries, and as to which the Reporting Person has sole investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 24

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 614

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F24 · price: This transaction was executed in multiple trades at prices ranging from $424.42 to $425.19. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F16 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person's family members are beneficiaries, and as to which the Reporting Person has sole investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 23

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 977

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F23 · price: This transaction was executed in multiple trades at prices ranging from $423.42 to $424.40. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F16 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person's family members are beneficiaries, and as to which the Reporting Person has sole investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 22

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 2,164

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F22 · price: This transaction was executed in multiple trades at prices ranging from $422.33 to $423.24. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F16 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person's family members are beneficiaries, and as to which the Reporting Person has sole investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 21

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 3,280

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F21 · price: This transaction was executed in multiple trades at prices ranging from $421.32 to $422.28. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F16 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person's family members are beneficiaries, and as to which the Reporting Person has sole investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 20

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 4,712

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F20 · price: This transaction was executed in multiple trades at prices ranging from $420.32 to $421.31. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F16 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person's family members are beneficiaries, and as to which the Reporting Person has sole investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 19

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 5,774

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F19 · price: This transaction was executed in multiple trades at prices ranging from $419.32 to $420.31. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F16 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person's family members are beneficiaries, and as to which the Reporting Person has sole investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 18

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 6,489

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F18 · price: This transaction was executed in multiple trades at prices ranging from $418.15 to $419.10. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F16 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person's family members are beneficiaries, and as to which the Reporting Person has sole investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 17

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 6,860

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F17 · price: This transaction was executed in multiple trades at prices ranging from $417.08 to $418.07. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F16 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person's family members are beneficiaries, and as to which the Reporting Person has sole investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 16

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 7,525

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F3 · price: This transaction was executed in multiple trades at prices ranging from $416.02 to $416.91. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F16 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person's family members are beneficiaries, and as to which the Reporting Person has sole investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 15

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 7,875

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F16 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person's family members are beneficiaries, and as to which the Reporting Person has sole investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 14

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 0

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F15 · price: This transaction was executed in multiple trades at prices ranging from $430.60 to $430.86. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person is a beneficiary, and as to which the Reporting Person and his spouse are co-trustees and have shared investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 13

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 65

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F14 · price: This transaction was executed in multiple trades at prices ranging from $429.45 to $429.61. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person is a beneficiary, and as to which the Reporting Person and his spouse are co-trustees and have shared investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 12

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 161

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F13 · price: This transaction was executed in multiple trades at prices ranging from $428.34 to $429.17. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person is a beneficiary, and as to which the Reporting Person and his spouse are co-trustees and have shared investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 11

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 650

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F12 · price: This transaction was executed in multiple trades at prices ranging from $425.73 to $426.37. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person is a beneficiary, and as to which the Reporting Person and his spouse are co-trustees and have shared investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 10

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 1,140

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F11 · price: This transaction was executed in multiple trades at prices ranging from $424.42 to $425.19. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person is a beneficiary, and as to which the Reporting Person and his spouse are co-trustees and have shared investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 9

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 1,814

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F10 · price: This transaction was executed in multiple trades at prices ranging from $423.42 to $424.40. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person is a beneficiary, and as to which the Reporting Person and his spouse are co-trustees and have shared investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 8

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 4,020

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F9 · price: This transaction was executed in multiple trades at prices ranging from $422.33 to $423.24. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person is a beneficiary, and as to which the Reporting Person and his spouse are co-trustees and have shared investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 7

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 6,093

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F8 · price: This transaction was executed in multiple trades at prices ranging from $421.32 to $422.28. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person is a beneficiary, and as to which the Reporting Person and his spouse are co-trustees and have shared investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 6

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 8,752

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F7 · price: This transaction was executed in multiple trades at prices ranging from $420.32 to $421.31. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person is a beneficiary, and as to which the Reporting Person and his spouse are co-trustees and have shared investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 5

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 10,723

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F6 · price: This transaction was executed in multiple trades at prices ranging from $419.32 to $420.31. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person is a beneficiary, and as to which the Reporting Person and his spouse are co-trustees and have shared investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 4

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 12,050

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F5 · price: This transaction was executed in multiple trades at prices ranging from $418.15 to $419.10. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person is a beneficiary, and as to which the Reporting Person and his spouse are co-trustees and have shared investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 3

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 12,740

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F4 · price: This transaction was executed in multiple trades at prices ranging from $417.08 to $418.07. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person is a beneficiary, and as to which the Reporting Person and his spouse are co-trustees and have shared investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 2

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 13,975

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F3 · price: This transaction was executed in multiple trades at prices ranging from $416.02 to $416.91. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person is a beneficiary, and as to which the Reporting Person and his spouse are co-trustees and have shared investment and voting power.

SEC source: 0001673232-25-000005 · primarydocument.xml · nonDerivative · entry 1

BENKOWITZ MICHAEL · CIK 0001673232 · PRESIDENT AND COO

10b5-1 filing: Plan reported

Ownership: Indirect · by Trust

Disclosed balance after: 14,625

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on June 3, 2025.

F2 · ownership.nature: Reflects the exercise of options, and sale of the resulting shares of common stock, held in a trust beneficially owned by the Reporting Person, of which the Reporting Person is a beneficiary, and as to which the Reporting Person and his spouse are co-trustees and have shared investment and voting power.

SEC source: 0001106578-25-000014 · primarydocument.xml · derivative · entry 13

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 230,000

Underlying: Common Stock · 4,000 shares

Expires 2026-03-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

SEC source: 0001106578-25-000014 · primarydocument.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

F4 · price: This transaction was executed in multiple trades at prices ranging from $430.60 to $430.94. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-25-000014 · primarydocument.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,730

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

F3 · price: This transaction was executed in multiple trades at prices ranging from $423.065 to $423.94. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-25-000014 · primarydocument.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,514

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

SEC source: 0001106578-25-000014 · primarydocument.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,929

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

F2 · price: This transaction was executed in multiple trades at prices ranging from $416.3797 to $416.38. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-25-000014 · primarydocument.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

SEC source: 0001106578-25-000013 · primarydocument.xml · derivative · entry 14

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 234,000

Underlying: Common Stock · 4,000 shares

Expires 2026-03-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

SEC source: 0001106578-25-000013 · primarydocument.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

F5 · price: This transaction was executed in multiple trades at prices ranging from $428.17 to $429.10. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-25-000013 · primarydocument.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

SEC source: 0001106578-25-000013 · primarydocument.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

SEC source: 0001106578-25-000013 · primarydocument.xml · derivative · entry 13

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 238,000

Underlying: Common Stock · 4,000 shares

Expires 2026-03-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

SEC source: 0001106578-25-000013 · primarydocument.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

F4 · price: This transaction was executed in multiple trades at prices ranging from $431.56 to $432.14. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-25-000013 · primarydocument.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,430

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

F3 · price: This transaction was executed in multiple trades at prices ranging from $430.16 to $430.42. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-25-000013 · primarydocument.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,230

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

F2 · price: This transaction was executed in multiple trades at prices ranging from $428.79 to $429.415. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-25-000013 · primarydocument.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

SEC source: 0001237334-25-000004 · primarydocument.xml · derivative · entry 3

CAUSEY CHRISTOPHER · CIK 0001237334 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,320

Underlying: Common Stock · 1,000 shares

Expires 2030-06-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001237334-25-000004 · primarydocument.xml · nonDerivative · entry 2

CAUSEY CHRISTOPHER · CIK 0001237334 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,865

SEC source: 0001237334-25-000004 · primarydocument.xml · nonDerivative · entry 1

CAUSEY CHRISTOPHER · CIK 0001237334 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,865

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001106578-25-000012 · primarydocument.xml · derivative · entry 13

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 242,000

Underlying: Common Stock · 4,000 shares

Expires 2026-03-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

SEC source: 0001106578-25-000012 · primarydocument.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

F5 · price: This transaction was executed in multiple trades at prices ranging from $435.84 to $436.84. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-25-000012 · primarydocument.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 814

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

F4 · price: This transaction was executed in multiple trades at prices ranging from $433.715 to $433.89. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-25-000012 · primarydocument.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

SEC source: 0001106578-25-000012 · primarydocument.xml · derivative · entry 12

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 246,000

Underlying: Common Stock · 4,000 shares

Expires 2026-03-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

SEC source: 0001106578-25-000012 · primarydocument.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on May 2, 2025. This plan will continue until the earlier of: (a) exhaustion of a tranche of 294,000 stock options that expire March 15, 2026; or (b) December 31, 2025.

F3 · price: This transaction was executed in multiple trades at prices ranging from $419.3025 to $420.27. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.