UTHR

SEC source: 0001106578-26-000027 · primarydocument.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 49,933

F1 · kind: This exercise of stock options and sale of the resulting shares of common stock was pursuant to a pre-arranged 10b5-1 trading plan adopted by the reporting person on November 7, 2025. This plan will continue until the earlier of: (a) the exercise of 1,734,410 stock options, all of which expire on March 17, 2027; or (b) December 31, 2026.

F2 · price: This transaction was executed in multiple trades at prices ranging from $552.37 to $552.93. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-26-000027 · primarydocument.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 50,013

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of stock options and sale of the resulting shares of common stock was pursuant to a pre-arranged 10b5-1 trading plan adopted by the reporting person on November 7, 2025. This plan will continue until the earlier of: (a) the exercise of 1,734,410 stock options, all of which expire on March 17, 2027; or (b) December 31, 2026.

SEC source: 0001231589-26-000009 · primarydocument.xml · derivative · entry 13

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,900

Underlying: Common Stock · 8,300 shares

Expires 2027-03-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This is an exercise of stock options and sale of the resulting shares pursuant to a pre-arranged 10b5-1 plan entered into by the reporting person on August 11, 2025.

SEC source: 0001231589-26-000009 · primarydocument.xml · nonDerivative · entry 12

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 45,172

F1 · kind: This is an exercise of stock options and sale of the resulting shares pursuant to a pre-arranged 10b5-1 plan entered into by the reporting person on August 11, 2025.

F12 · price: This transaction was executed in multiple trades at prices ranging from $571.53 to $571.72. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001231589-26-000009 · primarydocument.xml · nonDerivative · entry 11

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 45,372

F1 · kind: This is an exercise of stock options and sale of the resulting shares pursuant to a pre-arranged 10b5-1 plan entered into by the reporting person on August 11, 2025.

F11 · price: This transaction was executed in multiple trades at prices ranging from $569.485 to $569.775. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001231589-26-000009 · primarydocument.xml · nonDerivative · entry 10

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 46,082

F1 · kind: This is an exercise of stock options and sale of the resulting shares pursuant to a pre-arranged 10b5-1 plan entered into by the reporting person on August 11, 2025.

F10 · price: This transaction was executed in multiple trades at prices ranging from $568.17 to $569.16. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001231589-26-000009 · primarydocument.xml · nonDerivative · entry 9

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 46,772

F1 · kind: This is an exercise of stock options and sale of the resulting shares pursuant to a pre-arranged 10b5-1 plan entered into by the reporting person on August 11, 2025.

F9 · price: This transaction was executed in multiple trades at prices ranging from $567.17 to $568.11. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001231589-26-000009 · primarydocument.xml · nonDerivative · entry 8

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 48,175

F1 · kind: This is an exercise of stock options and sale of the resulting shares pursuant to a pre-arranged 10b5-1 plan entered into by the reporting person on August 11, 2025.

F8 · price: This transaction was executed in multiple trades at prices ranging from $566.12 to $567.09. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001231589-26-000009 · primarydocument.xml · nonDerivative · entry 7

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 49,804

F1 · kind: This is an exercise of stock options and sale of the resulting shares pursuant to a pre-arranged 10b5-1 plan entered into by the reporting person on August 11, 2025.

F7 · price: This transaction was executed in multiple trades at prices ranging from $565.09 to $566.03. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001231589-26-000009 · primarydocument.xml · nonDerivative · entry 6

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 50,347

F1 · kind: This is an exercise of stock options and sale of the resulting shares pursuant to a pre-arranged 10b5-1 plan entered into by the reporting person on August 11, 2025.

F6 · price: This transaction was executed in multiple trades at prices ranging from $564.09 to $565.03. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001231589-26-000009 · primarydocument.xml · nonDerivative · entry 5

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 51,462

F1 · kind: This is an exercise of stock options and sale of the resulting shares pursuant to a pre-arranged 10b5-1 plan entered into by the reporting person on August 11, 2025.

F5 · price: This transaction was executed in multiple trades at prices ranging from $563.03 to $564.02. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001231589-26-000009 · primarydocument.xml · nonDerivative · entry 4

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 51,833

F1 · kind: This is an exercise of stock options and sale of the resulting shares pursuant to a pre-arranged 10b5-1 plan entered into by the reporting person on August 11, 2025.

F4 · price: This transaction was executed in multiple trades at prices ranging from $562.00 to $562.90. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001231589-26-000009 · primarydocument.xml · nonDerivative · entry 3

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 52,607

F1 · kind: This is an exercise of stock options and sale of the resulting shares pursuant to a pre-arranged 10b5-1 plan entered into by the reporting person on August 11, 2025.

F3 · price: This transaction was executed in multiple trades at prices ranging from $560.885 to $561.86. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001231589-26-000009 · primarydocument.xml · nonDerivative · entry 2

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 52,958

F1 · kind: This is an exercise of stock options and sale of the resulting shares pursuant to a pre-arranged 10b5-1 plan entered into by the reporting person on August 11, 2025.

F2 · price: This transaction was executed in multiple trades at prices ranging from $559.83 to $560.77. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001231589-26-000009 · primarydocument.xml · nonDerivative · entry 1

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 53,472

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This is an exercise of stock options and sale of the resulting shares pursuant to a pre-arranged 10b5-1 plan entered into by the reporting person on August 11, 2025.

SEC source: 0001636178-26-000006 · primarydocument.xml · derivative · entry 19

EDGEMOND JAMES · CIK 0001636178 · CFO AND TREASURER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 122,500

Underlying: Common Stock · 10,000 shares

Expires 2027-03-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on October 31, 2025.

SEC source: 0001636178-26-000006 · primarydocument.xml · nonDerivative · entry 18

EDGEMOND JAMES · CIK 0001636178 · CFO AND TREASURER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 18,876

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on October 31, 2025.

F18 · price: This transaction was executed in multiple trades at prices ranging from $571.53 to $571.72. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001636178-26-000006 · primarydocument.xml · nonDerivative · entry 17

EDGEMOND JAMES · CIK 0001636178 · CFO AND TREASURER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 18,996

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on October 31, 2025.

F17 · price: This transaction was executed in multiple trades at prices ranging from $569.14 to $570.05. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001636178-26-000006 · primarydocument.xml · nonDerivative · entry 16

EDGEMOND JAMES · CIK 0001636178 · CFO AND TREASURER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,116

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on October 31, 2025.

F16 · price: This transaction was executed in multiple trades at prices ranging from $567.64 to $568.35. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001636178-26-000006 · primarydocument.xml · nonDerivative · entry 15

EDGEMOND JAMES · CIK 0001636178 · CFO AND TREASURER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,516

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on October 31, 2025.

F15 · price: This transaction was executed in multiple trades at prices ranging from $566.53 to $567.17. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001636178-26-000006 · primarydocument.xml · nonDerivative · entry 14

EDGEMOND JAMES · CIK 0001636178 · CFO AND TREASURER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,839

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on October 31, 2025.

F14 · price: This transaction was executed in multiple trades at prices ranging from $565.50 to $566.49. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001636178-26-000006 · primarydocument.xml · nonDerivative · entry 13

EDGEMOND JAMES · CIK 0001636178 · CFO AND TREASURER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,581

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on October 31, 2025.

F13 · price: This transaction was executed in multiple trades at prices ranging from $564.44 to $565.43. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001636178-26-000006 · primarydocument.xml · nonDerivative · entry 12

EDGEMOND JAMES · CIK 0001636178 · CFO AND TREASURER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,782

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on October 31, 2025.

F12 · price: This transaction was executed in multiple trades at prices ranging from $563.43 to $564.30. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001636178-26-000006 · primarydocument.xml · nonDerivative · entry 11

EDGEMOND JAMES · CIK 0001636178 · CFO AND TREASURER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,678

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on October 31, 2025.

F11 · price: This transaction was executed in multiple trades at prices ranging from $562.40 to $563.39. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001636178-26-000006 · primarydocument.xml · nonDerivative · entry 10

EDGEMOND JAMES · CIK 0001636178 · CFO AND TREASURER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,233

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on October 31, 2025.

F10 · price: This transaction was executed in multiple trades at prices ranging from $561.24 to $562.21. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001636178-26-000006 · primarydocument.xml · nonDerivative · entry 9

EDGEMOND JAMES · CIK 0001636178 · CFO AND TREASURER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,804

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on October 31, 2025.

F9 · price: This transaction was executed in multiple trades at prices ranging from $560.00 to $560.88. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001636178-26-000006 · primarydocument.xml · nonDerivative · entry 8

EDGEMOND JAMES · CIK 0001636178 · CFO AND TREASURER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,876

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on October 31, 2025.

F8 · price: This transaction was executed in multiple trades at prices ranging from $558.79 to $559.42. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001636178-26-000006 · primarydocument.xml · nonDerivative · entry 7

EDGEMOND JAMES · CIK 0001636178 · CFO AND TREASURER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,116

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on October 31, 2025.

F7 · price: This transaction was executed in multiple trades at prices ranging from $557.75 to $558.62. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001636178-26-000006 · primarydocument.xml · nonDerivative · entry 6

EDGEMOND JAMES · CIK 0001636178 · CFO AND TREASURER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,836

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on October 31, 2025.

F6 · price: This transaction was executed in multiple trades at prices ranging from $556.62 to $557.42. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001636178-26-000006 · primarydocument.xml · nonDerivative · entry 5

EDGEMOND JAMES · CIK 0001636178 · CFO AND TREASURER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,813

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on October 31, 2025.

F5 · price: This transaction was executed in multiple trades at prices ranging from $555.62 to $556.60. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001636178-26-000006 · primarydocument.xml · nonDerivative · entry 4

EDGEMOND JAMES · CIK 0001636178 · CFO AND TREASURER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 27,657

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on October 31, 2025.

F4 · price: This transaction was executed in multiple trades at prices ranging from $554.58 to $555.52. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001636178-26-000006 · primarydocument.xml · nonDerivative · entry 3

EDGEMOND JAMES · CIK 0001636178 · CFO AND TREASURER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 28,435

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on October 31, 2025.

F3 · price: This transaction was executed in multiple trades at prices ranging from $553.54 to $554.52. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001636178-26-000006 · primarydocument.xml · nonDerivative · entry 2

EDGEMOND JAMES · CIK 0001636178 · CFO AND TREASURER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 28,836

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on October 31, 2025.

F2 · price: This transaction was executed in multiple trades at prices ranging from $551.68 to $552.02. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001636178-26-000006 · primarydocument.xml · nonDerivative · entry 1

EDGEMOND JAMES · CIK 0001636178 · CFO AND TREASURER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 28,876

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on October 31, 2025.

SEC source: 0001106578-26-000026 · primarydocument.xml · derivative · entry 25

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,000

Underlying: Common Stock · 9,500 shares

Expires 2027-03-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of stock options and sale of the resulting shares of common stock was pursuant to a pre-arranged 10b5-1 trading plan adopted by the reporting person on November 7, 2025. This plan will continue until the earlier of: (a) the exercise of 1,734,410 stock options, all of which expire on March 17, 2027; or (b) December 31, 2026.

SEC source: 0001106578-26-000026 · primarydocument.xml · nonDerivative · entry 19

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 40,513

F1 · kind: This exercise of stock options and sale of the resulting shares of common stock was pursuant to a pre-arranged 10b5-1 trading plan adopted by the reporting person on November 7, 2025. This plan will continue until the earlier of: (a) the exercise of 1,734,410 stock options, all of which expire on March 17, 2027; or (b) December 31, 2026.

F17 · price: This transaction was executed in multiple trades at prices ranging from $571.53 to $571.73. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-26-000026 · primarydocument.xml · nonDerivative · entry 18

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 40,633

F1 · kind: This exercise of stock options and sale of the resulting shares of common stock was pursuant to a pre-arranged 10b5-1 trading plan adopted by the reporting person on November 7, 2025. This plan will continue until the earlier of: (a) the exercise of 1,734,410 stock options, all of which expire on March 17, 2027; or (b) December 31, 2026.

SEC source: 0001106578-26-000026 · primarydocument.xml · nonDerivative · entry 17

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 40,713

F1 · kind: This exercise of stock options and sale of the resulting shares of common stock was pursuant to a pre-arranged 10b5-1 trading plan adopted by the reporting person on November 7, 2025. This plan will continue until the earlier of: (a) the exercise of 1,734,410 stock options, all of which expire on March 17, 2027; or (b) December 31, 2026.

F16 · price: This transaction was executed in multiple trades at prices ranging from $568.16 to $569.13. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-26-000026 · primarydocument.xml · nonDerivative · entry 16

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 40,833

F1 · kind: This exercise of stock options and sale of the resulting shares of common stock was pursuant to a pre-arranged 10b5-1 trading plan adopted by the reporting person on November 7, 2025. This plan will continue until the earlier of: (a) the exercise of 1,734,410 stock options, all of which expire on March 17, 2027; or (b) December 31, 2026.

F15 · price: This transaction was executed in multiple trades at prices ranging from $567.13 to $567.92. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-26-000026 · primarydocument.xml · nonDerivative · entry 15

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 41,141

F1 · kind: This exercise of stock options and sale of the resulting shares of common stock was pursuant to a pre-arranged 10b5-1 trading plan adopted by the reporting person on November 7, 2025. This plan will continue until the earlier of: (a) the exercise of 1,734,410 stock options, all of which expire on March 17, 2027; or (b) December 31, 2026.

F14 · price: This transaction was executed in multiple trades at prices ranging from $566.06 to $567.01. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-26-000026 · primarydocument.xml · nonDerivative · entry 14

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 41,711

F1 · kind: This exercise of stock options and sale of the resulting shares of common stock was pursuant to a pre-arranged 10b5-1 trading plan adopted by the reporting person on November 7, 2025. This plan will continue until the earlier of: (a) the exercise of 1,734,410 stock options, all of which expire on March 17, 2027; or (b) December 31, 2026.

F13 · price: This transaction was executed in multiple trades at prices ranging from $565.06 to $566.03. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-26-000026 · primarydocument.xml · nonDerivative · entry 13

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 42,522

F1 · kind: This exercise of stock options and sale of the resulting shares of common stock was pursuant to a pre-arranged 10b5-1 trading plan adopted by the reporting person on November 7, 2025. This plan will continue until the earlier of: (a) the exercise of 1,734,410 stock options, all of which expire on March 17, 2027; or (b) December 31, 2026.

F12 · price: This transaction was executed in multiple trades at prices ranging from $564.06 to $565.05. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-26-000026 · primarydocument.xml · nonDerivative · entry 12

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 44,440

F1 · kind: This exercise of stock options and sale of the resulting shares of common stock was pursuant to a pre-arranged 10b5-1 trading plan adopted by the reporting person on November 7, 2025. This plan will continue until the earlier of: (a) the exercise of 1,734,410 stock options, all of which expire on March 17, 2027; or (b) December 31, 2026.

F11 · price: This transaction was executed in multiple trades at prices ranging from $563.035 to $563.99. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-26-000026 · primarydocument.xml · nonDerivative · entry 11

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 45,305

F1 · kind: This exercise of stock options and sale of the resulting shares of common stock was pursuant to a pre-arranged 10b5-1 trading plan adopted by the reporting person on November 7, 2025. This plan will continue until the earlier of: (a) the exercise of 1,734,410 stock options, all of which expire on March 17, 2027; or (b) December 31, 2026.

F10 · price: This transaction was executed in multiple trades at prices ranging from $562.00 to $562.93. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-26-000026 · primarydocument.xml · nonDerivative · entry 10

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 45,683

F1 · kind: This exercise of stock options and sale of the resulting shares of common stock was pursuant to a pre-arranged 10b5-1 trading plan adopted by the reporting person on November 7, 2025. This plan will continue until the earlier of: (a) the exercise of 1,734,410 stock options, all of which expire on March 17, 2027; or (b) December 31, 2026.

F9 · price: This transaction was executed in multiple trades at prices ranging from $560.99 to $561.98. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-26-000026 · primarydocument.xml · nonDerivative · entry 9

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 46,253

F1 · kind: This exercise of stock options and sale of the resulting shares of common stock was pursuant to a pre-arranged 10b5-1 trading plan adopted by the reporting person on November 7, 2025. This plan will continue until the earlier of: (a) the exercise of 1,734,410 stock options, all of which expire on March 17, 2027; or (b) December 31, 2026.

SEC source: 0001106578-26-000026 · primarydocument.xml · nonDerivative · entry 8

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 46,293

F1 · kind: This exercise of stock options and sale of the resulting shares of common stock was pursuant to a pre-arranged 10b5-1 trading plan adopted by the reporting person on November 7, 2025. This plan will continue until the earlier of: (a) the exercise of 1,734,410 stock options, all of which expire on March 17, 2027; or (b) December 31, 2026.

F8 · price: This transaction was executed in multiple trades at prices ranging from $558.01 to $558.93. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-26-000026 · primarydocument.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 46,733

F1 · kind: This exercise of stock options and sale of the resulting shares of common stock was pursuant to a pre-arranged 10b5-1 trading plan adopted by the reporting person on November 7, 2025. This plan will continue until the earlier of: (a) the exercise of 1,734,410 stock options, all of which expire on March 17, 2027; or (b) December 31, 2026.

F7 · price: This transaction was executed in multiple trades at prices ranging from $557.00 to $557.96. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-26-000026 · primarydocument.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 47,513

F1 · kind: This exercise of stock options and sale of the resulting shares of common stock was pursuant to a pre-arranged 10b5-1 trading plan adopted by the reporting person on November 7, 2025. This plan will continue until the earlier of: (a) the exercise of 1,734,410 stock options, all of which expire on March 17, 2027; or (b) December 31, 2026.

F6 · price: This transaction was executed in multiple trades at prices ranging from $556.00 to $556.96. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001106578-26-000026 · primarydocument.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairperson & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 48,321

F1 · kind: This exercise of stock options and sale of the resulting shares of common stock was pursuant to a pre-arranged 10b5-1 trading plan adopted by the reporting person on November 7, 2025. This plan will continue until the earlier of: (a) the exercise of 1,734,410 stock options, all of which expire on March 17, 2027; or (b) December 31, 2026.

F5 · price: This transaction was executed in multiple trades at prices ranging from $555.00 to $555.93. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.