UTHR

SEC source: 0001127602-20-020107 · form4.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,140

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

SEC source: 0001127602-20-020107 · form4.xml · derivative · entry 10

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 134,834

Underlying: Common Stock · 10,000 shares

Expires 2020-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

SEC source: 0001127602-20-020107 · form4.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F4 · price: This transaction was executed in multiple trades at prices ranging from $117.40 to $117.47. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-020107 · form4.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 749

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F3 · price: This transaction was executed in multiple trades at prices ranging from $116.32 to $117.03. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-020107 · form4.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,381

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $115.25 to $116.02. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-020107 · form4.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,140

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

SEC source: 0001127602-20-019938 · form4.xml · derivative · entry 16

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 144,834

Underlying: Common Stock · 10,000 shares

Expires 2020-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

SEC source: 0001127602-20-019938 · form4.xml · nonDerivative · entry 11

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F9 · price: This transaction was executed in multiple trades at prices ranging from $117.68 to $118.67. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019938 · form4.xml · nonDerivative · entry 10

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,138

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F8 · price: This transaction was executed in multiple trades at prices ranging from $116.67 to $117.585. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019938 · form4.xml · nonDerivative · entry 9

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,817

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F7 · price: This transaction was executed in multiple trades at prices ranging from $115.51 to $116.645. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019938 · form4.xml · nonDerivative · entry 8

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,140

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

SEC source: 0001127602-20-019938 · form4.xml · derivative · entry 15

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 154,834

Underlying: Common Stock · 10,000 shares

Expires 2020-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

SEC source: 0001127602-20-019938 · form4.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F6 · price: This transaction was executed in multiple trades at prices ranging from $115.21 to $115.36. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019938 · form4.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,043

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F5 · price: This transaction was executed in multiple trades at prices ranging from $114.18 to $115.165. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019938 · form4.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,302

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F4 · price: This transaction was executed in multiple trades at prices ranging from $113.17 to $114.16. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019938 · form4.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,140

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

SEC source: 0001127602-20-019938 · form4.xml · derivative · entry 14

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 164,834

Underlying: Common Stock · 10,000 shares

Expires 2020-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

SEC source: 0001127602-20-019938 · form4.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F3 · price: This transaction was executed in multiple trades at prices ranging from $114.24 to $114.73. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019938 · form4.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,267

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $113.20 to $114.16. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019938 · form4.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,140

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

SEC source: 0001127602-20-019506 · form4.xml · derivative · entry 16

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 174,834

Underlying: Common Stock · 10,000 shares

Expires 2020-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

SEC source: 0001127602-20-019506 · form4.xml · nonDerivative · entry 12

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F11 · price: This transaction was executed in multiple trades at prices ranging from $117.97 to $118.41. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019506 · form4.xml · nonDerivative · entry 11

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 864

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F10 · price: This transaction was executed in multiple trades at prices ranging from $116.97 to $117.965. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019506 · form4.xml · nonDerivative · entry 10

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,353

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F9 · price: This transaction was executed in multiple trades at prices ranging from $115.785 to $116.53. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019506 · form4.xml · nonDerivative · entry 9

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,932

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F8 · price: This transaction was executed in multiple trades at prices ranging from $114.75 to $115.73. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019506 · form4.xml · nonDerivative · entry 8

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,497

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F7 · price: This transaction was executed in multiple trades at prices ranging from $113.75 to $114.735. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019506 · form4.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,140

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

SEC source: 0001127602-20-019506 · form4.xml · derivative · entry 15

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 184,834

Underlying: Common Stock · 10,000 shares

Expires 2020-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

SEC source: 0001127602-20-019506 · form4.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F6 · price: This transaction was executed in multiple trades at prices ranging from $120.20 to $120.45. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019506 · form4.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 334

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F5 · price: This transaction was executed in multiple trades at prices ranging from $119.12 to $120.095. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019506 · form4.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,057

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F4 · price: This transaction was executed in multiple trades at prices ranging from $118.08 to $119.075. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019506 · form4.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,932

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F3 · price: This transaction was executed in multiple trades at prices ranging from $117.05 to $118.02. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019506 · form4.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,375

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $115.925 to $116.90. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019506 · form4.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,140

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

SEC source: 0001127602-20-019363 · form4.xml · derivative · entry 17

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 194,834

Underlying: Common Stock · 10,000 shares

Expires 2020-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

SEC source: 0001127602-20-019363 · form4.xml · nonDerivative · entry 12

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F10 · price: This transaction was executed in multiple trades at prices ranging from $124.87 to $125.08. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019363 · form4.xml · nonDerivative · entry 11

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 538

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F9 · price: This transaction was executed in multiple trades at prices ranging from $123.80 to $1224.74. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019363 · form4.xml · nonDerivative · entry 10

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,931

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F8 · price: This transaction was executed in multiple trades at prices ranging from $122.80 to $123.72. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019363 · form4.xml · nonDerivative · entry 9

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,140

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

SEC source: 0001127602-20-019364 · form4.xml · nonDerivative · entry 1

Thompson Tommy G · CIK 0001324863 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Family LLC

Disclosed balance after: 9,790

SEC source: 0001127602-20-019363 · form4.xml · derivative · entry 16

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 204,834

Underlying: Common Stock · 10,000 shares

Expires 2020-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

SEC source: 0001127602-20-019363 · form4.xml · nonDerivative · entry 8

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F7 · price: This transaction was executed in multiple trades at prices ranging from $126.44 to $127.25. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019363 · form4.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,563

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F6 · price: This transaction was executed in multiple trades at prices ranging from $125.385 to $126.26. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019363 · form4.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,113

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F5 · price: This transaction was executed in multiple trades at prices ranging from $124.36 to $125.31. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019363 · form4.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,140

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

SEC source: 0001127602-20-019158 · form4.xml · nonDerivative · entry 1

Olian Judy D. · CIK 0001605729 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,490

F1 · price: This transaction was executed in multiple trades at prices ranging from $124.9401 to $124.9656. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019363 · form4.xml · derivative · entry 15

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 214,834

Underlying: Common Stock · 10,000 shares

Expires 2020-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

SEC source: 0001127602-20-019363 · form4.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F4 · price: This transaction was executed in multiple trades at prices ranging from $125.57 to $125.85. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019363 · form4.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 516

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F3 · price: This transaction was executed in multiple trades at prices ranging from $124.57 to $125.55. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127602-20-019363 · form4.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,989

F1 · kind: This exercise of options and sale of options is pursuant to a prearranged 10b5-1 trading plan. The trading plan contemplates the exercise and sale of up to 364,834 options with an exercise price of $63.22/share, which were granted in December 2010 and are set to expire at the end of 2020. Assuming relevant conditions are met, this tranche of options will be exercised in daily installments of 10,000 shares during May-July, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $122.98 to $123.975. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.