UTHR

SEC source: 0001415889-22-012071 · form4-12052022_041215.xml · nonDerivative · entry 15

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F12 · price: This transaction was executed in multiple trades at prices ranging from $281.86 to $282.32. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-012071 · form4-12052022_041215.xml · nonDerivative · entry 14

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 556

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F11 · price: This transaction was executed in multiple trades at prices ranging from $280.84 to $281.79. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-012071 · form4-12052022_041215.xml · nonDerivative · entry 13

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,622

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F10 · price: This transaction was executed in multiple trades at prices ranging from $279.81 to $280.805. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-012071 · form4-12052022_041215.xml · nonDerivative · entry 12

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,655

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F9 · price: This transaction was executed in multiple trades at prices ranging from $278.805 to $279.79. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-012071 · form4-12052022_041215.xml · nonDerivative · entry 11

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,392

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F8 · price: This transaction was executed in multiple trades at prices ranging from $277.78 to $278.76. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-012071 · form4-12052022_041215.xml · nonDerivative · entry 10

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,603

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F7 · price: This transaction was executed in multiple trades at prices ranging from $276.47 to $277.37. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-012071 · form4-12052022_041215.xml · nonDerivative · entry 9

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,068

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-22-012071 · form4-12052022_041215.xml · nonDerivative · entry 8

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-22-011882 · form4-12012022_041214.xml · derivative · entry 3

SULLIVAN LOUIS W · CIK 0001193522 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,100

Underlying: Common Stock · 700 shares

Expires 2027-06-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person.

SEC source: 0001415889-22-011882 · form4-12012022_041214.xml · nonDerivative · entry 2

SULLIVAN LOUIS W · CIK 0001193522 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,180

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person.

SEC source: 0001415889-22-011882 · form4-12012022_041214.xml · nonDerivative · entry 1

SULLIVAN LOUIS W · CIK 0001193522 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,880

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person.

SEC source: 0001415889-22-011881 · form4-12012022_041208.xml · derivative · entry 7

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,500

Underlying: Common Stock · 6,000 shares

Expires 2026-03-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person.

SEC source: 0001415889-22-011881 · form4-12012022_041208.xml · nonDerivative · entry 6

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,397

SEC source: 0001415889-22-011881 · form4-12012022_041208.xml · nonDerivative · entry 5

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,923

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person.

F5 · price: This transaction was executed in multiple trades at prices ranging from $278.22 to $278.91. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011881 · form4-12012022_041208.xml · nonDerivative · entry 4

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,818

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person.

F4 · price: This transaction was executed in multiple trades at prices ranging from $277.215 to $278.20. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011881 · form4-12012022_041208.xml · nonDerivative · entry 3

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,868

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person.

F3 · price: This transaction was executed in multiple trades at prices ranging from $276.15 to $277.07. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011881 · form4-12012022_041208.xml · nonDerivative · entry 2

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,668

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $274.51 to $275.31. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011881 · form4-12012022_041208.xml · nonDerivative · entry 1

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,397

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person.

SEC source: 0001415889-22-012071 · form4-12052022_041215.xml · derivative · entry 18

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 840,000

Underlying: Common Stock · 8,000 shares

Expires 2023-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-22-012071 · form4-12052022_041215.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-22-012071 · form4-12052022_041215.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 311

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F6 · price: This transaction was executed in multiple trades at prices ranging from $279.00 to $279.89. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-012071 · form4-12052022_041215.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,227

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F5 · price: This transaction was executed in multiple trades at prices ranging from $277.77 to $278.755. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-012071 · form4-12052022_041215.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,388

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F4 · price: This transaction was executed in multiple trades at prices ranging from $276.68 to $277.62. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-012071 · form4-12052022_041215.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,683

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $275.65 to $276.625. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-012071 · form4-12052022_041215.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,568

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $274.63 to $275.59. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-012071 · form4-12052022_041215.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-22-011880 · form4-12012022_041201.xml · derivative · entry 17

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 848,000

Underlying: Common Stock · 8,000 shares

Expires 2023-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-22-011880 · form4-12012022_041201.xml · nonDerivative · entry 13

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F12 · price: This transaction was executed in multiple trades at prices ranging from $279.37 to $280.075. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011880 · form4-12012022_041201.xml · nonDerivative · entry 12

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,327

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F11 · price: This transaction was executed in multiple trades at prices ranging from $278.32 to $279.28. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011880 · form4-12012022_041201.xml · nonDerivative · entry 11

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,326

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F10 · price: This transaction was executed in multiple trades at prices ranging from $277.165 to $278.12. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011880 · form4-12012022_041201.xml · nonDerivative · entry 10

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,413

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F9 · price: This transaction was executed in multiple trades at prices ranging from $276.15 to $277.095. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011880 · form4-12012022_041201.xml · nonDerivative · entry 9

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,751

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F8 · price: This transaction was executed in multiple trades at prices ranging from $275.075 to $275.585. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011880 · form4-12012022_041201.xml · nonDerivative · entry 8

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,299

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F7 · price: This transaction was executed in multiple trades at prices ranging from $273.91 to $274.90. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011880 · form4-12012022_041201.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,548

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F6 · price: This transaction was executed in multiple trades at prices ranging from $272.87 to $273.48. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011880 · form4-12012022_041201.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,740

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F5 · price: This transaction was executed in multiple trades at prices ranging from $271.54 to $272.52. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011880 · form4-12012022_041201.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-22-011880 · form4-12012022_041201.xml · derivative · entry 16

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 856,000

Underlying: Common Stock · 8,000 shares

Expires 2023-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-22-011880 · form4-12012022_041201.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F4 · price: This transaction was executed in multiple trades at prices ranging from $271.07 to $271.39. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011880 · form4-12012022_041201.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 963

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $269.945 to $270.91. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011880 · form4-12012022_041201.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,226

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $268.945 to $269.94. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011880 · form4-12012022_041201.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-22-011821 · form4-11292022_041101.xml · derivative · entry 12

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 864,000

Underlying: Common Stock · 8,000 shares

Expires 2023-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-22-011821 · form4-11292022_041101.xml · nonDerivative · entry 8

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F6 · price: This transaction was executed in multiple trades at prices ranging from $267.41 to $268.28. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011821 · form4-11292022_041101.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 256

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F5 · price: This transaction was executed in multiple trades at prices ranging from $270.32 to $271.30. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011821 · form4-11292022_041101.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,810

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F4 · price: This transaction was executed in multiple trades at prices ranging from $269.288 to $270.28. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011821 · form4-11292022_041101.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-22-011821 · form4-11292022_041101.xml · derivative · entry 11

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 872,000

Underlying: Common Stock · 8,000 shares

Expires 2023-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-22-011821 · form4-11292022_041101.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-22-011821 · form4-11292022_041101.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 204

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $267.30 to $268.16. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011821 · form4-11292022_041101.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,878

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $266.30 to $267.28. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.