UTHR

SEC source: 0001415889-23-001462 · form4-01262023_040101.xml · derivative · entry 14

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 544,000

Underlying: Common Stock · 8,000 shares

Expires 2023-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-001462 · form4-01262023_040101.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F5 · price: This transaction was executed in multiple trades at prices ranging from $260.08 to $260.73. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001462 · form4-01262023_040101.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,200

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F4 · price: This transaction was executed in multiple trades at prices ranging from $259.08 to $260.04. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001462 · form4-01262023_040101.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,280

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $258.05 to $259.04. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001462 · form4-01262023_040101.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,825

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $256.975 to $257.65. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001462 · form4-01262023_040101.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-001372 · form4-01242023_040101.xml · derivative · entry 16

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 552,000

Underlying: Common Stock · 8,000 shares

Expires 2023-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-001372 · form4-01242023_040101.xml · nonDerivative · entry 12

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F11 · price: This transaction was executed in multiple trades at prices ranging from $261.33 to $261.56. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001372 · form4-01242023_040101.xml · nonDerivative · entry 11

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 693

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F10 · price: This transaction was executed in multiple trades at prices ranging from $260.31 to $261.105. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001372 · form4-01242023_040101.xml · nonDerivative · entry 10

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,436

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F9 · price: This transaction was executed in multiple trades at prices ranging from $259.27 to $260.235. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001372 · form4-01242023_040101.xml · nonDerivative · entry 9

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,598

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F8 · price: This transaction was executed in multiple trades at prices ranging from $258.22 to $259.11. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001372 · form4-01242023_040101.xml · nonDerivative · entry 8

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,955

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F7 · price: This transaction was executed in multiple trades at prices ranging from $257.22 to $258.215. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001372 · form4-01242023_040101.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-001372 · form4-01242023_040101.xml · derivative · entry 15

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 560,000

Underlying: Common Stock · 8,000 shares

Expires 2023-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-001372 · form4-01242023_040101.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F6 · price: This transaction was executed in multiple trades at prices ranging from $262.565 to $262.63. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001372 · form4-01242023_040101.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 281

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F5 · price: This transaction was executed in multiple trades at prices ranging from $261.54 to $262.41. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001372 · form4-01242023_040101.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,765

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F4 · price: This transaction was executed in multiple trades at prices ranging from $260.525 to $261.51. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001372 · form4-01242023_040101.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,101

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $259.495 to $260.32. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001372 · form4-01242023_040101.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,144

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $258.49 to $259.415. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001372 · form4-01242023_040101.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-001206 · form4-01192023_040102.xml · derivative · entry 5

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 68,500

Underlying: Common Stock · 6,000 shares

Expires 2026-03-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person.

SEC source: 0001415889-23-001206 · form4-01192023_040102.xml · nonDerivative · entry 4

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,397

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person.

F4 · price: This transaction was executed in multiple trades at prices ranging from $259.86 to $260.075. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001206 · form4-01192023_040102.xml · nonDerivative · entry 3

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,697

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person.

F3 · price: This transaction was executed in multiple trades at prices ranging from $258.73 to $259.64. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001206 · form4-01192023_040102.xml · nonDerivative · entry 2

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,197

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $257.72 to $258.70. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001206 · form4-01192023_040102.xml · nonDerivative · entry 1

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,397

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person.

SEC source: 0001415889-23-001275 · form4-01202023_040101.xml · derivative · entry 14

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 568,000

Underlying: Common Stock · 8,000 shares

Expires 2023-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-001275 · form4-01202023_040101.xml · nonDerivative · entry 10

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-001275 · form4-01202023_040101.xml · nonDerivative · entry 9

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 197

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F8 · price: This transaction was executed in multiple trades at prices ranging from $259.70 to $260.38. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001275 · form4-01202023_040101.xml · nonDerivative · entry 8

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,369

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F7 · price: This transaction was executed in multiple trades at prices ranging from $258.695 to $259.655. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001275 · form4-01202023_040101.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-001275 · form4-01202023_040101.xml · derivative · entry 13

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 576,000

Underlying: Common Stock · 8,000 shares

Expires 2023-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-001275 · form4-01202023_040101.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F6 · price: This transaction was executed in multiple trades at prices ranging from $262.835 to $262.95. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001275 · form4-01202023_040101.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 209

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F5 · price: This transaction was executed in multiple trades at prices ranging from $261.60 to $262.25. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001275 · form4-01202023_040101.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 762

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F4 · price: This transaction was executed in multiple trades at prices ranging from $260.58 to $261.495. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001275 · form4-01202023_040101.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,507

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $259.55 to $260.51. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001275 · form4-01202023_040101.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,978

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $258.55 to $259.545. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001275 · form4-01202023_040101.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-001063 · form4-01182023_040101.xml · derivative · entry 15

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 584,000

Underlying: Common Stock · 8,000 shares

Expires 2023-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-001063 · form4-01182023_040101.xml · nonDerivative · entry 11

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F10 · price: This transaction was executed in multiple trades at prices ranging from $262.66 to $263.55. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001063 · form4-01182023_040101.xml · nonDerivative · entry 10

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 513

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F9 · price: This transaction was executed in multiple trades at prices ranging from $261.365 to $262.175. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001063 · form4-01182023_040101.xml · nonDerivative · entry 9

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,000

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F8 · price: This transaction was executed in multiple trades at prices ranging from $260.345 to $261.215. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001063 · form4-01182023_040101.xml · nonDerivative · entry 8

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,732

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F7 · price: This transaction was executed in multiple trades at prices ranging from $259.315 to $260.29. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001063 · form4-01182023_040101.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-001063 · form4-01182023_040101.xml · derivative · entry 14

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 592,000

Underlying: Common Stock · 8,000 shares

Expires 2023-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-001063 · form4-01182023_040101.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F6 · price: This transaction was executed in multiple trades at prices ranging from $263.69 to $263.97. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001063 · form4-01182023_040101.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 703

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F5 · price: This transaction was executed in multiple trades at prices ranging from $262.655 to $263.635. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001063 · form4-01182023_040101.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,629

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F4 · price: This transaction was executed in multiple trades at prices ranging from $261.60 to $262.49. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001063 · form4-01182023_040101.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,763

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $260.555 to $261.52. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001063 · form4-01182023_040101.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,489

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $259.55 to $260.48. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-001063 · form4-01182023_040101.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.