UTHR

SEC source: 0001415889-23-007302 · form4-05042023_040502.xml · nonDerivative · entry 1

MAHON PAUL A · CIK 0001231589 · EVP & GENERAL COUNSEL

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,599

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of stock options and subsequent sale of shares was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person.

SEC source: 0001415889-23-007229 · form4-05032023_040533.xml · derivative · entry 9

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 8,000 shares

Expires 2023-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-007229 · form4-05032023_040533.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F6 · price: This transaction was executed in multiple trades at prices ranging from $231.695 to $232.08. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007229 · form4-05032023_040533.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 645

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F5 · price: This transaction was executed in multiple trades at prices ranging from $230.40 to $230.96. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007229 · form4-05032023_040533.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,195

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F4 · price: This transaction was executed in multiple trades at prices ranging from $229.21 to $230.205. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007229 · form4-05032023_040533.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,856

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $228.21 to $229.13. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007229 · form4-05032023_040533.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,714

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $227.21 to $228.205. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007229 · form4-05032023_040533.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-007092 · form4-05022023_040501.xml · derivative · entry 14

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,000

Underlying: Common Stock · 8,000 shares

Expires 2023-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-007092 · form4-05022023_040501.xml · nonDerivative · entry 10

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F9 · price: This transaction was executed in multiple trades at prices ranging from $232.37 to $233.245. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007092 · form4-05022023_040501.xml · nonDerivative · entry 9

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,205

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F8 · price: This transaction was executed in multiple trades at prices ranging from $231.345 to $232.34. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007092 · form4-05022023_040501.xml · nonDerivative · entry 8

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,604

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F7 · price: This transaction was executed in multiple trades at prices ranging from $230.33 to $231.32. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007092 · form4-05022023_040501.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,936

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F6 · price: This transaction was executed in multiple trades at prices ranging from $229.225 to $230.17. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007092 · form4-05022023_040501.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-007092 · form4-05022023_040501.xml · derivative · entry 13

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,000

Underlying: Common Stock · 8,000 shares

Expires 2023-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-007092 · form4-05022023_040501.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F5 · price: This transaction was executed in multiple trades at prices ranging from $230.38 to $230.43. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007092 · form4-05022023_040501.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 306

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F4 · price: This transaction was executed in multiple trades at prices ranging from $229.38 to $230.375. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007092 · form4-05022023_040501.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,420

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $228.38 to $229.34. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007092 · form4-05022023_040501.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,178

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $227.285 to $228.275. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007092 · form4-05022023_040501.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-007016 · form4-04282023_040401.xml · derivative · entry 14

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,000

Underlying: Common Stock · 8,000 shares

Expires 2023-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-007016 · form4-04282023_040401.xml · nonDerivative · entry 10

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F9 · price: This transaction was executed in multiple trades at prices ranging from $227.61 to $228.45. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007016 · form4-04282023_040401.xml · nonDerivative · entry 9

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,438

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F8 · price: This transaction was executed in multiple trades at prices ranging from $226.59 to $227.57. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007016 · form4-04282023_040401.xml · nonDerivative · entry 8

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,557

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F7 · price: This transaction was executed in multiple trades at prices ranging from $225.57 to $226.565. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007016 · form4-04282023_040401.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,908

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F6 · price: This transaction was executed in multiple trades at prices ranging from $224.475 to $225.28. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007016 · form4-04282023_040401.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,398

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F5 · price: This transaction was executed in multiple trades at prices ranging from $223.465 to $224.385. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007016 · form4-04282023_040401.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-007016 · form4-04282023_040401.xml · derivative · entry 13

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,000

Underlying: Common Stock · 8,000 shares

Expires 2023-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-007016 · form4-04282023_040401.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F4 · price: This transaction was executed in multiple trades at prices ranging from $226.825 to $227.735. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007016 · form4-04282023_040401.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 638

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $225.79 to $226.745. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007016 · form4-04282023_040401.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,311

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $224.79 to $225.785. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-007016 · form4-04282023_040401.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-006929 · form4-04262023_040401.xml · derivative · entry 16

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 8,000 shares

Expires 2023-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-006929 · form4-04262023_040401.xml · nonDerivative · entry 12

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F11 · price: This transaction was executed in multiple trades at prices ranging from $228.29 to $228.34. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-006929 · form4-04262023_040401.xml · nonDerivative · entry 11

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 312

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F10 · price: This transaction was executed in multiple trades at prices ranging from $227.195 to $228.115. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-006929 · form4-04262023_040401.xml · nonDerivative · entry 10

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,534

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F9 · price: This transaction was executed in multiple trades at prices ranging from $226.195 to $227.185. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-006929 · form4-04262023_040401.xml · nonDerivative · entry 9

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,585

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F8 · price: This transaction was executed in multiple trades at prices ranging from $225.19 to $226.185. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-006929 · form4-04262023_040401.xml · nonDerivative · entry 8

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,765

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F7 · price: This transaction was executed in multiple trades at prices ranging from $224.185 to $225.145. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-006929 · form4-04262023_040401.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-006929 · form4-04262023_040401.xml · derivative · entry 15

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,000

Underlying: Common Stock · 8,000 shares

Expires 2023-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-006929 · form4-04262023_040401.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F6 · price: This transaction was executed in multiple trades at prices ranging from $231.095 to $231.635. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-006929 · form4-04262023_040401.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 755

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F5 · price: This transaction was executed in multiple trades at prices ranging from $230.36 to $230.985. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-006929 · form4-04262023_040401.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,315

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F4 · price: This transaction was executed in multiple trades at prices ranging from $229.07 to $230.30. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-006929 · form4-04262023_040401.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,294

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $228.07 to $228.99. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-006929 · form4-04262023_040401.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,681

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $227.065 to $228.035. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-23-006929 · form4-04262023_040401.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,130

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.

SEC source: 0001415889-23-006806 · form4-04242023_040404.xml · derivative · entry 3

DWEK RAYMOND · CIK 0001231617 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,000 shares

Expires 2023-06-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of share tracking awards was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person. Share tracking awards are non-dilutive cash-settled stock appreciation rights, which may only be settled in cash and may not be converted into shares of common stock.

SEC source: 0001415889-23-006806 · form4-04242023_040404.xml · nonDerivative · entry 2

DWEK RAYMOND · CIK 0001231617 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F1 · kind: This exercise of share tracking awards was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person. Share tracking awards are non-dilutive cash-settled stock appreciation rights, which may only be settled in cash and may not be converted into shares of common stock.

SEC source: 0001415889-23-006806 · form4-04242023_040404.xml · nonDerivative · entry 1

DWEK RAYMOND · CIK 0001231617 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of share tracking awards was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person. Share tracking awards are non-dilutive cash-settled stock appreciation rights, which may only be settled in cash and may not be converted into shares of common stock.

SEC source: 0001415889-23-006805 · form4-04242023_040401.xml · derivative · entry 14

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,000

Underlying: Common Stock · 8,000 shares

Expires 2023-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person. This plan will continue until the earlier of: (a) exhaustion of a tranche of 1,000,000 stock options that expire December 31, 2023; or (b) July 31, 2023.