UTHR

SEC source: 0001415889-24-012192 · form4-05032024_040558.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,492

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F2 · price: This transaction was executed in multiple trades at prices ranging from $238.055 to $238.57. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-012192 · form4-05032024_040558.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,730

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-011870 · form4-05012024_040501.xml · derivative · entry 13

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 288,269

Underlying: Common Stock · 3,600 shares

Expires 2024-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-011870 · form4-05012024_040501.xml · nonDerivative · entry 11

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F9 · price: This transaction was executed in multiple trades at prices ranging from $236.115 to $236.605. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011870 · form4-05012024_040501.xml · nonDerivative · entry 10

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 381

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F8 · price: This transaction was executed in multiple trades at prices ranging from $235.045 to $236.04. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011870 · form4-05012024_040501.xml · nonDerivative · entry 9

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,730

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F7 · price: This transaction was executed in multiple trades at prices ranging from $234.04 to $235.025. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011870 · form4-05012024_040501.xml · nonDerivative · entry 8

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,730

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-011870 · form4-05012024_040501.xml · derivative · entry 12

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 291,869

Underlying: Common Stock · 3,600 shares

Expires 2024-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-011870 · form4-05012024_040501.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F6 · price: This transaction was executed in multiple trades at prices ranging from $240.28 to $240.85. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011870 · form4-05012024_040501.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 383

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F5 · price: This transaction was executed in multiple trades at prices ranging from $239.28 to $240.195. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011870 · form4-05012024_040501.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,115

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F4 · price: This transaction was executed in multiple trades at prices ranging from $238.15 to $239.045. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011870 · form4-05012024_040501.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,821

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F3 · price: This transaction was executed in multiple trades at prices ranging from $237.135 to $238.13. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011870 · form4-05012024_040501.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,417

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F2 · price: This transaction was executed in multiple trades at prices ranging from $236.065 to $237.01. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011870 · form4-05012024_040501.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,695

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-011870 · form4-05012024_040501.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,730

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-011662 · form4-04292024_040402.xml · derivative · entry 11

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 295,469

Underlying: Common Stock · 3,600 shares

Expires 2024-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-011662 · form4-04292024_040402.xml · nonDerivative · entry 9

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-011662 · form4-04292024_040402.xml · nonDerivative · entry 8

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 207

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F7 · price: This transaction was executed in multiple trades at prices ranging from $235.81 to $236.67. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011662 · form4-04292024_040402.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 624

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F6 · price: This transaction was executed in multiple trades at prices ranging from $234.80 to $235.795. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011662 · form4-04292024_040402.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,895

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F5 · price: This transaction was executed in multiple trades at prices ranging from $233.79 to $234.67. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011662 · form4-04292024_040402.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,730

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-011662 · form4-04292024_040402.xml · derivative · entry 10

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 299,069

Underlying: Common Stock · 3,600 shares

Expires 2024-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-011662 · form4-04292024_040402.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F4 · price: This transaction was executed in multiple trades at prices ranging from $236.615 to $237.045. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011662 · form4-04292024_040402.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 471

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F3 · price: This transaction was executed in multiple trades at prices ranging from $235.525 to $236.48. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011662 · form4-04292024_040402.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,674

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F2 · price: This transaction was executed in multiple trades at prices ranging from $234.495 to $235.49. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011662 · form4-04292024_040402.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,730

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-011518 · form4-04252024_040401.xml · derivative · entry 15

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 302,669

Underlying: Common Stock · 3,600 shares

Expires 2024-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-011518 · form4-04252024_040401.xml · nonDerivative · entry 13

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F10 · price: This transaction was executed in multiple trades at prices ranging from $240.14 to $240.88. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011518 · form4-04252024_040401.xml · nonDerivative · entry 12

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 805

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F9 · price: This transaction was executed in multiple trades at prices ranging from $239.05 to $239.985. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011518 · form4-04252024_040401.xml · nonDerivative · entry 11

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,022

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F8 · price: This transaction was executed in multiple trades at prices ranging from $237.97 to $238.83. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011518 · form4-04252024_040401.xml · nonDerivative · entry 10

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,063

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F7 · price: This transaction was executed in multiple trades at prices ranging from $236.96 to $237.94. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011518 · form4-04252024_040401.xml · nonDerivative · entry 9

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,549

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F6 · price: This transaction was executed in multiple trades at prices ranging from $235.33 to $235.335. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011518 · form4-04252024_040401.xml · nonDerivative · entry 8

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,694

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-011518 · form4-04252024_040401.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,730

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-011518 · form4-04252024_040401.xml · derivative · entry 14

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 306,269

Underlying: Common Stock · 3,600 shares

Expires 2024-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-011518 · form4-04252024_040401.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-011518 · form4-04252024_040401.xml · nonDerivative · entry 5

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 219

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F5 · price: This transaction was executed in multiple trades at prices ranging from $237.545 to $238.13. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011518 · form4-04252024_040401.xml · nonDerivative · entry 4

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 584

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F4 · price: This transaction was executed in multiple trades at prices ranging from $236.51 to $237.47. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011518 · form4-04252024_040401.xml · nonDerivative · entry 3

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,409

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F3 · price: This transaction was executed in multiple trades at prices ranging from $235.45 to $236.445. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011518 · form4-04252024_040401.xml · nonDerivative · entry 2

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,194

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F2 · price: This transaction was executed in multiple trades at prices ranging from $234.44 to $235.435. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011518 · form4-04252024_040401.xml · nonDerivative · entry 1

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,730

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-011371 · form4-04232024_040404.xml · derivative · entry 3

DWEK RAYMOND · CIK 0001231617 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,000 shares

Expires 2024-06-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of share tracking awards was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on November 27, 2023. Share tracking awards are non-dilutive cash-settled stock appreciation rights, which may only be settled in cash and may not be converted into shares of common stock.

SEC source: 0001415889-24-011371 · form4-04232024_040404.xml · nonDerivative · entry 2

DWEK RAYMOND · CIK 0001231617 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,750

F1 · kind: This exercise of share tracking awards was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on November 27, 2023. Share tracking awards are non-dilutive cash-settled stock appreciation rights, which may only be settled in cash and may not be converted into shares of common stock.

SEC source: 0001415889-24-011371 · form4-04232024_040404.xml · nonDerivative · entry 1

DWEK RAYMOND · CIK 0001231617 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,750

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise of share tracking awards was pursuant to a Rule 10b5-1 trading plan entered into by the reporting person on November 27, 2023. Share tracking awards are non-dilutive cash-settled stock appreciation rights, which may only be settled in cash and may not be converted into shares of common stock.

SEC source: 0001415889-24-011370 · form4-04232024_040401.xml · derivative · entry 12

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 309,869

Underlying: Common Stock · 3,600 shares

Expires 2024-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

SEC source: 0001415889-24-011370 · form4-04232024_040401.xml · nonDerivative · entry 10

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 130

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F9 · price: This transaction was executed in multiple trades at prices ranging from $238.31 to $238.41. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011370 · form4-04232024_040401.xml · nonDerivative · entry 9

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 274

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F8 · price: This transaction was executed in multiple trades at prices ranging from $237.31 to $238.305. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011370 · form4-04232024_040401.xml · nonDerivative · entry 8

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,156

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F7 · price: This transaction was executed in multiple trades at prices ranging from $236.21 to $237.185. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011370 · form4-04232024_040401.xml · nonDerivative · entry 7

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,875

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F6 · price: This transaction was executed in multiple trades at prices ranging from $235.21 to $236.20. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-24-011370 · form4-04232024_040401.xml · nonDerivative · entry 6

ROTHBLATT MARTINE A · CIK 0001106578 · Director · CHAIRPERSON & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,464

F1 · kind: This exercise and sale of stock options was pursuant to a pre-arranged 10b5-1 trading plan entered into by the reporting person on August 4, 2023. This plan will continue until the earlier of: (a) exhaustion of a tranche of 723,869 stock options that expire December 31, 2024; or (b) August 31, 2024.

F5 · price: This transaction was executed in multiple trades at prices ranging from $233.91 to $234.80. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.