TYRA

SEC source: 0001209191-23-020848 · doc4.xml · nonDerivative · entry 2

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,701,276

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in March 2022.

SEC source: 0001209191-23-020848 · doc4.xml · nonDerivative · entry 1

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,713,669

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-020846 · doc4.xml · derivative · entry 7

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 256,029

Underlying: Common Stock · 14,100 shares

Expires 2030-01-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: 25% of the shares subject to the option vested on January 27, 2021, and 1/48th of the shares subject to the option vest monthly thereafter.

SEC source: 0001209191-23-020846 · doc4.xml · nonDerivative · entry 2

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 527,981

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in March 2022.

SEC source: 0001209191-23-020846 · doc4.xml · nonDerivative · entry 1

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 542,081

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-019793 · doc4.xml · nonDerivative · entry 1

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,701,276

F1 · kind: These shares were acquired under the Issuer's 2021 Employee Stock Purchase Plan.

SEC source: 0001209191-23-019791 · doc4.xml · nonDerivative · entry 1

Tada Hiroomi · CIK 0001880593 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 83,130

F1 · kind: These shares were acquired under the Issuer's 2021 Employee Stock Purchase Plan.

SEC source: 0001209191-23-012330 · doc4.xml · nonDerivative · entry 1

Patel Piyush R. · CIK 0001881246 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 73,794

F1 · kind: Represents shares gifted to a family trust.

SEC source: 0000895345-23-000107 · form4.xml · nonDerivative · entry 2

MVA Investors, LLC · CIK 0001468223 · 10% owner

Davis Aaron I. · CIK 0001465914 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,527

F1 · ownership.direct: These securities are held directly by MVA Investors, LLC ("MVA Investors"), which may be deemed to be a member of a "group" for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, consisting of (i) MVA Investors, (ii) Boxer Capital, LLC, (iii) Boxer Asset Management Inc., (iv) Aaron I. Davis, (v) Joseph C. Lewis and (vi) Siddarth Subramony (collectively, the "Boxer Group"), and indirectly by Mr. Davis who is a member of and has voting and dispositive power over securities held by MVA Investors. Each member of the Boxer Group other than MVA Investors disclaims beneficial ownership of these securities to the extent it or he does not have a pecuniary interest therein.

SEC source: 0000895345-23-000107 · form4.xml · nonDerivative · entry 1

MVA Investors, LLC · CIK 0001468223 · 10% owner

Davis Aaron I. · CIK 0001465914 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 88,095

F1 · ownership.direct: These securities are held directly by MVA Investors, LLC ("MVA Investors"), which may be deemed to be a member of a "group" for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, consisting of (i) MVA Investors, (ii) Boxer Capital, LLC, (iii) Boxer Asset Management Inc., (iv) Aaron I. Davis, (v) Joseph C. Lewis and (vi) Siddarth Subramony (collectively, the "Boxer Group"), and indirectly by Mr. Davis who is a member of and has voting and dispositive power over securities held by MVA Investors. Each member of the Boxer Group other than MVA Investors disclaims beneficial ownership of these securities to the extent it or he does not have a pecuniary interest therein.

SEC source: 0001209191-23-000300 · doc4.xml · derivative · entry 2

Fuhrman Alan · CIK 0001303521 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 328,000

Underlying: Common Stock · 328,000 shares

Expires 2032-12-31

F1 · derivative.exercise_date: 25% of the shares subject to the option shall vest on January 1, 2024, and 1/36th of the remaining number of shares subject to the option vest monthly thereafter, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-23-000300 · doc4.xml · derivative · entry 1

Fuhrman Alan · CIK 0001303521 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,800

Underlying: Common Stock · 32,800 shares

Expires 2032-12-31

F1 · derivative.exercise_date: 25% of the shares subject to the option shall vest on January 1, 2024, and 1/36th of the remaining number of shares subject to the option vest monthly thereafter, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

F2 · derivative.exercise_date: The option vests based on achievement of a performance objective.

SEC source: 0001209191-22-053692 · doc4.xml · nonDerivative · entry 1

Patel Piyush R. · CIK 0001881246 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 82,236

F1 · kind: Represents shares gifted to a family trust.

SEC source: 0001209191-22-050601 · doc4.xml · nonDerivative · entry 1

Patel Piyush R. · CIK 0001881246 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 138,512

F1 · kind: These shares were acquired under the Issuer's 2021 Employee Stock Purchase Plan.

SEC source: 0001209191-22-050612 · doc4.xml · nonDerivative · entry 1

Tada Hiroomi · CIK 0001880593 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 81,237

F1 · kind: These shares were acquired under the Issuer's 2021 Employee Stock Purchase Plan.

SEC source: 0001209191-22-050613 · doc4.xml · nonDerivative · entry 1

van den Boom Esther · CIK 0001603563 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 121,897

F1 · kind: These shares were acquired under the Issuer's 2021 Employee Stock Purchase Plan.

SEC source: 0001209191-22-050599 · doc4.xml · nonDerivative · entry 1

Hudkins Robert L. · CIK 0001880597 · Chief Technology Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 273,576

F1 · kind: These shares were acquired under the Issuer's 2021 Employee Stock Purchase Plan.

SEC source: 0001209191-22-049216 · doc4.xml · derivative · entry 3

Patel Piyush R. · CIK 0001881246 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,924

Underlying: Common Stock · 30,924 shares

Expires 2032-09-05

F3 · derivative.exercise_date: 1/36th of the shares subject to the option vest monthly following September 6, 2022, the vesting commencement date, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-22-049216 · doc4.xml · derivative · entry 2

Patel Piyush R. · CIK 0001881246 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,000

Underlying: Common Stock · 105,000 shares

Expires 2032-09-05

F2 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly following September 6, 2022, the vesting commencement date, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-22-049219 · doc4.xml · derivative · entry 4

van den Boom Esther · CIK 0001603563 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 89,054

Underlying: Common Stock · 89,054 shares

Expires 2032-09-05

F4 · derivative.exercise_date: 1/36th of the shares subject to the option vest monthly following September 6, 2022, the vesting commencement date, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-22-049219 · doc4.xml · derivative · entry 3

van den Boom Esther · CIK 0001603563 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,000

Underlying: Common Stock · 105,000 shares

Expires 2032-09-05

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly following September 6, 2022, the vesting commencement date, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-22-049218 · doc4.xml · derivative · entry 2

Tada Hiroomi · CIK 0001880593 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 110,000

Underlying: Common Stock · 110,000 shares

Expires 2032-09-05

F2 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly following September 6, 2022, the vesting commencement date, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-22-049217 · doc4.xml · derivative · entry 2

Swanson Ronald V. · CIK 0001880662 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,000

Underlying: Common Stock · 105,000 shares

Expires 2032-09-05

F2 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly following September 6, 2022, the vesting commencement date, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-22-049215 · doc4.xml · derivative · entry 2

Hudkins Robert L. · CIK 0001880597 · Chief Technology Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,000

Underlying: Common Stock · 105,000 shares

Expires 2032-09-05

F2 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly following September 6, 2022, the vesting commencement date, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-22-049213 · doc4.xml · derivative · entry 2

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 270,000

Underlying: Common Stock · 270,000 shares

Expires 2032-09-05

F2 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly following September 6, 2022, the vesting commencement date, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-22-049212 · doc4.xml · derivative · entry 2

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 249,532

Underlying: Common Stock · 249,532 shares

Expires 2032-09-05

F2 · derivative.exercise_date: 1/36th of the shares subject to the option vest monthly following September 6, 2022, the vesting commencement date, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-22-049212 · doc4.xml · derivative · entry 1

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,000

Underlying: Common Stock · 105,000 shares

Expires 2032-09-05

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly following September 6, 2022, the vesting commencement date, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-22-036963 · doc4.xml · derivative · entry 1

Simson Jake · CIK 0001863094 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,500

Underlying: Common Stock · 14,500 shares

Expires 2032-06-12

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following June 13, 2022, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

F2 · ownership.direct: Under the Reporting Person's arrangement with RA Capital Management, L.P. (the "Adviser"), the Reporting Person holds the stock option for the benefit of the RA Capital Healthcare Fund, L.P. (the "Fund"), the RA Capital Nexus Fund, L.P. (the "Nexus Fund"), and a separately managed account (the "Account"). The Reporting Person is obligated to turn over to the Adviser any net cash or stock received upon exercise of the stock option, which will offset advisory fees owed by the Fund, the Nexus Fund, and the Account. The Reporting Person therefore disclaims beneficial ownership of the stock option and underlying Common Stock.

SEC source: 0001209191-22-037012 · doc4.xml · derivative · entry 1

Verjee Rehan · CIK 0001880637 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,500

Underlying: Common Stock · 14,500 shares

Expires 2032-06-12

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following June 13, 2022, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-22-036994 · doc4.xml · derivative · entry 1

Subramony Siddarth · CIK 0001880624 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,500

Underlying: Common Stock · 14,500 shares

Expires 2032-06-12

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following June 13, 2022, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

F2 · ownership.direct: These securities are owned directly by the Reporting Person, who may be deemed to be a member of a "group" for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, consisting of (i) Boxer Capital, LLC, (ii) Boxer Asset Management Inc., (iii) MVA Investors, LLC, (iv) Joseph C. Lewis, and (v) the Reporting Person (collectively, the "Boxer Group"). Each member of the Boxer Group other than the Reporting Person disclaims beneficial ownership of these securities to the extent it does not have a pecuniary interest therein.

SEC source: 0001209191-22-036981 · doc4.xml · derivative · entry 1

MORE ROBERT J · CIK 0001207792 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,500

Underlying: Common Stock · 14,500 shares

Expires 2032-06-12

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following June 13, 2022, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-22-036971 · doc4.xml · derivative · entry 1

KAPLAN GILLA · CIK 0001247024 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,500

Underlying: Common Stock · 14,500 shares

Expires 2032-06-12

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following June 13, 2022, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-22-036979 · doc4.xml · derivative · entry 1

Kjellson Nina S · CIK 0001381980 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,500

Underlying: Common Stock · 14,500 shares

Expires 2032-06-12

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following June 13, 2022, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-22-036966 · doc4.xml · derivative · entry 1

CHEN ISAN · CIK 0001586218 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,500

Underlying: Common Stock · 14,500 shares

Expires 2032-06-12

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following June 13, 2022, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001104659-22-071472 · tm2218398-2_4seq1.xml · derivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

RA Capital Nexus Fund, L.P. · CIK 0001780117 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 14,500

Underlying: Common Stock · 14,500 shares

Expires 2032-06-12

F2 · derivative.exercise_date: The option was granted to Mr., Jake Simson, a Partner of the Adviser who serves on the Issuer's board of directors, pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following June 13, 2022, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Mr Simson's continuous service to the Issuer through each vesting date.

F1 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund"), RA Capital Nexus Fund, L.P. (the "Nexus Fund") and a separately managed account (the "Account"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

F2 · ownership.nature: The option was granted to Mr., Jake Simson, a Partner of the Adviser who serves on the Issuer's board of directors, pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following June 13, 2022, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Mr Simson's continuous service to the Issuer through each vesting date.

F3 · ownership.nature: Under Mr. Simson's arrangement with the Adviser, Mr. Simson holds the option for the benefit of the Fund, the Nexus Fund, and the Account. Mr. Simson is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option, which will offset advisory fees owed by the Fund, the Nexus Fund, and the Account to the Adviser. The Reporting Persons therefore disclaim beneficial ownership of the option and underlying common stock except to the extent of their pecuniary interest.

SEC source: 0001209191-22-029441 · doc4.xml · derivative · entry 3

Fawaz Ali D. · CIK 0001928287 · General Counsel and Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 361,586

Underlying: Common Stock · 361,586 shares

Expires 2032-05-15

F2 · derivative.exercise_date: 25% of the shares subject to the option shall vest on May 16, 2023, and 1/36th of the remaining number of shares subject to the option vest monthly thereafter, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-22-029441 · doc4.xml · derivative · entry 2

Fawaz Ali D. · CIK 0001928287 · General Counsel and Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,752

Underlying: Common Stock · 3,752 shares

Expires 2032-05-15

F1 · derivative.exercise_date: The option vests based on achievement of a performance objective.

SEC source: 0001209191-22-029441 · doc4.xml · derivative · entry 1

Fawaz Ali D. · CIK 0001928287 · General Counsel and Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,301

Underlying: Common Stock · 2,301 shares

Expires 2032-05-15

F1 · derivative.exercise_date: The option vests based on achievement of a performance objective.

F2 · derivative.exercise_date: 25% of the shares subject to the option shall vest on May 16, 2023, and 1/36th of the remaining number of shares subject to the option vest monthly thereafter, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-22-049216 · doc4.xml · nonDerivative · entry 1

Patel Piyush R. · CIK 0001881246 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 137,472

F1 · kind: These shares were acquired under the Issuer's 2021 Employee Stock Purchase Plan.

SEC source: 0001209191-22-049219 · doc4.xml · nonDerivative · entry 1

van den Boom Esther · CIK 0001603563 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 120,445

F1 · kind: These shares were acquired under the Issuer's 2021 Employee Stock Purchase Plan.

SEC source: 0001209191-22-049218 · doc4.xml · nonDerivative · entry 1

Tada Hiroomi · CIK 0001880593 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,625

F1 · kind: These shares were acquired under the Issuer's 2021 Employee Stock Purchase Plan.

SEC source: 0001209191-22-049217 · doc4.xml · nonDerivative · entry 1

Swanson Ronald V. · CIK 0001880662 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 273,254

F1 · kind: These shares were acquired under the Issuer's 2021 Employee Stock Purchase Plan.

SEC source: 0001209191-22-049215 · doc4.xml · nonDerivative · entry 1

Hudkins Robert L. · CIK 0001880597 · Chief Technology Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 272,536

F1 · kind: These shares were acquired under the Issuer's 2021 Employee Stock Purchase Plan.

SEC source: 0001209191-22-049213 · doc4.xml · nonDerivative · entry 1

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,699,468

F1 · kind: These shares were acquired under the Issuer's 2021 Employee Stock Purchase Plan.

SEC source: 0000899243-21-049181 · doc4.xml · nonDerivative · entry 1

Boxer Capital, LLC · CIK 0001465837 · 10% owner

Boxer Asset Management Inc. · CIK 0001465836 · 10% owner

LEWIS JOSEPH · CIK 0001015747 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,448,359

F3 · price: Reflects the weighted average purchase price. The reporting person effected multiple same-way open market purchase transactions on the same day at different prices through a trade order executed by a broker dealer. The reporting person hereby undertakes to provide upon request by the Securities and Exchange Commission staff, the issuer, or a shareholder of the issuer, full information regarding the number of shares purchased at each separate price. The range of prices for such transaction is $12.6212 to $13.5758.

F1 · ownership.direct: These securities are owned directly by Boxer Capital, LLC ("Boxer Capital"), which may be deemed to be a member of a "group" for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, consisting of (i) Boxer Capital, (ii) Boxer Asset Management Inc. ("Boxer Management"), (iii) MVA Investors, LLC, (iv) Aaron I. Davis, and (v) Joseph C. Lewis (collectively, the "Boxer Group"). Each member of the Boxer Group other than Boxer Capital disclaims beneficial ownership of these securities to the extent it or he does not have a pecuniary interest therein.

F2 · ownership.direct: These securities are owned indirectly by Boxer Management and Joseph C. Lewis, by virtue of their ownership of Boxer Capital.

SEC source: 0001209191-21-063021 · doc4.xml · derivative · entry 3

Patel Piyush R. · CIK 0001881246 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,964

Underlying: Common Stock · 7,964 shares

Expires 2031-11-01

F2 · derivative.exercise_date: The option vests based on achievement of a performance objective.

SEC source: 0001209191-21-063021 · doc4.xml · derivative · entry 2

Patel Piyush R. · CIK 0001881246 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,964

Underlying: Common Stock · 7,964 shares

Expires 2031-11-01

F2 · derivative.exercise_date: The option vests based on achievement of a performance objective.

SEC source: 0001209191-21-063021 · doc4.xml · derivative · entry 1

Patel Piyush R. · CIK 0001881246 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 83,626

Underlying: Common Stock · 83,626 shares

Expires 2031-11-01

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly following November 2, 2021, the vesting commencement date, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-21-063023 · doc4.xml · derivative · entry 3

van den Boom Esther · CIK 0001603563 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,964

Underlying: Common Stock · 7,964 shares

Expires 2031-11-01

F2 · derivative.exercise_date: The option vests based on achievement of a performance objective.

SEC source: 0001209191-21-063023 · doc4.xml · derivative · entry 2

van den Boom Esther · CIK 0001603563 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,964

Underlying: Common Stock · 7,964 shares

Expires 2031-11-01

F2 · derivative.exercise_date: The option vests based on achievement of a performance objective.