TYRA

SEC source: 0001209191-23-040654 · doc4.xml · derivative · entry 8

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 164,997

Underlying: Common Stock · 17,281 shares

Expires 2030-01-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: 25% of the shares subject to the option vested on January 27, 2021, and 1/48th of the shares subject to the option vest monthly thereafter.

SEC source: 0001209191-23-040654 · doc4.xml · nonDerivative · entry 2

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 527,981

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 7, 2022.

F2 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $16.13 to $17.09. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-040654 · doc4.xml · nonDerivative · entry 1

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 545,262

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-040105 · doc4.xml · derivative · entry 11

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 182,278

Underlying: Common Stock · 13,524 shares

Expires 2030-01-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · derivative.exercise_date: 25% of the shares subject to the option vested on January 27, 2021, and 1/48th of the shares subject to the option vest monthly thereafter.

SEC source: 0001209191-23-040105 · doc4.xml · nonDerivative · entry 8

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 527,981

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 7, 2022.

F6 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $16.50 to $17.09. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-040105 · doc4.xml · nonDerivative · entry 7

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 541,505

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-040105 · doc4.xml · derivative · entry 10

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 195,802

Underlying: Common Stock · 16,028 shares

Expires 2030-01-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · derivative.exercise_date: 25% of the shares subject to the option vested on January 27, 2021, and 1/48th of the shares subject to the option vest monthly thereafter.

SEC source: 0001209191-23-040105 · doc4.xml · nonDerivative · entry 6

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 527,981

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 7, 2022.

F5 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $17.02 to $17.20. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-040105 · doc4.xml · nonDerivative · entry 5

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 536,116

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 7, 2022.

F4 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $16.01 to $17.01. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-040105 · doc4.xml · nonDerivative · entry 4

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 544,009

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-040105 · doc4.xml · derivative · entry 9

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 211,830

Underlying: Common Stock · 17,232 shares

Expires 2030-01-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · derivative.exercise_date: 25% of the shares subject to the option vested on January 27, 2021, and 1/48th of the shares subject to the option vest monthly thereafter.

SEC source: 0001209191-23-040105 · doc4.xml · nonDerivative · entry 3

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 527,981

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 7, 2022.

F3 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $17.02 to $17.69. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-040105 · doc4.xml · nonDerivative · entry 2

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 534,351

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 7, 2022.

F2 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $16.01 to $17.005. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-040105 · doc4.xml · nonDerivative · entry 1

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 545,213

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-039807 · doc4.xml · nonDerivative · entry 4

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,601,276

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F5 · price: Represents the weighted average sale price for the entire number of shares sold within a one dollar price range. The actual sale prices range between $17.41 to $17.75. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-039807 · doc4.xml · nonDerivative · entry 3

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,607,757

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F4 · price: Represents the weighted average sale price for the entire number of shares sold within a one dollar price range. The actual sale prices range between $16.335 to $17.195. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-039807 · doc4.xml · nonDerivative · entry 2

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,621,988

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F3 · price: Represents the weighted average sale price for the entire number of shares sold within a one dollar price range. The actual sale prices range between $17.35 to $17.42. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-039807 · doc4.xml · nonDerivative · entry 1

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,622,488

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F2 · price: Represents the weighted average sale price for the entire number of shares sold within a one dollar price range. The actual sale prices range between $16.29 to $17.29. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-038945 · doc4.xml · nonDerivative · entry 7

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,625,466

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F8 · price: Represents the weighted average sale price for the entire number of shares sold within a one dollar price range. The actual sale prices range between $18.11 to $18.395. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-038945 · doc4.xml · nonDerivative · entry 6

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,626,566

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F7 · price: Represents the weighted average sale price for the entire number of shares sold within a one dollar price range. The actual sale prices range between $17.075 to $18.035. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-038945 · doc4.xml · nonDerivative · entry 5

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,640,593

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F6 · price: Represents the weighted average sale price for the entire number of shares sold within a one dollar price range. The actual sale prices range between $16.00 to $16.905. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-038945 · doc4.xml · nonDerivative · entry 4

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,645,222

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F5 · price: Represents the weighted average sale price for the entire number of shares sold within a one dollar price range. The actual sale prices range between $16.04 to $16.82. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-038945 · doc4.xml · nonDerivative · entry 3

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,646,522

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F4 · price: Represents the weighted average sale price for the entire number of shares sold within a one dollar price range. The actual sale prices range between $18.00 to $19.00. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-038945 · doc4.xml · nonDerivative · entry 2

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,647,122

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F3 · price: Represents the weighted average sale price for the entire number of shares sold within a one dollar price range. The actual sale prices range between $17.00 to $17.98. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-038945 · doc4.xml · nonDerivative · entry 1

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,697,960

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F2 · price: Represents the weighted average sale price for the entire number of shares sold within a one dollar price range. The actual sale prices range between $16.00 to $16.97. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-037613 · doc4.xml · derivative · entry 6

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 376,837

Underlying: Common Stock · 12,773 shares

Expires 2031-03-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly following March 5, 2021, the vesting commencement date.

SEC source: 0001209191-23-037613 · doc4.xml · nonDerivative · entry 4

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,701,276

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in March 2022.

F3 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $16.00 to $16.60. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-037613 · doc4.xml · nonDerivative · entry 3

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,714,049

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-037611 · doc4.xml · derivative · entry 9

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 229,062

Underlying: Common Stock · 12,592 shares

Expires 2030-01-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: 25% of the shares subject to the option vested on January 27, 2021, and 1/48th of the shares subject to the option vest monthly thereafter.

SEC source: 0001209191-23-037611 · doc4.xml · nonDerivative · entry 6

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 527,981

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in March 2022.

F3 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $16.00 to $16.64. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-037611 · doc4.xml · nonDerivative · entry 5

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 540,573

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-037611 · doc4.xml · derivative · entry 8

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 241,654

Underlying: Common Stock · 120 shares

Expires 2030-01-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: 25% of the shares subject to the option vested on January 27, 2021, and 1/48th of the shares subject to the option vest monthly thereafter.

SEC source: 0001209191-23-037611 · doc4.xml · nonDerivative · entry 4

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 527,981

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in March 2022.

SEC source: 0001209191-23-037611 · doc4.xml · nonDerivative · entry 3

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 528,101

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-037613 · doc4.xml · derivative · entry 5

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 389,610

Underlying: Common Stock · 7,927 shares

Expires 2031-03-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly following March 5, 2021, the vesting commencement date.

SEC source: 0001209191-23-037613 · doc4.xml · nonDerivative · entry 2

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,701,276

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in March 2022.

F2 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $16.00 to $16.05. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-037613 · doc4.xml · nonDerivative · entry 1

Harris Todd · CIK 0001711463 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,709,203

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-037611 · doc4.xml · derivative · entry 7

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 241,774

Underlying: Common Stock · 5,628 shares

Expires 2030-01-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: 25% of the shares subject to the option vested on January 27, 2021, and 1/48th of the shares subject to the option vest monthly thereafter.

SEC source: 0001209191-23-037611 · doc4.xml · nonDerivative · entry 2

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 527,981

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in March 2022.

F2 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $16.00 to $16.38. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001209191-23-037611 · doc4.xml · nonDerivative · entry 1

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 533,609

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-033780 · doc4.xml · derivative · entry 1

Simson Jake · CIK 0001863094 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,500

Underlying: Common Stock · 14,500 shares

Expires 2033-05-30

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following May 31, 2023, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

F2 · ownership.direct: Under the Reporting Person's arrangement with RA Capital Management, L.P. (the "Adviser"), the Reporting Person holds the stock option for the benefit of the RA Capital Healthcare Fund, L.P. (the "Fund"), the RA Capital Nexus Fund, L.P. (the "Nexus Fund"), and a separately managed account (the "Account"). The Reporting Person is obligated to turn over to the Adviser any net cash or stock received upon exercise of the stock option, which will offset advisory fees owed by the Fund, the Nexus Fund, and the Account. The Reporting Person therefore disclaims beneficial ownership of the stock option and underlying Common Stock.

SEC source: 0001209191-23-033788 · doc4.xml · derivative · entry 1

KAPLAN GILLA · CIK 0001247024 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,500

Underlying: Common Stock · 14,500 shares

Expires 2033-05-30

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following May 31, 2023, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-23-033769 · doc4.xml · derivative · entry 1

CHEN ISAN · CIK 0001586218 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,500

Underlying: Common Stock · 14,500 shares

Expires 2033-05-30

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following May 31, 2023, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-23-033786 · doc4.xml · derivative · entry 1

Verjee Rehan · CIK 0001880637 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,500

Underlying: Common Stock · 14,500 shares

Expires 2033-05-30

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following May 31, 2023, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-23-033779 · doc4.xml · derivative · entry 1

Subramony Siddarth · CIK 0001880624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,500

Underlying: Common Stock · 14,500 shares

Expires 2033-05-30

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following May 31, 2023, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

F2 · ownership.direct: These securities are owned directly by the Reporting Person, who may be deemed to be a member of a "group" for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, consisting of (i) Boxer Capital, LLC, (ii) Boxer Asset Management Inc., (iii) MVA Investors, LLC, (iv) Joseph C. Lewis, and (v) the Reporting Person (collectively, the "Boxer Group"). Each member of the Boxer Group other than the Reporting Person disclaims beneficial ownership of these securities to the extent it does not have a pecuniary interest therein.

SEC source: 0001104659-23-067591 · tm2317680-1_4seq1.xml · derivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

RA Capital Nexus Fund, L.P. · CIK 0001780117 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 14,500

Underlying: Common Stock · 14,500 shares

Expires 2033-05-30

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following May 31, 2023, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

F1 · ownership.nature: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following May 31, 2023, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

F2 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund"), RA Capital Nexus Fund, L.P. (the "Nexus Fund") and a separately managed account (the "Account"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

F3 · ownership.nature: Under Mr. Simson's arrangement with the Adviser, Mr. Simson holds the option for the benefit of the Fund, the Nexus Fund, and the Account. Mr. Simson is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option, which will offset advisory fees owed by the Fund, the Nexus Fund, and the Account to the Adviser. The Reporting Persons therefore disclaim beneficial ownership of the option and underlying common stock except to the extent of their pecuniary interest.

SEC source: 0001209191-23-033775 · doc4.xml · derivative · entry 1

MORE ROBERT J · CIK 0001207792 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,500

Underlying: Common Stock · 14,500 shares

Expires 2033-05-30

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following May 31, 2023, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-23-033774 · doc4.xml · derivative · entry 1

Kjellson Nina S · CIK 0001381980 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,500

Underlying: Common Stock · 14,500 shares

Expires 2033-05-30

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following May 31, 2023, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0001209191-23-022432 · doc4.xml · derivative · entry 9

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 229,421

Underlying: Common Stock · 2,000 shares

Expires 2031-03-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: 25% of the shares subject to the option vested on January 27, 2021, and 1/48th of the shares subject to the option vest monthly thereafter.

SEC source: 0001209191-23-022432 · doc4.xml · nonDerivative · entry 6

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 527,981

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in March 2022.